| abstract |
The present invention provides a substituted diaminopyrimidine compound, a composition containing the compound and its application. The substituted diaminopyrimidine compound is a diaminopyrimidine compound represented by formula (I), or its crystal Form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate or solvate. The substituted diaminopyrimidine compound disclosed in the present invention and the composition comprising the compound have excellent inhibitory properties on EGFR kinase, and have better pharmacokinetic parameter characteristics at the same time, and can increase the drug concentration of the compound in animals, so as to Improve drug efficacy and safety. |