| abstract |
The present invention relates to imide-based compounds, including bifunctional compounds comprising them, which can be used as modulators of targeted ubiquitination, especially multifunctional compounds degraded and/or otherwise inhibited by bifunctional compounds according to the invention. Inhibitors of peptides and other proteins. Specifically, the description provides compounds containing on one end a ligand that binds to the cerebellin E3 ubiquitin ligase and on the other end a binding target protein such that the target protein is positioned in close proximity to the ubiquitin ligase part of the protein ligase to effect degradation (and inhibition) of the protein. Compounds can be synthesized that exhibit a wide range of pharmacological activities consistent with the degradation/inhibition of virtually any type of targeted polypeptide. |