| abstract |
Heterocyclic thromboxane synthetase inhibitors of the formula:-n wherein R', which is attached to the 2-, 3- or 4- position, is hydrogen, halogen, C 1 -C 4 alkyl, hydroxy or C 1 -C 4 alkoxy;n Y, which is attached to the 2- or 3-position, is -COOH, -COO(C 1 -C 4 alkyl) or-CONH 2 ; X is O, S, NH. N(C 1 -C 4 alkyl) or N(benzyi): and R. which is attached to the 5-, 6- or 7-position, is a group of the formula:-n or/3-or 4- pyridyl)-Z 2- whereinZ' is.CH 2 .,-CH 2 CH 2 -or-CH 2 CH 2 O. and Z 2 is-CH 2 .,-CH 2 CH 2 -.-CH=CH--CH 2 O-or-OCH 2 -: and their pharmaceutically acceptable satts; processes for their preparation, and pharmaceutical compositions containing them. |