| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f1130e23cff1328c0ae14101d12103f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0461
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate |
2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23a6ee141aa00866c2ef6d72bede0530
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_806cc365e7a10b0e939d3a647db1057b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b81703b8bd1a367fc3c593f379fa10a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b676a125ab133b7711f46f646237f574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41be62d07edc59b15895d35ac3a204c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e1ccaa089c43665410cbf44fdeaadf7 |
| publicationDate |
2017-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106905303-A |
| titleOfInvention |
A class of compounds targeting FAK and their markers, their preparation methods and applications |
| abstract |
The present invention provides a class of compounds targeting FAK, the structure of which is shown in the following formula (I), wherein X is a N atom or a C atom substituted by Cl; R 1 is -OH, -O-CH 2 -CH 2 -OH Or -O-CH 2 -CH 2 -F; R 2 is methylamino or dimethylamino. The present invention also provides a class of radiolabeled compounds targeting FAK. The compound of the present invention has an excellent inhibitory effect on FAK kinase activity in vitro; its radiolabel has ideal biodistribution in the body of S180 tumor-bearing mice. The invention also provides the preparation method of the compound and its radiolabel and the application in the preparation of tumor medicine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111233834-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021111311-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111233834-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114716385-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111285851-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114929675-A |
| priorityDate |
2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |