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filingDate 2002-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdb046ab51f01cf6a17dbbbbc0e5f12b
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publicationDate 2004-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1380644-A1
titleOfInvention The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role
abstract The present invention relates to the use ofninhibitors of the expressed proteins of TCF target genesnwhose expression is regulated by TCF/β-catenin complexesnfor the preparation of a therapeutical composition for thentreatment of cancers in which TCF/β-catenin signaling isnderegulated. Such inhibitors can be antibodies, smallnmolecules, antisense RNA and dsRNA for use in RNAi. Theninvention also relates to these inhibitors per se .
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