http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109134492-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2017-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109134492-B |
| titleOfInvention | Thienopyrimidone compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof |
| abstract | The thienopyrimidone compound or the pharmaceutically acceptable salt thereof has a novel chemical structure, has a very good selective inhibition effect on DPP-IV through in vitro and in vivo experiments, hardly influences the activity of DPP-VIII and DPP-IX while effectively inhibiting the activity of DPP-IV, and has a low potassium ion channel inhibition rate, so that the toxicity of the compound is expected to be low after the compound is developed into a medicament. Compared with the marketed once-a-week oral drug trelagliptin, the thienopyrimidinone compound has equivalent or higher bioavailability, and the compound is expected to achieve the treatment effect of being orally taken for a long time after being developed, so that the convenience and compliance of patients are greatly improved. And the preparation method is simple, the raw materials are easy to obtain, and the method is suitable for industrial large-scale production. |
| priorityDate | 2017-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 301.