http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110950793-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110950793-B |
| titleOfInvention | Preparation method of chiral diaryl indole methane compound |
| abstract | The invention discloses a preparation method of a chiral diaryl indole methane compound, which comprises the following steps: under the nitrogen atmosphere, in a water-oil two-phase system, reacting a 2- (aryl (p-toluenesulfonyl) methyl) phenol compound shown in a formula (1) and hydroxyindole shown in a formula (2) at the temperature of 20-30 ℃ for 1-48h under the combined action of an acid binding agent and a chiral dual-function catalyst, and carrying out post-treatment on the obtained reaction liquid to obtain a chiral diarylindole methane compound shown in a formula (3); the chiral bifunctional catalyst contains at least one tertiary amine and a nitrogen squaric acid functional group. The preparation method provided by the invention has the advantages of mild conditions, good stereoselectivity, convenient and easily obtained reaction raw materials and strong operability. |
| priorityDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.