| abstract |
A compound, pharmaceutically acceptable salt thereof, or hydrate thereofnhaving a PGD 2 -antagonistic activity, and an inhibitory activity against infiltration ofneosinophils, useful for treating mast cell dysfunction-associated diseases, such asnsystemic mastocytosis and disorder of systemic mast cell activation, as well asntracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria,nischemic reperfusion injury, inflammation and atopic dermatitis, which is shown bynthe formula (I):n nis provided. |