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filingDate 1998-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbe8c3fdaa68040908643674ad0fc859
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publicationDate 1999-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0891783-A1
titleOfInvention Device for tissue engineering bone comprising biodegradable thermoplastic copolyester and cultured cells
abstract A device for bone tissue engineering is described which comprises anscaffold material consisting of a bioactive, osteoconductive and bone-bondingnsegmented thermoplastic copolyester and cultured osteogenicnor osteoprogenitor cells, especially bone cells. The copolyester consistsnessentially of a multiplicity of recurring long-chain ester units andnshort-chain ester units, the long-chain ester units comprising from 35nto 80% by weight of the copolyester and being represented by thenformulan -OLO-CO- or -OLO-CO-R-CO- nand the short-chain ester units being represented by the formulan -OEO-CO-R-CO- and/or -O-Q-CO- nwhereinn L is a divalent group remaining after removal of terminalnhydroxyl groups from a poly(oxyalkylene) glycol with annaverage molecular weight of between 300 and 3000; R is a divalent group remaining after removal of carboxyl groupsnfrom a dicarboxylic acid having a molecular weight of lessnthan 300; Q is an alkylene group having 1-6 carbon atoms and/or ancyclohexylene of phenylene group; and E is an alkylene group having 2-6 carbon atoms.
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