| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25e70f1d04d1fdffca0a301d73478008 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate |
2000-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_deca65af6c0d348239755e8b65afc5db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac61ab5f1524834f2978290ebfd9d058 |
| publicationDate |
2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1130031-A1 |
| titleOfInvention |
Method for inhibiting angiogenesis using molecules that enhance plasmin formation or prolong plasmin activity |
| abstract |
Angiogenesis, the generation of new blood vessels, is a complex process that isncontrolled by a multitude of factors such as the extracellular matrix, componentsnof the blood clotting system and angiogenic factors. The formation of bloodnvessels is accompanied by the formation of a so-called provisional matrix.nEndothelial cells use the provisional matrix, among others, as a substrate fornadhesion, migration and invasion. The provisional matrix is continuously buildnup and broken down until the new vessel is properly formed. This remodeling ofnthe provisional matrix is regulated by the balanced action of various proteins. Ankey protein in the remodeling of the provisional matrix is the serine proteasenplasmin. The present invention provides means and methods based onnproteinaceous molecules that enhance or sustain levels of plasmin near or at thensite of unwanted angiogenesis through activation off plasminogen through tissuenplasminogen activator. Through the means and methods of the invention thenremodeling process of the provisional matrix can be tailored toward specificnneeds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1380290-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8114832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8158585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004004698-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004004698-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067187-B2 |
| priorityDate |
2000-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |