| abstract |
The compounds of the formula:n and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof wherein R' is a hydrogen atom or a group selected from OH, OSO 3 H or a pharmaceutically acceptable salt or C 1-4 alkyl ester thereof, OR 2 , SR 3 , OCOR 2 , OCO 2 R 3 or OCONHR 3 , where R 2 is a C 1-6 alkyl group or an optionally substituted benzyl group and R 3 is a C 1-6 alkyl group or an optionally substituted benzyl or an optionally substituted phenyl group; and R 22 is a hydrogen atom, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 alkynyl wherein the triple bond is not present on the carbon adjacent to the sulphur atom, aralkyl, C 1-6 alkanoyl, aralkanoyl, aryloxyalkanoyl or arylcarbonyl, any of such R 22 groups being optionally substituted; with the proviso that when R 22 is 2-aminoethyl R' must be SR 3 or OSO a H or a pharmaceutically acceptable salt or C 1-4 alkyl ester thereof; have been found to be antibacterially active. Their use is described as are processes for their preparation. |