| abstract |
The present invention relates to an anti-HIV composition and to its method of manufacture.The composition of the present invention comprises a polyanion and a molecule capable of inducing the exposure of the CD4i epitope of the viral protein gp120. The polyanion can be chosen, for example, from the group consisting of heparin, heparan sulfate, and a polyanion equivalent to heparin or heparan sulfate. The molecule capable of inducing exposure of the CD4i epitope of the viral protein gp120 is a CD4 peptide or a derivative thereof. The present invention also relates to the use of said composition for the manufacture of a medicament, in particular of a medicament intended for the treatment of AIDS. |