http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3301086-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e04a9c30b01a6909696dc92e883f241c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 |
| filingDate | 2012-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f050415c7e461d504e594635aed78c9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_931a6cf7fc852fe521cefdf86a9f61a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b44db5f970986c78667d5bdfc4969f33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c415c75bff687ff875c049f5274292f8 |
| publicationDate | 2018-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3301086-A1 |
| titleOfInvention | Production of a composition containing a complex between a membrane composed of a lipid monolayer and a nucleic acid, and, a lipid membrane for encapsulating the complex therein |
| abstract | The present invention relates to a method for producing a composition containing a complex between a membrane composed of a lipid monolayer (reversed micelle) and a nucleic acid, and a lipid membrane for encapsulating the complex therein, comprising the following steps A to D: nStep A: preparing a complex between the nucleic acid and a liposome comprising a cationic lipid represented by the formula (I) and/or a cationic lipid other than cationic lipid represented by the formula (I); nStep B: preparing a dispersion liquid by dispersing the complex in water or ethanol aqueous solution; nStep C: preparing a solution by dissolving the formula (I) and/or the cationic lipid other than cationic lipid represented by the formula (I) in ethanol or an ethanol aqueous solution; and nStep D: mixing the dispersion liquid and the solution, and optionally adding water; nwherein the formula (I) isn n(wherein: nR 1 and R 2 are, the same or different, each linear or branched alkyl, alkenyl or alkynyl having 12 to 24 carbon atoms, nX 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, nX 3 is absent or is alkyl having 1 to 6 carbon atoms, or alkenyl having 3 to 6 carbon atoms, nwhen X 3 is absent, nY is absent, a and b are 0, L 3 is a single bond, R 3 is alkyl having 1 to 6 carbon atoms, alkenyl having 3 to 6 carbon atoms, or alkyl having 1 to 6 carbon atoms or alkenyl having 3 to 6 carbon atoms substituted with 1 to 3 substituent(s), which is(are), the same or different, amino, monoalkylamino, dialkylamino, trialkylammonio, hydroxy, alkoxy, carbamoyl, monoalkylcarbamoyl, or dialkylcarbamoyl, and L 1 and L 2 are -O-, nY is absent, a and b are, the same or different, 0 to 3, and are not 0 at the same time, L 3 is a single bond, R 3 is alkyl having 1 to 6 carbon atoms, alkenyl having 3 to 6 carbon atoms, or alkyl having 1 to 6 carbon atoms or alkenyl having 3 to 6 carbon atoms substituted with 1 to 3 substituent(s), which is(are), the same or different, amino, monoalkylamino, dialkylamino, trialkylammonio, hydroxy, alkoxy, carbamoyl, monoalkylcarbamoyl, or dialkylcarbamoyl, L 1 and L 2 are, the same or different, -O-, -CO-O- or -O-CO-, nY is absent, a and b are, the same or different, 0 to 3, L 3 is a single bond, R 3 is a hydrogen atom, and L 1 and L 2 are, the same or different, -O-, -CO-O- or -O-CO-, or nY is absent, a and b are, the same or different, 0 to 3, L 3 is -CO- or -CO-O-, R 3 is alkyl having 1 to 6 carbon atoms or alkenyl having 3 to 6 carbon atoms substituted with 1 to 3 substituent(s), which is(are), the same or different, amino, monoalkylamino, dialkylamino, trialkylammonio, hydroxy, alkoxy, carbamoyl, monoalkylcarbamoyl, or dialkylcarbamoyl, wherein at least one of the substituents is amino, monoalkylamino, dialkylamino, or trialkylammonio, and L 1 and L 2 are , the same or different, -O-, -CO-O- or -O-CO-, and nwhen X 3 is alkyl having 1 to 6 carbon atoms or alkenyl having 3 to 6 carbon atoms, Y is a pharmaceutically acceptable anion, a and b are, the same or different, 0 to 3, L 3 is a single bond, R 3 is alkyl having 1 to 6 carbon atoms, alkenyl having 3 to 6 carbon atoms, L 1 and L 2 are, the same or different, -O-, -CO-O- or -O-CO-). |
| priorityDate | 2011-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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