| abstract |
Antisense oligonucleotides comprising a nucleotide sequencencomplementary to the nucleotide sequence of SEQ ID NO:1 or NO:2 are disclosed.nThe antisense oligonucleotides are used for treatment of specific types of Duchennenmuscular dystrophy which is attributed to a change in number of the nucleotidesncomposing one or more exons adjacent to exon 43 or 53, respectively, in humanndystrophin mRNA, wherein said change is due to deletion of one or more nucleotidesnfrom the normal nucleotide sequence for said exons, wherein the net of said changenin number of the nucleotides is expressed as a reduction of (3×N+1) nucleotides,nwherein N is zero or a natural number. |