| abstract |
A benzoylaminophenoxybutanoic acid derivative of general formula:n [wherein A represents oxygen, sulfur or sulfinyl, R¹ represents hydrogen or methyl, R² represents a group of the general formula:n [wherein nB represents oxygen, sulfur nor NR˝ (wherein R˝ represents hydrogen or alkyl, R³, R⁴, R⁵, R⁶, R⁷ and R⁸ represent independently, hydrogen, alkyl, halogen or trifluoromethyl, m represents 0 or 1, n is from 1 to 4, and R⁹ and R¹⁰ represent, independently, hydrogen, alkyl, optionally substituted phenylalkyl, optionally substituted benzoyl or tetrahydronaphthyl, with the proviso that R⁹ and R¹⁰ do not simultaneously represent hydrogen or non-toxic salts thereof, possess inhibitory activity on 5α-reductase, which is indicative of utility in treating and/or preventing alopecia, acne or prostatic hypertrophy. |