| abstract |
Compounds of the general formula (I) which are metabolically stablenand have an antagonistic activity against PGD 2 receptor:n nwherein Y is bicyclic ring; R 1 is optionally substituted heteroaryl;nR 2 is hydrogen, etc.; R 3 is -CH 2 -CH 2 -CH 2 -CH 2 -CH=CH-COOR 4 , -CH 2 -CH 2 -CH 2 -CH 2 -X 1 -CH 2 -COOR 4 ,n-CH 2 -CH=CH-CH 2 -X 1 -CH 2 -COOR 4 or -CH 2 -CH 2 -CH 2 -CH 2 -COOR 4 ;nR 4 is hydrogen, etc.; X 1 is -O-, etc. |