| abstract |
Compounds of formula (I):n n[in which: R 1 and R 2 are each hydrogen or alkyl, orntogether a group of formula -(CH 2 ) k - in which k isnan integer; R 3 is hydrogen, alkyl, alkoxy, halogen ornhydroxy; A and B are each hydrogen, alkyl, aralkyl,naliphatic carboxylic acyl, aryl-substituted aliphaticncarboxylic acyl, aromatic carboxylic acyl or carbamoyl,nor A and B together represent >C=O, >C=S,n-C(=O)-C(=O)-, -CH 2 C(=O)-, -CH 2 CH 2 -, -SO 2 - orn-CH 2 SO 2 -; X is a group of formula: nW-(CH 2 ) m -X 1 - in which W is aryl or heterocyclic,nX 1 is a single bond, oxygen, sulphur or >NR 4 innwhich R 4 is hydrogen, alkyl, aralkyl or aryl, and m isn0 or an integer; Y is a group of formula: n-(CH 2 ) n -Y 1 -, in which Y 1 is a single bond,noxygen or sulphur, and n is an integer; Z is a group ofnformula (i), (ii), (iii), (iv), (v) or (vi): n n n n in which R 5 is hydrogen, carboxyalkyl,nalkanoyloxyalkyl, cycloalkyl-substitutednalkanoyloxyalkyl, cycloalkylcarbonyloxyalkyl,nalkoxycarbonyloxyalkyl, cycloalkyl-substitutednalkoxycarbonyloxyalkyl or cycloalkyloxycarbonyloxyalkylngroup]; nand salts, esters and solvates thereof and pro-drugsntherefor are useful for the treatment and/or prophylaxisnof a variety of disorders, including one or more of:nhyperlipemia, hyperglycemia, obesity, glucose toleranceninsufficiency, insulin resistance and diabeticncomplications. |