| abstract |
A compound of the formula (I):n nwherein A is alkylene optionally having an unsaturated bond; R is -C(=O)-R 1 ;nR 1 is hydroxy or the like; m is 0 or 1; p is 0 or 1; X 1 and X 3 are eachnindependently optionally substituted aryl or optionally substituted heteroarylnor the like; X 2 is a bond, -CH 2 -, -S-, -SO 2 -, -CH 2 -O-, -O-CH 2 -, -CH 2 -S-, -S-CH 2 -,nor the like; X 4 is -CH 2 -, -CH 2 -CH 2 -, -C(=O)-, or the like, nhaving a dual antagonistic activity against both a thromboxane A 2 receptornand a prostaglandin D 2 receptor is found. |