| abstract |
A preparation method of a 21-halogenated steroid compound, comprising the following steps: using the compound of formula I as a raw material, first reacting with a halogenating reagent at the 21-position in a mixed solvent of an organic solvent and water, and then reacting under acidic conditions The hydrolysis reaction gives the 21-halogenated steroid compound of formula II. The above-mentioned preparation method is simple, the conditions are mild, and it has wide applicability to the target product 21-halogenated steroid compound of formula II, and the yield of the 21-halogenated steroid compound is high, and the purity is high, avoiding the long and complicated synthetic route of the traditional method. The problem of low yield. |