| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20a95ca057a9c8b468f75af83b6fbfd1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-277 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-41 |
| filingDate |
2014-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4f7c9d3e6c889e07c39726de969b322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c12cd7e28dee8e730211333acebc6ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92bf268eaedc909ed736fdf20e9a5c21 |
| publicationDate |
2015-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-104447406-A |
| titleOfInvention |
A kind of α-cyano-4-hydroxycinnamic acid derivative and its preparation method and application |
| abstract |
The invention discloses an alpha-cyano-4-hydroxycinnamic acid derivative with aldose reductase inhibitory activity, a preparation method and application thereof. The structure of the compound is shown in formula I. The preparation method is as follows: first reacting α-cyano-4-hydroxycinnamic acid with N-tert-butoxyacyl (Boc)-protected diamine compounds to obtain N-Boc-protected α-cyanocinnamic diamide. After deprotecting Boc, the compound reacts with N-acyl α-amino acid (natural or unnatural) to obtain α-cyano-4-hydroxycinnamic acid derivatives. The compound of the present invention has inhibitory activity on aldose reductase, and can be used in the preparation of medicines for treating diabetic complications such as diabetic retinopathy, diabetic senile dementia, nerve terminal disorders and the like. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107082754-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107082754-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109303772-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109303772-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106187891-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112500314-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016082798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112500314-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106187891-B |
| priorityDate |
2014-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |