| abstract |
The present invention provides a kind of synthetic method of the triaryl substituted chiral compound shown in formula (1), described synthetic method is: in water-oil two-phase system, the 2-(aryl group shown in raw material formula (2) (p-toluenesulfonyl) methyl) phenol and the 2-naphthol shown in formula (3) react under the effect of acid-binding agent, chiral catalyst, TLC tracking monitors to reaction completely, afterward reaction solution is through aftertreatment, Obtain the triaryl substituted chiral compound shown in product formula (1); The present invention uses the chiral catalyst containing at least one tertiary amine and nitrogen squarylium functional group as the catalytic system, reacts in water-oil two-phase, post-treatment The isolated product triaryl-substituted chiral compound can be used as a class of important organic intermediates in the fields of medicine, pesticides and the like; the method of the invention has the advantages of low solvent pollution, fast reaction speed, high yield, good asymmetric selectivity, and low reaction bottom. It has a wide range of substances, and the reaction reagents are cheap and easy to obtain, which has important application value; |