http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369762-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 |
| filingDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369762-B |
| titleOfInvention | Process for the preparation of 17-carboxylic acid steroids |
| abstract | The invention discloses a preparation method of a 17-formic acid steroid compound, which takes a 17-ethanone steroid compound shown in a formula I as an initial raw material, carries out a trihalogenation reaction with a halogenating reagent under an alkaline condition, and then is hydrolyzed into acid under the alkaline condition to obtain a 17-formic acid steroid compound II. The preparation method is simple, the conditions are mild, the target product 17-formic acid steroid compound shown in the formula II has wide applicability, high yield and high purity, and the halogen which is high in toxicity, easy to volatilize, difficult to transport and store, and pollutes the environment in the traditional haloform reaction is avoided. The adopted reagent has low toxicity, difficult volatilization, convenient transportation and storage, small environmental pollution, high yield up to 95.3 percent and crude product purity up to 96.5 percent. Is convenient for large-scale industrialized production. The structural formulas of the compounds of formula I and formula II are respectively as follows: |
| priorityDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.