| abstract |
The present invention relates to a phenylbenzyl ether derivative and a preparation method thereof. Some of its compounds are labeled with radionuclides as Aβ plaque imaging agents, and the phenylbenzyl ether derivative is used in the preparation of diagnostic and Drug use in the treatment of Alzheimer's disease. Phenyl benzyl ether derivatives, the structural formula of which is shown in formula (I); the present invention has developed a new class of phenyl benzyl ether derivatives with high affinity to Aβ plaques in the brain of AD patients, with different chemical structures The compounds disclosed in the prior art belong to brand-new compounds for the diagnosis and treatment of Alzheimer's disease; the obtained Aβ plaque imaging agent has good stability in vivo, low fat solubility, fast brain clearance, and does not exist in vivo The problem of deradioactive nuclides has huge application prospects and market value; |