| abstract |
The invention belongs to the technical field of medicine, and in particular relates to compounds or salts thereof with thienopyrimidinone as the core nucleus, their preparation methods, compositions and such compounds as dipeptidyl peptidase (DPP-IV) inhibitors in the prevention or treatment of Use in the treatment of a disease that would benefit from inhibition of DPP-IV. The preparation process of the compound of the present invention is simple, the raw materials are easy to obtain, and it is suitable for large-scale industrial production. It has been verified by in vitro experiments that it has a very good selective inhibitory effect on DPP-IV. While effectively inhibiting the activity of DPP-IV, it also inhibits DPP-IV The activities of VIII and DPP-IX have almost no influence, and it can be predicted that the toxicity of the compound of the present invention will be very low after being developed into medicine, which has outstanding advantages. |