| abstract |
Compounds of the formufa:n whereinn R 1 , which is attached to a carbon atom of ring "B", is hydrogen, halo, C,-C, alkyl, or -S(C 1 -C 4 alkyl); Y. which is attached to ring "A", is -CN, -COOH, -COO(C 1 -C 4 aikyl) or -CONH 2 : X is O, S. NH, N(C,-C, alkyl) or -CH=CH; and R. which is attached to a carbon atom of ring "8", is a group of the formula:n where Z is -CH 2 -, -CH=CH-, -OCH 2 -, -CO- or -S-: and the pharmaceuticaliv. acceptable salts thereof. n The compounds in which Y is -COOH, -CCO(C 1 -C 4 alkyl) and -CONH 2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates. |