| abstract |
The present invention provides Indole derivatives represented by the formula (I)n n wherein R¹, R² and R³ independently represent hydrogen or lower alkyl; nR⁴ represents hydrogen, lower alkyl or cycloalkyl; nR⁵ represents hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, -CHR⁷R⁸ where R⁷ and R⁸ independently represent hydrogen, alkyl, alkenyl, alkynyl, substituted or unsubstituted cycloalkyl, -(CH₂) m OR⁹ (wherein m is an integer of 1 - 3 and R⁹ is lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, or substituted or unsubstituted thienyl],n n (wherein p is an integer of 1 - 3) orn n (wherein Y is CH₂, O, S, CH₂-CH₂, CH=C, CH₂-O or CH₂-S); nR⁶ represents hydrogen, lower alkyl or lower alkoxy or halogen; nX represents O or S(O)q (wherein q is an integer of 0-2); nand n represents an integer of 1-6} or pharmaceutically acceptable salts thereof. n The compound shows prominent inhibition effects on steroid 5 α-reductase activity, and are useful in treating benign prostatic hypertrophy, prostate cancer, baldness and acne. |