| abstract |
The present invention relates to compounds of general formula (I), wherein R 1 , R 2 and R 3 are defined herein, which compounds are useful as inhibitors of protein kinases, especially FMS-like tyrosine kinase 3 (FLT3) inhibitors agent. The present invention also relates to the use of said compound in therapy, the pharmaceutical composition comprising said compound, and the preparation of said compound for medicine, wherein said medicine is used to prevent or treat malignant hematological diseases (such as AML, MLL , T-ALL, B-ALL, and CMML), myeloproliferative diseases, other proliferative diseases (such as cancer), autoimmune diseases, and skin diseases (such as psoriasis and atopic dermatitis). |