| abstract |
1492997 Insulin derivatives NATIONAL RESEARCH DEVELOPMENT CORP 21 July 1976 [28 July 1975] 31475/75 Addition to 1408757 Heading A5B [Also in Division C3] A pharmaceutical composition comprises an N - substituted insulin wherein the primary amino group of the B 29 (lysine) amino acid unit carries a carbamoyl group, N - substitution being absent from the primary group of the A 1 (glycine) and B 1 (phenylalanine) amino acid units, together with a physiologically - acceptable diluent or carrier. The composition is preferably in a form for parenteral administration and the preferred compound is B 29 (lysine) - N - carbamylinsulin. |