abstract |
Compounds of formula (I): <IMAGE> (I) [wherein: R1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups; R2 represents a group of formula <IMAGE> in which <IMAGE> represents an alicyclic amine group having from 4 to 8 ring atoms, optionally having a single double bond, optionally containing an additional hetero-atom and optionally having an oxo group on the ring; X represents a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl group, an alkylsulphonyl group, a hydroxy group, a halogen atom or various substituted alkyl groups; Y represents a hydrogen atom, an alkyl group, an aliphatic acyl group or an acylimidoyl group; and R3 represents a carboxy group or a protected carboxy group] and pharmaceutically acceptable salts thereof have valuable antibacterial activity, especially in vivo. |