| abstract |
The invention discloses a compound and its preparation method and application in the preparation of a medicine for treating disorders of glucose metabolism. The structure of the compound is shown in formula I. The compounds of the present invention have significant inhibitory activity on aldose reductase, and have certain antioxidant properties. The application of the compounds of the present invention in preparing medicines for treating disorders of glucose metabolism, medicines for treating diabetic complications and treating diseases caused by oxidative stress is the first report. Compared with other prior art, the compound of the present invention has novel structure, simple preparation process and better curative effect than positive control drug epalrestat. |