| abstract |
The present invention provides compounds representednby formula (I) and pharmaceutically acceptable salts andnsolvates thereof:n nwherein X represents CH or N; Z represents -O-, -NH- or -nC(=O)-; R and R' represent a hydrogen atom, hydroxyl, anhalogen atom, optionally substituted alkyl, optionallynsubstituted alkenyl optionally substituted alkoxy, amino,naminocarbonyl, or an optionally substituted heterocyclic group;nand A represents an optionally substituted specific carbocyclicnor heterocyclic group. The compounds according to the presentninvention have excellent TGFβ inhibitory activity. |