| abstract |
The invention relates to a novel intermediate of telapristone acetate, a preparation method and application thereof. 3,3,20,20-bis(ethylenedioxy)-17α,21-bishydroxyl-19-norpregna-5(10),9(11)- The diene method has mild reaction conditions, easy control of the operation process, simple and easy-to-obtain raw materials and reagents, low cost, high yield, and is suitable for industrial production. The resulting 3,3,20,20-bis(ethylenedioxy Base)-17α, 21-dihydroxy-19-norpregna-5(10), 9(11)-diene can be used for further preparation to obtain telapristone acetate. |