| abstract |
New antibiotics having β-lactamase inhibitory activity, i.e. pluracidomycin B, C, and D and their analogs, are of the formula:n wherein either R is carboxymethylsulfinyl, formylsulfinyl, dihydroxymethylsulfinyl, hydroxymethylsulfinyl, carboxymethylthio or dihydroxymethylthio and R is sulfo or R is sulfo and R 1 is hydrogen. The antiobiotics and the salts thereof are useful as medicaments, veterinary drugs and disinfectants for inhibiting the growth of both gram-positive and gram-negative pathogenic microorganisms. The invention includes their production, a new microorganism for use in their production, and formulations containing them. |