| abstract |
The present invention provides a transgenic rodent, wherein the genome of said rodent comprising the mutant of NGF-β gene, said rodent expressing the mutein of NGF-β. The present invention also provides the method for obtaining the transgenic rodent, and the methods of preparing the corresponding mutein of mutant NGF-β gene, and the protein obtained using this method. The present invention provides a new way to produce human NGF, and exploit a new way to investigate the function of Mutant NGF-β and its receptor in the level of whole animal, and to screen and purify the mutant NGF-β of high activity and safety. |