| abstract |
A thien[3,2-d]pyrimidin-4-one compound, its preparation method, pharmaceutical composition and its pharmacological use, the general structural formula of which is shown in formula (I). This type of compound has a good inhibitory effect on DPPIV (dipeptide kininase IV), and is a strong DPPIV inhibitor, which can indirectly increase the content of GLP-1 in the body, thereby causing a series of physiological effects in the body. It plays the role of treating type 2 diabetes and is expected to be developed into a new drug for treating diabetes. |