| abstract |
A piperidine derivative of formula (1) or salts thereof:n wherein R 1 and R 2 independently represent H or together represent O, R 3 represents H, -R 5 -COOR 6 , or -COOR 6 (wherein R 5 is a lower alkylene group, -CONH-, or -CONHCH 2 , and R 6 is H or a lower alkyl group), R 4 represents H, an aralkyloxy carbonyl group, an aminomethyl carbonyl group, or an aralkyloxy carbonyl aminomethyl carbonyl group, A represents O or a double bond, and the broken line has the meaning that a bonding hand may be present; and preventive and therapeutic agents for allergies, antihistaminic agents, and antileucotriene agents comprising the derivative or salts as their effective component. n The compound of formula (1) has excellent antihistaminic activities and antileukotriene activities, which are well balanced, and is useful as a drug for the prevention and treatment of allergies such as asthma, allergic rhinitis, allergic dermatosis and urticaria. |