| abstract |
2- (pyridyl and imidazolyl) indoles of formula 1 wherein R 1 is hydrogen or lower alkyl, Ar in each case represents 3-pyridyl or 1-imidazolyl which is unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl. R 2 and R 3 independently of one another are hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, carboxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, carboxy, lower alkoxycarbonyl or lower alkyl- (thio, sulfinyl or sulfonyl), or R 2 and R 3 together, on adjacent ones Are carbon atoms, lower alkylenedioxy;n n n A alkylene having 3 to 12 carbon atoms, the number of carbon atoms between the indole and group B being 3 to 12, alkenylene or alkynylene each having 2 to 12 carbon atoms, lower alkylenephenylene-lower (alkylene or alkenylene), lower alkylene-phenylene, Lower alkylene (thio or oxy) lower alkylene, lower alkylene (thio or oxy) phenylene or lower alkylene phenylene (thio or oxy) lower alkylene and B is carboxy, esterified carboxy, carbamoyl, mono- or di-lower alkylcarbamoyl, hydroxymethyl, cyano, hydroxycarbamoyl , 5-tetrazolyl or formyl; their imidazolyl or pyridyl N-oxides, and their sets inhibit thromboxane synthetase. They are manufactured in a manner known per se. |