| abstract |
A peptide of the formula: nR a -Ser-Thr-Thr-Thr-Asn-Tyr-R b (I) nwhere R a represents an amino terminal residue Ala- or D-Ala and R b represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II):- nR¹-R²-R³-R⁴-R⁵ (II) nwhere R¹ is an amino terminal residue Thr-, Ser-, Asn-,Leu-,Ile-,Arg- or Glu- nR² is Thr, Ser or Asp nR³ is Thr, Ser, Asn, Arg, Gln, Lys or Trp nR⁴ is Tyr nand R⁵ is a carboxy terminal amino group or a derivative thereof with a corresponding D- amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals, or a physiologically acceptable salt thereof. |