| abstract |
Piperidine derivatives of general formula (I) or pharmaceutically acceptable salts thereof are useful in the manufacture of a medicament for use as a serotonin antagonist:n n wherein A¹ represents an unsubstituted or substituted pyridyl, piperidyl, piperidino, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino or piperazinyl group, a substituted alkyl group having from 1 to 8 carbon atoms, a substituted cycloalkyl group having from 4 to 8 carbon atoms, or an unsubstituted or substituted alkoxyl group having 1 to 8 carbon atoms, nX¹ represents a hydrogen atom or a halogen atom, nY¹ represents one of the organic groups: n-CONH-, -NHCO-, -CONHCH₂-, -(CH₂) n -, -COO-, nwherein n is an integer of from 0 to 4, and nZ¹ represents one of the organic groups: n-CH=CH-, -S-CH₂-, -S-, -CH₂-CH₂-. |