| abstract |
A cinnamoylamide derivative of the general formula:n [wherein,n (i) R¹, R² and R³, which may be the same or different, each represents a halogen atom, a straight-chain or branched-chain alkoxy group of from 1 to 7 carbon atom(s), a straight-chain or branched-chain alkyl group of from 1 to 7 carbon atom(s) or a nitro group, and one of R⁴ and R⁵ represents a methyl group and the other represents a hydrogen atom, or (ii) one of R¹, R² and R³ represents 4-isobutyl, 4-butyl, 4-propyl, 4-butoxy or 4-sec-butyl, and the other two each represent a hydrogen atom, R⁴ represents a methyl group and R⁵ represents a hydrogen atom] and non-toxic salts thereof possess inhibitory activity on 5α-reductase, indicative of utility for treating and/or preventing alopecia, acne or prostatic hypertropy. |