| abstract |
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, preparations thereof, conjugates thereof, derivatives thereof, forms thereof are against Fms protein kinase or against Fms and Kit protein kinase or against Fms and Flt-3 protein kinase active. Also described are methods of using the same to treat diseases and disorders, including those associated with the activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase, including rheumatoid arthritis, osteoarthritis, Inflammation, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanin tumors, multiple myeloma, metastatic breast cancer, prostate cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors. |