http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_4e2f32ba4669f823005b42b057d4342b
Outgoing Links
Predicate | Object |
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family-name | Wei Li Li . |
name | Wei Li Wei Li . |
given-name | Wei Wei Li |
organization-name | Brain Imaging and Analysis Center, Duke University Medical Center; Durham North Carolina USA Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States; Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, United States Departments of Epidemiology Department of Anorectal Surgery, Jinan People’s Hospital, Shandong First Medical University, Jinan 271199, Shandong, China Department of Physiology & Neurobiology, University of Connecticut, Storrs, CT 06269; Tasly R&D Institute Tianjin Tasly Group Co., Ltd. Tianjin 300410 China School of Life Science and Technology, Beijing Institute of Technology; Beijing BIT & GY Pharmaceutical R&D State Key Laboratory of Chem/Bio‐Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and Devices College of Chemistry and Chemical Engineering The National Supercomputing Center in Changsha Hunan University Changsha 410082 P. R. China National Climate Center, Beijing 100081, China. College of Science and Engineering, Jiaozuo Normal College, Jiaozuo, Henan, 454000, China Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio Department of Neurosurgery, First Affiliated Hospital, Jinan University, Guangzhou 510630, China. tliwei@jnu.edu.cn College of Material Science and Engineering Hunan University No. 2, South of Lushan Road Changsha 410082 China College of Optoelectronic Engineering, Chengdu University of Information Technology 1 , Chengdu 610225, China Division of Virology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010. Department of Endocrinology, Affiliated Cixi Hospital,Wenzhou Medical University, Cixi; Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang, China. *Department of Medicine, Rheumatic and Autoimmune Diseases Section, and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455; and Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, China Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , No. 26 Shengli Street , Jiang'an District, Wuhan 430014, Hubei, China Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States Department of Medical Ultrasonics, Ultrasonics Artificial Intelligence X-Lab, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Aquatic Plant Research Center, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; Research Center for Ecology, College of Science, Tibet University, Lhasa 850000, China Shenyang Institute of Automation, Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, China Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, China Xuchang Central Hospital, Henan, China Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.; These authors contributed equally to this work. School of Resource and Environmental Sciences, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Wuhan University, Wuhan 430072, P. R. China College of Life Sciences, Yangtze University , Jingzhou 434025, Hubei Province , China College of Food Science and Technology; Nanjing Agricultural University; Nanjing; P. R. China Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Departments of Cancer and Cell Biology and Bioinformatics, Genomics Institute of the Novartis Research Foundation (GNF), 10675 John J. Hopkins Drive, San Diego, CA 92121; and Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037 School of Educational Science and Technology, Northwest Minzu University, Lanzhou, Gansu, China Dan L. Duncan Cancer Center,; Department of Molecular and Cellular Biology, Department of Basic Veterinary Medicine, College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China. School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, Nanjing University, Nanjing 210093, P. R. China Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, St. Jude Children’s Research Hospital, Memphis, Tennessee 38103 Environment and Resource College, Shanxi University, Taiyuan 030006, China. School of Information Engineering, Nanchang University, Jiangxi, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China (Q.L., L.Y., A.G., R.R., Jianlin Zhang, L.C., X.W., Y.L., W.Q., L.C., W.L., W.W., Jie Zhang, Y.Z., M.Z., C.Z.). Chair of Macromolecular Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstr. 4, 01069 Dresden, Germany Institute of Cerebrovascular Disease Research Xuanwu Hospital of Capital Medical University Beijing China; Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases Beijing China 1Tianjin Women’s and Children’s Health Center Tianjin, China Key Laboratory of Hunan Province on Information Photonics and Frees pace Optical Communications, College of Physics and Electronics, Hunan Institute of Science and Technology, Yueyang 414006, People’s Republic of China National Key Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha 410078, China. College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China; State Key Laboratory of Component‐based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China; Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China Department of Biliary Tract Surgery I, Third Affiliated Hospital of Second Military Medical University, Shanghai, China (mainland) Key Laboratory of Natural Products Chemical Biological; Ministry of Education; School of Pharmacy; Shandong University; Jinan 250012 Department of Endocrinology Affiliated Hospital of Xuzhou Medical University Xuzhou China Division of Intelligent and Bio-mimetic Machinery , The State Key Laboratory of Tribology, Tsinghua University, Beijing 100084 , China Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Uva Cancer Center, Charlottesville, VA, USA School of Materials Science and Engineering, Tianjin Key Lab for Photoelectric Materials & Devices, National Demonstration Center for Experimental Function Materials Education, Tianjin University of Technology, Tianjin 300384, China Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200032, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 200433, China International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China; National Engineering Research Center for Antibody Medicine & Shanghai Key Laboratory of Cell Engineering & Antibody, 399 Libing Road, Shanghai 201203, China College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China (LD,XZ,HA,WL,YW,LZ,TW) Department of Neurosurgery Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA State Key Laboratory and Institute of Elemento-organic Chemistry; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Nankai University; Tianjin 300071; China Department of Urology, Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China Robert Stempel College of Public Health and Social Work, Florida International University , Miami, Florida, USA School of Power and Mechanical Engineering, Wuhan University, Wuhan, People’s Republic of China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests, College of Plant Protection, Hunan Agricultural University, Changsha 410128, China Lab of Radiation Damage Research, The General Hospital of the PLA Rocket Force, Beijing, China Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, Jiangsu, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology Chinese Academy of Sciences Beijing 100101 China School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China Research Institute of Natural Gas Technology, Southwest Oil and Gas Field Company, Petro-China, Chengdu, Sichuan 610213, People’s Republic of China State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and Prevention Beijing China Department of Neurology, Beijing Chuiyangliu Hospital, Beijing 100022, China School of Pharmacy Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing China Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139 Department of Medical Imaging, Qianfoshan Hospital affiliated to Shandong University, Jinan, PR China Department of Rehabilitation, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ, United Kingdom Center for Medical Genetics, Beijing Children’s Hospital, Capital Medical University, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing, China; Department of Clinical Laboratory Dongying People's Hospital Dongying Shandong 257091 China The School of Law Zhejiang University of Finance & Economics Hangzhou Zhejiang China School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, PR China School of Control Science and Engineering, Shandong University , 250061 Ji’nan , China Department of Emergency, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China (mainland) State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics &Molecular Imaging Key Laboratory; Systems Biology Theme; Department of Biomedical Engineering; College of Life Science and Technology; Huazhong University of Science and Technology From the Department of Internal Medicine (W.H., J.S., A.M., H.H., W.L., T.K., M.K., K.A.), School of Medicine; and the Department of Chemistry (S.A.), Fukuoka University, Fukuoka, Japan. Key Laboratory of the Three Gorges Reservoir Region's Eco‐Environment Ministry of Education Chongqing University Chongqing China; College of Environment and Ecology Chongqing University Chongqing China Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA. The First Affiliated Hospital of Jilin University, China. Department of General Surgery, The First People's Hospital of Lianyungang, Lianyungang City, Jiangsu Province, China. State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China Porter Neuroscience Research Center, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140 Beijing Key Laboratory for Genetics of Birth Defects , Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Genetics and Birth Defects Control Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China National Standard Laboratory of Pharmacology for Chinese Materia Medica, School of Pharmacy Nanjing University of Chinese Medicine Nanjing China Section 2, Department of Cardiology Xi'an International Medical Center Hospital Shaanxi China Department of Endocrinology the Affiliated Hospital of Xuzhou Medical College Xuzhou China Department of Pharmaceutics School of Pharmacy North China University of Science and Technology Tangshan China Department of Anesthesia, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China From Royal Brompton & Harefield NHS Trust (W.L., M.H.), and the European Scanning Clinic (C.F.), London, UK. Department of Pancreatic Surgery, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China. Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an China Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong 272000, P.R. China GPL Photonics Laboratory, State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, P. R. China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods Guangdong Research Center for Engineering Technology in Bioactive Natural Products College of Food Science South China Agricultural University Guangzhou China National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.; Laboratory of Molecular and Cellular Biology, Hebei Normal University, Shijiazhuang, Hebei 050016, China.; State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China. Department of Hematology, Cancer Center The First Hospital of Jilin University Changchun People's Republic of China Department of Endocrinology, The Affiliated Hospital of Xuzhou Medical College Xuzhou China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods; College of Food Sciences; South China Agricultural University; Guangzhou; China Academy of Agriculture and Forestry Sciences of Qinghai University (Qinhai Academy of Agriculture and Forestry Sciences), Xining, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China; Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, China; Key Laboratory of the Tibet Plateau Biotechnology, Ministry of Education, Xining, China Department of Gynecology, Zhenjiang Maternity and Child Health Hospital, Zhenjiang, Jiangsu 212001, P.R. China Department of Obstetrics and Gynecology, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, P.R. China Department of Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou, China Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China Key Laboratory of Environmental Medicine Engineering, Ministry of Education. Department of Epidemiology and Health Statistics, School of Public Health, Nanjing, Jiangsu, China. State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 China; Collaborative Innovation Center of Quantum Matter Beijing 100084 P. R. China Department of Medicine, Division of Hematology and Oncology, Tufts Medical Center, Boston, USA School of Basic Medical Sciences, Chengdu University, Chengdu, 610106, China College of Food Science and Nutritional Engineering, National Engineering Research Centre for Fruits and Vegetables Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education China Agricultural University Beijing China Weapon Industry Health Research Institute, Xian, Shaanxi, People's Republic of China Department of Clinical Nutrition, Shanghai Tenth People’s Hospital, Tongji University of Medicine, 301 Yanchang Road, Shanghai 200072, China; Shanghai Clinical Nutrition Quality Control Center, Shanghai Tenth People’s Hospital, Tongji University of Medicine, 301 Yanchang Road, Shanghai 200072, China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department Epidemiology and Health Statistics, School of Public Health Southeast University Nanjing China School of Electrical & Computer Engineering and Birck Nanotechnology Center Purdue University West Lafayette IN 47907 USA; State Key Lab of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Guangxi Institute of Dermatology State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen 518055 China Tobacco Research Institute, Chinese Academy of Agricultural Sciences , Qingdao , China Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, Zhejiang University (Yuquan Campus), Hangzhou 310027, China Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, P.R. China. Department of Dermatovenereology West China Hospital, Sichuan University Chengdu Sichuan Province China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430071 China Department of Plastic and Burns Surgery, West China Hospital, Sichuan University, Chengdu 610041, China The First Bethune Hospital of Jilin University, Changchun, PR China State Key Laboratory of Plant Physiology and Biochemistry College of Life Sciences Zhejiang University Hangzhou 310058 China Department of Scientific Research and Postgraduate Education, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, China. Gusu Laboratory of Materials, Suzhou, Jiangsu 215123, People’s Republic of China; Hefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China Department of Neurology Affiliated Hospital of Beihua University Jilin 132011 China Medical college, Hubei University of Arts and Sciences, Xiangyang, China; Occupational and Environmental Department, Health Science Centre, Peking University State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics, Sun Yat-sen University, Guangzhou 510275, People’s Republic of China; School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China Department of Neurosurgery; the First Affiliated Hospital, Jinan University; Guangzhou 510630 China Ministry of Education Key Laboratory of Systems Biomedicine Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, and National Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China Department of Physics, Emory University , Atlanta, Georgia 30322-2430, USA Department of Radiation Oncology, Hubei Cancer Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Monogenic Disease Research Center for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom Department of Otoalryngology-Head Neck Surgery, Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China. Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266000, China The Research Center of Military Exercise Science, The Army Engineering University of PLA, Nanjing, China Cancer Center, Jilin University First Hospital, Changchun, China Institute of Farming and Cultivation Heilongjiang Provincial Academy of Agricultural Sciences Harbin 150086 China Department of Neurology Zhengzhou University People's Hospital (Henan Provincial People's Hospital) Zhengzhou China Department of Materials Science Fudan University Shanghai 200433 P. R. China Department of Dermatology, The First Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology Baotou China Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis and Test East China University of Science and Technology Shanghai 200237 People's Republic of China Department of Thoracic Surgery, Linyi People's Hospital, Linyi 276000, China Department of Dermatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health Center for Physical and Chemical Evidence Examination, Department of Public Security Technology, Railway Police College, Zhengzhou, P.R. China Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, People’s Republic of China Cancer Center The First Hospital of Jilin University Changchun China Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China College of Physics and Optoelectronics, Taiyuan University of Technology, Taiyuan 030024, P.R. China Department of Otolaryngology‐Head and Neck Surgery The Second Xiangya Hospital, Central South University Changsha China 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Department of Biostatistics, Harvard School of Public Health, 2Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, 3Microarray Core Facility and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA 3Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China Guangxi Key Laboratory of Low Carbon Energy Materials, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China Key Laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences; Beijing China Hubei Key Laboratory of Biomass Fibers and Eco‐dyeing and Finishing College of Chemistry and Chemical Engineering Wuhan Textile University Wuhan 430200 P. R. China Tsinghua‐Peking Center for Life Sciences School of Life Sciences and MOE Key Laboratory for Protein Science Tsinghua University Beijing China Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, and Zhejiang Normal University, Jinhua, Zhejiang 321004, China Department of Plastic and Reconstructive Surgery, The General Hospital of North Theater, PLA, Shenyang, China Division of Neonatology Department of Pediatrics Affiliated Hospital of Southwest Medical University Luzhou Sichuan China Cancer Center of the First Hospital of Jilin University, Changchun, Jilin, 130021, China. Electronic address: drweili@yahoo.com. Department of Neurology, Army Medical Center of PLA, Chongqing, China. School of Pharmacy, Shenyang Pharmaceutical University State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, P.O. Box 53, 100029 Beijing, China Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics − Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China Center for Genetic Medicine Research, Children’s National Medical Center, Department of Genomics and Precision Medicine, George Washington University , Washington, DC, USA Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, United States; Program of Environmental Toxicology, University of California, Riverside, California 92521, United States *Division of Host Defense and Digital Medicine Initiative, Department of General Surgery, ChengDu XinHua Hospital, ChengDu, Sichuan Province, China; Shanghai Public Health Clinical Centre and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, , 518120 Shenzhen, China Department of Cancer Center, Beijing Ditan Hospital, Capital Medical University , Beijing , People’s Republic of China Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and Toxicology Beijing 100850 China BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China; BGI-Shenzhen, Shenzhen, China School of Chemical Engineering Guizhou Minzu University Guiyang P. R. China School of Pharmacy East China University of Science and Technology 130 Meilong Road Shanghai 200237 the People's Republic of China Cancer Center the First Hospital of Jilin University Changchun China Key Laboratory of Systems Bioengineering MOE, Key Laboratory for Green Chemical Technology MOE Tianjin University; Collaborative Innovation Center of Chemical Science and Chemical Engineering Tianjin People's Republic of China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan. liwei@phar.toho-u.ac.jp State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China School of Science, and Advanced Functional Material and Photoelectric Technology Research Institution; Hubei University of Automotive Technology; Shiyan 442002; People's Republic of China Institute of Model Animal,Wuhan University,Wuhan,China; Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan,China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100039, China School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China; Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China; Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, Nanjing University, Nanjing 210093, China School of Materials Science and Engineering, Beihang University, Beijing 100191, People’s Republic of China Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.; Gynecology and Obstetrics, University Hospital, Linköping, Sweden. Department of Hepatology, Qingdao Sixth People's Hospital China. Department of Plastic Surgery, Chongqing University Central Hospital, Chongqing 400000, P.R. China National Key Laboratory of Veterinary Public Health Security, China Agricultural University, Beijing, China; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, China; College of Veterinary Medicine, China Agricultural University, Beijing, China Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405. Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin, China. Department of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University Beijing, China. Department of Human Anatomy, Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan 430022, China Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China; Department of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou China SEU-FEI Nano-Pico Center, Key Lab of MEMS of Ministry of Education, Southeast University, Nanjing 210096, P. R. China Center of Interventional Oncology and Liver Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, P.R. China; Cancer Center, the First Affiliated Hospital, Jilin University, Changchun, Jilin, China Engineering Research Center of Cell & Therapeutic Antibody, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, and School of Chinese Traditional Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Traditional Chinese Pharmacology, College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun, China Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Cardiology Department, Royal Brompton Hospital Guy’s and St Thomas’ NHS Foundation Trust London United Kingdom; National Heart and Lung Institute Imperial College London London United Kingdom Department of Chemistry, Zhejiang University Department of Materials Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan Department of Echocardiography, Zhongshan Hospital Fudan University Shanghai China Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, P.R. China Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China Cancer Center of the First Hospital of Jilin University, Changchun, Jilin 130021 China. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China Department of Bone and Joint, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, P.R. China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020,China. Department of Medicinal Chemistry; College of Pharmacy; Chongqing Medical University; Chongqing 400016; China Tianjin Women and Children’s Health Center, Tianjin, China Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL, USA Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong Province, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China University of Pennsylvania , Philadelphia , PA 19104 , USA Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China Clinical Medical Research Center, First Affiliated Hospital of South University of Science and Technology of China, Luohu Dsitrict, Shenzhen 518020, China University of Sheffield College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China; National & Local Joint Engineering Research, Center for Ginseng Breeding and Development, Changchun 130118, P. R. China Department of Neurology and Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital, Shandong University, Jinan, Shandong , China Department of Anesthesiology Department of Radiology, First People’s Hospital of Yunnan, Kunming, Yunnan, China (mainland) College of Aerospace Science and Engineering, National University of Defense Technology, 410073 Changsha, China College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China State Key Lab of Transducer Technology; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050; China Stem Cell and Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China; Investigation performed at Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China Department of Central Laboratory, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R. China State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China Departments of 1Hepatobiliary Surgery, 6The First Hospital of Jilin University, Changchun, Jilin, China. Department of Pharmacy, Qishan Hospital, Yantai, China College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China Tribology Research Institute, Key Laboratory for Advanced Technology of Materials of Ministry of Education, Southwest Jiaotong University, Chengdu 610031, P.R.China.liweijiani@home.swjtu.edu.cn. Institute of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China Department of Cancer Center Beijing Ditan Hospital Capital Medical University Beijing China Department of Gastroenterology, Wenjiang District People’s Hospital of Chengdu Faculty of Pharmaceutical Sciences, Toho University Department of Hepatobiliary Surgery, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, China Department of Medical Ultrasonics, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China. Department of Dermatology and Venereology, Rare Diseases Center West China Hospital, Sichuan University Chengdu China a State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University , Shanghai , 200240 , China; b Institute of Biomedical Materials, School of Materials Science and Engineering, Shanghai Jiao Tong University , Shanghai , 200240 , China Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 150040 Harbin, China Department of Neurology, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P.R. China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China Dan L Duncan Cancer Center, 1 Baylor Plaza 450A, Houston, TX 77030, USA; Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China. wmail@medmail.com.cn Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, and ‡Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, 94 Weijin Road, Tianjin 300071, People’s Republic of China Marshall Laboratory of Biomedical Engineering Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Guangdong 518060, P.R.China Eye Institute of Xiamen University & Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China Department of Endocrinology, Suzhou Hospital of Anhui Medical University Suzhou, China. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield S3 7HQ, United Kingdom School of Pharmaceutical Sciences, Shandong University, Jinan, China. Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P. R. China; Medical College, Hubei University of Arts and Science, XiangYang, HuBei, P. R. China Institute of Advanced Wear & Corrosion Resistant and Functional Materials; Jinan University; Guangzhou 510632; China; Shaoguan Research Institute of Jinan University Department of Neurosurgery, Liaocheng Brain Hospital, Liaocheng, Shandong Province, China Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, People’s Republic of China; Collaborative Innovation Center of Advanced Microstructures, Nanjing 210093, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 P. R. China State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Wuhan 430074 China Department of Neurology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou, China. Department of Stomatology, Changzheng Hospital, Naval Medical University, Shanghai 200003, P. R. China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China School of Science, Xihua University, Chengdu, Sichuan 610039, China Department of Cardiology Second Hospital of Hebei Medical University Shijiazhuang China Department of Orthopedics, The Second Clinical Medical School, Department of Clinical Skills Training Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Beijing, People’s Republic of China National Center for Cardiovascular Diseases of China, Beijing 100037, China. China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China;; Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China;; Department of Radiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Xi'an Jiaotong University Xi'an China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University) Ministry of Education Xi'an China Research Unit, Division of Health Research, Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, China Anhui Institute for Drug Control, Hefei 2300351, China. liwow@126.com Academy of Agriculture and Forestry, Qinghai University, Xining, Qinghai 810016 China; Key Laboratory of Potato Breeding in Qinghai Province, Xining, Qinghai 810016 China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai 810016 China; Key Laboratory of Qinghai Tibet Plateau Biotechnology, Ministry of Education Xining, Qinghai 810016 China; Northwest Potato Engineering Research Center, Ministry of Education, Xining, Qinghai 810016 China Neuroscience Program University of California at Los Angeles Los Angeles California Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, P. R. China Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China Lab of Radiation Damage Research, The General Hospital of the PLA Rocket Force, Beijing, 100088, China Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794, United States Laboratory Animal Center, Zhejiang University Hangzhou, Zhejiang, China. Laboratory Animal Center, Zhejiang Academy of Medical Sciences Hangzhou, Zhejiang, China. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research China National Institute for Communicable Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, Peoples Republic of China Graduate School of Anhui University of CM. Department of Pain Medicine Chongqing Traditional Chinese Medicine Hospital Chongqing China Department of Vascular Surgery, The Second Hospital of Yinzhou District, Ningbo, China Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Beijing 100101, People’s Republic of China Laboratory of Fruit Cell and Molecular Breeding China Agricultural University Beijing China National Laboratory of Solid State Microstructures; School of Electronic Science and Engineering; Collaborative Innovation Center of Advanced Microstructures; and Jiangsu Provincial Key Laboratory of Advance Photonic and Electronic Materials; Nanjing University School of Science, and Advanced Functional Material and Photoelectric Technology Research Institution; Hubei University of Automotive Technology; Shiyan; People's Republic of China Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University , Luzhou 646000, Sichuan , China Department of Clinical Laboratory, Traditional Chinese Medicine Hospital, Nantong, Jiangsu 226001, P.R. China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, P. R. China; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Maoming, 525100, P. R. China Shandong Medical College, Jinan, Shandong, China Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: liwei@mrbc-nccd.com. The First Affiliated Hospital of Jilin University Changchun China School of Mechanical Engineering, China University of Mining and Technology, Xuzhou 221116, China From TissueTech, Inc., and the Ocular Surface Center, Miami, Florida; and the2Eye Institute and Xiamen Eye Center, Xiamen University School of Medicine, Xiamen, Fujian, China. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China School of Pharmaceutical Chemical and Materials Engineering; Taizhou University; Taizhou; P. R. China Faculty of Pharmaceutical Science Toho University 2‐2‐1 Miyama Funabashi‐shi, Chiba 274‐8510 Japan Sichuan Research Center of New Materials, Institute of Chemical Materials, China Academy of Engineering Physics, 596 Yinhe Road, Shuangliu, Chengdu 610200, China Authors' Affiliations: 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China; and 2Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota Center for Functional Cancer Epigenetics, Dana–Farber Cancer Institute, Boston, MA 02215;; Department of Biostatistics and Computational Biology, Dana–Farber Cancer Institute, Boston, MA 02215;; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115;; Center for Genetic Medicine Research, Children’s National Health System, Washington, DC 20010;; Department of Genomics and Precision Medicine, The George Washington School of Medicine and Health Sciences, Washington, DC 20010; Ausnutria Dairy (China) Company, Limited, Changsha, Hunan 410200, People’s Republic of China Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States Department of Cardiology, Wuhan No. 1 Hospital Wuhan Hospital of Traditional Chinese and Western Medicine Wuhan People's Republic of China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, and Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China Department of Orthopedics, Xiangtan Chinese Medicine Hospital, Xiangtan, Hunan, China Department of Interventional Radiology, Xuanwu Hospital of Capital Medical University Beijing, China. Department of Geriatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of pediatrics, The First Hospital of Jilin University Department of Emergency, Peking Union Medical College Hospital, Beijing 100730, China. Corresponding author: Yu Xuezhong, Email: yxz@medmail.com. grid.13402.34 000000041759700X Department of Environmental Engineering Zhejiang University 310058 Hangzhou People’s Republic of China Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen University, Xiamen, Fujian, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China; Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, Fujian, China Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Department of Radiology Zhuhai People's Hospital Medical Group (Zhuhai Hospital Affiliated with Jinan University, The First Affiliated Hospital of Faculty of Medicine Macau University of Technology) Zhuhai China Institute of Agricultural Quality Standards and Testing Technology Research, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtse River) Ministry of Agriculture, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, PR China Key Laboratory for Biotech Drugs of the National Health Commission, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China. Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215;; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA 02115; Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center For Child Health Hangzhou China Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China China Medical City, Jiangsu Center for Stem Cell Engineering and Technology, Taizhou, People's Republic of China. From the Department of Clinical Neurosciences and Hotchkiss Brain Institute (R.D., E.E.S.) and Departments of Radiology and Clinical Neurosciences (C.R.M.), University of Calgary; Department of Medicine and Diagnostic Radiology (M.G.F.), McGill University, Montreal; Population Health Research Institute, Hamilton Health Sciences (K.M.S., K.B., D.D., S.R., K.T., S.Y., S.S.A.), Department of Medicine (K.M.S., K.B., S.R., K.T., S.Y., S.S.A.), Department of Electrical and Computer Engineering, School of... Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology Chinese Academy of Sciences Beijing China; Institute for Stem Cell and Regenerative Medicine Chinese Academy of Sciences Beijing China; Beijing Institute for Stem Cell and Regenerative Medicine Beijing China; University of the Chinese Academy of Sciences Beijing China Department of Histology and Embryology, the Fourth Military University, Xi'an. Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Oral Pathology Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology Beijing China TissueTech, Inc. and Ocular Surface Center, Miami, Florida. From the Bascom Palmer Eye Institute and the Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University School of Medicine Xiamen University Xiamen 361102 China State Key Laboratory of Silicon Materials School of Materials Science and Engineering Cyrus Tang Center for Sensor Materials and Application Zhejiang University Hangzhou 310027 China Department of Molecular and Cellular Biology Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA; Division of Biostatistics Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Nanjing University School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Institute of Theoretical and Computational Chemistry, , Nanjing 210093, People’s Republic of China Center for Molecular and Tumor Virology, Department of Microbiology and Immunology, and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 Medical Imaging Center Zhuhai People's Hospital Zhuhai China School of Psychology JiangXi Normal University Nanchang China Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada, and Department of Mechanical & Industrial Engineering, University of Toronto, 5 King’s College Road, Toronto, Ontario M5S 3G8, Canada Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang Province China School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China (W.L., X.C., Z.M., H.W., D.Z., W.L.); State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China (X.H., Q.X.); and Department of Plant Pathology and Microbiology, University of Cal From TissueTech, Inc. and Ocular Surface Center, Miami, Florida; and Department of Gynaecology and Obstetrics, The Third People's Hospital of Linyi Linyi, Shandong, P. R. China. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, People’s Republic of China School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics, Sun Yat-sen University, Guangzhou 510275, China Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290 School of Energy and Power Engineering, Changsha University of Science and Technology, Changsha, Hunan, 410004, China Department of Nuclear Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China-471003. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China Department of Pharmaceutical Analysis; School of Pharmacy; Shandong University of Traditional Chinese Medicine; Jinan 250355; China Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital), Nanjing 210029, Jiangsu, China. Corresponding author: Zhang Jinsong, Email: zhangjso@njmu.edu.cn. Department of Dermatology and Norris Comprehensive Cancer Center School of Life Science Guizhou Normal University Guiyang China Department of Orthpaedics, West China Hospital of Sichuan University, Chengdu 610041, China. Department of Medicinal Chemistry; School of Pharmacy; Chongqing Medical University; Chongqing 400016; P. R. China Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110042, P.R.�China Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Pediatric Dentistry, University of Illinois at Chicago, College of Dentistry, 801 S. Paulina Street, Chicago, IL 60612, USA Department of Forensic Pathology, College of Forensic Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, and University of Cincinnati Drug Discovery Center, University of Cincinnati, Cincinnati, Ohio 45237 Shanghai Key Laboratory of Psychotic Disorders; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; Shanghai China Department of Chemistry Laboratory of Advanced Materials, and iChEM Fudan University Shanghai 200433 P.R. China Department of the General Surgery State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China. Aflac Cancer & Blood Disorders Center of Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea Molecular Imaging Center, Mallinckrodt Institute of Radiology and Departments of Molecular Biology and Pharmacology, Cell Biology and Physiology, and Internal Medicine, and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110 Department of Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha, China Assisted Reproduction Center, Northwest Women's and Children's Hospital Xi'an People's Republic of China Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami School of Medicine Miami Florida 33136 Department of Geriatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China 430074; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan, China 430074 College of Pharmacy, Zunyi Medical University, Zunyi 563006, China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi 563006, China Institute of Theoretical and Computational Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Department of Pediatrics, Department of Biochemistry & Molecular Biology Penn State University College of Medicine Hershey Pennsylvania Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, P.R. China; Department of Respiratory and Gastroenterology, Xingtai First Hospital, Xingtai, Hebei, 054001, China Department of Sports Rehabilitation, College of Human Kinesiology Shenyang Sport University Shenyang China Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States Department of Hepatology, Qingdao Sixth People's Hospital, Qingdao, Shandong 266033, P.R. China Douglas Houston is with the Department of Planning, Policy, and Design, School of Social Ecology, University of California, Irvine. Wei Li is with the Department of Landscape Architecture and Urban Planning, Texas A&M University, College Station. Jun Wu is with the Program in Public Health and Department of Epidemiology, University of California, Irvine. State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences P.O. Box 2871, Shuangqing Rd 18, Haidian District Beijing 100085 People's Republic of China Department of Chemistry; University of Victoria; Victoria, Canada Tianjin Women’s and Children’s Health Center, Tianjin, China State Key Laboratory of Functional Materials for Informatics and Shanghai Center for Superconductivity; Shanghai Institute of Microsystem and Information Technology; Chinese Academy of Sciences; Shanghai 200050; P. R. China Laboratory of Basic Medicine, The General Hospital of Western Theater Command, Chengdu 610083, China School of Energy and Power Engineering, Changsha University of Science & Technology, Changsha, Hunan 410114, China; Key Laboratory of Energy Efficiency and Clean Utilization, Education Department of Hunan Province, Changsha University of Science & Technology, Changsha, Hunan 410114, China Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences P.O. Box 2871 Beijing 100085 People's Republic of China Department of Cardiovascular Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China. School of Business Administration, Hunan University, Changsha 410082, China. Stem Cell and Cancer Center; The First Affiliated Hospital; Jilin University; Changchun P. R. China General Hospital of Northern Theater Command, PLA Shenyang, Liaoning, People's Republic of China. Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China Key Laboratory of Industrial Fermentation Microbiology Ministry of Education Tianjin Industrial Microbiology Key Laboratory College of Biotechnology Tianjin University of Science and Technology Tianjin People's Republic of China College of Plant Protection, Hunan Agricultural University, Changsha 410128, China Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada. School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University Cancer and Stem Cell Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, P. R. China Department of Rheumatology and Immunology Second Affiliated Hospital of Harbin Medical University Harbin China Department of Plant Pathology, The Ohio State University, Columbus, Ohio, USA Center for Cancer Research, and Pharmaceutical Sciences (Z.L., W.L.), University of Tennessee Health Science Center, Memphis, Tennessee 38163 Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing China Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. 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China The Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine Sichuan Agricultural University Chengdu Sichuan Province 611130 China 2Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina. Cancer Center The First Hospital of Jilin University Changchun Jilin China Department of Plastic and Burns Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China. State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Municipal Key Laboratory of Advanced Fiber and Energy Storage, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China State Key Laboratory of Metastable Materials Science and Technology School of Materials Science and Engineering Yanshan University Qinhuangdao 066004 P. R. China Department of Obstetrics and Gynecology, Xiangyang No.1 People's Hospital Hubei University of Medicine Xiangyang Hubei China Breast Center of Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100144, China. Key Laboratory of Optical and Magnetic Resonance Spectroscopy, Department of Physics, East China Normal University, Shanghai 200062, China Department of Vascular and Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, China Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland Third Medical Department, Tianjin Teda Hospital, Tianjin 300457, P.R. 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Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang China CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China 1 , Hefei, Anhui 230027, China Department of Otorhinolaryngology Head and Neck Surgery, First People's Hospital of Anqing, 246003, China. 738721296@qq.com Medical College Guizhou University Guiyang 550002 Guizhou China CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing 100190, China State Key Lab of New Ceramic and Fine Processing; School of Materials Science & Engineering; Tsinghua University; Beijing 100084; China Department of General Surgery Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Department of Obstetrics and Gynecology, Xiangyang No.1 People’s Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, China (mainland) State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China Stem Cell and Cancer Center; First Affiliated Hospital; Jilin University; Changchun Jilin P.R. China Department of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. Interventional Medical Center, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, P.R. China Department of Clinical Laboratory Tianjin Huan Hu Hospital Tianjin 300060 China; Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration Tianjin 300060 China Science and Technology on Plasma Physics Laboratory Rigel PharmaceuticalsSouth San FranciscoCaliforniaUSA Crop Research Institute, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China; Shandong Engineering Laboratory of Featured Crops, Jinan, China Library of Beijing Institute of Technology Beijing 100081 People's Republic of China School of Health Professions, University of Alabama at Birmingham, Birmingham, AL. Department of Hematology, The First Bethune Hospital of Jilin University, Changchun 130021, China. Division of Biostatistics, Dan L. Duncan Cancer Center,; Department of Molecular and Cellular Biology, and Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine Xiamen University Xiamen China Chair of Macromolecular Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstr. 4, 01069 Dresden, Germany; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Forest Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, PR China The Lab of Military Conditioning and Motor Function Assessment, the People's Liberation Army University of Science and Technology, Nanjing, Jiangsu Province, China Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University, Guangzhou 510060, China. From the Occupational and Environmental Medicine, Department of Clinical and Experimental Medicine (X.-M.Y., L.J.W., N.S.) and Obstetrics and Gynaecology, Department of Clinical and Experimental Medicine (L.J.W., W.L.), Linköping University, Sweden; Vascular Surgery, Linköping University Hospital, Sweden (C.F.); and Department of Internal Medicine, University of Alberta, Edmonton, Canada (N.S.). Monogenic Disease Research Center for Neurological Disorders Beijing Tiantan Hospital, Capital Medical University Beijing China Department of Urology Surgery, The First Affiliated Hospital of Soochow University, Soochow, China Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China Thyroid Cancer Research Laboratory, Medical Service, Veterans Affairs Medical Center, Lexington, Kentucky 40511; and the Thyroid Oncology Program, Division of Hematology/Oncology, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536-0093 Institute of Biomaterials; Department of Materials Science and Engineering; University of Erlangen-Nuremberg; 91058 Erlangen; Germany Dan L Duncan Cancer Center (L.W., W.L.), Baylor College of Medicine, Houston, Texas 77030 Tribology Research Institute Key Laboratory for Advanced Technology of Materials of Ministry of Education Southwest Jiaotong University Chengdu China Department of Hematology/Oncology, the first Hospital of Jilin University 130021, China. Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China Department of Physiology and Obstetrics and Gynecology (T.B., W.L., M.C.A., S.G.M., J.R.G.C.), University of Toronto, Toronto, Ontario M5S 1A8, Canada Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, China Departments of Medicine, Molecular Genetics and Microbiology, Pathology and Laboratory Medicine, and Pediatrics, and Center for Mammalian Genetics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Carlton and Elm Streets, Buffalo, NY 14263; Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, United Kingdom; and Molecular Staging Inc., 66... Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Haikou Hainan Province China; Key Laboratory of Molecular Biology Hainan Medical College Haikou Hainan Province China Nanjing Municipal Center for Disease Control and Prevention, Jiangsu, PR China College of Engineering, Peking University, Beijing, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China From the Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Medical School, Houston Huaiyin District Center for Disease Prevention and Control, Jinan 250022, China. Department of Human Anatomy, Histology and Embryology Air Force Medical University Xi’an China Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, PR China School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing, P.R. China College of Chemistry & Molecular Engineering Qingdao University of Science & Technology Qingdao China Laboratory of Advanced Materials Department of Chemistry Fudan University Songhu 2205 200433 Shanghai China School of Materials Science and Engineering, Shaanxi Normal University, Xi'an 710062, P. R. China Department of Pharmacology Harold C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center 6001 Forest Park Road Dallas TX 75390 USA State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China; National Stem Cell Resource Center, Chinese Academy of Sciences, Beijing, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China School of Biotechnology, State Key Laboratory of Bioreactor Engineering, R&D Center of Separation and Extraction Technology in Fermentation Industry East China University of Science and Technology Shanghai China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology (SCICBT) Shanghai China School of Materials Science and Engineering Nanchang Hangkong University Nanchang 330063 P. R. China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China Department of Clinical Nutrition, Zhu Jiang Hospital, Southern Medical University, Guangzhou, China. Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-41296 Göteborg, Sweden; Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P. R. China Department of Cancer Center, The First Hospital of Jilin University, Changchun 130021, China Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China. Key Laboratory of Environment and Energy Chemistry of Guangdong Higher Education Institutes, MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Institute of Optoelectronic and Functional Composite Materials, Sun Yat-sen University, Guangzhou 510275, P. R. China State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430200, China Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road 18, Beijing 100085, China International Joint Cancer Institute The Second Military Medical University Shanghai 200433 China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China 1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, Shanghai 20092, China, 2Dan L. Duncan Cancer Center and 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; 1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, Shanghai 20092, China, 2Dan L. Duncan Cancer Center and 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; 1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, Shanghai 20092, China, 2Dan L. Duncan Cancer Center and 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and Laboratory of Advanced Materials; Fudan University; Shanghai 200433, P. R. China State Key Laboratory of Cotton Biology, Institute of Cotton Research, the Chinese Academy of Agricultural Sciences Anyang 455004 China Cancer Center, First Hospital of Jilin University, Changchun, China. Engineering Research Center of High Performance Polymer and Molding Technology Qingdao University of Science and Technology Qingdao P. R. China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, People's Republic of China Department of Oral Pathology, Peking University School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology, Beijing, China Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Faculty of Pharmaceutical Sciences Toho University Chiba Japan Department of Medical Oncology, Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China State Key Laboratory of Animal Nutrition Key Laboratory of Animal (Poultry) Genetics Breeding and Reproduction Ministry of Agriculture Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 China Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China From TissueTech, Inc. and the Ocular Surface Center, Miami, Florida. 1Department of Hematology and Oncology, the First Clinical Hospital of Jilin University, Changchun, China; and Dalian University of Technology 2 State Key Laboratory of Fine Chemicals, Department of Polymer Science and Engineering, School of Chemical Engineering, , Liaoning, People's Republic of China Cardiac Division, Department of Echocardiography, Royal Brompton and Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, Chelsea, London, UK Tasly R&D Institute Tasly Pharmaceutical Co., Ltd. Tianjin 300410 P. R. China Department of Chemistry; Capital Normal University; Beijing 100048, China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College , Bengbu , China; Center for Clinical Medicine of Respiratory Disease (Tumor) in Anhui , Bengbu , China; Provincial Key Laboratory of Respiratory Disease in Anhui , Bengbu , China Research Institute of Natural Gas Technology, PetroChina Southwest Oil & Gasfield Company, Chengdu 610213, China Authors' Affiliations: 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University; 2Department of General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China; and 3Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University Chengdu China Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of University of South China, Hengyang, Hunan, China (mainland) Department of Cell and Molecular Biology, Genomics Institute, Novartis Research Foundation (GNF), San Diego, CA 92121, USA. College of Optoelectronic Engineering, Chengdu University of Information Technology, Chengdu 610225, China Department of Cardiology, Wuhan No. 1 Hospital, Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, Hubei, China State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China From the Department of Neurology (W.L., L.L., M.Z., Y.W., C.L., X.L., S.H., C.L., Y.W.) and Radiology (J.C.), Research Institute of Surgery, Daping Hospital, Third Military Medical University, China; and Department of Neurology, Medical University of South Carolina (W.F.). Sichuan University, China Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou City, Jiangsu Province, PR China College of Chemistry and Pharmaceutical Sciences; Qingdao Agricultural University; Qingdao 266109; China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education Institute for Clean Energy and Advanced Materials School of Materials and Energy Southwest University Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies Southwest University Chongqing 400715 China Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, Tennessee 38163, United States School of Biomedical Engineering, International Health Science Innovation Center, Shenzhen Key Laboratory of Nano-Biosensing Technology, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, Guangzhou, China Department of Biomedical Engineering Case Western Reserve University Cleveland Ohio USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China People’ Hospital of Liaocheng, Liaocheng, China The Department of Oncology, Affiliated with Shuyang Hospital of Xuzhou Medical University, Suqian City, Jiangsu Province, China Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Street, Xicheng District, Beijing 100050, China.; Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Street, Xicheng District, Beijing 100050, China. From Adult Congenital Heart Disease Centre, (E.L.H., M.A.G., A.U.., B.S., H.U., W.L., V.S., P.O., D.F.S., S.V.B.-N.), Cardiac Morphology Unit (K.P.M., S.Y.H.), and Non-Invasive Cardiology Department (P.W.), Royal Brompton Hospital, London, United Kingdom; National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College London, United Kingdom (E.L.H., M.A.G., G.C.S., P.J.K., D.J.P., D.F.S., S.V.B.-N.); Division of... School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China School of Materials Science and Engineering Nankai University Tianjin 300350 China Department of Physiology, University of Kentucky, Lexington, Kentucky Department of Scientific Research and Postgraduate Education The First Affiliated Hospital of Xinxiang Medical University Weihui China Department of Physics, Emory University, Atlanta, Georgia 30322, United States fv Chinese Academy of Sciences, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology , Beijing , China. Tokyo Institute of Technology, Department of Materials Science and Engineering, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, Alabama, USA The Second Department of General Surgery, Zhuhai City People’s Hospital, Jinan University, Zhuhai City, Guangdong Province, China Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201800, China Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease; Department of Respiration, First Affiliated Hospital, Bengbu Medical College, Bengbu, Anhui Province, China College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China, School of Wine & Food Sciences, EH Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, New South Wales 2678, Australia, and College of Biological Engineering, Hubei University of Technology, Wuhan 430068, China Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. School of Mathematics and Physics, North China Electric Power University, Beinong Road 2, Huilongguan, Beijing 102206, P. R. China; Institute of Clusters and Low Dimensional Nanomaterials, North China Electric Power University, Beinong Road 2, Huilongguan, Beijing 102206, P. R. China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China Tea Plant Biology Key Laboratory of Henan Province, College of Life Sciences, Xinyang Normal University, Xinyang, Henan 464000, People’s Republic of China Department of Neurosurgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China Photonics and Optoelectronics Group Department of Physics and Center for NanoSciences Ludwig‐Maximilians‐Universität München Amalienstr. 54 80799 Munich Germany; Present address: Department of Physics and Stephenson Institute for Renewable Energy University of Liverpool Chadwick Building, Peach Street Liverpool L69 7ZF United Kingdom Key Laboratory of Surficial Geochemistry, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, China; Environmental Soil Chemistry Group, Delaware Environmental Institute and Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19716, United States Advanced Functional Material and Photoelectric Technology Research Institution; School of Science; Hubei University of Automotive Technology; Shiyan 442002; People's Republic of China Center of Rare Earth and Inorganic Functional Materials, National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.; School of Physics, Huazhong University of Science and Technology, Wuhan 430074, China. CSIRO Manufacturing; The Commonwealth Scientific and Industrial Research Organization (CSIRO); Australia Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan. Department of Chemistry Laboratory of Advanced Materials and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China Authors' Affiliations: 1Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, 2Division of Medical Oncology, Department of Internal Medicine and the Comprehensive Cancer Center, and 3Department of Pathology, The Ohio State University College of Medicine; 4Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio; 5Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas; 6INSERM UMR 1011-Bâtiment J&K, Université Lille-Nord de France, Faculté de Médecine de Lille-Pôle Recherche, Lille cedex, France; 7Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois; 8Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 9Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 610041 China Institute of Nanochemistry and Nanobiology; School of Environmental and Chemical Engineering; Shanghai University; Shanghai 200444; China College of Chemistry and Materials Science; Hubei Engineering University; Hubei; China Division of Intelligent and Biomechanical System, State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Haidian, Beijing, China Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, China; Chongqing Key Laboratory of Intelligent Medicine Engineering for Hepatopancreatobiliary Diseases, University of Chinese Academy of Sciences, Chongqing 401147, China Laboratory of Basic Medical Sciences, The General Hospital of Western Theater Command, Chengdu 610083, China Nanjing University Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, , Nanjing 210093, People's Republic of China School of Mathematics and Physics North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China; Institute of Clusters and Low Dimensional Nanomaterials North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China Department of Medicine Department of Laboratory, First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Department of Endocrine and Metabolism, Yanan University Affiliated Hospital, Yan’an, China School of Biotechnology, Yeungnam University, Gyeongsan, Korea Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Departments of Medicine, Indiana University, School of Medicine, Indianapolis, Indiana 46202 Beijing Institute of Radiation Medicine, Beijing, China; State Key laboratory of Proteomics, Beijing, China Soochow Institute for Energy and Materials Innovations College of Physics Optoelectronics and Energy Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215006 China; Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow University Suzhou 215006 China College of Artificial Intelligence, North China University of Science and Technology, Tangshan 063210, China; Hebei Key Laboratory of Industrial Intelligent Perception, Tangshan 063210, China Tasly Academy Tianjin Tasly Group Co., Ltd. Tianjin 300410 China 4Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts. Medical College, Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China College of Chemistry and Chemical Engineering, Liaoning Key Laboratory of Synthesis and Application of Functional Compound Bohai University Jinzhou China Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado Department of Dermatology & Rare Disease Center West China Hospital, Sichuan University Chengdu Sichuan China Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111 * Medicine and Research Imaging Institute; University of Texas Health Science Center at San Antonio; TX USA; Department of Ophthalmology; University of Texas Health Science Center at San Antonio; TX USA Department of Anatomy and Neurobiology, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong City, Jiangsu, China. Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200433, China Department of Chemistry, Michigan State University, East Lansing, Michigan 48824 Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China Department of Otolaryngology, Union Hospital Affiliated Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022, China. Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China Department of Gynecology & Obstetrics, College of Clinical Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China Dan L. Duncan Cancer Center, and; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX; Laboratory of Membrane Biology, New York Blood Center, New York, NY; Department of Obstetrics and Gynecology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, P.R. China Hospital of Stomatology, Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Guangzhou China The Key Laboratory of Urinary Tract Tumors and Calculi, Department of Urology Surgery, The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, China Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan city, Shandong, China Department of Endocrinology, Affiliated Hospital of Yan'an University, Yan'an 716000, China. Orthopedics Department of Navy General Hospital, Beijing 100048, China grid.21940.3e 0000000419368278 Department of Bioengineering Rice University Houston TX USA National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai 200433, China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510 Department of Orthopaedic Surgery Center for Orthopaedic Surgery The Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong China School of Aerospace, Mechanical and Mechatronic Engineering The University of Sydney Sydney NSW 2006 Australia Department of Pesticide Science; College of Plant Protection; Nanjing Agricultural University; Nanjing 210095; People's Republic of China Department of Chemistry and Laboratory of Advanced Materials; Fudan University; Shanghai, P. R. China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China (J.L., W.L., T.T., Z.-G.S., H.Li.).; Institute of Model Animal of Wuhan University, China (J.L., W.L., K.-Q.D., S.T., H. Liu, H.S., Q.F., Z.L., Z.C., T.T., S.G., F.H., M.H., X.C., Y.-X.J., P.Z., Z.-G.S., X.-J.Z., H. Li). Beijing Institute of Petrochemical Technology Beijing China Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Engineering, China Agricultural University, 17 Qinghua Donglu, P.O. Box 50, Beijing 100083, China Zhengzhou Key Laboratory of Criminal Science and Technology, Department of Criminal Science and Technology, Railway Police College, Zhengzhou 450053, China; Institute of Environmental and Ecological Safety Technology, Institute of Public Safety Research, Zhengzhou University, Zhengzhou 450001, China Department of Lymphoma, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China School of Chemistry and Chemical Engineering; Key Laboratory of Mesoscopic Chemistry of Ministry of Education; Institute of Theoretical and Computational Chemistry; Nanjing University; Nanjing Cancer Center of the First Hospital of Jilin University Changchun China 1Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Graduate School of the Chinese Academy of Sciences Department of Physiology, Wayne State University, Detroit, Michigan, USA Institute of the Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing, 100124, China Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, School of Chemistry and Chemical Engineering, Chongqing University, Shazhengjie 174, Chongqing 400044, China Section of Plant Pathology & Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, U.S.A.;; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, P.R. China School of Public Policy and Administration Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120/200092, China; School of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Baoding 071000, China Department of Cardiology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China College of Chinese Material Medicine, Jilin Agricultural University, Changchun 130118, China Department of Urology, Shenzhen Long-hua District Central Hospital, The Affiliated Central Hospital of Shenzhen Long-hua District, Guangdong Medical University, Shenzhen, China. Tasly Academy Tasly Holding Group Co., Ltd Tianjin China; State Key Laboratory of Core Technology in Innovative Chinese Medicine Tasly Pharmaceutical Group Co., Ltd. Tianjin China; National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China Department of Urology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Rehabilitation, Binzhou Medical University Hospital, Shandong, Binzhou, China Department of Physiology Wayne State University Detroit Michigan USA College of Environmental Science and Engineering, Dalian Maritime University, No. 1 Linghai Road, Dalian 116026, China Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Disease, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China. Research Laboratory of Hepatobiliary Tumor, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, China Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213001, China Research Center of Health Management Guangxi Zhuang Autonomous Region People's Hospital and Guangxi Academy of Medical Sciences Nanning China; Department of Health Management Guangxi Zhuang Autonomous Region People's Hospital and Guangxi Academy of Medical Sciences Nanning China Department of Medical Oncology; Shanghai Pulmonary Hospital; Tongji University Medical School Cancer Institute; Tongji University School of Medicine; Shanghai China School of Medicine, Chengdu University, Chengdu 610106, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi’an 710061, China Peking University School and Hospital of Stomatology Department of Oral and Maxillofacial Surgery, , Beijing, China Division of Biostatistics (L.W., W.L.), Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Houston, Texas 77030 School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Institute of Theoretical and Computational Chemistry, Nanjing University 14 , Nanjing 210023, People’s Republic of China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Fudan University Shanghai 200433 China State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, and Department of Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 Department of NeurosurgeryDrum Tower HospitalMedical School of Nanjing UniversityNanjingChina Key Laboratory of Advanced Display and System Applications of Ministry of Education, Shanghai University, 149 Yanchang Road, Shanghai 200072, China 1Department of Neurology, ThirdXiangya Hospital, Central South University, Changsha 410013, China; 2Neuromedical Center, First Hospital of Changsha, Changsha 410005, China. E-mail: 14726977743@163.com. Key Lab. of Pollution Processes and Environmental Criteria (Ministry of Education) College of Environmental Science and Engineering, Nankai Univ. Weijin Road 94 Tianjin 300071 China State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Wushan Road 381, Guangzhou 510640, Guangdong Province, P. R. China Departments of Lymphoma Tianjin Medical University Cancer Institute and Hospital Tianjin China Academy of Agriculture and Forestry Sciences, Qinghai University, Xining, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China; Scientific Observing and Experimental Station of Crop Pest in Xining, Ministry of Agriculture, Xining, China; Key Laboratory of Agricultural Integrated Pest Management of Qinghai Province, Xining, China Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State University Atlanta Georgia 30303 USA; School of Pharmacy Jining Medical University Rizhao, Shandong 276826 P. R. China Physician Assistant Studies, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Forest Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University Beijing 100083 China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; Center for Medical Genetics, Beijing Children's Hospital, Capital Medical University, Beijing Pediatric Research Institute, Beijing, China; Center of Alzheimer Disease, Beijing Institute for Brain Disorders, Beijing, China Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, 200433, Shanghai, China Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, China College of Life Science and Technology; Beijing University of Chemical Technology; Beijing; China; School of Food Science and Technology Guangdong Medical University, China Department of Oncology, Jilin University First Affiliated Hospital, Changchun, Jilin 130021, China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun 130118, P. R. China Precision Medicine Research Center for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University , Beijing, China Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China School of Pharmaceutical Sciences Sun Yat‐Sen University Guangzhou China 1Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.; 3Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Burns, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu 610072, P.R. China Department of Neurology, Beijing Tiantan Hospital , Capital Medicine University , Beijing 100050, China. School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing, 210093, People’s Republic of China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People’s Republic of China Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou, Guangdong510627China Department of Gastrointestinal Surgery; The First Hospital of Jilin University; Changchun; People's Republic of China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Huazhong Agricultural University Wuhan China Crop Research Institute Shandong Academy of Agricultural Sciences Jinan China; Ministry of Agriculture, Key Laboratory of Wheat Biology and Genetic Improvement on North Yellow and Huai River Valley Jinan China; National Engineering Research Center for Wheat and Maize Jinan China School of Physics and Information Engineering, Fuzhou University, Fuzhou 350116, China Department of Neurology, Henry Ford Hospital, Detroit, MI, USA Center for Natural Products Research, Chinese Academy of Sciences, Chengdu Institute of Biology, 9 Section 4, Renmin Road South, Chengdu 610041, China Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA Department of Anesthesia Renmin Hospital of Wuhan University Wuhan China Department of Cardiology, Affiliated Hospital of Guizhou Medical University, No. 29 Guiyi Street, Beijing Road, Yunyan District, Guiyang City, Guizhou Province, China Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University,Guangzhou 510060, China. lwxsbs@medmail.com.cn Ausnutria Institute of Food and Nutrition, Ausnutria Dairy (China) Co., Ltd., Changsha 410219, Hunan, China Jiangsu Institute of Schistosomiasis, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 214064, China. College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea Southwest University Research Center of Psychology and Social Development, Faculty of Psychology, , Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education , Chongqing 400715, China Department of Cardiology, Huazhong University of Science and Technology, Wuhan, China Department of Hematology, Cancer Center, the First Bethune Hospital of Jilin University, Changchun, Jilin, China Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China; Department of Dermatology & Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China From Boston University and the Veterans Affairs Boston Health Care System, Boston, Massachusetts; and University of Rochester, Rochester, New York. School of Physics and Technology, Wuhan University, Wuhan 430072, China From the Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of the Chinese Academy of Sciences, 74519, Beijing, China; Key Laboratory of Organ Regeneration and Reconstruction, Chinese Academy of Sciences, Chaoyang District, Beijing, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, Beijing, China; Harbin Normal University, China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Key Lab of Heat Transfer Enhancement and Energy Conservation of Ministry of Education, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China Department of Anesthesiology, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China Hebei University College of Life Sciences, Institute of Life Sciences and Green Development, , Baoding 071000, China; Hebei Basic Science Center for Biotic Interaction, Institute of Life Sciences and Green Development , Hebei University, Baoding 071000, China Department of Radiology, Pukou Branch of Jiangsu People's Hospital (Nanjing Pukou District Central Hospital), Nanjing, Jiangsu 210018, P.R. China Department of Materials Science State Key Laboratory of Molecular Engineering of Polymers Institute of Brain Intelligence Science and Technology Fudan University Shanghai 200433 P. R. China Institute of Crop Cultivation and Tillage, Heilongjiang Academy of Agricultural Sciences, Heilongjiang 150086, Harbin, China Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China; Department of Neurology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Department of Echocardiography, Shanghai Institute of Medical Imaging, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital , Beijing , China Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; International Joint Cancer Institute, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China Department of Otolaryngology-Head & Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha, 410013, China State Key Lab of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China College of Agronomy, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan 611130, P.R. China Department of Medicine, Hematology-Oncology Division, and Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 Department of Pharmaceutical Engineering Institute of Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China Institute of Advanced Wear & Corrosion Resistant and Functional Materials Jinan University 601 Huangpu Avenue West Guangzhou 510632 China College of Physics and Material Science; Henan Normal University; Xinxiang 453007; China School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China; Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China Tribology Research Institute, Key Laboratory for Advanced Technology of Materials of Ministry of Education Southwest Jiaotong University Chengdu China Department of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Department of Biochemistry and Molecular Biology, School of Life Science, Hubei University, Wuhan, China International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, PR China ARC Centre of Excellence in Exciton Science Monash University Wellington Road Clayton Victoria 3800 Australia Department of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China (mainland) Department of Dermatovenereology and West China Hospital Sichuan University Chengdu Sichuan China Department of Cancer Center, The First Hospital of Jilin University , Changchun 130021, China Department of Orthopedics, Linyi Second People’s Hospital, Linyi, China; School of Material Science and Engineering; School of Chemistry and Chemical Engineering; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; Tianjin University of Technology; Tianjin 300384 Key Laboratory of Microbiology, School of Life Science, Heilongjiang University, Harbin, People’s Republic of China; Key Laboratory of Northwest Water Resources, Environment and Ecology, Ministry of Education, Xi’an University of Architecture and Technology, Xi’an 710055, China Center of Interventional Oncology and Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics; Peking University; Beijing, P. R. China Department of Cardiology Zhongda Hospital School of Medicine Southeast University Nanjing China; Department of Cardiology Affiliated Hospital of Yangzhou University Yangzhou University Yangzhou China Department of Respiratory Medicine the Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004 China School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China School of Science; Jiangnan University; Wuxi 214122; China School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, Jilin 130022, P. R. China Department of Pharmaceutical SciencesUniversity of Tennessee Health Science CenterMemphisTennesseeUSA State Key Laboratory of Organic-Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods; Engineering Research Center for Natural Actives; College of Food Science; South China Agricultural University; Guangzhou 510642 Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki 00014 Finland Instrumental Analysis & Research Center, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai 200030, China. Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Hematology, The First Hospital, Jilin University, Changchun, China Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China State Key Laboratory for Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, the People’s Republic of China. State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China School of Information Engineering, Chang’an University, Xi’an 710064, China Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu, People’s Republic of China School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou; P. R. China Department of Biostatistics and Computational Biology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA 02215; Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080; Office of Clinical Research, Children's Hospital of Nanjing Medical University, Nanjing, China. From the Department of Surgery (A.G., M.S., R.A., W.L., S.H., G.T.) and the Interdepartmental Program in Vascular Biology and Therapeutics (A.G., M.S., R.A., W.L., G.T.), Yale University School of Medicine, New Haven, CT; the Veterans Affairs Connecticut Healthcare System, West Haven, CT (A.G., G.T.); and the Department of Surgery, St Mary's Hospital, Waterbury, CT (H.A., J.A.S.). Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences & Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China; Key Laboratory of Ministry of Education, Department of Molecular Biology, Fudan University, Shanghai, China; Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China Department of Emergency, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China Department of Thoracic Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130012, China Department of General Surgery, Xuzhou First People's Hospital, Jiangsu Xuzhou 221002, China. Department of Respiratory, Tianjin Teda Hospital, Tianjin 300457, China. Graduate Department, Weifang Medical University, Weifang, Shandong, P.R. China School of Naval Architecture and Ocean Engineering, Huazhong University of Science and Technology , Wuhan 430074, People's Republic of China hustliw@hust.edu.cn , cybhust@hust.edu.cn School of Mathematics and Physics, North China Electric Power University, Beinong Road 2, Huilongguan, Beijing 102206, China; Institute of Clusters and Low Dimensional Nanomaterials, North China Electric Power University, Beijing 102206, China Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Department of Anesthesiology, Renmin Hospital of Wuhan University Wuhan 430060, China. Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138 Institute of Dermatology Guangzhou Medical University Guangzhou China; Department of Dermatology Guangzhou Institute of Dermatology Guangzhou China Department of Chemistry; Capital Normal University; Beijing, China Stomatologic Hospital and College, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, Anhui 230032, China From the NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital (R.R., M.A.G., S.Y.H., S.E., L.S., W.L., T.W., M.S., K.P.M., P.J.K., D.J.P., S.V.B.-N.), National Heart and Lung Institute (M.A.G., S.Y.H., S.E., L.S., W.L., T.W., M.S., K.P.M., P.J.K., M.R., D.J.P., S.V.B.-N.), Royal Brompton Hospital, Imperial College London, London, United Kingdom; and Section of Clinical Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (R.R.). Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. College of Food Science and Technology; Nanjing Agricultural University; P R China College of Materials and Chemical Engineering; State Key Laboratory of Marine Resource Utilization in South China Sea; Hainan University; Haikou 570228; China State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China; Collaborative Innovation Center of Quantum Matter, Beijing 100084, China School of Pharmaceutical Science and Technology (SPST), Tianjin University, Tianjin 300072, P.R. China Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China Department of Chemistry and Institute of Biomedical Science Fudan University Shanghai 200433 (P. R. China Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan China Department of Dermatology & Rare Disease Center West China Hospital of Sichuan University 37# Guoxue Alley, Wuhou District Chengdu China Department of Pathology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China Department of Energy Engineering, Zhejiang University, Hangzhou 310027, China School of Chemistry and Physics Queensland University of Technology Brisbane Queensland 4001 Australia Department of Pediatrics, Nanjing BenQ Hospital Co., Ltd., The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu 210019, China.hailangli@hotmail.com. College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang Road, Nanjing, Jiangsu 210095, P. R. China Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Shanghai Institute of Applied Physics Chinese Academy Science Shanghai Synchrotron Radiation Facility Shanghai 201204 P. R. China Master of Physician Assistant Studies, School of Health and Rehabilitation Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA Office of the Texas State Chemist, Texas AgriLife Research Texas A&M University 445 Agronomy Rd. College Station TX 77843 USA Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215 PhD; Department of Anatomic Pathology, William Beaumont Hospital, 3601 W. 13 Mile Rd., Royal Oak, MI, USA; phone: 248-898-9060; fax: 248-898-8020; e mail: ping.zhang@beaumont.edu. Ultrasound Department, Second Affiliated Hospital of Harbin Medical University, Harbin, China Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada, Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland ImmunoGen, Inc., 830 Winter Street, Waltham, Massachusetts 02451, United States CAS Key Lab for Biologic Effects of Nanomaterials and Nanosafety and Beijing Synchrotron Lab Institute of High Energy Physics, Chinese Academy of Science, Beijing 100049 P. R. China Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Department of Cosmetic Laser Center Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China Laboratory of Cancer Cell Biology, Tianjin Cancer Research Institute, Tianjin Key Laboratory of Cancer Prevention and Therapy National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin China Jiangsu Academy of Agricultural Sciences, Institute of Plant Protection, Nanjing, Jiangsu province, Nanjing , Jiangsu, China, 210014, , ; ImmunoGen, Inc., Waltham, Massachusetts. Henan University of Science and Technology Luoyang 471003 China National Engineering Laboratory for Industrial Wastewater Treatment, School of Resources and Environmental Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, P.R. China Cancer Center of the First Hospital of Jilin University, Changchun, China State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Cell Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College 100005, Beijing, China Department of Cardiology Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai China BUAA-UOW Joint Research Centre and School of Physics, Beihang University, Beijing 100191, China; International Research Institute of Multidisciplinary Science, Beihang University, Beijing 100191, China Drug Discovery Center Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School Shenzhen 518055 China CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Infectious Diseases, First Affiliated Hospital of Bengbu Medical College, Bengbu, China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM); Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM); Nanjing Tech University (NanjingTech); Nanjing 211816; P.R. China International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai, China Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming, 650093, P. R. China; National Engineering Laboratory for Vacuum Metallurgy, Kunming University of Science and Technology, Kunming, 650093, P. R. China; Sino-Platinum Metals Co., Ltd., Kunming, 650101, P. R. China From the Program in Cell Biology (K.C., M.F., R.L.S.), Case Western Reserve University; and Department of Cell Biology (M.F., W.L., R.L.S.), Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio. College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, People’s Republic of China Department of Neurology National Neuroscience Institute Singapore; Parkinson's Disease and Movement Disorders Center National Neuroscience Institute Singapore Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Zhangjiang Hi-tech Park, Shanghai 201203, China, Shanghai R&D Center for Standardization of Traditional Chinese Medicines, 199 Guoshoujing Road, Zhangjiang Hi-tech Park, Shanghai 201203, China, and Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China Department of Orthopedics, The First Hospital of Harbin City, Harbin, Heilongjiang 150010, P.R. China Department of Pharmaceutical Science, University of Tennessee Health Science Center, Memphis, TN, USA Medical Research and Biometrics Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Beijing China Beijing Key Laboratory for Genetics of Birth Defects Beijing Pediatric Research Institute; MOE Key Laboratory of Major Diseases in Children; Genetics and Birth Defects Control Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China; Henan Key Laboratory of Pediatric Inherited & Metabolic Diseases Henan Children's Hospital Zhengzhou Hospital of Beijing Children's Hospital Zhengzhou China Key Laboratory for Green Chemical Technology, Ministry of Education, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P. R. China Department of Medicinal Chemistry & Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Shanghai 201203, China School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China Department of Urological Surgery, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 18000, China Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Collaborative Innovation Center of Chemistry for Energy Materials; Fudan University; Shanghai 200433 Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, United States Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, Fujian, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China; Xiamen University Affiliated Xiamen Eye Center, Xiamen University, Xiamen, Fujian, China ARC Centre of Excellence in Exciton Science Monash University Victoria 3800 Australia; Department of Chemical Engineering Monash University Victoria 3800 Australia Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering, Zhejiang University (Yuquan Campus), Hangzhou, People’s Republic of China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, P. R. China 7Department of Hematology, Cancer Center, The First Hospital of Jilin University, Changchun, China. Department of Computer & Electrical Engineering and Computer Science, California State University, Bakersfield, California 93311, USA Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South University Changsha Hunan China; Department of Radiology The Third Xiangya Hospital of Central South University Changsha Hunan China Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. lizhixia@medmail.com.cn. Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P. R. China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics Chinese Academy of Sciences (CAS) No.19 Yuquan Road, Shijingshan District Beijing 100049 China Oncology Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China University of Science and Technology of China 1 Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, , Hefei, Anhui 230026, China; University of Science and Technology of China, Hefei 2 CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics, , Anhui 230026, China Department of Gynecology and Obstetrics, the People’s Hospital of Three Gorges University/The First People’s Hospital of Yichang, Yichang, China Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China Neurology, Hainan Medical University, Haikou, Hainan, China. School of Mathematics and Physics; North China Electric Power University; Beijing 102206; P. R. China; Institute of Clusters and Low Dimensional Nanomaterials College of Finance and Economics, Gansu Agricultural University, Lanzhou, Gansu Province, China College of Horticulture, Gansu Agricultural University, Lanzhou, China College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China 1Cell Adhesion and Extracellular Matrix Biology Program, and; 3The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Jilin, China Chongqing Municipal Center for Disease Control and Prevention , Chongqing 400707 , China Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences Beijing P. R. China Department of Geriatrics, Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China College of Pharmaceutical Sciences, Capital Medical Univesity, Beijing 100069, PR China Shanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China Institute of Harbin Hematology & Oncology, The First Hospital of Harbin, Harbin 150010, Heilongjiang, China National Engineering Laboratory for AIDS Vaccine; School of Life Sciences; Jilin University; Changchun; China College of Veterinary Medicine Northeast Agricultural University 59 Mucai Street Harbin 150030 China 2Division of Biostatistics, Dan L Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas. Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: liwei@mrbc-nccd.com. Center for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China Department of Pulmonary and Critical Care Medicine, National Centre for Respiratory Medicine, Center of Respiratory Medicine, National Clinical Research Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China Department of Polymer Science and Engineering; School of Material Science and Chemical Engineering; Ningbo University; Ningbo; P. R. China Department of Pediatrics, Dongguan Hospital, Jinan University Dongguan 523905, Guangdong Province, China. Division of Cardiovascular Medicine, Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas Key Laboratory of Biomass Chemical Engineering of Ministry of Education Institute of Industrial Ecology and Environment College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Surgery, Shanghai 200025, China. Department of Biology, Centre for Research in Mass Spectrometry, and Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3, Division of Clinical Biochemistry, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1L5, and Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5 Heilongjiang Highway Survey and Design Institute, Harbin 150080, China State Key Laboratory of Molecular Developmental Biology Institute of Genetics & Developmental Biology Chinese Academy of Sciences Beijing China The Institute for Advanced Studies and Hongyi Honor College, Wuhan University, Wuhan 430072, China Department of Hepatobiliary and Pancreas Surgery, First Affiliated Hospital, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, PR China. Cancer and Stem Cell Center, First Affiliated Hospital, Jilin University Changchun 130061, Jilin, P. R. China. Cancer Center of the First Hospital of Jilin University, Changchun, China. Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, United States State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China Department of Dermatology, Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100010, China. Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. Retinal Neurophysiology Section, National Eye Institute, National Institutes of Health , Bethesda , MD 20892 , USA Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA Department of Respiratory Diseases, Nanfang Hospital, the Southern Medical University, Guangzhou, China. Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P. R. China; Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P. R. China Department of Special Ward, Tianjin Second People’s Hospital, Tianjin, 300192, PR China Department of Gastroenterology, Heze Municipal Hospital, Heze, Shandong, China Department of Immunology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, #1665 Kong Jiang Road, Shanghai 200092, China Departments of Microbiology and Immunology, Indiana University, School of Medicine, Indianapolis, Indiana, USA From the Department of Physiology (Z.B., W.L., T.H.N., A.K., G.K.), New York Medical College, Valhalla, NY; the Department of Pathophysiology (A.K.), Semmelweis University, Budapest, Hungary; and the Division of Clinical Physiology Z.B., N.E., A.T.), Institute of Cardiology, University of Debrecen, Debrecen, Hungary. School of Material Science and Engineering School of Chemistry and Chemical Engineering Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion Tianjin University of Technology Tianjin 300384 P. R. China State Key Lab of Urban Water Resource and Environment; School of Chemistry and Chemical Engineering; Harbin Institute of Technology; Harbin; P. R. China Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Physics and Chemistry of Luminescence, South China University of Technology, Guangzhou 510640, P. R. China Applied Materials Physics, Department of Materials Science and Engineering , , Brinellvägen 23, Stockholm, SE-10044 , Sweden; Royal Institute of Technology , , Brinellvägen 23, Stockholm, SE-10044 , Sweden Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, China Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 200031, China. Clinical Laboratory, Zhejiang University School of Medicine Children's Hospital, Hangzhou, China; Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States The Second Affiliated Hospital, Department of Breast and Thyroid Surgery, Hengyang Medical School University of South China Hengyang Hunan China; Clinical Research Center for Breast and Thyroid Disease Prevention and Control in Hunan Province, Hengyang Medical School University of South China Hengyang Hunan China Authors' Affiliations: 1The World Class Institute; 2Chemical Biology Research Center; Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Republic of Korea; 3The Hormel Institute, University of Minnesota, Austin, Minnesota; 4Department of Cardiothoracic Surgery, The Second Xiangya Hospital; 5Clinical Center for Gene Diagnosis and Therapy, The Second Xiangya Hospital; 6Cancer Research Institute; Central South University, Changsha; 7Basic Medical College, Zhengzhou University, ZhengZhou; 8China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, China; and 9Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts; Authors' Affiliations: 1The World Class Institute; 2Chemical Biology Research Center; Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Republic of Korea; 3The Hormel Institute, University of Minnesota, Austin, Minnesota; 4Department of Cardiothoracic Surgery, The Second Xiangya Hospital; 5Clinical Center for Gene Diagnosis and Therapy, The Second Xiangya Hospital; 6Cancer Research Institute; Central South University, Changsha; 7Basic Medical College, Zhengzhou University, ZhengZhou; 8China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, China; and 9Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts Department of Chemistry Capital Normal University Beijing 100048 P. R. China Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, 475004, China State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices South China University of Technology Wushan Road 381, Tianhe District Guangzhou 510640 Guangdong Province P. R. China Authors' Affiliations: Departments of 1Microbiology and 2Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University; 3Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China; and 4Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine & The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Authors' Affiliations: Departments of 1Microbiology and 2Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University; 3Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China; and 4Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine & The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois The First Hospital of Jilin University, Changchun 130021, China. Department of Pathology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China School of Health and Rehabilitation Sciences IUPUI Indianapolis IN USA Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Xi'an Jiaotong University Xi'an China Jiangsu Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China; Jiangsu Key Laboratory of Crop Cultivation and Physiology, Yangzhou University, Yangzhou 225009, China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China; Center for Systems Biology, Soochow University, Suzhou, China From the Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Key Laboratory of Network Control and Intelligent Instrument, Chongqing University of Posts and Telecommunications, Ministry of Education, Chongqing 400065, China Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, China Department of Oncology, The First Hospital of Jilin University, Changchun, China. Department of Otorhinolaryngology, Jining First People's Hospital, Jining, Shandong 272111, P.R. China North Branch Bio-Technology Co., Ltd. of Jiangsu Province, Taizhou, Jiangsu People's Republic of China. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. weili819@yahoo.com Department of Respiratory and Critical Care Medicine the Second Hospital of Jilin University Changchun Jilin 130041 China Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong, China Department of Vascular Surgery Peking University People's Hospital Beijing People's Republic of China School of Materials Science and Engineering Nankai University Tianjin 300350 China; Tianjin Key Laboratory of Metal and Molecule‐Based Material Chemistry Nankai University Tianjin 300350 China State Key Laboratory of Urban Water Resource and Environment, Shenzhen Graduate School. Harbin Institute of Technology Department of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China; Department of Physical Medicine and Rehabilitation, Qilu Hospital of Shandong University, Jinan, China Departments of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Obstetrics Jinan City People's Hospital Jinan Shandong China Departments of Microbiology and Immunology, Indiana University, Indianapolis, Indiana, USA Department of Urology, The People’s Hospital of Guangxi Zhuang Autonomous Region, NanNing, China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan 611130, China Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People’s Republic of China Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin, PR China; Center for Intelligent Medical Electronics, School of Information Science and Technology, Fudan University, Shanghai, China Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China College of Horticulture, Gansu Agricultural University, Lanzhou 730070, Gansu Province, China College of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430200, China; Hubei Key Laboratory of Biomass Fiber and Eco-dyeing & Finishing,Wuhan Textile University, Wuhan 430200, China Department of Energy Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China Wenzhou Medical College, China Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282 College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China School of Mathematics, Physics and Optoelectronic Engineering, and Collaborative Innovation Center for Optoelectronic Technology, Hubei University of Automotive Technology, Shiyan, Hubei, P. R. China; Shiyan Industrial Technology Research Institute of Chinese Academy of Engineering, Shiyan 442002, People's Republic of China College of Pharmacy, Chungnam National University, Daejeon, Korea College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, People’s Republic of China Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China State Key Laboratory of Microbial Technology School of Life Science Shandong University Jinan 250100 China Department of Breast and Thyroid Surgery China‐Japan Union Hospital of Jilin University Changchun Jilin China State Key Laboratory of Molecular and Developmental Biology Institute of Genetics & Developmental Biology Chinese Academy of Sciences Beijing 100101 China Department of Clinical Laboratory, Institute of Medicine and Physics, Renmin Hospital of Wuhan University, Key Laboratory of Artificial Micro- and Nano- Structures of Ministry of Education, School of Physics & technology, Wuhan University, Wuhan 430072, China Shenzhen SiBiono GeneTech Co. Ltd., Shenzhen, China. Jilin Animal Disease Control Center Changchun China School of Chinese Pharmacy, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405 Laboratory Medicine Center, Lanzhou University Second Hospital, Langzhou, China Department of Physics; Nanchang University; Nanchang 330031; P. R. China School of Material Science and Engineering National Engineering Research Center for Tissue Restoration and Reconstruction Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province South China University of Technology Guangzhou 510640 P. R. China Department of Neurology, West China Hospital Sichuan University Chengdu People's Republic of China Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, TX 77030, USA. wei.li@uth.tmc.edu State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China College of Physics and Electronic Engineering; Henan Normal University; Xinxiang; People's Republic of China Beijing Huilongguan Hospital, Huilongguan Clinical Medical School of Peking University, Beijing, China Dongguan Polytechnic, Dongguan 523808, China State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology, Zhejiang University of Technology, Hangzhou 310032, China. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China. Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Department of Cardiology, Section 2, Xi’an International Medical Center Hospital, Xi’an City, Shaanxi 710100, China Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region “Hypertension Research Laboratory” Xinjiang Clinical Medical Research Center for Hypertension (Cardio‐Cerebrovascular) Diseases Urumqi 830001 China Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, United States Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, The Sino-US Center for Lymphoma and Leukemia Research, Tianjin 300060, China Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Department of PET Center and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of medicine, Hubei, China Department of Hematology Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, and Department of Cell and Developmental Biology, Department of Medicine, Hematology-Oncology Division, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072, P. R. China Department of Orthopedics, General Hospital of PLA, Beijing, China; Department of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China 2Infectious Disease Division, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 Department of Anesthesiology, The Second Hospital of Hebei Medical University, 215 Heping West Road Shijiazhuang, Hebei 050000, China Department of Nephrology, The First Affiliated Hospital Sun Yat‐Sen University Guangzhou China; Key Laboratory of Nephrology Ministry of Health of China Guangzhou China; Guangdong Provincial Key Laboratory of Nephrology Guangzhou China Department of Histology and Embryology, College of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Department of Orthopedic Trauma and Hand Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi 530021, P. R. China. Michigan State University, East Lansing, MI, USA Guangdong Provincial Key Laboratory of Stomatology Department of Oral Medicine Guanghua School of Stomatology Sun Yat‐sen University Guangzhou P.R. China First Affiliated Hospital, Jilin University, Changchun, People’s Republic of China Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, Harbin, China Cancer Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. State Key Laboratory of Cotton Biology, Institute of Cotton Research of the Chinese Academy of Agricultural Sciences, Anyang 455000, Henan, People's Republic of China School of Economics and Management Wuhan University, Wuhan, Hubei, PR China; Research Center of Hubei Micro & Small Enterprises Development, School of Economics and Management, Hubei Engineering University, Xiaogan, People’s Republic of China Hubei Provincial Collaborative Innovation Center of Biomass Resources Transformation and Utilization; College of Chemistry and Materials Science; Hubei Engineering University; P. R. China Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China Donghu Experimental Station of Lake Ecosystems State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology The Chinese Academy of Sciences Wuhan China Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China ∥The State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People’s Republic of China; Department of Biology, Zhaoqing College, Zhaoqing 526000, Guangdong Province, China. Department of Histology and Embryology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Mechanical and Aerospace Engineering Benjamin M. Statler College of Engineering and Mineral Resources West Virginia University Morgantown WV 26506 USA Department of Biological Chemistry University of California Irvine Irvine CA USA Tianjin Women’s and Children’s Health Center, Tianjin 300070, China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China Department of Intensive Care Unit, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA Northeast Agricultural University, College of Resources and Environment, Harbin, Heilongjiang, China; Northeast Agricultural University, College of Agriculture, Harbin, Heilongjiang, China Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Weigang 1, Xuanwu District, Nanjing, Jiangsu 210095, People’s Republic of China Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi’an Medical University, Xi’an, China Nanjing Normal University School of Materials Science and Engineering; Nanchang Hangkong University; Nanchang; People's Republic of China Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, People’s Republic of China Deptartment of Hematology and Onocology, The First Clinical Hospital of Jilin University, Changchun 130021 China. Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, FL 32610; Departments of Physiology and Medicine/Infectious Diseases, University of Geneva, 1211 Geneva, Switzerland; and Departments of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 Institute of Cerebrovascular Disease Research, Xuanwu Hospital of Capital Medical University , 45 Changchun Street, Beijing 100053 , China; Beijing Geriatric Medical Research Center , Beijing 100053 , China Department of Neurology, General Hospital of Northern Theatre Command, Shenyang, China Biostatistics and Computational Biology, and; Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115; and Department of Biochemistry and Molecular Biology 1 and 2 and 3; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury 1 and 2 and 3; Department of Neurosurgery, Research Institute of Surgery and Daping Hospital; Third Military Medical University, Chongqing 400042, China 1 and 2 and 3 Department of Clinical Laboratory, Tianjin Huan Hu Hospital Department of Joint Surgery, Weifang People's Hospital Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, North Carolina 27695, United States MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 P.R. China Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, Hainan Province, P.R. China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, P.R. China Department of Infectious Disease Henan Provincial People’s Hospital People’s Hospital of Zhengzhou University People’s Hospital of Henan University Zhengzhou China Department of Rheumatology Shanghai East Hospital, Tongji University School of Medicine Shanghai China Department of Dermatovenereology West China Hospital Sichuan University Chengdu China Department of Pathophysiology, Medical School, Shihezi University, Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University, Shihezi 832002, China. Tianjin Medical University Cancer Institute and Hospital, Tianjin, China From the Department of Pediatrics (Y.W., X.Z., H.J., H.W., W.L., J.D.), Central Laboratory (D.B.), the Department of Electron Microscopy (X.T., Y.R.), and the Institute of Cardiovascular Research (C.T.), Peking University First Hospital, Beijing; and Key Laboratory of Molecular Cardiovascular Diseases (C.T., J.D.), Ministry of Education, Beijing, P.R. China. Department of Medicinal Chemistry, School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China College of Chinese Medicinal Materials, Jilin Agricultural University , Changchun 130118, China National Clinical Research Center for Cardiovascular Diseases, National Health Commission Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases Beijing China Hainan Jiuzhitang Pharmaceutical Co.,Ltd. Haikou 570311,China. Department of Materials Science and Metallurgy; University of Cambridge; Cambridge CB3 0FS, UK School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China Shanghai Medical College, Fudan University, Shanghai, China Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Ultrasomics Artificial Intelligence X-Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States Department of Nuclear Radiation Injury and Monitoring, The PLA Rocket Force Characteristic Medical Center, Beijing, China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China Department of Medical Imaging Jiangsu Vocational College of Medicine Yancheng China Department of Chemistry and Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China, Livzon Pharmaceutical Research Institute, Zhuhai 519020, P. R. China, and Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, P. R. China Health Management Centre, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Sustainable Advanced Materials (Sêr SAM), Department of Physics, Swansea University, Singleton Park, Swansea, Wales SA2 8PP, U.K. Cancer Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, Chaoyang, People's Republic of China. leways@ioz.ac.cn. University of Chinese Academy of Sciences, Beijing, People's Republic of China. leways@ioz.ac.cn. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China The Department of Orthopedic Rehabilitation, Institute of Sports Medicine of China, Beijing, P. R. China Department of Noncommunicable Disease Control and Prevention Tianjin Centers for Disease Control and Prevention Tianjin China Department of Molecular and Cellular Biology,; Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of Education Hubei Province Key Laboratory of Allergy and Immunology Wuhan University Wuhan Hubei 430072 P. R. China Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China Medical Research and Biometrics Center, National Center for Cardiovascular Diseases, Beijing, China Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital Hangzhou China; Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Hangzhou China Marshall University; Department of Biomedical Sciences; Huntington; USA Hubei Key Laboratory of Regional Development and Environmental Response, Faculty of Resources and Environmental Science Hubei University Wuhan China Departments of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China Department of Ultrasound, Renmin Hospital Hubei University of Medicine Shiyan China Department of Infectious Diseases, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China Division of Infectious Diseases, Department of Medicine, Center for Antibody Therapeutics University of Pittsburgh Medical School Pittsburgh Pennsylvania USA Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan Stem Cell and Cancer Center, First Affiliated Hospital Jilin University Changchun Jilin 130061 People's Republic of China Laboratory of Macromolecular Chemistry and Paper Chemistry, Department of Chemistry, Technische Universität Darmstadt, Petersenstrasse 22, 64287 Darmstadt, Germany BGI Genomics, BGI‐Shenzhen Shenzhen China From the Cardiovascular Divisions, Beth Israel Hospital (M.V.M., W.J.M.) and Brigham and Women’s Hospital (M.V.M., P.G., A.P.S.); the Department of Radiology, Beth Israel Hospital (W.L., R.R.E., W.J.M.); and Harvard Medical School, Boston, Mass. College of Food Science & Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization and Hunan Provincial Key Laboratory of Biology and Control of Plant Diseases and Insect Pests, Hunan Agricultural University, Changsha, Hunan 410128, China (W.L., Y.N., L.D., G.L.W.); State Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Central Laboratory, General Hospital of Western Theater Command, Chengdu, Sichuan, China Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050061, China Cancer Center The First Hospital of Jilin University Changchun Jilin 130021 China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding 071002, P. R. China Neurology, National Neuroscience Institute Singapore City Singapore Cancer CenterThe First Hospital, Jilin University, Changchun, China Medical Research and Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Institute of Coordination Catalysis, College of Chemistry and Bio‐engineering Yichun University Yichun 336000 People's Republic of China Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing Medical University, Chongqing, China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research College of Life Science and Technology Huazhong Agricultural University Wuhan China Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States School of Materials Science and Engineering Beijing Key Laboratory for Magnetoelectric Materials and Devices Beijing Innovation Centre for Engineering Science and Advanced Technology Peking University Beijing 100871 China College of Chemistry and Pharmaceutical Sciences; Qingdao Agricultural University; Qingdao 266109; P. R. China Department of Gastrointestinal Surgery, Peking University International Hospital, Beijing, China Key Lab of Artificial Micro- and Nano-Structures of Ministry of Education of China, School of Physics and Technology, Wuhan University, Wuhan 430072, P. R. China Department of Colorectal and Anal Surgery, the Second Hospital of Jilin University, Changchun Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Soochow University Suzhou 215123 China Hangzhou Institute of Technology, Xidian University Key Laboratory of Strongly-Coupled Quantum Matter Physics; Chinese Academy of Sciences; Department of Physics; University of Science and Technology of China; Hefei Department of Cardiothoracic Surgery, Changzheng Hospital Second Military Medical University 31st Floor, 415#, Rd Fengyang 200003 Shanghai China; Department of Cardiothoracic Surgery 161 Hospital of Chinese People’s Liberation Army 430012 Wuhan China Department of PET Center and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of MedicineShiyan, Hubei ProvinceP.R. China Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of China; Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 8234, PHENIX, F-75005 Paris, France College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, No. 928, Second Street, Xiasha Higher Education Zone, Hangzhou 310018, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, and Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Graduate School Fourth Military Medical University Xi'an China Department of Cardiology, Tangdu Hospital of the Fourth Military Medical University, Xi’an, China Departments of General Surgery Department of Pathology, Corewell Health (East), Royal Oak, MI, USA Inst. of Genomics and Bioinformatics South China Agricultural Univ. Guangzhou 510642 China Neuroscience Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA Key Laboratory of Drug Quality Control & Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, PR China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, PR China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China College of Earth Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Jiangsu, Nanjing 210002, China Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands Department of Orthopedics; General Hospital of PLA; Beijing 100853; China Key Laboratory for Green Chemical Technology MOE and ‡Key Laboratory of Systems Bioengineering MOE, School of Chemical Engineering and Technology, Tianjin University, Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300072, People’s Republic of China Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101, China International Iberian Nanotechnology Laboratory (INL); 4715-330 Braga; Portugal Department of Urology The Second Hospital of Hebei Medical University Shijiazhuang China Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China Department of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China North Branch Bio‐Technology Co, Ltd of Jiangsu Province Taizhou Jiangsu, 225300 China Department of Medical Cosmetology, Shanghai Dermatology Hospital, Tongji University School of Medicine, Shanghai 200443, China Peking University People's Hospital, Beijing, China Institute of Crop Tillage and Cultivation Heilongjiang Academy of Agricultural Sciences Harbin 150086 Heilongjiang Province China Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Orthopaedic Department Peking University Third Hospital Beijing China; Beijing Key Laboratory of Spinal Disease Research Beijing China; Engineering Research Center of Bone and Joint Precision Medicine Ministry of Education Beijing China Xidian University BGI‐Shenzhen Shenzhen China; Guangdong Provincial Key Laboratory of Human Disease Genomics Shenzhen Key Laboratory of Genomics BGI-Shenzhen Shanghai China; BGI Education Center University of Chinese Academy of Sciences Shenzhen China Cancer Center, The First Hospital of Jilin University, Changchun, China Pharmacology Research Center, First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, China School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, P. R. China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, P. R. China; Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin, 300350, P. R. China Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Gansu Provincial Second People's Hospital; Lanzhou; China 730046 Academy of Agriculture and Forestry Sciences, Qinghai University, Xining, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China; Key Laboratory of Agricultural Integrated Pest Management of Qinghai Province, Scientific Observing and Experimental Station of Crop Pest in Xining, Ministry of Agriculture, Xining, China The Derald H. Ruttenberg Cancer Center and The Brookdale Center for Molecular and Developmental Biology, The Mount Sinai Medical Center, New York, NY 10029; and Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia Shenzhen University Department of Otorhinolaryngology Head and Neck Surgery,Eye Ear Nose and Throat Hospital,Fudan University. The Second Department of General Surgery, Cangzhou Central Hospital, Cangzhou, China Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, Connecticut, USA Department of Urology, Shenzhen Longhua District Central Hospital, The Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, Guangdong Province, China Medical Image Computing Laboratory of Ministry of Education, Northeastern University, Shenyang 110819, China; College of Computer Science and Engineering, Northeastern University, Shenyang 110819, China Department of Infectious Diseases, Henan Provincial People’s Hospital, Zhengzhou, Henan, China Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030 State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P.R. China.; Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China. Department of Ophthalmology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen City, Guangdong Province, 518000 P. R. China School of Life Science and Technology, China Pharmaceutical University, Nanjing, China Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, P.R. China Department of Microbiology, Miami University, Oxford, Ohio, USA Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Chinese Academy of Sciences State Key Laboratory of Membrane Biology The State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 P. R. China; Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China School of Chemistry and Chemical Engineering Institute of Theoretical and Computational Chemistry, Nanjing University Nanjing China Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, PR China Department of Plant Pathology, University of California, Davis, California 95616 Department of Publication, Shenyang Agricultural University, Shenyang, China, 110866 Beijing Key Laboratory for Genetics of Birth Defects and; MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital/Capital Medical University/National Center for Children’s Health, Beijing, China;; Shunyi Women and Children’s Hospital of Beijing Children’s Hospital, Beijing, China; and Triticeae Research Institute, Sichuan Agricultural University, Yaan, Sichuan 625014, China.; Key Laboratory of Southwestern Crop Germplasm Utilization, Ministry of Agriculture, Sichuan Agricultural University, Yaan 625014, Sichuan, China.; Agriculture & Agri-Food Canada, Eastern Cereal and Oilseed Research Centre, Ottawa, ON K1A 0C6, Canada.; Agronomy College, Sichuan Agricultural University, Yaan, Sichuan 625014, China. Department of Neurology Dongguan People's Hospital Dongguan China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China School of Chemistry and Chemical Engineering; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; Tianjin University of Technology; Tianjin 300384; China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China. Department of Neurosurgery, The Sixth Affiliated Hospital, Jinan University, Dongguan, Guangdong 523560, China Department of neurosurgery, Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. Environmental Soil Chemistry Group, Delaware Environmental Institute and Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19716, United States; Key Laboratory of Surficial Geochemistry, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, People’s Republic of China Department of Cadiovascular Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China; Department of Oral Radiology School and Hospital of Stomatology Wuhan University Wuhan China Department of Medical Oncology, Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 PR China Department of Biosystems Engineering, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba South China Normal University; China China Tobacco Jiangsu Industrial Co. Ltd, Nanjing, 210019, China Department of Ultrasonography, Tianjin Huanhu Hospital Tianjin 300350, China. Cancer Center of the First Hospital of Jilin University, Changchun, Jilin, China; Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China;; Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou, People's Republic of China;; Hainan Engineering Research Center of Agarwood, Haikou, People's Republic of China The GPL Photonics Laboratory State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China University of Utah, Department of Chemistry, Salt Lake City, Utah 84112 Laboratoire des Sciences du Climat et de l’Environnement/Institut Pierre Simon Laplace, Commissariat à l'Énergie Atomique et aux Énergies Alternatives–CNRS–Université de Versailles Saint-Quentin, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France; Hunan Provincial Key Laboratory of Two‐Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Brain Imaging and Analysis Center, School of Medicine Duke University Durham NC USA Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA Department of Engineering Technology and Texas Center for Superconductivity, University of Houston, Houston, Texas 77204, United States College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education, Hunan University, Changsha, China Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Pathology, Immunology, and Laboratory Medicine University of Florida Gainesville FL USA Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612 From the Departments of Cardiovascular Surgery (Y.L., S.H.) and Cardiology (B.X., R.G.), Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences; Department of Biostatistics, National Center for Cardiovascular Disease (W.L.); and Key Laboratory of Cardiovascular Regenerative Medicine, Ministry of Health (Z.Z., S.Z.), Beijing, China. Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi 214122, China State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People’s Republic of China; Center for mRNA Translational Research, Fudan University, Shanghai, People’s Republic of China Cancer Center, The First Bethune Hospital of Jilin University, Changchun, China Department of Physiology, Wayne State University, Detroit, MI, 48201, United States Department of Medical Oncology, The First Hospital of Jilin University, Changchun, China Guiyang University of Chinese Medicine, Guiyang, Guizhou, 550018, China Department of Chemistry; Collaborative Innovation Center of Chemistry for Energy Materials; Fudan University; Shanghai 200438; China Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany Department of Dermatology Huashan Hospital Fudan University Shanghai China Institute for Clean Energy and Advanced Materials, School of Materials & Energy; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Southwest University, Chongqing 400715, China Department of Physiology Wayne State University Detroit Michigan Department of Pediatric Cardiology Guangdong Cardiovascular Institute, Affiliated South China Hospital, Southern Medical University, Guangdong General Hospital Guangzhou China; Department of Cardiology Guangzhou Women and Children's Medical Center Guangzhou China Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, China. Department of Oncology No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China Wake Forest Institute For Regenerative Medicine, Wake Forest University, Winston-Salem, NC, 27103, USA; Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China Heart and Lung Research Institute, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. ‡State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;; §Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China; and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. College of Marine Life Sciences Ocean University of China Qingdao China Department of Mechanical Engineering, Division of Intelligent and Biomimetic Machinery, State Key Laboratory of Tribology, Tsinghua University, Beijing, China Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease Department of Respiration First Affiliated Hospital Bengbu Medical College Bengbu Anhui Province China Department of Microbiology and Immunology,Indiana University School of Medicine,Indianapolis,IN 1Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan. Human Cancer Genetics Program and Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Pathogen Biology Nanjing Medical University Nanjing Jiangsu P. R. China Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People’s Repubic of China International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China From the Department of Clinical Cardiology (A.P.B., R.S., P.R.K., A.J.S.C., S.D.A.), National Heart & Lung Institute, Imperial College of Science, Technology and Medicine, London, UK; Adult Congenital Heart Program (W.L., M.L., M.A.G.) and Department of Clinical Biochemistry (M.K.), Royal Brompton Hospital, London, UK; and Franz-Volhard-Klinik (Charité, Campus Berlin-Buch) at Max-Delbrück-Centrum for Molecular Medicine (S.D.A.), Berlin, Germany. Key Laboratory for Automobile Materials (JLU), Ministry of Education, College of Materials of Science and Engineering, and ‡Key Laboratory of Coherent Light and Atomic and Molecular Spectroscopy of Ministry Education, College of Physics, Jilin University, Changchun 130012, P. R. China Department of Dermatology and Venerology, West China Hospital, Sichuan University, Chengdu, China.; Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China. National Center for Soybean Improvement, National Key Lab of Crop Genetics and Germplasm Enhancement Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural University Nanjing 210095 China; Institute of Farming and Cultivation Heilongjiang Provincial Academy of Agricultural Sciences Harbin 150086 China College of life Sciences, Sichuan Normal University, Chengdu 610101, P.R. China. Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei 430068, China Department of Geriatric Neurology, Nanjing Medical University Affiliated to Nanjing Brain Hospital, Nanjing, Jiangsu, PR China 1Key Laboratory of Soil Microbiology , Ministry of Agriculture, Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China Department of Breast and Thyroid Surgery, Clinical Research Center for Breast & Thyroid Disease Prevention in Hunan Province (2018SK4001), The Second Hospital, University of South China, Hengyang 421001, China College of Plant Protection, Shanxi Agricultural University, Taiyuan, People’s Republic of China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China School of Physics and Wuhan National High Magnetic Field Center; Huazhong University of Science and Technology; Wuhan 430074; China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China Biomedical Engineering Institute, School of Control Science and Engineering, Shandong University, Jinan, People’s Republic of China Orthopaedic Department, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China Huazhong Agricultural University No. 1 Shizishan Street, Hongshan District Wuhan Hubei Province 430070 China ChiFeng University, Hongshan, Chifeng, Inner Mongolia, People’s Republic of China Department of Rehabilitation Binzhou Medical University Hospital Binzhou China University of Cambridge, Department of Haematology, Division of Structural Medicine, Thrombosis Research Unit, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, U.K. Key Laboratory for Green Chemical Technology MOE; Tianjin University; Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin); Tianjin 300072; People's Republic of China Chinese Academy of Sciences; University of Chinese Academy of Sciences State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University , Wuhan, Hubei 430079, China; Department of Oral Radiology, School & Hospital of Stomatology, Wuhan University , Wuhan, Hubei 430079, China Department of Medical Oncology Shanghai Pulmonary Hospital & Thoracic Cancer Institute Tongji University School of Medicine Shanghai China Department of Chemistry and Biochemistry, and Center for Molecular Design and Biomimicry, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan Key Laboratory of Aquatic Genomics Ministry of Agriculture Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China Department of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (mainland) Department of Environmental Engineering, Zhejiang University (Yuquan Campus), Hangzhou 310027, China Crop Tillage and Cultivation Institute, Heilongjiang Academy of Agricultural Science Harbin China Department of Medical Ultrasonics, Ultrasomics Artificial Intelligence X-Lab, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China GPL Photonics Laboratory State Key Laboratory of Applied Optics Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 P. R. China Department of Cardiac Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi 710071, China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China Department of Neurobiology The University of Alabama at Birmingham Birmingham AL USA Department of Orthopedics, the First Affiliated Hospital of Hebei North University, Zhangjiakou, China. Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China College of Life Sciences, Yangtze University, Jingzhou, Hubei, 434025, China College of Life Science, Yangtze University, Jingzhou, China;; Institute of Biomedicine, Yangtze University, Jingzhou, China School of Nursing Third Military Medical University Chongqing China Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Institute of Cell Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China Microelectronics Research Center; The University of Texas at Austin; Austin; USA; Department of Electrical and Computer Engineering State Key Lab of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China Key Laboratory of Aquatic Genomics, Ministry of Agriculture, Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation, Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong, China. The First Hospital of Jilin University; Changchun; China Department of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou China 2Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China. Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA Department of Thoracic Surgery General Hospital of Chinese People's Armed Police Force Beijing China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases; West China Hospital of Stomatology; Sichuan University; Chengdu; China Department of Pharmaceutical Sciences, College of Pharmacy; The University of Tennessee Health Science Center; Memphis TN 38163 United States Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States Department of Orthopaedics, Xiaoshan Traditional Chinese Medical Hospital, 311201 Hangzhou, China 2 Institute of Psychological Health Education, Fudan University, Shanghai, China State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100101, China. Institution of Genomics and Bioinformatics, South China Agricultural University, Guangzhou, China Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering, Zhejiang University, Yuquan Campus, Hangzhou 310027, China Department of Orthopedics, Shenzhen Pingle Orthopaedic Hospital, Shenzhen 518038, Guangdong, China Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department document (Approval number: 2014-405)], Hengyang, Hunan 421001, P.R. China Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan Affiliated Hospital of Chengde Medical University, Chengde Science and Technology on Aerospace Chemical Power Laboratory, Hubei Institute of Aerospace Chemotechnology, Xiangyang 441003, Hubei, China Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Japan Institute of Bioinformatics, Harbin Institute of Technology, Harbin, China Institute of Millet Crops Hebei Academy of Agriculture and Forestry Sciences Shijiazhuang 050035 China Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P.R. China Jilin University State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Qianjin Street 2699 Changchun 130012 P. R. China Fudan University Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials, , Shanghai 200433, China Department of Endocrinology, Suzhou Hospital of Anhui Medical University, Suzhou, China Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.; Tianjin Neurological Institute, Neurology, Key Laboratory of Post Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China.; Department of Neurology, Henry Ford Hospital, Detroit, Michigan. Ntional Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong 510006, China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, People’s Republic of China. School of Civil Engineering and Architecture, Chongqing University of Science and Technology, Chongqing 401331, China Monogenic Disease Research Center for Neurological Disorders Beijing Tiantan Hospital Capital Medical University Beijing China Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing From the Clinical Laboratory Center, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China (Xue, Wang, W. Li, Q.L. Li, Xu, Niu, Liu). State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Key Laboratory of Aquatic Genomics, Ministry of Agriculture, Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China; Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation, Ministry of Agriculture, Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China Department of Rehabilitation Medicine Binzhou Medical University Hospital Binzhou Shandong China; Medical Research Center Binzhou Medical University Hospital Binzhou Shandong China; Institute for Metabolic & Neuropsychiatric Disorders Binzhou Medical University Hospital Binzhou Shandong China Cancer Center, First Hospital Affiliated to Jilin University, Jilin, China Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA. Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA. Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA. Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA. Department of Pharmaceutical Chemistry; University of California; San Francisco; CA; 94158-2280; USA Department of Animal Science, College of Animal Sciences Zhejiang University Hangzhou China Hainan Key Laboratory for Research and Development of Natural Products from Li folk Medicine, Institute of Bioscience and Biotechnology, Chinese Academy of Agricultural Sciences, Haikou, P.R. China; Hainan Institute for Tropical Agricultural Resources, Chinese Academy of Agricultural Sciences, Haikou, P.R. China Qingdao Agricultural University, Qingdao, China Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China International Medical Department, Peking Union Medical College Hospital, Beijing, China Michigan State University 1 Department of Chemistry, , East Lansing, Michigan 48824, USA Department of Physics, Southern University of Science and Technology, Shenzhen 518055, China Retinal Neurophysiology Section, National Eye Institute, US National Institutes of Health, Bethesda, MD 20892, USA Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States Department of Obstetrics and Gynecology, ShengJing Hospital of China Medical University, Liaoning, P. R. China Institute of Chemical Biology and Nanomedicine (ICBN); State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Hunan University; Changsha 410082 Materials Genome Institute Shanghai University Shanghai 200444 P. R. China Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, People’s Republic of China Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Ministry of Health, Beijing, China School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China. weiwei99231@sina.com Department of Urology The First Affiliated Hospital of Xiamen University, The First Clinical College of Fujian Medical University Xiamen Fujian China Department of Medical Oncology, Zhongshan Hospital Fudan University Shanghai 20032 P. R. China College of Mechanical Science and Engineering, Northeast Petroleum University, Daqing 163318, China Horticultural and Garden College, Hainan University, Haikou 570228, China. 339567149@qq.com Retinal Neurophysiology Section, National Eye Institute, NIH, Bethesda, MD 20892; 1Human Cancer Genetics Program, Comprehensive Cancer Center; College of Veterinary Medicine; Northeast Agricultural University; Harbin; P. R. China *Division of Rheumatology and Immunology,; †Department of Pediatrics, and Center for Gastroenterology Research on Absorptive and Secretory Processes, Tufts University School of Medicine and New England Medical Center, and Triticeae Research Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China; Provincial Key Laboratory of Respiratory Disease in Anhui, Bengbu 233004, China Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Materials Genome Institute Shanghai University Shanghai 200444 China Department of Intensive Care Unit, Jinan Central Hospital Affiliated to Shandong University , Jinan , Shandong, 250013 , China Eye Institute and Affiliated Xiamen Eye Center, Xiamen University School of Medicine, Xiamen, Fujian, China 2Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Hunan University, Changsha 410082, China Hangzhou Jichenjunchuang Medical Laboratory, Co. Ltd Hangzhou China Department of PET-CT/MRI, Harbin Medical University, Harbin Medical University Cancer Hospital Harbin 150081, Heilongjiang, China. Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, P.R. China Department of Neurology, Dongguan People’s Hospital (Affiliated Dongguan Hospital, South Medical University), Dongguan, Guangdong Province, China College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China Department of Chemistry, Merkert Chemistry Center Boston College Chestnut Hill MA 02467 USA Department of Electronic Engineering, Shantou University, Shantou City, Guangdong Province, China Key Laboratory of Green Chemistry and Technology of Ministry of Education; College of Chemistry; Sichuan University; Chengdu 610064; PR China Department of Urology of the First People's Hospital of Yunnan Province Kunming China; Medical College of Kunming University of Science and Technology Kunming China First Affiliated Hospital, Bengbu Medical College, Bengbu, People’s Republic of China Department of Oral Facial Development, Indiana University School of Dentistry, Indianapolis, Indiana, at the time of this study. She is now Research Faculty, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana. University of Science and Technology of China Department of Precision Machinery and Precision Instrumentation, , Hefei, Anhui 230026, China Key Laboratory of Bio‐based Material Science and Technology of Ministry of Education Northeast Forestry University Hexing Road 26 Harbin 150040 P. R. China Academy of Agriculture and Forestry Sciences, Qinghai University, Xining, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China; Ministry of Agriculture, Scientific Observing and Experimental Station of Crop Pest in Xining, Xining, China; Key Laboratory of Agricultural Integrated Pest Management of Qinghai Province, Xining, China Department of Neurology The First Hospital of Changsha Changsha P. R. China Department of Chemistry and Chemical Engineering, Northeast Petroleum University, Heilongjiang 163318, People’s Republic of China Department of Lymphoma National Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital Tianjin China Department of Pharmacy Southwest Hospital Third Military Medical University Chongqing China Department of Neurosurgery, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210008, China From the Cardiovascular Research Department, Genentech, Inc, South San Francisco, and Affymetrix, Inc, Santa Clara (T.A.A., B.S., G.d.F.), Calif. International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China. Authors' Affiliations: 1Department of Microbiology and Immunology, Sylvester Cancer Center, 2Bascom-Palmer Eye Institute, 3Diabetes Research Institute, and 4Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami; 5Center for Supramolecular Science and Department of Chemistry, and 6University of Miami Center for Advanced Microscopy (UMCAM), University of Miami, Coral Gables, Florida; and 721st Century Biochemicals, Inc., Marlborough, Massachusetts Department of Pharmaceutical Sciences, College of Pharmacy, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA. wli@utmem.edu Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology , Shanghai, 200040 , P.R. China Medical Research & Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China State Key Laboratory of Pharmaceutical Biotechnology; Institute of Functional Biomolecules; School of Life Sciences; Nanjing University; Nanjing 210046 Microelectronics Research Center, Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, Texas 78758, United States Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Master of Physician Assistant Studies, School of Health and Rehabilitation Sciences, Indiana University–Purdue University Indianapolis, Indianapolis, IN, USA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. The Second Clinical School of North Sichuan Medical College, Nanchong, China Department of Chemical Engineering, Loughborough University, Loughborough LE113TU, U.K. Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Laboratory of Advanced Materials; iChEM (Collaborative Innovation Center of Chemistry for Energy Materials); Fudan University Hubei Collaboration Innovation Center for Biomass Conversion and Utilization, Hubei Engineering University, Hubei Xiaogan 432100, PR China Department of Otolaryngology, Ezhou Central Hospital, Ezhou City, Hubei Province 436000, P.R. China College of Veterinary Medicine, Northeast Agricultural University, Harbin, China State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China Cancer Center First Hospital of Jilin University Changchun Jilin China Department of Anesthesiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, Hainan Province, PR China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, PR China Department of Chemical Engineering, Texas Tech University, Lubbock, Texas State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China Department of Radiology The Third Xiangya Hospital of Central South University Changsha Hunan China; Cell Transplantation and Gene Therapy Institute The Third Xiangya Hospital of Central South University Changsha Hunan China Department of Echocardiography, Fudan University, Zhongshan Hospital College of Pharmacy Beihua University Jilin 132013 P. R. China School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Key Laboratory of Materials‐Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region Engineering Research Center of Materials‐Oriented Chemical Engineering of Xinjiang Bintuan Shihezi University Shihezi 832003 China College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China; College of Life Sciences, Jilin Agricultural University, Changchun 130118, P. R. China 2Department of PhysiologyWayne State University, Detroit, Michigan, USA Rice Research Institute, Yunnan Agriculture University, Kunming, Yunnan, China Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University Tianjin Key Laboratory of Biosensing and Molecular Recognition, Key Laboratory of Functional Polymer Materials, Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, Heilongjiang 150030, China. Key Laboratory of Marine Drugs, Chinese Ministry of Education; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, Shandong, P. R. China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266200, P. R. China Department of Anesthesiology, Sun Yat-sen University Cancer Center, Guangzhou 530060, China; Email:liw@sysucc.org.cn. Department of Rehabilitation Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong, China Department of Anatomic and Clinical Pathology, Beaumont Health System, Royal Oak, MI 48073, USA Department of Medical Ultrasonics, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China Xi’an University of Science and Technology 1 Department of Basic Courses, Mechanics Research Center, , Xi’an, Shaanxi 710054, China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China, and School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332 Alcohol and Drug Abuse Research Center McLean Hospital, Harvard Medical School 115 Mill Street Belmont MA 02478‐9106 USA Retinal Neurophysiology Section, National Eye Institute, Bethesda, MD 4 State Key Laboratory of Stem Cell and Reproductive Biology , Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China; University of the Chinese Academy of Sciences , Beijing 100049, China; Institute of Reproductive Health and Perinatology , Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623 Guangzhou, China State Key Laboratory of Low‐Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 P. R. China; Collaborative Innovation Center of Quantum Matter Beijing 100084 P. R. China Laboratory Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China Radiotherapy Technology Center Of The Affiliated Hospital Of Qingdao University, Qingdao, Shandong, China Laboratory of Molecular and Cellular Physiology, School of Life Sciences, Northeast Normal University, Changchun, Jilin, China; and Department of Critical Care Medicine The Affiliated Hospital of Guizhou Medical University Guiyang China Center for Supramolecular Science and Department of Chemistry, University of Miami, Coral Gables, Florida 33124-0431. Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, 200072, China. Department of Endocrinology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China Department of Medicinal Chemistry Institute for Therapeutics Discovery and Development University of Minnesota 717 Delaware Street SE Minneapolis MN 55414 USA Department of Stomatology Beijing Chao‐Yang Hospital Capital Medical University Beijing China Department of Neurology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki FI‐00014 Helsinki Finland Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources, Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266520, China. Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, PR China 6Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas. From the Department of Neurology (J.F., Q.C.), Ruijin Hospital; Department of Neurology (J.F., W.Y., W.L.), Ninth Hospital; and the School of Public Health (G.-X.J., Q.C.), Shanghai Jiao Tong University, Shanghai, China; and Department of Public Health Sciences (G.-X.J.), Karolinska Institute, Stockholm, Sweden. State Key Lab of Advanced Technologies for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan; P. R. China Chair of Macromolecular Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden Mommsenstrasse 4, 01069 Dresden, Germany Faculty of Psychology and MOE Key Laboratory of Cognition and Personality Southwest University Chongqing China Department of Neurology General Hospital of Northern Theater Command Shenyang China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China Center for Interventional Oncology, Beijing You'an Hospital, Capital Medical University, Beijing, People's Republic of China. From Stroke Clinical Research Unit, Department of Neurology (B.W., M.L., H.L., W.L., S.T., S.Z., Y.F.), Key Laboratory of Human Disease Biotherapy of the State and Ministry of Education (M.L.), West China Hospital, Sichuan University, China. Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China Department of Biological Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450003, P.R. China School of Pharmacy Fudan University Shanghai China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China 1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Australia; 3The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia College of Chemistry and Materials, Jiangxi Agricultural University, Nanchang 330045, PR China HLA Laboratory, Beijing Red Cross Blood Center, Beijing, 100088 PR China. Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin, China (mainland) Foshan First People Hospital, Foshan 528000, China. College of Artificial Intelligence, Nankai University , Tongyan Road, 300350 Tianjin , China; AI Lab, Tencent , Gaoxin 9th South Road, 518000 Shenzhen , China Medical Research and Biometrics Center, National Center for Cardiovascular Disease, Beijing 102300, China Department of Physiology & Neurobiology, University of Connecticut, Storrs, Connecticut 06269 USA Department of General Surgery, Jiangyin Hospital Affiliated to Nantong University, Jiangyin, Jiangsu 214400, P.R. China College of Textiles, Donghua University, Shanghai 201620, China State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China Department of Physics, Tsinghua University, Beijing 100084, P. R. China Shanghai Key Laboratory of Functional Materials Chemistry; and Research Center of Analysis and Test, East China University of Science and Technology, Meilong Rd 130, Shanghai 200237, People’s Republic of China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 20120 P.R. China Center for Advancing Electronics Dresden Faculty of Chemistry and Food Chemistry Technische Universität Dresden 01062 Dresden Germany Department of Gerontology; Union Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040 China;; Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27695; Division of Biometrics, National Center for Cardiovascular Diseases, Cardiovascular Institute & Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China. liwei@mrbc-nccd.com. Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH; Cancer Research Institute, Key laboratory of Chinese Ministry of Education, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China Department of Chemistry/Shanghai Key Lab of Chemical Biology for Protein Research & Institute of Biomedical Science; Fudan University; Shanghai 200433; China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, and Institute for Advanced Materials; School of Physics and Telecommunication of South China Normal University; Guangzhou 510006; People's Republic of China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University Shanghai China; International Research Center for Marine Biosciences, Ministry of Science and Technology Shanghai Ocean University Shanghai China Department of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, China; National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China; Songshan Lake Materials Laboratory Dongguan China Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China Department of Cardiology, 305 Hospital of PLA Beijing 100017, China. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China School of Chemical Science and Technology, Yunnan University, Kunming, People’s Republic of China; School of Pharmaceutical Sciences, Kunming Medical University, Kunming, People’s Republic of China Tianjin Key Laboratory of Advanced Fibers and Energy Storage, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, P. R. China College of Public Health, Zhengzhou University Zhengzhou Henan China Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA School of Chemical Engineering and Technology, Tianjin University, 300072 Tianjin, P.R. China College of Forestry Northwest A&F University Yangling Shaanxi China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Anhui Institute for Food and Drug Control, Department of Antibiotics, Hefei, Anhui 230051, People’s Republic of China College of Chemistry & Environmental Science, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China Department of Urology People's Hospital of Guangxi Zhuang Autonomous Region Nanning China Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University; Xiamen, Fujian, China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University 210023 Nanjing P. R. China Sydney Medical School Nepean The University of Sydney Penrith Australia Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City 450008, China State Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang 455000, China; Western Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Changji 831100, China School of Horticulture Anhui Agricultural University Hefei 230036 China Lanzhou Center for Disease Control and Prevention, Lanzhou 730050, China Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 Department of Hepatobiliary Surgery, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan, China. Department of Neurology, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin, China; Neurology, Henry Ford Hospital, Detroit, MI, USA School of Science, Nanchang Institute of Technology, Nanchang 330099, P. R. China; Key Laboratory of Optoelectronic Materials and New Energy Technology, Nanchang Institute of Technology, Nanchang 330099, P. R. China; Nanchang Key Laboratory of Photoelectric Conversion and Energy Storage Materials, Nanchang 330099, P. R. China Sanquan College of Xinxiang Medical University, Henan, China State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, China (Z.J.C., L.W., W.S., Y.Zhang, C.Z., Y.H.S., W.L., T.T.S., X.Y.Z., X.G.L., X.S.Z.); Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093–0116 (Y.C., Y.Zhao); and State Key Labora Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical University Weihui China Department of Orthopaedics, The First Bethune Hospital of Jilin University, Street Xinmin 71, Changchun 130021, China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China; Hunan Provincial Key Laboratory for Biology and Control of Plant Diseases and Insect Pests and College of Plant Protection Hunan Agricultural University Changsha Hunan China; Department of Plant Pathology The Ohio State University Columbus OH USA National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China School of Pharmacy, Fujian Medical University, Fuzhou 350001, Fujian Province, China. Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA Department of Urology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China College of Life Science and Technology, Jinan University, Guangzhou 510642, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangzhou 510632, China College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China Beijing Key Laboratory for Genetics of Birth Defects Beijing Pediatric Research Institute MOE Key Laboratory of Major Diseases in Children Beijing Children's Hospital National Center for Children's Health Capital Medical University Beijing China Cancer Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun, P.R. China State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Municipal Key Lab of Advanced Fiber and Energy Storage, School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun 130022, China. Department of Burns, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu, China. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China Department of Respiration, First Affiliated Hospital of Bengbu Medical College, Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, Bengbu, Anhui, P.R. China State Key Laboratory of Separation Membranes and Membrane Processes, Tiangong University, Tianjin 300387, China; School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China Science and Technology on Aerospace Chemical Power Laboratory, Hubei Institute of Aerospace Chemotechnology, Xiangyang 441003, Hubei China Authors' Affiliations: 1Laboratory of Cancer Molecular Genetics, Medical College of Soochow University; Departments of 2Radiotherapy & Oncology and 3Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou; 4Department of Otorhinolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou; and 5The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, China Beijing Key Laboratory for Genetics of Birth Defects Beijing Pediatric Research Institute China; MOE Key Laboratory of Major Diseases in Children Capital Medical University Beijing China; Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, P. R. China Medical Imaging Center the First Affiliated Hospital Jinan University Guangzhou China *Department of Haematology, Division of Structural Medicine, Thrombosis Research Unit, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom; and Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Shihezi University School of Medicine Shihezi China; Shihezi University School of Medicine in the First Affiliated Hospital Clinical Laboratory Shihezi China From Royal Brompton Hospital and Imperial College School of Medicine, London, United Kingdom. Department of General Surgery, The Second Hospital of Jilin University, Changchun Jilin, China Department of Respiratory Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China. Institute of Hepatology The Third People's Hospital of Shenzhen Shenzhen China Crop Research Institute Shandong Academy of Agricultural Sciences Jinan China; Ministry of Agriculture Key Laboratory of Wheat Biology and Genetic Improvement on North Yellow and Huai River Valley Jinan China; National Engineering Laboratory for Wheat and Maize Jinan Shandong China Department of General Surgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital Sichuan University Chengdu China Translational Medicine Center, Baotou Central Hospital, Donghe, Baotou 014040, P.R. China. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Neurology Fourth People's Hospital of Langfang Langfang China National Cancer Institute, Frederick, Maryland 21702-1201, United States; Department of Medicine, Center for Antibody Therapeutics, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, United States Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China; Guangzhou University of Chinese Medicine, Guangzhou 510006, China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China School of Pharmacy; Nanjing University of Chinese Medicine; Nanjing China Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China grid.413109.e 0000000097356249 Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology Tianjin University of Science and Technology 300457 Tianjin People’s Republic of China State Key Laboratory of Virology Wuhan Institute of Virology University of Chinese Academy of Sciences Wuhan 430071 China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China The Department of Dermatology and the USC Norris Comprehensive Cancer Center, the University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA Department of Medicine, Nanjing Medical University, Nanjing 210029, China; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong 250012 China Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuhan, P.R. China Department of Geriatrics, Peking University People’s Hospital, Beijing, China Department of Chemistry and Biochemistry, and Center for Single Molecule Biophysics, Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, Arizona 85287-5601, United States Central Lab, General Hospital of Western Theater Command of PLA, Sichuan Province, China State Key Laboratory of Forest and Soil Ecology Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110164 China School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China From the Eye Institute and affiliated Xiamen Eye Center of Xiamen University, Fujian, China; and the *Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610; Institute of Advanced Materials and Manufacturing Technology, Wuhan University of Technology, Wuhan 430070, China; SAIC-GM-Wuling Automobile Co., Ltd., Liuzhou 545007, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun Jilin 130012 China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China;; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China; The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Lihu Street 1800, Wuxi 214122, China Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China Beijing You’an Hospital Capital Medical University 8, Xi Tou Tiao, Youanmen wai Fengtai District Beijing 100069 China College of Life Science, Sichuan Normal University, Chengdu, 610061, PR China Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA Beijing University of Chinese Medicine, Beijing 100029, China Center for Systems Biology and Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Department of Immunology, Medical College of Qingdao University , Qingdao, Shandong Province , China College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, People’s Republic of China Nanjing Medical University, 211166, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China Orthopaedic Department, Peking University Third Hospital, Haidian District, Beijing, China Key Laboratory for Colloid and Interface Chemistry of the Education Ministry, Shandong University, Jinan, Shandong 250100, People’s Republic of China Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan Microelectronics Research Center, University of Texas at Austin, Austin, TX 78758 Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China. liweijiani@126.com Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Room 101–106, Block A, Shilong West Road, Mentougou District, Beijing, China Environmental Soil Chemistry Group, Delaware Environmental Institute and Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware, 19716, United States; Department of Geosciences, Stony Brook University, Stony Brook, New York, 11794, United States Faculty of Conservation Biology in Southwest Forestry College, Kunming 650224, China. Shaanxi Key Laboratory of Photoelectric Functional Materials and Devices, Engineering Research Center of Light Stabilizers for Polymer Materials, Universities of Shaanxi Province, Xi'an 710021, China; School of Materials and Chemical Engineering, Xi'an Technological University, Xi'an 710021, China Department of Clinical Laboratory, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, PR China Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health. Hangzhou 310052, PR China. Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, People's Republic of China Infection Department, Beijing You'an Hospital, Capital Medical University, Beijing, China. School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA College of Chinese Medicinal Materials Jilin Agricultural University Changchun 130118 China School of Mathematics and Physics North China Electric Power University Beinong Road 2, Huilongguan Beijing 102206 P. R. China; Institute of Clusters and Low Dimensional Nanomaterials North China Electric Power University Beinong Road 2, Huilongguan Beijing 102206 P. R. China School of Materials Science and Engineering; Fujian University of Technology; Fuzhou 350108; PR China; Institute of Materials Surface Technology Department of Cancer Biology and Genetics The Ohio State University Columbus Ohio USA TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China Viticulture and Wine Research Institute Guangxi Academy of Agricultural Sciences People's Republic of China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China Fudan University Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, and School of Chemistry and Materials CHINA School of Pharmacy & Minhang Hospital, Fudan University, Shanghai 201301, P. R. China Department of Cardiothoracic Surgery General Hospital of Central Theater Command Wuhan China Laboratory of Fruit Cell and Molecular Breeding College of Horticulture China Agricultural University Beijing 100193 China Department of Neurology West China Hospital Sichuan University Chengdu Sichuan China State Key Laboratory of Oral Diseases, West China College of Stomatology Sichuan University Chengdu, P.R. China Departments of Chemistry, Biology and Modeling, Pharmacopeia, Departments of Discovery Chemistry, Macromolecular Structure, and Immunology, Bristol-Myers Squibb, PO Box 4000, Princeton, New Jersey 08543-4000 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute Tongji University School of Medicine Shanghai China State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China Stem Cell and Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China Department of Pediatric Dentistry College of Dentistry, UIC Chicago IL Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China, Stem Cell and Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China (mainland) Guangxi Provincial Institute of Dermatology, Nanning, Guangxi China Information and Communication Technology Group Corporation Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar 161005, China Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu, China (mainland) State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , 100101, Beijing, China; University of Chinese Academy of Sciences , 100049, Beijing, China; Beijing Institute for Stem Cell and Regenerative Medicine , 100101, Beijing, China Department of Radiotherapy and Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences China Agricultural University Beijing 100193 China Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China. weieq2001@yahoo.com Materials Research Laboratory, ‡Department of Chemistry and Biochemistry, §Materials Department, and ⊥Department of Chemical Engineering, University of California, Santa Barbara, California 93106, United States Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Laboratory of Advanced Materials; Fudan University; Shanghai 200433 School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Nanjing University, Nanjing 210093, People’s Republic of China Department of General Surgery, Jilin University Second Hospital, Changchun, China Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China Mammary Department Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Infectious Diseases Beijing Youan Hospital, Capital Medical University Beijing China Co-Innovation Center for Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, Nanjing, China Cancer Center; Beijing Ditan Hospital, Capital Medical University; Beijing China National University of Defense Technology College of Optoelectric Science and Engineering, , Changsha, Hunan 410073, China The Children's Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang 310052 China Institute of Advanced Synthesis; School of Chemistry and Molecular Engineering; Nanjing Tech University; Nanjing 211816; China Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, China Department of Dermatology and Norris-USC Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Institute of Computational Quantum Chemistry, College of Chemistry and Material Science, Hebei Normal University; Shijiazhuang 050024 People's Republic of China Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. lsnlw@sina.com National University of Defense Technology College of Optoelectronics Science and Engineering, , Changsha, Hunan 410073, China Department of Clinical Research, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Pharmacology, Third-Grade Pharmacology Laboratory of State Administration of Traditional Chinese Medicine, Wannan Medical College, Wuhu, Anhui, China Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School–University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA Faculty of Pharmaceutical Science, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, and School of Chinese Traditional Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing, China School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, P. R. China; Department of Computer & Electrical Engineering and Computer Science, California State University, 9001 Stockdale Highway, Bakersfield, California 93311, USA Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom Hough Ear Institute, Oklahoma City, OK 73112, USA Department of Dermatology and the USC-Norris Comprehensive Cancer Center, the University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University 4 , Sapporo 001-0021, Japan Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, P.R. China College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China Environmental Soil Chemistry Group, Delaware Environmental Institute and Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19717, United States School of Materials Science and Engineering TKL of Metal and Molecule-Based Material Chemistry Nankai University Tianjin 300350 China Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, UVA Cancer Center, Charlottesville, VA, USA State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China LightSpeed Studios, USA Department of Orthopedics Zhujiang Hospital Southern Medical University 253 Industrial Avenue, Haizhu 510280 Guangzhou China Key Laboratory of Low‐Grade Energy Utilization Technologies and Systems (Chongqing University) Ministry of Education Chongqing 400030 China; Institute of Engineering Thermophysics School of Energy and Power Engineering Chongqing University Chongqing 400030 China The Armed Police General Hospital, Beijing 100039, China Department of Land Resources and Environmental Sciences, Montana State University , Bozeman, MT, USA Key Laboratory of Systems Biomedicine (Ministry of Education), Center for Comparative Biomedicine, Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China;; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA; Department of Hepato-Pancreatic Surgery, The Third Hospital of Bethune Medical College (China-Japan Union Hospital), Jilin University, Changchun, Jilin 130033, China Cell Transplantation and Gene Therapy Institute, Changsha, Hunan 410013, P.R. China Department of Laboratory Medicine, Western Theater Command Air Force Hospital, Chengdu, 610065, China Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Genetics and Birth Defects Control Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China; Henan Key Laboratory of Pediatric Inherited & Metabolic Diseases, Henan Children's Hospital Zhengzhou Hospital of Beijing Children's Hospital Zhengzhou China From the Adult Congenital Heart Unit (S.V.B.-N., W.L., O.G., P.A.D., M.A.G.) and the Cardiovascular Magnetic Resonance Unit (S.V.B.-N., P.J.K., J.C.M., D.J.P.), Royal Brompton Hospital, London, United Kingdom; and the National Heart and Lung Institute (S.V.B.-N., P.J.K., W.L., M.K., S.Y.H., D.J.P., M.A.G.), Imperial College, London, United Kingdom. Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China; Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China Center for Antibody Therapeutics, Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Department of Food Science & Technology Faculty of Science National University of Singapore Singapore Singapore Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China, Department of Chemistry, Fudan University, Shanghai, China, and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China State Key Laboratory of Metastable Materials Science and Technology; Yanshan University; 066004 Qinhuangdao; PR China The First Hospital of Jilin University Changchun China Department of Surgical Oncology, Xianyang Hospital of Yan'an University, Xianyang, Shannxi, China Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China Department of Pediatric Cardiology Beijing Anzhen Hospital Beijing Institute of Heart, Lung, and Blood Vessel Disease Capital Medical University Beijing China Department of Plant Science and Landscape Architecture University of Connecticut Storrs CT USA Materials Research Laboratory 3 , UC Santa Barbara, Santa Barbara, California 93106, USA Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis Indiana USA Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China,E-mail: liwei160@yahoo.com. Department of Chemistry Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials iChEM and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China Stanford Institute for Materials and Energy Sciences, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, United States; Geballe Laboratory for Advanced Materials, Departments of Physics and Applied Physics, Stanford University, Stanford, California 94305, United States CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China School of Material Science and Engineering, University of Jinan, Jinan 250022, P. R. China Medical Research & Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, and Peking Union Medical College Beijing China Division of Cardiovascular Medicine Department of Medicine Stanford University School of Medicine Stanford California Department of Endocrinology, The First Hospital of Qiqihar, Qiqihar 161000, China Laboratory of Advanced Materials Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative Materials iChEM and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 China Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China. Xiangya Hospital of Zhongnan University, Changsha 410008, Hunan Province. From the National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College London, London, United Kingdom (A.S.J., C.S.B., R.R., G.-P.D., W.L., K.D., J.S.W., D.J.P., M.A.G., S.V.B.-N.); Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (A.S.J.); Adult Congenital Heart Program, Knight Cardiovascular Institute, Oregon Health and Science University Portland (C.S.B.); Section... Department of Cardiovascular Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China Department of Anesthesiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China Department of Earth System Science, Tsinghua University, Beijing 100084, China Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany Yawei10@sina.com Department of physical and chemical testing, Shandong Center for Food Safety Risk Assessment, Shandong Center for Disease Control and Prevention, Jinan, People’s Republic of China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China Schools of Biological and Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, U.K. Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou China; Zhejiang Provincial Key Laboratory of Medical Genetics Wenzhou Medical University Wenzhou China Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics, College of Optoelectronic Science and Engineering, , Wuhan 430074, People's Republic of China Department of Neurology National Neuroscience Institute Singapore; Parkinson's Disease and Movement Disorders Centre National Neuroscience Institute Singapore Jiangxi University of Traditional Chinese Medicine 56 Yangming Road Nanchang 330006 People's Republic of China Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China; Jiangsu Institute of Clinical Immunology, Suzhou, China; Center for Systems Biology, Soochow University, Suzhou, China Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine, 70, Cheomdanro, Dong-gu, Daegu 41062, Republic of Korea Beijing Key Laboratory for Genetics of Birth Defects MOE Key Laboratory of Major Diseases in Children Center for Medical Genetics Beijing Pediatric Research Institute Beijing Children’s Hospital Capital Medical University National Center for Children’s Health China Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Department of Chemistry & Institutes of Biomedical Sciences; Fudan University; Shanghai 200433, China Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, USA Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom State Key Lab. of Water Environment Simulation; School of Environment, Beijing Normal Univ.; Beijing 100875 China Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China Laboratory of Advanced Materials Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials iChEM and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China Harbin First Hospital Affiliated to Harbin Institute of Technology; Beijing; China Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, China. School of Medicine, Chengdu University, Chengdu, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China Pharmacology College, Nanjing University of Chinese Medicine, Nanjing 210046, China. 7Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.; 8Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. First Hospital of Hunan University of Chinese Medicine, Hunan, China College of Animal Science and Technology, Yangzhou University, Yangzhou, China. Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Gynecology, Ningbo Yinzhou People’s Hospital, Ningbo, China Department of Orthopaedic Surgery Operations, University of Utah, Salt Lake City, UT Science and Technology on Aerospace Chemical Power Laboratory, Hubei Institute of Aerospace Chemotechnology, Xiangyang 441003, China School of Chemistry and Physics, Queensland University of Technology, 2 George Street, Brisbane, QLD 4000, Australia Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan Department of Chemical Engineering Massachusetts Institute of Technology 77 Massachusetts Ave. Cambridge MA 02139 USA Department of Gastrointestinal Surgery Zhejiang Cancer Hospital Hangzhou China Department of Dermatology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China; Jiangsu Province Ecology and Environment Protection Key Laboratory of Chemical Safety and Health Risk, Nanjing 210023, Jiangsu, China Beijing Drainage Group Co. Ltd, B 37 Chegongzhuang Street North Lane, Beijing 100044, China Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado80523, United States 14 Department of Critical Care Medicine, Wuhan No.1 Hospital (Wuhan Integrated TCM and Western Medicine Hospital), Wuhan 430022, China. Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Department of Respiratory, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China. Department of Medicine, Norris Cancer Center, University of Southern California, Los Angeles, CA 90027, U.S.A. Beijing Key Laboratory for Magnetoelectric Materials and Devices, Beijing Innovation Centre for Engineering Science and Advanced Technology, Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China School of Medicine Tsinghua University Beijing 100084 China Beijing Institute of Radiation Medicine Beijing China; Beijing Proteomics Research Center Beijing China; State Key Laboratory of Proteomics Beijing China College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, University of Tennessee, Memphis, Tennessee 38163, United States Department of Pharmacy, Plastic Surgery Hospital (Institute) Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China BGI Genomics, BGI‑Shenzhen, Shenzhen, Guangdong 518083, P.R. China Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka 816-8580, Japan Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Hainan Province Haikou PR. China; Key Laboratory of Molecular Biology Hainan Medical College Hainan Province Haikou PR. China Department of Medicinal Chemistry & Key Laboratory of Smart Drug Delivery Ministry of Education & PLA School of Pharmacy Fudan University Shanghai China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, Zhejiang Provincial Key Laboratory for Chinese Medicine Screening, Exploitation & Medicinal Effectiveness Appraise for Cardio-cerebral Vascular & Nervous System, The Key Laboratory of Biomedical Engineering Ministry of Education, China, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China, and Institute of Materia Medica, Shandong Academy of Medical... Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and Advanced Materials Laboratory, Fudan University, Shanghai 200433, People’s Republic of China Wei Li is with the Department of Epidemiology and Florida International University–Research Center in Minority Institutions, Robert Stempel College of Public Health and Social Work, Florida International University, Miami. Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian, China Department of Immunology and Pathogen Biology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China. liviy@163.com Neuroapoptosis Laboratory, Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Department of Medicine, Baylor College of Medicine, Houston, TX;; Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, China; State Key Laboratory of Silicon Materials, Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province, and School of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, China Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei City, Anhui 230601, P. R. China Laboratory of Basic Medicine, General Hospital of Western Theater Command, Chengdu 610083, China. Laboratory of Membrane Biology and Department of Urology Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University Huai'an China Department of Medical Cosmetology Shanghai Dermatology Hospital Shanghai People's Republic of China Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China Key Lab for Arteriosclerology of Hunan Province, Post-Doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease, University of South China, Hengyang City, Hunan Province, People's Republic of China. Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China Department of Gastroenterology, People’s Hospital of Ningxiang, Changsha, Hunan Province, 410600, China Royal Brompton Hospital, London, UK, and Umeå Heart Centre, Umeå, Sweden. Department of Medical Centre for Cosmetic Plastic Surgery Southwest Hospital of Third Military Medical University Chongqing China College of Automation; Harbin Engineering University; Harbin; China Department of Psychiatry, Yale School of Medicine, Yale University Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China. Shenzhen Webio Co., Ltd., Shenzhen 518110, China 3Department of Biostatistics and Computational Biology, and; 9Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 1 Department of Emergency Medicine, North Shore University Hospital—New York University School of Medicine, Manhasset, New York, USA Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China Department of Orthopaedics, Tangdu Hospital The Fourth Military Medical University Xi'an 710000 Shaanxi Province P. R. China Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Genetics and Birth Defects Control Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China. Department of Oncology, Interventional Radiology, Beijing Ditan Hospital, Capital Medical University, Beijing, China Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China; Department of Rheumatology and Immunology The Second Affiliated Hospital of Harbin Medical University Harbin China Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of Education; School of Materials & Energy, Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies Southwest University Chongqing 400715 P. R. China Waksman Institute, Rutgers University, Piscataway, NJ 08854-8020; Department of Chemistry and Chemical Biology & Department of Pharmaceutical Chemistry, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States The Key Laboratory of Pathobiology, Ministry of Education, Basic Medical College, Jilin University, Changchun, Jilin Province, P.R. China Department of Respiratory Medicine, Suzhou Municipal Hospital Suzhou Hospital Affiliated Nanjing Medical University Suzhou Jiangsu China Key Laboratory of Environmental Medicine Engineering, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Ministry of Education, Nanjing, Jiangsu, China. Beihang University From the Ocular Surface Center and Ocular Surface Research & Education Foundation, Miami, Florida; the Beijing Harmony Health Medical Diagnostics Co., Ltd., Beijing 101111, P.R. China Department of Otorhinolaryngology, The First Hospital of China Medical University, Shenyang, China Department of Respiratory Medicine, Suzhou Municipal Hospital, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, China Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P. R. China; Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P. R. China Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering, Zhejiang University (Yuquan Campus), Hangzhou, 310027, China; Institute of Environmental Engineering, Zhejiang University (Zijingang Campus), Hangzhou, 310058, China State Key Laboratory of Functional Materials for Informatics and Shanghai Center for Superconductivity, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China; State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China Key Laboratory of Physical and Chemical Analysis for Electric Power of Hainan Province, Hairui Road No. 23, Haikou 570100, China; Hebei Key Laboratory of Green and Efficient New Electrical Materials and Equipment, North China Electric Power University, Yonghua North Street No. 619, Baoding 071003, China Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing China Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China. E-mail: jdyylw@163.com. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, P.R. China Department of Neurology, Jinling Hospital, Second Military Medical University, Nanjing, China Clinical laboratory of Pathology, Liuzhou People's Hospital, Liuzhou, China. Department of Neurosurgery, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, China From the Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Division of Birth Cohort Study Fujian Maternity and Child Health Hospital Affiliated Hospital of Fujian Medical University Fuzhou China; Fujian Obstetrics and Gynecology Hospital Fuzhou China Department of Neurology, Shaanxi Provincal People's Hospital, Xi'an 710068, China. International Joint Research Laboratory of Nano-Micro Architecture Chemistry; Institute of Theoretical Chemistry; Jilin University; Changchun; People's Republic of China Department of Histology and Embryology, Fourth Military Medical University Harbin Institute of Hematology & Oncology, Harbin 150010, Heilongjiang Province, China. Department of Hepatology The Second People’s Hospital of Fuyang City Fuyang China School of Dentistry, Tianjin Medical University, Tianjin 300070, PR China. Materials Genome Institute Shanghai University Shanghai China Department of Cardiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai, People's Republic of China. From the Molecular Cardiology Research Laboratory, Department of Cardiology (Q.Z., H.W., Q.W., W.L., G.L., J.-W.H., X.-M.C., J.C., W.-P.X., Y.-G.L., Y.-P.W.) and Department of Pediatrics (S.-S.W.), Affiliated Xinhua Hospital, Shanghai Jiaotong University (SJTU) School of Medicine, China. Department of Medical Oncology, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, Suzhou 215006 Jiangsu, China Interventional Neuroradiology Department, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, China Department of Biology, Georgia State University, 24 Peachtree Center Ave., Atlanta, Georgia 30303 Department of Urologic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China Department of Chinese Materia Medica, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, P.R. China Department of Otolaryngology, Head and Neck Surgery, Jining No. 1 People’s Hospital, Jining, Shandong, China (mainland) Fiberhome Telecommunication Technologies Co.Ltd Medical Research and Biometrics Center, National Center for Cardiovascular Diseases Beijing China School of Mathematics and Physics, North China Electric Power University, Beinong Road 2, Changping, Beijing, 102206, P. R. China; Institute of Clusters and Low Dimensional Nanomaterials, North China Electric Power University, Beinong Road 2, Changping, Beijing, 102206, P. R. China; Hebei Key Laboratory of Physics and Energy Technology, North China Electric Power University, Baoding, 071000, China Key Laboratory of Mesoscopic Chemistry of Ministry of Education School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Department of Clinical Laboratory School of Medicine Children's Hospital Zhejiang University Hangzhou China Biomedical Engineering Institute, School of Control Science and Engineering, Shandong University, Jinan250061, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, P.R. China Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China 0000 0000 9735 6249 grid.413109.e Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology Tianjin University of Science and Technology 300457 Tianjin People’s Republic of China Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKLMMD); Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT); Department of Materials Science and Engineering; College of Engineering; Peking University Xiamen University affiliated Xiamen Eye Center, Xiamen, China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai 201203, China; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing 100853, China; College of Pharmacy, Liaocheng University, 1 Hunan Road, Liaocheng, Shandong 25000, China Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, NSW, Australia Chair of Macromolecular Chemistry; Faculty of Chemistry and Food Chemistry; School of Science; Technische Universitat Dresden; 01069 Dresden Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, CB3 0FS, U.K.; School of Physics and National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China Qinghai University, Xining, Qinghai 810016, China; Key Laboratory of Qinghai Tibet Plateau Biotechnology, Ministry of Education, Xining, Qinghai 810016, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai 810016, China; Northwest Potato Engineering Research Center, Ministry of Education, Xining, Qinghai 810016, China Department of Radiology, Third Affiliated Hospital of Southern Medical University and Academy of Orthopedics, 183 Zhongshan Da Dao Xi, Guangdong Province, Guangzhou 510630, China Department of Bone Join/Bone Tumor, Shenzhen Second People's Hospital, Shenzhen 518000, P.R. China. State Key Laboratory of Cotton Biology Institute of Cotton Research Chinese Academy of Agricultural Sciences Anyang China Department of Electronic and Electrical Engineering The University of Sheffield Sheffield UK Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Room 561, Memphis, Tennessee 38163, United States Department of Pathology The Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai China b Department of Pharmaceutical Sciences , College of Pharmacy, The University of Tennessee Health Science Center , Memphis, Tennessee, USA Department of Central Laboratory, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China Cancer Center, First Hospital of Jilin University, Changchun, Jilin Province - China Key Laboratory of Laboratory Medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou China Laboratory of Advanced Materials and Energy Electrochemistry Institute of New Carbon Materials College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 China Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA Fujian Provincial Key Laboratory of Ophthalmology and Visual Science School of Medicine, Eye Institute of Xiamen University, Xiamen University Xiamen China; Department of Ophthalmology Xiang′an Hospital of Xiamen University Xiamen China; Department of Ophthalmology Xiamen University Affiliated Xiamen Eye Center Xiamen China College of Chemistry Jilin University Changchun 130012 P. R. China; Department of Gastric and Colorectal Surgery The First Hospital of Jilin University Jilin University Changchun 130021 P. R. China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Institute of Computational Quantum Chemistry; College of Chemistry and Material Science; Hebei Normal University; Shijiazhuang 050024; P. R. China Tasly Academy Tasly Holding Group Co. Ltd Tianjin 300410 China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and Engineering Wuhan University of Technology 122 Luoshi road Wuhan 430070 P. R. China Department of Medical Ultrasonics Institute of Diagnostic and Interventional Ultrasound the First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 P.R. China; University of Chinese Academy of Sciences Beijing 100039 P.R. China Department of Neurology, People’s Hospital of Zhengzhou University, Henan People’s Hospital, Zhengzhou, Henan, China Department of Anaesthesiology, Renmin Hospital of Wuhan University, Wuhan, China School of Science, Key Laboratory for Physical Electronics and Devices of the Ministry of Education, and Shaanxi Key Lab of Information Photonic Technique, Xi’an Jiaotong University, Xi’an 710049, China Department of Oncology, The First Hospital of Jilin University, Changchun City, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China Department of Geriatric Psychiatry Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine Shanghai China; Alzheimer's Disease and Related Disorders Center of Shanghai Jiaotong University Shanghai China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou 215021, China; Jiangsu Institute of Clinical Immunology, Suzhou 215006, China College of Food Science and Engineering Dalian Ocean University Dalian 116023 China; Liaoning Provincial Aquatic Products Analyzing Testing and Processing Technology Scientific Service Centre Dalian 116023 China Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Route Trans-Canadienne, Kirkland, Québec, Canada H9H 3L1, and Department of Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8066 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou, Nano Science and Technology, Jiangsu Key Laboratory for Carbon‐Based Functional Materials Soochow University Suzhou Jiangsu 215123 P. R. China Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Sichuan, 610041, Chengdu, China The ART Center, Northwest Women’s and Children’s Hospital, Xi'an, China The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116000, China Department of pharmaceutical and fine chemicals, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, People’s Republic of China; Department of Geriatrics, Clinical Laboratory, Xiangya Hospital Central South University Changsha Hunan China Department of Neurology, National Neuroscience Institute, Singapore 308433; Parkinson’s Disease and Movement Disorders Centre, National Neuroscience Institute, NPF International Center of Excellence, Singapore Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials School of Materials Science and Engineering Peking University Beijing Beijing 100871 P. R. China Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 P.R. China Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, P.R. China and State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China Department of Pathology, Beaumont Labs, Royal Oak, MI, USA Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02115 Department of Anesthesiology Renmin Hospital of Wuhan University Wuhan China The Second Department of General Surgery, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University), Xiangzhou District, Zhuhai City, Guangdong Province, China National Centre for Cardiovascular Diseases, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China. Department of Physics, Stevens Institute of Technology, Hoboken, New Jersey Department of Geriatrics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ecology, Evolution and Organismal Biology, Iowa State University, 133 Bessey Hall, Ames, IA 50011, USA. Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, 2 Zizhulin, Nanjing, Jiangsu 210009, China Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, People’s Republic of China Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8066, and College of Science, Northwest A&F University, Yangling, Shaanxi 712100, The People's Republic of China xumu@rci.rutgers.edu Marine Engineering College, Dalian Maritime University, Dalian 116026, China State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China; College of Life Sciences Shanxi Agricultural University Taigu 030801 China School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China;; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, Jiangsu, China;; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea University of Chinese Academy of Sciences Department of Chemical Engineering, Wuhan University of Science and Engineering, Wuhan 430073, China, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China, and CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan,450052, China From the Royal Brompton and Harefield NHS Foundation Trust, London, UK (S.V.B.-N., G.-P.D., R.R.G., A.J.B., T.K., W.L., D.J.P., H.U., B.S., M.A.G., D.F.S.); and National Heart and Lung Institute, Imperial College London and NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College London, London, UK (S.V.B.-N., W.L., D.J.P., M.A.G., D.F.S.). Department of CT Chengde Central Hospital Chengde China Fujian Obstetrics and Gynecology Hospital, Fuzhou, China; Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, Fuzhou, China Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China Institute of Robotics and Autonomous Systems Tianjin Key Laboratory of Process Measurement and Control, , School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China Key Laboratory of Unconventional Metallurgy, Ministry of Education, Kunming University of Science and Technology, Kunming 650093, People’s Republic of China Department of Radiology, Pathology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China. College of Food Science; South China Agricultural University; Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods; Guangdong Research Center for Engineering Technology in Bioactive Natural Products; Guangzhou 510642 Fourth Oil Production Plant of Qinghai Oilfield, China National Petroleum Corporation, Jiuquan 736202, China Department of Physics, Emory University, Atlanta, GA, United States. National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China Department of Neurosurgery, Taipei Municipal Wanfang Hospital (Managed by Taipei Medical University), Taipei, Taiwan Cancer Center, The First Hospital of Jilin University Changchun China *Department of Biostatistics and Computational Biology, Dana–Farber Cancer Institute, 44 Binney Street, Boston, MA 02115;; Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115; and The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022, PR China; Laboratory of Green Chemistry and Process Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China From the Adult Congenital Heart Disease Centre and Centre for Pulmonary Hypertension (A.U., S.V.B.-N., G.P.D., K.D., O.G., M.S.S., K.A., M.A.G., W.L.), Department of Echocardiography (D.G.G., M.Y.H.), and Cardiac Magnetic Resonance Unit (S.V.B.-N.), Royal Brompton Hospital, London, UK; National Heart and Lung Institute at Imperial College, London, UK (A.U., S.V.B.-N., G.P.D., K.D., O.G., M.S.S., K.A., M.A.G., W.L.); and Department of Pediatric Cardiology, University Hospital of Schleswig-Holstein,... Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Qilu Hospital Shandong University Jinan China Division of Advanced Nanomaterials Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences (CAS) Suzhou 215123 P. R. China; School of Nano Technology and Nano Bionics University of Science and Technology of China Hefei 230026 P. R. China Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, China; ICU, Bazhong District People’s Hospital, Bazhong, China. University of Michigan, USA Departments of Urology and Pathology, The University of Texas M. D. Anderson Cancer Center. China Electronics Standardization Institute, Beijing, China Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun 130062, China Chemical Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140 North Branch Bio‐Technology Co. Ltd of Anhui Province Wuhu Anhui China Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, Jiangsu, China Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland) Medical Research and Biometrics Center, National Center for Cardiovascular Diseases of China Beijing China School of Pharmaceutical Engineering; Shenyang Pharmaceutical University; Shenyang 110016; China From the Royal Brompton Adult Congenital Heart Programme, and Department of Clinical Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK, and Department of Cardiology, Wilhelmina Children’s Hospital, Utrecht, The Netherlands Department of Materials Science and Engineering, College of Engineering Peking University Beijing 100871 China; Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL‐MMD) Beijing Innovation Center for Engineering Science and Advanced Technology (BIC‐ESAT) Beijing 100871 China School of Information, North China University of Technology, Beijing 100144, China Department of Clinical Laboratory, Chongqing Emergency Medical Center, Chongqing University Center Hospital, School of Medicine, Chongqing University, Chongqing 400014, China Pediatric Asthma Department, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China (mainland) Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois Institute of Theoretical and Computational Chemistry Department of Chemistry, , Key Laboratory of Mesoscopic Chemistry of Ministry of Education (MOE), , Nanjing 210093, People’s Republic of China; Nanjing University Department of Chemistry, , Key Laboratory of Mesoscopic Chemistry of Ministry of Education (MOE), , Nanjing 210093, People’s Republic of China Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China Center of Energy Storage Materials & Technology, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, National Laboratory of Solid State Microstructures and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P. R. China Department of Pharmacology, New York University Medical Center, 550 First Avenue, New York, New York 10016 Institute of New Catalytic Materials Science, College of Chemistry, Nankai University, Tianjin 300071, and China and NanoScience Technology Center, Department of Mechanical, Materials, Aerospace Engineering, University of Central Florida, Orlando, Florida 32826 Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin, P. R. China Department of Materials Science and Engineering University of Erlangen‐Nuremberg, Institute of Biomaterials Erlangen 91058 Germany Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030;; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Hematology, Henan Provincial Hematology Hospital, Zhengzhou, Henan 450000, China Contribution from the Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China Chinese Education Ministry’s Key Laboratory of Western Resources and Modern Biotechnology Key Laboratory of Biotechnology Shaanxi Province College of Life Sciences Northwest University Xi'an Shaanxi 710069 China Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China; Department of Dermatology Affiliated Hangzhou Clinical College Anhui Medical University Hangzhou China Center of Interventional Oncology & Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China Health and Diseases Preventive Center of Shandong Province, Jinan, China National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University Suzhou 215123 China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China. lwmail@medmail.com.cn The Cancer Hospital of the University of Chinese Academy of Science (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Science Hangzhou Zhejiang China; Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science Zhejiang University Hangzhou China †Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China Department of Cell and Developmental Biology, Department of Biochemistry and Biophysics, and Hematology−Oncology Division of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Key Laboratory of Natural Products Chemical Biology, Ministry of Education, School of Pharmacy, Shandong University, Jinan, 250012, P. R. China Hebei Provincial Key Laboratory of Neuropharmacology, Department of Pharmacy, Hebei North University, Zhangjiakou, China Department of Pediatrics, Aflac Cancer and Blood Disorders Center Emory University Atlanta Georgia Department of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital , Zhuhai , China Department of Dermatology, The USC‐Norris Comprehensive Cancer Center University of Southern California Keck Medical Center Los Angeles California USA State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology , , 100101, Beijing, China; Chinese Academy of Sciences , , 100101, Beijing, China School of Water and Environment, Chang'an University, Xi'an 710054, China Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 610031 China; Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, and Department of Chemical Technology, School of Chemical Engineering, Tianjin University, Tianjin 300072, P. R. China Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200032, China Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States Institute of Plant Protection Jiangsu Academy of Agricultural Sciences Nanjing China From the Cerebrovascular Unit and Ataxia Research Center, Hôpital Neurologique, Lyon, France (P.T., N.N., L.D., J.H., G.R., P.N., J.C.G., W.L.); the Biostatistical Unit of Claude Bernard University (P.A.); the Department of Neuroradiology, Hôpital Neurologique, Lyon, France (J.C.F., F.T., Y.B.); the Emergency Units of Lyon Hospitals (D.M., J.F.); the Emergency Unit of Moutiers Hospital (A.L.G., X.L.) Moutiers, France; and the Hematological and Coagulation Laboratory (P.F., M.D.), Hôpital... Orthopedic Oncology Institute, Tangdu Hospital, the Fourth Military Medical University, 710038, Xi'an Shaanxi, PR China. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China Genetic Laboratory of Shenzhen Longgang Maternal and Child Health Hospital, Guangdong, Shenzhen, China; School of Life Sciences, Zhengzhou University, Zhengzhou, China;; Laboratory of Membrane Biology, New York Blood Center, New York, NY;; Department of Immunotherapy, Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States; Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics, Peking University, Beijing, 100871, China Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province; College of Advanced Materials and Energy; Institute of Surface Micro and Nano Materials; Xuchang University; P. R. China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing, China. Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Japan Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education First Hospital Jilin University Changchun China Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213;; School of Medicine, University of Tsinghua, Beijing, China 100084; Department of Thoracic Surgery, General Hospital of Chengdu Military Region, Chengdu 610083, P.R. China Department of Orthopedics, The First Hospital of Harbin, Harbin, Heilongjiang, China (mainland) Beixcell (Beijing) Biotechnology Ltd, Beijing, China College of Information Systems and Management, National University of Defense Technology, Changsha 410073, China Second Department of General Surgery, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Stem Cell and Cancer Center, First Hospital, Jilin University Changchun, Jilin 130021, China. From the Eye Institute of Xiamen University, Xiamen, Fujian, China; 3Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China; 6Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian, China; 7Medical College of X School of Chemical Engineering, Tianjin University, Tianjin 300072, China Department of Radiology, Tianjin Medical University Cancer Institute and Hospital , National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, China BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China; Hainan Engineering Research Center of Agarwood, Haikou, People's Republic of China Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA Medical Innovation Experimental Center, the First Hospital of Hunan University of Chinese Medicine Changsha 410000, China. Jinan University Applied Materials Physics, Department of Materials Science and Engineering, Royal Institute of Technology, Stockholm SE-100 44, Sweden National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and Toxicology Beijing China Department of Medical Oncology, The First Hospital of Jilin University, Changchun, 130021, China Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China. liwei71@126.com Department of Chemistry; Boston College; Chestnut Hill; USA Department of General Internal Medicine, The Fifth Affiliated Hospital of Zhengzhou University, Zhenzhou, Henan 450052, P.R. China Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical, Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China; Henan Zhiwei Biomedicine Co., Ltd., Xinxiang, Henan 453007, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China Medical Research & Biometrics Center, Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of, Jiangsu Higher Education Institutions Soochow University Suzhou 215123 Jiangsu China Department of Urology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland) Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, College of Environment and Ecology, Chongqing University, Chongqing 400044, China Rheumatic and Autoimmune Diseases Division, and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 Department of Genetics Medical College of Soochow University Suzhou China Department of Anesthesia, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong 272007, China. School of Control Science and Engineering, Shandong University, Jinan, China Nursing Department, Affiliated Hospital of Jining Medical University, Jining, China State Key Lab of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China Department of Hepatology The Second People's Hospital of Fuyang City Fuyang China Goodwe Biotechnology Taizhou Co., Ltd., Taizhou 225300, Jiangsu, China. National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China Orthopedics Department, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research and Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Peking University, Beijing, China 2Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China Division of Biostatistics Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA; Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX USA Chair of Macromolecular Chemistry Faculty of Chemistry and Food Chemistry Technische Universität Dresden Mommsenstr. 4 01069 Dresden Germany Department of Neurology, West China Hospital Sichuan University Chengdu China Department of Chemistry; Capital Normal University; Beijing; China Department of Spinal Surgery, Huzhou Central Hospital, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China The 990th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army Xinyang Henan Province People's Republic of China School of Chemistry and Chemical Engineering; University of Jinan; Jinan 250022; P.R. China College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida. Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation , Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 51038 , China College of Urban and Environmental Sciences, Laboratory for Earth Surface Processes, Sino−French Institute for Earth System Science, Peking University, Beijing 100871, P. R. China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China; Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China; College of Veterinary Medicine, China Agricultural University, Beijing, China Department of Anorectal Surgery, Jinan City People's Hospital Jinan 271199, Shangdong, China. *Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109;; ‡Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Hematology/Oncology, First Hospital of Jilin University, Changchun 130021, China. Cell Transplantation and Gene Therapy Institute The Third Xiangya Hospital Central South University Changsha Hunan China; Engineering and Technology Research Center for Xenotransplantation of Human Province Changsha Hunan China Department of Radiology, Shanghai Eighth People's Hospital, Shanghai 200235, China. Faculty of Pharmaceutical Sciences, Toho University, Funabashi 274-8510, Japan Department of Neurosurgery, Zhongnan hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University , Wuhan, China Department of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China College of Electrical and Information Engineering, Lanzhou University of Technology 1 , Lanzhou 730050, China; Key Laboratory of Gansu Advanced Control for Industrial Processes 3 , Lanzhou 730050, China Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Department of Respiratory Medicine, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland) Yale School of Medicine, New Haven, CT, USA Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, People's Republic of China Department of Dermatology Children's Hospital School of Medicine University of Zhejiang Hangzhou China Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China. Department of Clinical Laboratory, Children's Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health 310052 Hangzhou China Department of Burns Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, China School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational Chemistry, Nanjing University Nanjing China From the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People’s Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of... National Clinical Research Center for Geriatrics State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China Wayne State University Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China. Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400044, China Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Hematology, Qilu Hospital, Shandong University, Jinan, China Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, People’s Republic of China Medical Research and Biometrics Center, National Center for Cardiovascular Diseases of China, Beijing, China. State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China College of Chinese Material Medicine, Jilin Agricultural University, Changchun, Jilin 130118, China College of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan, People’s Republic of China Center on Addiction, Learning, Memory, Department of Neuroscience, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas Department of Mechanical Engineering; The University of Texas at Austin; Austin; USA School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Chemistry; Collaborative Innovation Center of Chemistry for Energy Materials; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Fudan University; Shanghai 200433 Department of Anesthesiology, Provincial Hospital Affiliated with Shandong First Medical University, Jinan 250021, Shandong, P.R. China Department of Orthopedics & Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui, China Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, 100850, China Biomedical Engineering Institute School of Control Science and Engineering Shandong University Jinan China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China Department of Neurology, Army Medical Center of PLA, Army Medical University, Chongqing, China Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China Department of UAV Engineering, Shijiazhuang Campus, Army Engineering University, Shijiazhuang 050003, China Chair of Macromolecular Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstr. 4, Dresden 01069, Germany From the Departments of Surgery (W.L., Q.L., L.Q., R.A., G.T.), Medicine (Y.Q., F.J.G.), and Pharmacology (W.C.S.), Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT; Department of Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom (M.T.); Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA (B.R.P.); and the Veterans Affairs... *Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612; and Department of Pathology, Corewell Health East, Royal Oak, MI, USA Lehigh University 1 Department of Physics, , Bethlehem, Pennslyvania 18015, USA State Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China (J.L., Y.N., X.W., W. Liu, G.-L.W.); Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Changsha Hunan 410128, China (J.L., W. Li, L.D., Z.W., G.-L.W); and Graduate School of Peking Union Medical College, Beijing 100730, China Departments of 1Protein Engineering, 2Molecular Biology, 3Protein Chemistry, 4Tumor Biology and Angiogenesis, and 5Pathology, Genentech, South San Francisco, California Clinical Laboratory, Qingdao Women and Children’s Hospital Affiliated, Qingdao University, Qingdao 266034, China Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, P.R. China National Engineering Research Center for the Emergency Strategic Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland) Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology Southern Medical University Guangzhou China Department of Endocrinology Key Laboratory of Endocrinology of National Health Commission Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Los Alamos National Laboratory, Computer, Computational, and Statistical Sciences Division, Los Alamos, NM 87545, USA Department of Pharmacognosy, Toho University, Funabashi, Chiba, Japan Department of Chemistry, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China Beijing University of Posts and Telecommunications, Haidian District, Beijing Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China;; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China Department of Pharmacy Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA Department of Pathophysiology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China The Hormel Institute, University of Minnesota, Austin, Minnesota, USA Research Department of Natural Medicine, Shenyang Pharmaceutical University, PR China. From the Department of Surgery (Y.J., G.L., Q.L., R.A., L.Q., W.L., A.G., G.T.), Department of Internal Medicine (Y.Q., D.M.G.), and Vascular Biology and Therapeutics Program (Y.Q., D.M.G., A.G., J.D.H., G.T.), Yale University School of Medicine, New Haven, CT; Department of Vascular Surgery, Peking University People’s Hospital, Beijing, P. R. China (Y.J., Q.L., W.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (J.D.H.); and Veterans Affairs Connecticut Healthcare System,... Oncology Center The First Hospital of Jilin University Changchun China Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing 211816 P. R. China Biomedical Engineering Institute, School of Control Science and Engineering, Shandong University, Jinan 250012, China. Department of Geriatrics, Shanghai Tenth People's Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, 200072, China Department of Internal Medicine, Emergency Center, East Hospital, Tongji University School of Medicine, Shanghai, China. Liver Diseases Research Center, The Second Xiangya Hospital Central South University Changsha Hunan China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China; Key Laboratory of Environmental Materials & Environmental Engineering of Jiangsu Province, Yangzhou 225002, Jiangsu, P. R. China College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States Department of Chemical and Environmental Engineering , University of California at Riverside, Riverside, California 92521 United States Rigel Pharmaceuticals Incorporated, South San Francisco, California Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298 Sichuan Dian Hong Pharmaceutical Development Co.,Ltd. Chengdu 610000,China. State Key Laboratory of Chemo/Biosensing and Chemometrics; Molecular Science and Biomedicine Laboratory; College of Chemistry and Chemical Engineering; Hunan University; Changsha 410082 Laboratory of Fruit Cell and Molecular Breeding China Agricultural University Beijing 100193 China Master of Physician Assistant Studies Program, Indiana University, Indianapolis, Indiana, USA Emergency Department of Benxi Central Hospital, Benxi City, Liaoning Province 117000, China College of Chinese Medicinal Materials, Jilin Agricultural University, China; Institute of Special Wild Economic Animals and Plant, CAAS, China College of Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of Education Ministry of China, Wuhan 430074, China College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China Department of Landscape Architecture and Urban Planning, School of Architecture, Texas A&M University, College Station, TX, USA Tianjin Key Laboratory of Functional Crystal Materials; Institute of Functional Crystal; Tianjin University of Technology; Tianjin 300384; China National Engineering Research Center for the Emergence Drugs; Beijing Institute of Pharmacology and Toxicology; Beijing 100850; China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Ghuangzhou 510006, China Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. China Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of Otorhinolaryngology,Tangshan Maternal and Child Health Hospital of Hebei Province. Jiangsu Center for Stem Cell Engineering and Technology, China Medical City, Taizhou, People's Republic of China. Fudan University Shanghai 201204 China National Key Laboratory of Optical Field Manipulation Science and Technology, Chinese Academy of Sciences, Chengdu 610209, China; Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; University of Chinese Academy of Sciences, Beijing 100049, China Medical Central Laboratory, Chengdu Military General Hospital, Chengdu, Sichuan, China State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyBeijingChina Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, China School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, New South Wales 2006, Australia Hand and Foot Surgery & Plastic Surgery, Affiliated Shunde Hospital of Guangzhou Medical University, Shunde District, Foshan, P. R. China Department of Cell Biology, College of Life Sciences Wuhan University Wuhan China Department of Biological Chemistry, University of California, Irvine, California Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University Wuhan China; Department of Oral Radiology School and Hospital of Stomatology, Wuhan University Wuhan China Royal Brompton Hospital and Harefield NHS Foundation Trust; National Heart and Lung Institute, Imperial College London, London, United Kingdom Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, People's Republic of China. College of Chinese Medicinal Materials Jilin Agricultural University Changchun China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development Changchun 130118 China National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China Department of Laboratory Medicine, Bethune International Peace Hospital, Shijiazhuang city, Hebei province, People's Republic of China. Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China. Department of neurosurgery, The Affiliated Mindong Hospital of Fujian Medical University, No. 89 Heshan Road, Fuan 355000, Fujian, China Division of Cardiology, Emory University, Atlanta, Georgia; and Cancer Center of the First Hospital of Jilin University Changchun Jilin China Department of Urology The First Affiliated Hospital of Chengdu Medical College Chengdu China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan Hubei China; Department of Oral Radiology of School & Hospital of Stomatology Wuhan University Wuhan Hubei China Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai 200011, China School of Nursing; Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China E-mail: weilee2004@yahoo.com.cn. College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing, Jiangsu 210095, People’s Republic of China Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment; Department of Vascular Surgery; Department of General Surgery, the First Hospital of Hebei Medical University, Hebei, Shijiazhuang, China. State Key Laboratory of Cancer Biology 1 , , , Xi’an 710032 , China; Department of Immunology 1 , , , Xi’an 710032 , China; Fourth Military Medical University 1 , , , Xi’an 710032 , China Sanya Institute of Oceanography, Ocean University of China, Sanya 572000, People’s Republic of China; College of Food Science and Engineering, Ocean University of China, Qingdao 266400, People’s Republic of China The First Hospital of Jilin University, Changchun, China Central Laborontory of Lianyungang Hospital Affiliated to Xuzhou Medical College. Lianyungang 22200, Jiangsu Province, China. E-mail: medical1121@126.com. Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland) Key Laboratory for Power Machinery and Engineering of MOE; Shanghai Jiao Tong University; Shanghai 200240; P. R. China Guangdong Provincial Engineering Technology Research Center for Optical Agricultural; College of Materials and Energy; South China Agricultural University; Guangzhou 510642; China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China Second Department of Surgery, Fukui Medical University, Fukui 9101193, Japan Department of Oncology, First Affiliated Hospital, Nanjing Medical University, Gulou, Nanjing, Jiangsu�210029, P.R.�China Department of General Surgery, Sir Run Run Shaw hospital, School of Medicine, Institution of Micro-Invasive Surgery, Zhejiang University, Hangzhou 310016, China. Department of Medical Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University Faculty of Pharmaceutical Science, Toho University, Funabashi, Japan Division of Experimental Pathology, Department of Clinical & Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linköping 58185, Sweden 1 Division of Biostatistics, Dan L. Duncan Cancer Center and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA and 3State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China; 1 Division of Biostatistics, Dan L. Duncan Cancer Center and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA and 3State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing 210093, P. R. China, and College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City, Henan Province, China College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, P. R. China Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu, Korea School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China;; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, Jiangsu, China;; Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China College of Chinese Medicine Materials Jilin Agricultural University Changchun 130118 China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai Shanghai 200433 P. R. China Shaanxi Key Laboratory for Animal Conservation, College of Life Sciences Northwest University Xi'an China State Key Laboratory of Organic−Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Key Laboratory for Green Chemical Technology MOE, †Key Laboratory of Systems Bioengineering MOE, §School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People’s Republic of China Department of Anesthesiology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Center for Diabetes and Metabolism Research, Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China School of Food & Biological Engineering, Jiangsu University, Zhenjiang, PR China Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Changping District, Beijing 102206, China Department of Oncology, The First People’s Hospital of Tianmen, Tianmen 431700, Hubei Province, China Department of Dermatology & Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; National Autoimmune Bullous Disease Cooperative Group, China *Cancer Biology Research Center and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 P.R. China Department of Medicine, University of Cambridge, Cambridge, United Kingdom Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China Department of Gynaecology The Forth Hospital Affiliated to Jiangsu University Zhenjiang China Department of Radiology Tianjin Medical University Cancer Institute and Hospital Tianjin China; National Clinical Research Center for Cancer Tianjin China; Key Laboratory of Cancer Prevention and Therapy Tianjin China; Tianjin's Clinical Research Center for Cancer Tianjin China Research Laboratory of Pharmaceutical Chemistry and Biological Materials, School of Pharmacy, Chongqing Medical University, Chongqing, China Cancer Center Beijing Ditan Hospital Capital Medical University Beijing China Department of Geriatric Psychiatry , Shanghai Mental Health Center, , Shanghai , China; Shanghai Jiao Tong University School of Medicine , Shanghai Mental Health Center, , Shanghai , China; Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University , Shanghai , China Department of Central Laboratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. International Joint Cancer Institute, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, FL; Vascular Biology Institute, University of Miami School of Medicine, Miami, FL. Medical Heredity Research Center, Northwest Women’s and Children’s Hospital, Shaanxi, Xi’an 710003, P.R. China 1Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China. Cancer Center First Affiliated Hospital, Jilin University Changchun China Shanghai Tenth People's Hospital; Tongji University School of Medicine; Shanghai 200072; China Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine , Daegu , , South Korea Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Institute of MicrobiologyChinese Academy of Sciences 100101 Beijing China Institute of High‐Performance Polymer Qingdao University of Science & Technology Qingdao Shandong China; Environmental Science Department, College of Environmental Science and Engineering Peking University Beijing China; Chemistry Department Hong Kong Baptist University Kowloon Hong Kong China College of Landscape Architecture, Fujian Agriculture and Forestry University, Fuzhou, P. R. China Department of Endocrinology and Metabolism Center for Diabetes and Metabolism Research West China Hospital Sichuan University Chengdu 610041 China From the Departments of Pathology II (W.L., X.M.Y., U.T.B.), Internal Medicine (W.L., X.M.Y., A.G.O.), and Clinical Research Centre (W.L., X.M.Y., A.G.O.), Faculty of Health Sciences, University of Linköping, Sweden. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University , 100070 Beijing , China; China National Clinical Research Centre for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University , 100070 Beijing , China State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences Beijing China Department of Chinese Material Medicine, Chinese Material Medicine College of Jilin Agricultural University Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Beijing Genomics Institute/Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China.; Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410000, P.R. China; Cell Transplantation and Gene Therapy Institute, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, 410000, P.R. China Department of Neurology and Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China Biomedical Engineering Institute, School of Control Science and Engineering, Shandong University, Jinan 1 Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, 200092, China, 2Department of Biological Sciences, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, 3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, 4Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, 450 Brookline Ave, Boston, MA, 02115, USA, 5Department of Information Technology, China Novartis Institutes for BioMedical Research Co.,Ltd., Shanghai 201203, China and 6Division of Biostatistics, Dan L Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People's Republic of China. Plastic Department of Chongqing Emergency Medical Center of Chongqing University, Chongqing, China Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China Medicine–Oncology, The First Hospital of Jilin University, Changchun, China Department of NeuroscienceAlbert Einstein College of Medicine 1410 Pelham Pkwy S Bronx NY 10464 USA Pennington Biomedical Research Center (Y.W., P.T.K., R.H., W.L., W.X., S.H., D.H.R., G.H.), Baton Rouge, Louisiana 70808 Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, United States Stem Cell and Cancer Center, The First Hospital of Jilin University, Changchun, China *Research Unit, Division of Health Research, Saskatchewan Cancer Agency; and; †Department of Oncology,; ‡Department of Immunology, and Department of Respiratory Medicine, Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004, Shaanxi Province, P. R. China. Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China Zhenjiang Maternal and Child Health Hospital , Zhenjiang, Jiangsu Province, , China Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Sino‐US Center for Lymphoma and Leukemia Research Tianjin China Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, and Laboratory of Physical Chemistry, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China The State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China CAS Key Laboratory of Receptor Research; and the State Key Laboratory of Drug Research; Shanghai Institute of Materia Medica (SIMM); Chinese Academy of Sciences; Shanghai 201203 Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015, United States State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Department of Immunology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 Department of Chemical Engineering, University of Washington, Box 351750, Seattle, Washington 98195, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R.China National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China. liwow@126.com Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University , Xiamen , China College of Civil Engineering, Hunan University, Changsha 410082, China. lwei6851@yahoo.com.cn Department of Genetics, Northwest Women’s and Children’s Hospital, Xi’an, Shaanxi Province, China State Key Lab of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian 116023, China. School of Pharmacy, Nanjing University of Chinese Medicine, China Department of Dermatology, USC Laboratories for Investigative Dermatology, USC/Norris Cancer Center, The Keck Medical Center and the Los Angeles Greater VA Healthcare System, University of Southern California, Los Angeles, California. cq Capital Medical University, Center for Medical Genetics, Beijing Children's Hospital , Beijing , China. Cancer Center The First Hospital of Jilin University Changchun Jilin P. R. China School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China School of Science, Nanchang Institute of Technology, Nanchang, 330099, China Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China Department of General Surgery, Qingdao Eighth People’s Hospital, Qingdao, Shandong, China School of Materials Science and Engineering and ‡State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China Division of Host Defense, Research Center of Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, PR China Department of Pediatrics, Dongguan Taiping People's Hospital, Dongguan, Guangdong 523905, China. Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands Ageing Bone Research Program, Sydney Medical School Nepean, University of Sydney, Penrith, Australia Sangon Biotech (Shanghai) Co., Ltd., Shanghai 201611, China. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States Westfälische Wilhelms-Universität Münster Organisch-Chemisches Institut Corrensstrasse 40 48149 Münster Germany School of Materials Science and Engineering, Nanchang Hangkong University, Nanchang 330063, People's Republic of China Department of Clinical Laboratory, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. University of Alabama, Tuscaloosa, AL, USA From the Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, London, United Kingdom. T. Wong, C. Millington-Sanders, and D.P. Francis are currently at the Waller Cardiology Department, St Mary’s Hospital, London, United Kingdom. P.A. Davlouros is currently at the Congenital Heart Programme, Department of Cardiology, Patras University Hospital, Rion, Patras, Greece. Department of Dermatology, Huashan Hospital Fudan University, Shanghai Institute of Dermatology Shanghai China Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215;; Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA 02215;; Center for Genetic Medicine Research, Children’s National Hospital, Washington, DC 20010;; Department of Genomics and Precision Medicine, The George Washington School of Medicine and Health Sciences, Washington, DC 20010; Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, and Department of Chemistry, University of California, Davis, California 95616 Cancer Center The First Hospital, Jilin University Changchun China State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China; State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, California, USA Department of Otorhinolaryngology‒Head Neck Surgery, Third Xiangya Hospital Central South University Changsha Hunan PR China Department of Oral and Maxillofacial Surgery, Changzhou Stomatologic Hospital, Changzhou, China Department of Biostatistics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China State Key Laboratory of Molecular Developmental Biology; Institute of Genetics & Developmental Biology; Chinese Academy of Sciences; Beijing, China; Center of Alzheimer Disease; Beijing Institute for Brain Disorders; Beijing China; Beijing Children's Hospital; Capital Medical University; Beijing, China Department of Stomatology, Tianjin Medical University General Hospital, Tianjin 300052, China Department of Chemistry and Biochemistry, College of Sciences, The University of Texas at Arlington, Arlington, Texas 76019, United States Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, No. 8 3rd South Street, Zhongguancun, Beijing 100190, China College of Physics and Optoelectronics, Taiyuan University of Technology, Taiyuan 030024, P. R. China Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China Obstetrics and Gynaecology, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden College of Big Data and Intelligent Engineering, Southwest Forestry University, Kunming 650224, China Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang China School of Chemistry and Chemical Engineering Shanxi University 030006 Taiyuan Shanxi China State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Cell Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China Department of Respiratory Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong, China 1Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200032, China; Department of Neurology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative Drugs School of Pharmacy Anhui Medical University Hefei Anhui People's Republic of China Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong, China Tobacco Research Institute, Chinese Academy of Agricultural Sciences , Qingdao, Shandong 266101 , China From the Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, OH (N.G., W.L., B.W., R.L.S., T.M.M.); and Department of Biological Geological and Environmental Sciences, Cleveland State University, Cleveland, OH (N.G., T.M.M.). Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China; National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing 100081, China Beijing Key Laboratory of Magnetoelectric Materials and Devices, School of Materials Science and Engineering, Beijing Innovation Centre for Engineering Science and Advanced Technology, Peking University, Beijing 100871, China Beijing Key Laboratory of Gene Engineering and Biotechnology, Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing, China; State Key Lab of Reproductive Medicine Nanjing Medical University Nanjing China Maternal and Child Health & Family Planning Service Center, Gongshu District, Hangzhou, People's Republic of China. Department of Cardiology, Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton & Harefield NHS Trust, National Heart & Lung Institute, Imperial College, London, UK 1Department of Oncology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China. Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China Department of Gastrointestinal Surgery The First Affiliated Hospital of Shantou University Medical College Shantou China Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China Sino-Platinum Metals Co., Ltd., Kunming 650093, China Fudan University Shanghai Cancer Center and the Shanghai Key Laboratory of Medical Epigenetics Institutes of Biomedical Sciences Shanghai Stomatological Hospital Fudan University Shanghai 200433 China 0000 0004 1759 700X grid.13402.34 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Institute of Industrial Ecology and Environment, College of Chemical and Biological Engineering Zhejiang University (Yuquan Campus) 310027 Hangzhou China Department of Liver Diseases, Fuyang Second People's Hospital, Fuyang, China. College of Life Sciences, Northwest University, Xi’an, 710069, China Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory, Beijing Normal University, Beijing 100875, PR China Institute of Semiconductors, Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Geosciences, Stony Brook University, Stony Brook, New York 11794-2100 Department of Anatomic Pathology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48073, USA College of Food Science & Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida, USA Department of Medical Ultrasonics The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou People's Republic of China Jiangsu key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Pharmacy Nanjing University of Chinese Medicine Nanjing China Department of Respiratory Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an - PR China Institute of Crop Cultivation and Tillage, Heilongjiang Academy of Agricultural Sciences Harbin China Department of Emergency Medicine The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA College of Animal Science and Technology Anhui Agricultural University Hefei China *Thomas E. Starzl Transplantation Institute and Departments of; †Surgery and Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology; School of Chemistry and Chemical Engineering; Guangxi University; Nanning 530004; P. R. China Department of Cardiovascular Research and National Centre for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China. School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 611731, China Beijing Key Lab of Microstructure and Properties of Solids, Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing 100124, China Department of Medicine; Division of Infectious Diseases; University of Florida College of Medicine; Gainesville; FL; USA *Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, Newark, NJ 07103; and aDivision of Rheumatology and Immunology, Harvard Medical School, Hematology Division, Brigham and Women's Hospital, Boston, Massachusetts 02115 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Sepsis Laboratory, Center for Translational Medicine, Huaihe Hospital, Henan University, Henan, China. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China. Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China School of Chemistry and Chemical Engineering Chongqing University Chongqing P. R. China Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA Department of Breast Cancer, The First People’s Hospital of Foshan, Foshan State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China. liweimiaoer@163.com College of Pharmaceutical Sciences Zhejiang University 866 Yuhangtang Road Hangzhou Zhejiang 310058 P. R. China Command Control Engineering College, Army Engineering University of PLA, Nanjing 210007, China Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW 2006, Australia College of Information Science and Electronic Engineering; Zhejiang University; Hangzhou; China Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 75858, United States State Key Laboratory of Mycology; Institute of Microbiology; Chinese Academy of Sciences; 100101 Beijing; China School of Life Sciences, Guizhou Normal University, Guiyang 550025, China Department of SurgeryYale University China; Department of SurgeryTianjin Medical University Cancer Hospital China Department of Neurology, Army Medical Center of PLA, Chongqing, China College of Chinese Medicinal Materials; Jilin Agricultural University; Changchun 130118; China; Institute of Special Wild Economic Animals and Plant International Joint Cancer Institute, Second Military Medical University, Shanghai, PR China Division of Spine, Department of Neurosurgery, China International Neuroscience Institute (CHINA-INI), Capital Medical University, Xuanwu Hospital, Beijing, China; Research Center of Spine and Spinal Cord, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China; Lab of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHINA-INI), Capital Medical University, Xuanwu Hospital, Beijing, China Department of Radiology, Wuxi No. 2 Peolpe's Hospital, Affiliated Wuxi Clinical College of Nangtong University, Wuxi, Jiangsu 214042, China Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH;; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Center for Advancing Electronics Dresden (cfaed) and Faculty of Chemistry and Food Chemistry Technische Universität Dresden 01062 Dresden Germany Interdisciplinary Graduate Program in Genetics, University of Iowa, IA 52242, USA. Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China Nanjing University School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Theoretical and Computational Chemistry, , Nanjing 210093, People's Republic of China Department of Pharmacy, Shunyi Maternal and Child Health Hospital, Beijing 101300, China. New Energy Research Institute College of Environment and Energy South China University of Technology Guangzhou 510006 China Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. The First Hospital, Institute of Immunology and International Center of Future Science of Jilin University Changchun China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University 215123 Suzhou Jiangsu China Department of Medicinal Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA Departments of Molecular and Cellular Biology and Cellular Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263; Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China; Comparative Medicine Program, Texas A&M University, 4473 TAMU, College Station, TX 77843; Department of Basic Medical Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW17... W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Division of Endocrinology, Diabetes, and Metabolism, Departments of Internal Medicine and Molecular Medicine and Therapeutics, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, Ohio, USA. Department of Chemical Engineering, Beijing Institute of Petro-chemical Technology, Beijing 102617, China Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China, Toho University, Funabashi, Chiba 274-8510, Japan, and Mount Sinai School of Medicine, New York, New York 10029 Department of Translational Medicine Genetron Health (Beijing) Technology, Co. Ltd. Beijing China Guangzhou Institute for Drug Control, Guangzhou, P.R. China Institute for Molecules and Materials, Radboud University, Nijmegen, 6525 AJ, The Netherlands Changchun BCHT Biotechnology Company Changchun China 15Sumitomo Pharma Oncology, Inc., Cambridge, Massachusetts. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China; Department of Oral Radiology School and Hospital of Stomatology Wuhan University Wuhan China Department of Immunology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China. Wenjiang District People’s Hospital, Chengdu, China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research Tianjin China Jiangsu Beike Biotechnology Ltd. Taizhou Jiangsu China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072; China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing 210093, People’s Republic of China Department of Biomedical Engineering Duke University Durham NC 27708 USA Department of Oncology The First Affiliated Hospital of Soochow University Suzhou China Departments of Gerontology (W.L.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Stomatology; Harbin Children's Hospital; Harbin; China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science Zhejiang University Hangzhou People's Republic of China Medical Research and Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China a Department of Civil and Environmental Engineering , University of Auckland , New Zealand Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China; Key Laboratory of Hearing Medicine, Ministry of Health, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China College of Food Science and Nutritional Engineering, National Engineering Research Centre for Fruits and Vegetables Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing, China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Endocrine, National Health and Family Planning Commission, Beijing, China Divisions of Pediatric Gastroenterology/Nutrition, The Floating Hospital for Children, New England Medical Center Hospitals, Center for Gastroenterology Research on Absorptive and Secretory Processes, Tufts University School of Medicine, Boston, Massachusetts Key Laboratory of Aquatic Products Processing and Utilization of Liaoning Province, Dalian Ocean University, Dalian 116023, P.R. China Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha, China; Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, China Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130061, PR China State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China Department of Pharmaceutical Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, P.R. China; Present address: CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, P.R. China Nanjing University Department of Chemistry, Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, , Nanjing 210093, People’s Republic of China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing , China; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences , Beijing , China; Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101 , China; University of Chinese Academy of Sciences , Beijing 100049 , China †Department of Medicine, Center for Immunology, University of Minnesota, Minneapolis, MN 55455 Shandong Provincial Western Hospital, Jinan, , Shandong, China Monogenic Disease Research Center for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China Academy of Traditional Chinese Medicine, Changchun, Jilin 130021, P.R. China School of Life Science, Southwest University, Chongqing 400715, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; 122 Luoshi Road Wuhan 430070 P.R. China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China Department of Geriatrics, Clinical Laboratory, Xiangya Hospital of Central South University, Changsha 410008, China Department of Thoracic Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 China Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. jinhongfang51@126.com. Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi 832003, People’s Republic of China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Dongchuan Road 500 Shanghai 200241 China Department of Materials Science and the Advanced Films Research Center of the China Educational Ministry, Fudan University, Shanghai 200433, P. R. China Center for Applied Statistics and School of Statistics, Renmin University of China, Beijing, China Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055 Department of Biomedical Engineering Fourth Military Medical University Xi’an China Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, People’s Republic of China Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education of China, School of Physics and Technology, Wuhan University, Wuhan 430072, P. R. China Key Laboratory of Cancer Prevention and Therapy, Department of Lymphoma, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC.; Department of Genomics and Precision Medicine, George Washington University, Washington, DC. School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, South China University of Technology, Guangzhou 510641, China National Demonstration Center of Chemistry and Chemical Engineering Experimental Teaching, School of Chemical Engineering, Beijing Institute of Petrochemical Technology 1 , Beijing 102617, China Department of Pediatric Dentistry, College of Dentistry University of Illinois at Chicago Chicago Illinois USA State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, PR China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China State Key Laboratory of Toxicology and Medical Countermeasures; Beijing; China; Beijing Institute of Pharmacology and Toxicology; Beijing Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA; State Key Laboratory of Pathogen Biosecurity, Beijing Institute of Biotechnology, Beijing, China School of Naval Architecture and Ocean Engineering, Huazhong University of Science and Technology , Wuhan 430074, People's Republic of China State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin 300387, China; School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China Department of Neurosurgery, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei 054000, P.R. China Center of Energy Storage Materials & Technology College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materials National Laboratory of Solid‐State Microstructures and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 P. R. China Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Beijing University of Posts and Telecommunications Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China b Institute of Biotechnology, Qinghai Academy of Agriculture and Forestry , Xining 810016 , Qinghai , P.R. China From Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom (G.-P.D., A.K., R.A.-G., L.S., A.U., W.L., S.B.-N., S.J.W., K.D., M.A.G.); NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, United Kingdom (G.-P.D., A.K., R.A.-G., L.S., A.U., W.L., S.B.-N., S.J.W., K.D., M.A.G.); National Heart and Lung Institute, Imperial College School of Medicine,... State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Engineering Center for Biomedicine, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. mizu@zju.edu.cn. The State Key Laboratory of Power Transmission Equipment & System Security and New Technology; Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China Department of Psychiatry, Yale School of Medicine Yale University New Haven Connecticut USA State Key Laboratory of Advanced Electromagnetic Engineering and Technology; School of Electrical and Electronic Engineering; and State Key Laboratory of Materials Processing and Die & Mould Technology; School of Materials Science and Engineering; Huazhong University of Science and Technology Contribution from the Department of Chemistry, Institute of Theoretical and Computational Chemistry, Lab of Mesoscopic Chemistry, Nanjing University, Nanjing, 210093, People's Republic of China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Haikou Hainan Province 571199 People's Republic of China; Key Laboratory of Molecular Biology Hainan Medical College Haikou 571199 People's Republic of China Department of Otorhinolarnygology, Central South University, Changsha 410013, China. Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and Energy South China Agricultural University Guangzhou 510642 China; Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of Macau Macau 999078 China Department of Neurology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China Department of Chemistry; Huaibei Normal University; Huaibei; P.R. China Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA. Key Laboratory of Medicinal Chemistry; and Molecular Diagnosis of the Ministry of Education; College of Chemistry & Environmental Science; HeBei University; Baoding 071002 School of Chemistry and Chemical Engineering; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; Tianjin University of Technology; Tianjin 300384; P. R. China College of Information Science and Engineering Jiaxing University Jiaxing 314001 China School of Mathematical Sciences Peking University Beijing China Institution of Genomics and Bioinformatics, South China Agricultural University, Guangzhou 510642, China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Haidian District, Beijing, 100085, P.R. China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China 20Department of Hematology and Oncology, The First Hospital of Jilin University, Jilin, China Medical Research & Biometrics Center, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University , Nanjing 211166, China; Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention , Nanjing 210028, China The Institute for Population and Development Studies, School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics University of Science and Technology of China Hefei China Division of Functional Materials; Central Iron and Steel Research Institute; Beijing; China People's Hospital, Peking University, Beijing, China; and School of Pharmaceutical Chemical and Materials Engineering, Taizhou University, Taizhou, 318000, P. R. China School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, 391 Binshui Xidao, Tianjin, Xiqing District, 300384, China Medical Health and Intelligent Simulation Laboratory Health Science and Environmental Engineering School Shenzhen Technology University Shenzhen China Engineering Research Center of High Performance Polymer and Molding Technology, Ministry of Education, Qingdao University of Science and Technology, Qingdao 266042, China From the Division of Pathology II, Faculty of Health Sciences, Linköping University, Linköping, Sweden (W.L., X.-M.Y.); the Department of Pathology, Gade Institute, University of Bergen, Bergen, Norway (H.D.); and the James Graham Brown Cancer Center, University of Louisville, Louisville, Ky (J.W.E.). Key Laboratory of Protein Chemistry and Fish Developmental Biology of the Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha 410081, People's Republic of China Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki FI‐00014 Helsinki Finland Second Department of Surgery, Harbin Fifth Hospital, Harbin, 150040, China Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; and Cancer Center, the First Hospital Jilin University Changchun China Department of Cardiology, Qinghai Provincial Hospital, Xining Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, PR China Department of Obstetrics and Gynecology Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine 150040 Harbin China Key Laboratory for the Physics and Chemistry of Nanodevices, Department of Electronics Peking University Beijing 100871 China College of Chemistry Jilin University 2699 Qianjin Street Changchun 130012 P. R. China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 Jiangsu China Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, and Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan Department of Otolaryngology Head and Neck Surgery,Children's Hospital of Nanjing Medical University,Nanjing,210008,China. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650201 China; Kunming College of Life Sciences University of the Chinese Academy of Sciences Kunming 650204 China Department of Mechanical and Aerospace Engineering West Virginia University Morgantown WV 26506 USA Laboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China, Department of Chemical Engineering, Wuhan University of Science and Engineering, Wuhan 430073, China, Department of Chemistry, Guizhou University, Guiyang, Guizhou 550025, China, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China, and Institut für Physikalische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China Department of Pharmaceutical Sciences University of Tennessee Health Science Center Memphis TN USA Human Cancer Genetics Program, Department of Pathology, and Departments of Internal Medicine and Radiology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210; and Department of Pathology, Helsinki University Central Hospital, FIN-00029, Helsinki, Finland Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130061, P.R. China Nephropathy Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Radiology, Northshore University HealthSystem Evanston Illinois USA; Pritzker School of Medicine, University of Chicago Chicago Illinois USA Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100039, China High Technology Research Center, and Department of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan Department of Neurosurgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, People’s Republic of China State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China a College of Food Science and Technology, Huazhong Agricultural University , No. 1 Shizishan Road, Wuhan , 430070 , China Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei 430060, P.R. China International Iberian Nanotechnology Laboratory (INL) Av. Mestre Jose Veiga 4715-330 Braga Portugal Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao City 266000, China Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, and Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965 Department of Chemistry Laboratory of Advanced Materials State Key Laboratory of Molecular Engineering of Polymers, and Collaborative Innovation Center of Chemistry for Energy Materials Fudan University Shanghai 200433 P. R. China Key Laboratory of Applied Physics and Chemistry in Space of Ministry of Education, School of Science; Northwestern Polytechnical University; Xi'an China Department of Hematology, The First Affiliated Hospital of Jilin University, Changchun 130000,Jilin Province, China. Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China Powder Metallurgy Research Institute, Central South University, Changsha 410083, China Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021 China. From the Department of Molecular Cardiology (P.A.K., R.C.P., J.A., S.M.), Department of Cellular and Molecular Medicine (W.L.), Lerner Research Institute, Cleveland Clinic, Cleveland, OH; and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI (R.L.S.). Hubei Key Laboratory of Biomass Fiber and Eco-dyeing & Finishing, College of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430073, People’s Republic of China Division of Vascular and Endovascular Surgery, Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, NY, USA School of Perfume and Aroma Technology Shanghai Institute of Technology Haiquan Road 100 Shanghai 201418 China State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China Experimental Research Center of Medical and Psychological Science, School of Psychology Third Military Medical University Chongqing China Department of Pathology The First Affiliated Hospital, Sun Yat‐sen University Guangzhou PR China Department of Pharmacy, The Third People’s Hospital of Shenzhen, Shenzhen, China Institute of Dermatology, Anhui Medical University, Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Department of Internal Medicine and The Heart and Lung Research Institute The Ohio State University Columbus OH 43210 USA Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China; Research Center for Analysis and Measurement, Kunming University of Science and Technology, Kunming 650093, China Human Cancer Genetics Program and Departments of Molecular Virology, Immunology, and Medical Genetics (H.H., S.L., R.N., W.L., K.A., N. S., B.W., K.J., D.E.S., A.d.l.C.), Columbus, Ohio 43210; Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China School of Molecular Sciences and The Biodesign Institute Arizona State University Tempe AZ 85287 USA Departments of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA Department of Materials Science and Engineering University of Delaware Newark DE 19716 USA; Computer, Computational and Statistical Sciences Division Los Alamos National Laboratory Los Alamos NM 87545 USA Guangdong Provincial Engineering Technology Research Center for Optical Agriculture College of Materials and Energy South China Agricultural University Guangzhou 510642 P. R. China College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P. R. China Department of Medical Oncology, Shanghai Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China. Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei, 430068, China Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Molecular Engineering of Polymers, Fudan University , China Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, China (W.Li). School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P.R. of China, Department of Chemistry, Guizhou University, Guiyang, Guizhou 550025, P.R of China, and Institut für Physikalische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany Life Science College, Sichuan Normal University, Chengdu, China Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China Institute of New Energy for Vehicles School of Materials Science and Engineering Tongji University Shanghai 201804 China School of Medicine, Guizhou University, Guiyang, Guizhou 550025, China Wei Li, Chuan Xie, Zhen Yang, Jiang Chen, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. Department of TCM Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China. Department of Infectious Diseases, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Pediatrics Department, The People’s Hospital of Jiulongpo District, Chongqing, China Department of Medical Genetics, China Medical University, Shenyang City, China. China Mobile (Zhejiang) Innovation Research Co., Ltd., Hangzhou 310016, China Institute of Rehabilitation Engineering and Technology, University of Shanghai for Science and Technology, Shanghai, China Beijing Genomics Institute (BGI), Chinese Academy of Sciences (CAS), Beijing, China. IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, USA. Department of Neurology, National Neuroscience Institute, Singapore Max Planck Institute of Colloids and Interfaces, D-14424, Potsdam, Germany, and State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, Peopleʼs Republic of China China Aerospace Science and Industry Corporation, Beijing 100081, China Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, Hubei, China Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Shenyang, China Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Clinical Laboratory, Zhejiang University School of Medicine Children's Hospital, Hangzhou, China Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Tongjia Lane No. 24, Nanjing 210009, China Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China Drug Research Program, Division of Pharmaceutical Chemistry Technology Faculty of Pharmacy University of Helsinki FI‐00014 Helsinki Finland Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, California 94720, United States College of Chinese Medicinal Materials, Jilin Agricultural University , Changchun 130118, Jilin , China Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Department of Chemistry and Physics, Shandong Center for Food Safety Risk Assessment, Shandong Center for Disease Control and Prevention, Jinan, People’s Republic of China; Academy of Preventive Medicine, Shandong University, Jinan, People’s Republic of China Central Laboratory of Health Quarantine, Shenzhen International Travel Health Care Center, Shenzhen Customs District, Shenzhen 518033, China Unit on Retinal Neurophysiology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2510 Authors' Affiliations: Departments of 1Pharmacology and Experimental Therapeutics, and 2Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland; 3Department of Pathology, New York University School of Medicine, New York, New York; and 4Department of Urology, Sun Yat-sen University, Guangzhou, China *Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine; and Department of Pediatrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China State Key Laboratory of Hybrid Rice, College of Life Sciences Wuhan University Wuhan 430072 China; Hubei Hongshan Laboratory Wuhan 430072 China Department of Urology, Zhongshan City People’s Hospital, Zhongshan 528400, China Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: liwei@mrbc-nccd.com. Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139 Sorbonne Université, CNRS, Physico-chimie des Électrolytes et Nano-systèmes Interfaciaux, PHENIX, F-75005 Paris, France Center for Supramolecular Science and Department of Chemistry, University of Miami, Coral Gables, Florida 33124-0431, United States School of Science, and Advanced Functional Material and Photoelectric Technology Research Institution, Hubei University of Automotive Technology , Shiyan 442002, People’s Republic of China Department of Medical Oncology Shanghai Pulmonary Hospital Tongji University Medical School Cancer Institute Tongji University School of Medicine Shanghai China Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China Tasly R&D Institute Tianjin Tasly Group Co. Ltd Tianjin 300410 People's Republic of China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences at Wuhan University, Wuhan 430072, China Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China, and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China The First Bethune Hospital of Jilin University, Changchun, China. International Joint Cancer Institute, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China; College of Pharmacy, Liaocheng University, 1 Hu'nan Road, Liaocheng, Shandong 25200, PR China Columbia University/New York State Psychiatric Institute, New York, New York Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University; Changchun People's Republic of China The Second Department of General Surgery, Cangzhou Central Hospital, Cangzhou 061000, Hebei, China The State Key Laboratory of Natural and Biomimetic Drugs; School of Pharmaceutical Sciences; Peking University; Beijing 100191; China Beijing Genomics Institute (BGI), Chinese Academy of Sciences, I-Zone, Shunyi, Beijing 101300 and James D. Watson Institute of Genome Sciences (WIGS), Zhijiang Campus, Zhejiang University, Hangzhou 310008, China The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai 264000 P. R. China Department of Immunology and Pathogen Biology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun 130118, P. R. China; Key Laboratory of Biotechnology and Bioresources Utilization, College of Life Science, Dalian Minzu University, Dalian 116600, P. R. China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Otolaryngology‑Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China Division of Obstetrics and Gynaecology Department of Clinical and Experimental Medicine Faculty of Health Sciences Linköping University Linköping Sweden Department of Hematology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan 250012 P. R. China School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou; China Department of Urology,Shenzhen Longhua District Central Hospital,The Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, Guangdong Province,China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China; Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL‐MMD) Beijing Innovation Centre for Engineering Science and Advanced Technology (BIC‐ESAT) Beijing 100871 China Key Laboratory for Biology and Control of Plant Diseases and Insect Pests, College of Plant Protection Hunan Agricultural University Changsha Hunan China Orthopaedic Department, Peking University Third Hospital, Beijing, China (mainland) Department of Cancer Research Center, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China. Department of Rheumatism and Immunology, The 2 Affiliated Hospital, Harbin Medical University, Nangang District, Harbin, China. Emergency Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China Cancer Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Gastroenterology Shengli Oilfield Central Hospital Dongying China Department of Physiology and Cell Biology, 305B Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210; Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210 Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University, Changchun 130061, People’s Republic of China 1 State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People’s Republic of China College of Pharmacy, Chungnam National University Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy South China Agricultural University Guangzhou 510642 China Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai Shanghai 200433 China Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an Shaanxi, People’s Republic of China Department of Ophthalmology, Xiang'an Hospital of Xiamen University; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Xiamen University Affiliated Xiamen Eye Center, Xiamen, Fujian, China First Affiliated Hospital of China Medical University, Shenyang 110001, China. daxao@sina.com Shun Lu, Shanghai Jiao Tong University; Jianhua Chang, Fudan University Shanghai Cancer Center; Mo Chen, Ye Hua, and Weiguo Su, Hutchison MediPharma Limited, Shanghai; Xiaoqing Liu, The 307 Hospital of Chinese People’s Liberation Army; Jie Wang and Tongtong An, Beijing Cancer Hospital; Zhe Liu, Capital Medical University, Beijing; Jianhua Shi, Linyi Cancer Hospital, Linyi; You Lu, Sichuan University, Chengdu; Wei Li, The First Hospital of Jilin University, Changchun; Jin-ji Yang, Guangdong General... Department of Vascular Surgery, Peking University People’s Hospital, Beijing, China Department of Medical Oncology Zhongshan Hospital Fudan University Shanghai China College of Landscape Architecture and Forestry, Qingdao Agricultural University, Qingdao, Shandong, P. R. China The Division of Dermatology and the University of Southern California/Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033; The Greater Los Angles Veterans Administration Heath System, Los Angeles, California 90073 Department of Pathophysiology, School of Basic Medicine, Wannan Medical College Wuhu 241002, Anhui, PRC. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China Department of Abdominal surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China. lwxsbs@medmail.com.cn Cancer Research Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute Capital Medical University Beijing China *Thomas E. Starzl Transplantation Institute and Department of Surgery, Department of PET Center and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University 410082 Changsha P. R. China School of Municipal and Environmental Engineering, Shenyang Jianzhu University, Shenyang, People’s Republic of China Department of Gastroenterology Heze Municipal Hospital Heze China Department of Pharmaceutical Analysis; School of Pharmacy; Shandong University of Traditional Chinese Medicine; Shandong 250355; China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Retinal Neurophysiology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States Department of Study Center, The First Hospital of Harbin City, Harbin Medical University, Harbin 150001, China; Department of Study Center, Medical Science Institute of Harbin, Harbin 150001, China Department of Cardiology The affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine Nanjing Medical University Taizhou P.R. China Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, United States Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022, China Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA, 2Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA and 4State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210000, China; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA, 2Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA, 3Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA and 4State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210000, China Materials Research Laboratory, University of California, Santa Barbara, California 93106, United States Department of Ophthalmology, Jining No.1 People’s Hospital, Jining, Shandong, China Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of ASIC & System, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, P. R. China Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKLMMD); Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT); College of Engineering; Peking University; Beijing 100871 Department of Spine Surgery, Hiser Medical Center of Qingdao, Qingdao, Shandong 266000, P.R. China College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China College of Chemical and Biological Engineering, Guilin University of Technology, Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, Guilin, 541004, P. R. China Department of Otorhinolaryngology, the Affiliated Hospital of Medical College , Qingdao University, Qingdao, 266003,China. liweishang2004@yahoo.com.cn Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China; School of Microelectronics, University of Chinese Academy of Sciences, Beijing 100049, China Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital and Melanoma Institute Australia Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Mechanical and Biomedical Engineering; City University of Hong Kong; Kowloon, Hong Kong SAR Tianjin Centers for Disease Control and Prevention, Tianjin, China Physical and Life Sciences Directorate Lawrence Livermore National Laboratory Livermore California USA State Key Laboratory of Organic-Inorganic Composites; College of Chemical Engineering; Beijing University of Chemical Technology; Beijing 100029; PR China State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China Department of Microbiology; Miami University; Oxford OH USA Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, 11794-3400, USA. Department of Anatomy and Cell Biology, University of Iowa College of Medicine, 1-532 Bowen Science Building, 51 Newton Rd., Iowa City, Iowa 52242,USA. State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin 300387, China; Tianjin Municipal Key Lab of Advanced Fiber and Energy Storage Technology, Tianjin 300387, China; School of Material Science and Engineering, Tiangong University, Tianjin 300387, China Weill Cornell Medical College, 1300 York Avenue LC216, New York, NY, 10065, USA. Institute of Translational Medicine; Medical College; Yangzhou University; Yangzhou 225001; China CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety (NCNST-IHEP); Institute of High Energy Physics (IHEP), Chinese Academy of Sciences, Beijing 100049, China Department of Otolaryngology,Tangshan Maternal and Child Care Service Centre. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, People’s Republic of China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Health Science Center, Xi'an, Shaanxi 710061, P.R. China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Jilin University Changchun 130012 China Department of Genetics and Reproductive Medicine, Shunyi Maternal and Children’s Hospital of Beijing Children’s Hospital, Capital Medical University , Beijing , China; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health , Beijing , China Department of Echocardiography and Congenital Heart Disease, Royal Brompton & Harefield National Health Service Foundation Trust, London, United Kingdom Capital Medical University Beijing Children's Hospital, , Beijing 100045, China CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei Anhui China Guangzhou University of Chinese Medicine, Guangzhou, China College of Chemistry and Molecular Sciences; Hubei Key Laboratory of Electrochemical Power Sources; Wuhan University; Wuhan; P. R. China Beijing National Laboratory for Molecular Sciences (BNLMS), (The State Key Laboratory of Rare Earth Materials Chemistry and Applications), College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China From the Department of Pediatrics, Yale University, New Haven, CT; the Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson; and the Department of Cell Biology and Neuroscience, University of South Alabama, Mobile. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China Department of Nephrology, The Third Xiangya Hospital Central South University Changsha Hunan China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun Jilin 130022 P. R. China; University of Chinese Academy of Sciences Beijing 100039 P. R. China Medical Research & Biometrics Center, Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China From the Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, 710061 Shaanxi Province, China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China Department of Pharmacology, Weill Cornell Medical College, New York, NY Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, China Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT), Department of Materials Science and Engineering College of Engineering, Peking University, Beijing 100871, China The Affiliated Hospital of Guizhou Medical University, Guizhou 550004, China. Cancer Center, the First Hospital of Jilin University, Changchun, China Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Department of Nephrology, Wuhan Forth Hospital, Puai Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Contribution from the Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario, M5S 3H6 Canada Department of Oral and Maxillofacial Surgery Department of Geriatrics, Hainan Provincial People's Hospital, Haikou 570311, China. the Eye Institute and Affiliated Xiamen Eye Center, Xiamen University Medical College, Xiamen, Fujian, China. Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen, 6525 AJ, The Netherlands Department of Neurology Linyi People's Hospital Linyi Shandong Province China Institute for Molecules and Materials Radboud University Heyendaalseweg 135 Nijmegen 6525AJ The Netherlands Department of Dermatology and The USC-Norris Comprehensive Cancer Center, University of Southern California Keck Medical Center, Los Angeles, California, USA. Department of Pathology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, P.R. China Department of Chemistry, Capital Normal University, Beijing 100048, P. R. China Department of Otoalryngology-Head Neck Surgery, Third Xiangya Hospital, Central South University Changsha, Hunan, China. Department of Epidemiology, Robert Stempel College of Public Health, Florida International University School of Public Health, Weifang Medical University, Weifang, China Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China Shanghai Key Laboratory of Material Laser Processing and Modification, Shanghai Jiao Tong University, Shanghai 200240, China; Institute of Advanced Steels and Materials, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China National Engineering Laboratory of Crop Stress Resistance Breeding, School of Life Sciences, Anhui Agricultural University, Hefei, China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin province, China Department of Cardiology Renmin Hospital of Wuhan University Hubei China; Cardiovascular Research Institute of Wuhan University Hubei China; Hubei Key Laboratory of Cardiology Hubei China Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan, and Division of Pharmacognostical Biotechnology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China Department of Family and Preventive Medicine University of Utah Salt Lake City Utah Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China;; Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen UniversityXiamen, Fujian, China;; The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China Crop Research Institute Shandong Academy of Agricultural Sciences Jinan China; Ministry of Agriculture and Rural Affairs Key Laboratory of Wheat Biology and Genetic Improvement on North Yellow and Huai River Valley Jinan China; National Engineering Laboratory for Wheat and Maize Jinan Shandong China Department of Otorhinolaryngology,Tangshan Maternal and Child Health Hospital. Faculty of Pharmaceutical Sciences Toho University Miyama 2‐2‐1 Funabashi Chiba 274‐8510 Japan School of Chemical Engineering; Changchun University of Technology; Changchun; P. R. China Department of Cardiology, The Affiliated Hospital of Guizhou Medical University Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Department of Pharmacy, Wuhan General Hospital of Guangzhou Command Beijing Genomics Institute/Center of Genomics and Bioinformatics, Chinese Academy of Sciences, 101300, Beijing, China;Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China BGI Genomics, BGI-Shenzhen, Shenzhen, China School of Public Health, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China Department of Hemapoietic Disorders, the First Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun, People’s Republic of China Department of Oncology The First Hospital of Jilin University Jilin China Guangdong Provincial Engineering Technology Research Center for Optical Agriculture; College of Materials and Energy; South China Agricultural University; Guangzhou 510642; P. R. China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Haikou China Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, United States. Electronic address: wei.li@uci.edu. Chair of Macromolecular Chemistry Faculty of Chemistry and Food Chemistry School of Science Technische Universität Dresden Mommsenstraße 4 01069 Dresden Germany; School of Chemistry and Chemical Engineering Shihezi University 832003 Shihezi China Department of Endocrinology Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital Beijing China School of Pharmacy Nanjing University of Chinese Medicine Nanjing China College of Animal Science, Heilongjiang Bayi Agricultural University, Daqing, People's Republic of China. Musculoskeletal Ageing Research Program, Penrith, New South Wales, Australia School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, P. R. China Cancer Center, The First Hospital of Jilin University Changchun 130021 China Department of Chemical Engineering, Texas Tech University 2 , Lubbock, Texas 79409, USA Department of Chemistry; Trinity University; San Antonio; USA 3Tianjin Women’s and Children’s Health Center, Tianjin, China Jiangsu university, Zhenjiang 212000, Jiangsu Province, China. Department of Medical Oncology The First Hospital of Jilin University Changchun China Department of Geriatric, The Tenth People's Hospital Affiliated to Tongji University China. Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, China; Department of Clinical Laboratory, The 89th Hospital of The People’s Liberation Army, Weifang, Shandong, China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China From the Department of Cellular and Molecular Medicine, Lerner Research Institute, The Cleveland Clinic, OH (W.L., T.M.M.); Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH (W.L., T.M.M.); Instituto de Quimica Medica, Consejo Superior De Investigaciones Cientificas (IQM-CSIC), Madrid, Spain (A.G.,M.-J.P.-P.); Department of Biological Sciences, Case Western Reserve University, Cleveland, OH (H.Y.); Department of Neurology, Columbia... School of Life Sciences, Zhengzhou University, Zhengzhou, China;; Laboratory of Membrane Biology, New York Blood Center, New York, NY;; Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Endocrinology, The Affiliated Hospital of Xuzhou Medical University, People's Republic of China College of Material Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China Institute of Communicable Disease Prevention and Control , China Center for Disease Prevention and Control, Beijing 102206, China Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China Alzheimer’s Disease and Related Disorders Center; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China Central Laboratory, General Hospital of Western Theater Command, Chengdu, Sichuan 610016, P.R. China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei, P. R. China Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China School of Ecology and Environmental Science, Yunnan University, Kunming 650500, China School of Microelectronics, Northwestern Polytechnical University, Xi'an, 710072, PR China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education; Department of Oral Radiology Tianjin Women and Children’s Health Center Tianjin China Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi China Division of Functional Materials; Central Iron & Steel Research Institute; Beijing 100081; China Department of Gastroenterology, Chinese PLA General Hospital of Jinan Military Command, Jinan, China State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University Hangzhou 310027 China Department of Plant Pathology, University of California, Davis, CA 95616; Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Hubei Key Laboratory of Biomass Fibers and Eco - dyeing & Finishing Department of Chemistry and Chemical Engineering Wuhan Textile University Wuhan 430073 China Department of Vascular Surgery, Peking University People’s Hospital (W.L.), Peking University, Beijing, China. College of Agriculture, Ningxia University, Yinchuan 750021, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, China Beijing Neurosurgical Institute, Beijing Tiantan Hospital, China Department of Chemistry and Centre for Research in Mass Spectrometry, York University, Toronto, Ontario, Canada M3J 1P3, Applied Biosystems/MDS SCIEX, 71 Four Valley Drive, Concord, Ontario, Canada L4K 4V8, Applied Biosystems, 500 Old Connecticut Path, Framingham, Massachusetts 01701, Division of Clinical Biochemistry, St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1L5, and... Texas A&M University, Texas AgriLife Research, Office of the Texas State Chemist, 445 Agronomy Rd, College Station, TX 77843 Department of Pharmacology, Wannan Medical College, Wuhu 241002, China Institute of New Catalytic Materials Science, Institute of New Energy Material Chemistry, Department of Materials Chemistry, Nankai University, Tianjin 300071, China Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Department of Orthopedics (spine), First Affiliated Hospital of Anhui Medical University, Hefei, China Authors' Affiliations: 1Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio; and 2Preclinical Research and Development, GTx Inc., and 3Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China; Center for Plant Ecology, Core Botanical Gardens, Chinese Academy of Sciences, Wuhan, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China; Department of Medicinal Chemistry, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, China College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Guangdong Provincial Engineering Technology Research Center for Environmentally-friendly Aquaculture, Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Science, South China Normal University, Guangzhou, China; Royal Brompton and Harefield NHS Foundation Trust, London, UK Department of Hematology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan 250012 P.R. China Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, People’s Republic of China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583 (S.C., Z.V., W.L., M.B.D.); and Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 (H.A.) Graduate School of Engineering Kobe University Kobe 657-8501 Japan Department of Urology, Shanghai Tenth People’s Hospital Tongji University School of Medicine Shanghai China Department of Pathology, Osaka City University Medical School, Osaka, Japan. Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 3Beijing Institute of Biotechnology, Haidian District, Beijing, China.; 4Laboratory of Nuclear and Radiation Damage, The General Hospital of the PLA Rocket Force, Beijing, China. Institute of Unconventional Oil and Gas, Northeast Petroleum University, Daqing, 163318, China aDivision of Rheumatology and Immunology, Brigham and Women's Hospital, Smith Building, Boston, Massachusetts 02115 Department of Blood Transfusion, The Second Affiliated Hospital of Kunming Medical University, Kunming, China Department of Dermatology, Soochow University Affiliated Children’s Hospital, 303 Jingde Road, Suzhou 215003, China Affiliated Hospital & Clnical Medical College of Chengdu University, Chengdu 610081, P. R. China College of Packaging and Material Engineering, Hunan University of Technology, Zhuzhou, 412007, China Indiana Center for AIDS Research and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA Division of Functional Materials; Central Iron and Steel Research Institute; Beijing 100081; China Huazhong University of Science and Technology 1 School of Automation, , Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of Education Ministry of China 3 , Wuhan 430074, China State Key Laboratory for Infectious Disease Control and Prevention,Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention. Department of Pediatric Dentistry, College of Dentistry University of Illinois Chicago Chicago Illinois USA College of Life science, Sichuan University, Chengdu, China. Department of Otology and Skull Base Surgery Eye Ear Nose and Throat Hospital, Fudan University Shanghai China; Key Laboratory of Hearing Medicine, Ministry of Health Eye Ear Nose and Throat Hospital, Fudan University Shanghai China State Key Laboratory of Fine Chemicals; College of Chemical Engineering; Dalian University of Technology; Dalian 116024; P. R. China 1 Department of Computer Science and Engineering, University of California, Riverside, Riverside CA 92507, USA and 2School of Information Science and Technology, Tsinghua University, Beijing, China 100084 Cytovia Therapeutics, Inc., Natick, MA 01760, USA School of Material Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China State Key Laboratory of Tree Genetics and Breeding , National Engineering Research Center of Tree Breeding and Ecological Restoration, , 85 Qinghua East Road, Beijing, 100083 , China; College of Biological Sciences and Technology, Beijing Forestry University , National Engineering Research Center of Tree Breeding and Ecological Restoration, , 85 Qinghua East Road, Beijing, 100083 , China Department of Computer Science and Engineering, University of California, Riverside, California. School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, China Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, Laboratory for the Studying of Complementary and Medicinal Resources, The Kochi University of Technology, Tosayamada-cho, Kochi, 782-8502, Japan, Department of Plant Resources, G.P.O. Box 2270, Lalitpur, Kathmandu, Nepal, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1,... Department of Medicine, Division of Dermatology, and Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033 Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield, S3 7HQ, United Kingdom International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China From the Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital (G.-P.D., K.D., W.L., S.V.B.-N., C.S.B., B.J., B.B., M.J.M., M.A.G.); Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College (G.-P.D., D.O., P.A.P.-W.); and Cardiac Performance Unit, Department of Cardiology, St Mary’s Hospital (D.P.F.), London, UK. Experimental Parasitology, Department of Veterinary Sciences, Faculty of Veterinary Medicine Ludwig‐Maximilians‐Universität, LMU Munich Germany Department of Emergency The First Hospital of Jilin University Changchun China Gastrointestinal Cancer Center Chongqing University Cancer Hospital Chongqing China School of Chemistry & Environmental Engineering; Changchun University of Science and Technology; Changchun; P. R. China Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA State Key Laboratory of Medical Molecular Biology, Haihe Laboratory of Cell Ecosystem, Department of Cell Biology, School of Basic Medicine Peking Union Medical College Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P.R. China.; Cardiovascular Research Institute, Wuhan University, Wuhan, P.R. China.; Hubei Key Laboratory of Cardiology, Wuhan, P.R. China. Outpatient Department, West China Hospital of Sichuan University, Chengdu 610041, China From the Division of Pediatrics, Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA; and the Department of Obstetrics and Gynecology, School of Medicine, University of Southern California and Huntington Memorial Hospital, Pasadena, CA. School of Materials Science and Engineering National Institute for Advanced Materials TKL of Metal and Molecule-Based Material Chemistry Nankai University Tianjin 300350 China Department of Clinical Laboratory The Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center For Child Health Hangzhou China Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA; Koch Institute of Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA State Key Laboratory of Organic‐Inorganic Composites College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China College of Life and Environment Sciences Huangshan University Huangshan Anhui P. R. China Department of Anorectal Hemorrhoids, Gaozhou People’s Hospital , Gaozhou City , Guangdong Province, 525200 China Laboratory of Biochemical Genetics (WL,RMK) and Pathology Core (Z-XY), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland Eye Institute of Xiamen University and Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences 315201 Ningbo P. R. China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China Dongfeng Liuzhou Motor Company, Liuzhou 545616, China School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.; Jiangsu Center for Stem Cell Engineering and Technology, China Medical City, Taizhou, People's Republic of China. The Ben May Institute and Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois 60637 Division of Functional Material Central Iron and Steel Research Institute Beijing 100081 P. R. China Department of Surgical Intensive Care Unit, Peking University First Hospital, Beijing 100034, China.Li Wei is working on the Department of Internal medicine, Taiyuan Xinghualing District Central Hospital, Taiyuan 030002, Shanxi, China. Corresponding author: Li Shuangling, Email: lishuangling888@hotmail.com. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China Division of Biostatistics, Dan L Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China From the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.) Pearl River Fisheries Research Institute Chinese Academic of Fisheries Sciences Guangzhou People's Republic of China Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, East Road of North 3rd Ring, Chaoyang District, Beijing 100029, China Chongqing Institute of Green and Intelligent Technology; Chinese Academy of Sciences; Chongqing 400714; China; Chongqing School Department of Neurosurgery Second affiliated Hospital Third Military Medical University Chongqing China Yueyang Engineering Technology Research Center of Breast Disease Diagnosis and Treatment, Yueyang People’s Hospital, Yueyang Hospital Affiliated to Hunan Normal University, Yueyang 414006, Hunan, P.R. China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China State Key Laboratory of Chemical Resources Engineering; Beijing University of Chemical Technology; Beijing 100029; China Department of Nephrology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Infectious Diseases and Immunology, University of Sydney, NSW. Department of Laboratory Center, National Clinical Research Center for Child Health, The Children's Hospital Zhejiang University School of Medicine Hangzhou China Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China; Markey Cancer Center, University of Kentucky, Lexington, KY, USA; Center for Systems Biology, Soochow University, Suzhou, China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China; Jiangsu Institute of Clinical Immunology, Suzhou, China Beihang University 1 School of Automation Science and Electrical Engineering, , Beijing 100191, China TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, P.R. China Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States Experimental Animal Center Zhejiang Academy of Medical Sciences (ZJAMS) Hangzhou Zhejiang China Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China Nuclear Medicine, Tianjin Medical University General Hospital Airport Site; Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China School of Life Sciences & Technology, Tongji University, Shanghai, 200092, China Department of Thoracic surgery Affiliated Hospital of Hebei University Baoding China Department of Chemistry, Columbia University, New York, New York 10027, Institute of Chemical Sciences, University of Urbino, Piazza Rinascimento, 6 Urbino, Italy 61029, and E. I. Dupont, Central Research, Experimental Station, Wilmington, Delaware 19880 Institute of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing, 100124, P.R. China From TissueTech, Inc. and the Ocular Surface Center, Miami, Florida; and the Department of Medical Oncology, Jiangsu Province Hospital, Nanjing, Jiangsu, P.R. China Medical Research and Biometrics Center National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P.R. China; National Clinical Research Center for Cardiovascular Diseases Beijing P.R. China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Water and Soil Conservation, Northwest A&F University, 712100 Yangling, People’s Republic of China; Department of Urology First People's Hospital of Yunnan Province Kunming PR China Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, College of Life Science and Technology, Harbin Normal University, 150025, China Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No.127, Dongming Road, Jinshui District, Zhengzhou, 450008, China School of Materials Science and Engineering, Beijing Key Laboratory for Magnetoelectric Materials and Devices, Beijing Innovation Center for Engineering Science and Advanced Technology, Peking University, Beijing 100871, China Department of TCM Orthopedics & Traumatology Jing'An District Central Hospital of Shanghai (Huashan Hospital Fudan University Jing'An Branch) Shanghai China Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Department of Medical Imaging, Jiangsu Vocational College of Medicine, Yancheng, China The State Key Laboratory of Environment-Friendly Energy Materials, School of Materials and Chemistry, School of Information Engineering, School of Mathematics and Science, Southwest University of Science and Technology, Mianyang 621010, China Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University Xuzhou People's Republic of China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, The Institute for Advanced Studies, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan, Hubei, 430072, P. R. China The Second Affiliated Hospital of Guangxi Medical University, Department of Nephrology, Nanning, Guangxi, China State Key Laboratory of Explosion Science and Safety Protection, Beijing Institute of Technology, Beijing 100081, China School of Mechanical Engineering, Zhengzhou University of Science and Technology, Zhenghzou, P.R.China Key Laboratory of Optoelectronic Technology & Systems (Ministry of Education), Chongqing University, Chongqing 400044, China School of Basic Medical Sciences Zhengzhou University Zhengzhou Henan Province China Graduate School of the Fourth Military Medical University Xi'an 710032 People's Republic of China Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China. Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, and College of Science, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China UCL Division of Surgery and Interventional Science, University College London, London, UK. TissueTech, Inc., and Ocular Surface Center, Miami, Florida, USA Key Laboratory of Medical Image Computing of Ministry of Education, Northeastern University, Shenyang, Liaoning, China Department of Physiology and Neurobiology, School of Basic Medicine Sciences Zhengzhou University Zhengzhou China The People's Hospital of Fujian Traditional Medical University, Fuzhou, Fujian, People's Republic of China. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China Division of Pediatric Gastroenterology and Nutrition The Floating Hospital for Children New England Medical Center Tufts University School of Medicine Boston Massachusetts U.S.A.; Department of Pediatrics Sophia Children's Hospital Erasmus University Rotterdam The Netherlands Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, P R China Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, and NMPA Key Laboratory for Dental Materials Beijing China Department of Chemistry & Biochemistry, Utah State University, Logan, Utah 84322, United States Environmental Soil Chemistry Group, Delaware Environmental Institute and Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19717-1303 United States Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing 210009, China Department of Clinical Laboratory The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health Hangzhou Zhejiang China Human Cancer Genetics Program, Ohio State University, Columbus, OH 43210, USA.; Department of Molecular Virology, Immunology and Medical Genetics, School of Biomedical Science, Ohio State University, Columbus, OH 43210, USA. School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, P. R. China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Centre for Advanced Computations in Engineering Science, Department of Mechanical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 Key Laboratory of Luminescence Analysis and Molecular Sensing Southwest University, Ministry of Education 2 Tiansheng, Beibei Chongqing 400715 P. R. China; School of Materials and Energy Southwest University Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies 2 Tiansheng, Beibei Chongqing 400715 P. R. China Nursing School Guizhou University of Traditional Chinese Medicine Guiyang China School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 P. R. China Department of Biochemistry and Molecular Biology, College of Life Science, Sichuan Normal University , Chengdu , China Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011; Department of Dermatology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100029, P.R. China Department of Pathophysiology, Wannan Medical College Wuhu 241002, Anhui, China. Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Oncology, Sir Run Run Hospital of Nanjing Medical University, Nanjing 211166, China Eye Institute and affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian;; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian; Department for Population and Development Studies, School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China School of Forensic Medicine, Xinxiang Medical University, Xinxiang 453003, China From Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, National Heart and Lung Institute, Biomedical Research Unit, Royal Brompton Hospital, Imperial College, London, United Kingdom (A.K., W.L., G.-P.D., K.D., S.J.W., M.A.G.); and Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (C.S.H., A.S.J., L.S.). Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education & West China School of Pharmacy, Sichuan University, No.17, Section 3, Southern Renmin Road, Chengdu 610041, P. R. China Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China 1Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; 2Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China. Department of Neurosurgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China Department of Urology, Shanghai Tenth People's Hospital Tongji University Shanghai China Department of Biological Chemistry, School of Medicine University of California Irvine California USA Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. lwxsbs@medmail.com.cn Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin China; Pharmaceutical Sciences Toho University Funabashi Chiba Japan Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China. State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Hunan University; Changsha 410082; P. R. China Northwest A & F University, Shaanxi Branch of National Stem Cell Engineering & Technology Center, Yangling 712100, China. State Key Laboratory of Ophthalmology, Guangdong Provincial Key Lab of Ophthalmology Visual Science, Zhongshan Ophthalmic Center, Sun Yat‐sen University Guangzhou China; Retinal Neurobiology Section National Eye Institute Bethesda Maryland School of Medicine Tsinghua University Beijing China Department of Chemistry and Supercomputing Institute, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455-0431 and Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322 Department of UrologyThe Second Hospital of Hebei Medical UniversityShijiazhuangChina First Hospital Affiliated to Jilin University, Jilin, China. Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), San 31 Hyoja-dong, Pohang 790-784, Republic of Korea, and General Motors R&D Center, Warren, Michigan 48090 Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617,China Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China; University of the Chinese Academy of Sciences Beijing China Beijing Key Lab of Nano-Photonics and Ultrafine Optoelectronic Systems, Beijing Institute of Technology, Beijing 100081, P. R. China Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, China Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Hand and Foot Surgery & Plastic Surgery, Affiliated Shunde Hospital of Guangzhou Medical University, Shunde District, Foshan, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China Wuhan University School of Electrical and Engineering, , Bayi Road, Wuhan, China Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, China 1The Hormel Institute, University of Minnesota, Austin, Minnesota. Hepatobiliary Surgery Burnham Institute, Cancer Research Center and Infectious and Inflammatory Disease Center, 10901 North Torrey Pines Road, La Jolla, CA 92037;The Scripps Research Institute, Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037; National Center for Biodefense, George Mason University, 10900 University Boulevard, PWII Building, Room 160, MSN 1A8, Manassas, VA 20110; and Advanced Biosystems, 5904 Richmond Highway, Suite 300, Alexandria, VA 22303 Department of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland) Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea. The ART Center, Northwest Women’s and Children’s Hospital, Xi’an, China Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China. Nursing Department of Affiliated Hospital of Jining Medical University, 89# Guhuai Road, Rencheng District, Jining 272000, Shandong Province, China Key Laboratory of Tumor Cellular & Molecular Pathology, College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan 421001, P.R. China State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science and Laboratory for Advanced Materials, and ‡Department of Chemistry, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19716, United States; Key Laboratory of Surficial Geochemistry, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, People’s Republic of China Department of Family and Preventative Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA Department of Radiology Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital Shanghai China Tianjin Key Laboratory of Film Electronic and Communication Devices School of Electrical and Electronic Engineering, Tianjin University of Technology, Tianjin 300384, China Laboratory of Nuclear and Radiation Damage, The General Hospital of The Second Artillery Corps of Chinese PLA, Beijing 100088, P.R. China Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe 657-8501, Japan Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China From the Adult Congenital Heart Programme (K.D., G.-P.D., C.S.B., S.V.B.-N., W.L., A.U., S.B., M.A.G.), Department of Cardiology, Royal Brompton Hospital, London, United Kingdom; Department of Clinical Cardiology (K.D., D.O.O., G.-P.D., T.V.S., R.W., M.F.P., P.A.P.-W.), National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom; and International Centre for Circulatory Health (T.V.S., D.P.F.), St. Mary’s Hospital & Imperial College, London, United Kingdom. Fiberhome Telecommunication Technologies Co. Ltd. Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Civil and Environmental Engineering, Shenyang Jianzhu University, Shenyang, People’s Republic of China State Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, China; Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, Zhengzhou, China Key Laboratory of Oral Diseases Research of Anhui Province, Stomatologic Hospital and College, Anhui Medical University , Hefei, Anhui 230032, China Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China Food Research Program, Agriculture and Agri-Food Canada, Guelph, N1G 5C9 Ontario Canada, and Department of Food Science, University of Guelph, Guelph, N1G 2W1 Ontario, Canada School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, Shenyang, China 3Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania. Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou University Department of NeurosurgeryJinling Hospital, Nanjing University School of Medicine, Nanjing Jiangsu Province, People’s Republic of China 881 Madison Avenue, Room 561, Memphis, TN 38163, United States Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan. Department of Liver Surgery and Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, P.R. China Department of Otolaryngology/Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China Department of Gastroenterological Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China Semiconductor and Dimensional Metrology Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20878, United States 2Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. School of Materials Science and Engineering, Fujian University of Technology, 3 Xueyuan Road, Fuzhou 350108, PR China; Institute of Materials Surface Technology, Fujian University of Technology, 3 Xueyuan Road, Fuzhou 350108, PR China College of Life Sciences Sichuan Normal Univ Chengdu 610101 P.R. China Blood Transfusion Department, the Second Affiliated Hospital of Kunming Medical University, Kunming, P.R. China. aState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China bPopulation Health Research Institute, McMaster University-Hamilton Health Sciences, Hamilton, Ontario, Canada cLaboratory of Human Genetics dBeijing Hypertension League Institute eCenter of Disease Control & Prevention, Beijing, China. College of Food Science and Technology, Nanjing Agricultural University Nanjing PR China China Industrial Control Systems Cyber Emergency Response Team, Beijing, China Department of Laboratory Medicine Maternity and Child Healthcare Hospital of Nanshan District Shenzhen China College of Educational Science and Technology, Northwest Minzu University, Lanzhou, P.R. People’s Republic of China The First Hospital of Jilin University, 130021 Changchun, China. Department of Radiology, NorthShore University HealthSystem, Evanston, IL, USA 1Shanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. Oncology Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1-5EH, United Kingdom Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute and Affiliated Xiamen Eye Center, Xiamen University, Xiamen 361005, China. Department of Physics, Emory University , Atlanta, Georgia, USA Universität Hamburg Institut für Angewandte Physik, , Jungiusstr. 11, 20355 Hamburg, Germany Chongqing Engineering Research Center for Rapeseed College of Agronomy and Biotechnology Southwest University Chongqing China Department of Cardiology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, China The First Hospital of Jilin University; Changchun China School of Chinese Materia Medica Guangdong Pharmaceutical University Guangzhou China Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) E. L. Ginzton Laboratory Department of Electrical Engineering Stanford University Stanford CA 94305 USA Health Management Center, The People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning City, P.R. China Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. xidili@public.guangzhou.gd.cn Department of Neurology, Qilu Hospital of Shandong University, Jian, China. Department of Radiology, First People’s Hospital of Yunnan Province, Kunming, Yunnan, China; Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China Department of Cardiology, Second Affiliated Hospital, The Air Force Medical University, 1 Xinsi Road, Xi’an 710038, China Key Laboratory of Tropical–Subtropical Fishery Resource Application, Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, PR China and Shanghai Key Laboratory of Molecular Catalysis and Laboratory of Advanced Materials, Department of Chemistry Fudan University Shanghai 200433 P. R. China Department of Physiology School of Basic Medical Sciences Zhengzhou University Zhengzhou China School of Physics; Huazhong University of Science and Technology; Wuhan; China Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Medical College of Xiamen University Xiamen 361102 China Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, P. R. China Department of Molecular and Cellular Biology (I.U.A., W.E.B., M.N., W.L., N.L.W.), Houston Texas 77030; Duncan Cancer Center (W.L.), Houston Texas 77030 Old Dominion Univ. (United States) College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, P.R. China Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China College of Energy, Soochow Institute for Energy and Materials Innovations, and Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou 215123, China Life Science College Jilin University Changchun Peoples Republic of China State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China National Institute for Communicable Disease Control and Prevention (ICDC), Chinese Center for Disease Control and Prevention (China CDC), Changping, Beijing, China.; State Key Laboratory of Infectious Disease Prevention and Control, Beijing, China.; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Beijing, China. School of Environmental Science and Engineering, Hebei University of Science and Technology, 70 Yuhua East Road, Shijiazhuang 050018, China National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China. Depatment of Endocrinology the Affiliated Hospital of Xuzhou Medical College Xuzhou China Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, R.P. China; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, R.P. China Drug Discovery Center, Key Laboratory of Chemical Genomics, Shenzhen Graduate School, Peking University, Shenzhen, China Department of Cardiology, the Affiliated Hospital of Yangzhou University, Hanjiang District, Yangzhou College of Life Science, Sichuan Normal University, Chengdu 610101, China Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Wake Forest Institute for Regenerative Medicine Wake Forest School of Medicine Winston‐Salem NC USA Department of laboratory medicine, Beijing Jishuitan Hospital, Beijing 100035, China. Royal Brompton Hospital London UK Department of Pharmaceutical Sciences and Drug Discovery Center College of Pharmacy University of Tennessee Health Science Center Memphis Tennessee USA College of Chemical and Biological Engineering Guilin University of Technology Guangxi Key Laboratory of Electrochemical Guilin 541004 P. R. China School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062, People’s Republic of China Departments of Chemistry, Radiology, and Psychology, Michigan State University, East Lansing, Michigan 48824, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy, and College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, Tennessee 38163 Department of Haematology and OncologyThe First Hospital, Jilin University, Changchun, China Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China. Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States Institute of Harbin Hematology & Oncology, The First Hospital of Harbin, Harbin, Heilongjiang, China Department of Infectious Diseases, Yongchuan Hospital Chongqing Medical University Yongchuan Chongqing 402160 China Department of Neurosurgery The First Hospital of Changsha Changsha Hunan China Department of Orthopaedics, Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China. sx_wjw@sina.com Department of Clinical Pharmacology Xiangya Hospital Central South University Changsha Hunan China; Hunan Key Laboratory of Pharmacogenetics Institute of Clinical Pharmacology Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan China Huazhong University of Science and Technology Department of Neurosurgery Jinling Hospital, School of Medicine, Nanjing University Nanjing China Department of Materials Science & Engineering, University of Delaware, Newark, Delaware19716, United States; Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico87545, United States Department of Orthopaedic Surgery, The First Hospital of Harbin Harbin, Heilongjiang, China. Department of Mechanical and Biomedical Engineering City University of Hong Kong 83 Tat Chee Ave Kowloon Hong Kong SAR 999077 China Department of Cardiology Xinhua Hospital affiliated with the School of Medicine Shanghai JiaoTong University Shanghai China International Joint Cancer Institute, the Second Military Medical University, Shanghai, China; State Key Laboratory of Antibody Medicine and Targeting Therapy and Shanghai Key Laboratory of Cell Engineering, Shanghai, China; PLA General Hospital Cancer Center, PLA Graduate School of Medicine, Beijing, China College of Life Science, Shannxi Normal University, Xi'an 710062, China. Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland). State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China School of Food Science and Pharmaceutical Engineering Nanjing Normal University Nanjing P. R. China Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang China Chengdu Institute of Biology Chinese Academy of Sciences PO Box 416 Chengdu 610041 People's Republic of China; Graduate School of the Chinese Academy of Sciences Beijing 100039 China School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China Shihezi University School of Medicine Xinjiang China Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Marine Engineering College, Dalian Maritime University, Dalian 116026, China; State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China College of Biomedical Engineering & Instrument Science Zhejiang University Hangzhou China Department of Dermatology, Huashan Hospital Fudan University , Shanghai , China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao, 266042, China Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China Department of Biological Chemistry, School of Medicine University of California Irvine CA USA Institute of Physics, Czech Academy of Sciences, Na Slovance 2, 18200 Prague, Czech Republic Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome ResearchHuazhong University of Science and TechnologyWuhan Hubei China Department of Medicine, Division of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, California 90033;; The Ben May Institute for Cancer Research, and State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, and College of Life Sciences Nankai University Tianjin 300071 P. R. China School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA; Department of Emergency Medicine, North Shore University Hospital, The Hofstra North Shore-LIJ School of Medicine at the Hofstra University, Manhasset, NY 11030, USA State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry School of Pharmacy China Pharmaceutical University Nanjing 210009 P. R. China Adult Congenital Heart Centre, National Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London, UK; National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, UK Eye Institute of Xiamen University, Xiamen, China College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, People’s Republic of China Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China Key Laboratory for Biobased Materials and Energy of Ministry of Education, Guangdong Provincial Engineering Technology Research Center for Optical Agriculture, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, P. R. China Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Department of Biological Chemistry, Division of Computational Biomedicine, School of Medicine, University of California, Irvine, CA State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; International School of Materials Science and Engineering; Wuhan University of Technology; Wuhan 430070; China Shanghai Key Laboratory of Molecular Imaging; Shanghai University of Medicine and Health Sciences; Shanghai 201318; China Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York Institute of Chemical Biology and Drug Discovery Stony Brook University Stony Brook NY 11794 USA Department of Medical Ultrasonics, Ultrasomics Artificial Intelligence X-Lab, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts At the time of the study Anthony Fabio, Erin K. Sauber-Schatz, and Kamil E. Barbour were with the Center for Injury Research and Control, Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA. Wei Li was with Bayer HealthCare Pharmaceuticals, Montville, NJ. Department of Microbiology and Immunology, Indiana University School of Medicine Indianapolis IN USA Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. Triticeae Research Institute Sichuan Agricultural University Chengdu China School of Law, Zhejiang University of Finance and Economics, Hangzhou, Zhejiang 310018, China Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, FL 33136 Shanghai University Department of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507, Zhengmin Road, Yangpu District, Shanghai 200433, P.R. China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences 865 Changning Road Shanghai 200050 P. R. China; Department of Physics and State Key Laboratory of Surface Physics Fudan University Shanghai 200433 China School of Mathematics and Physics North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China; Institute of Clusters and Low Dimensional Nanomaterials North China Electric Power University Beinong Road 2, Changping Beijing 102206 P. R. China; Hebei Key Laboratory of Physics and Energy Technology North China Electric Power University Baoding 071000 China Department of Anesthesiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, PR China. liweigzcn@21cn.com 2 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA 02115, USA; 3 Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA Research and Medical Service, WJB Dorn Veterans Medical Center, and the Department of Medicine, University of South Carolina School of Medicine (J.H., S.Y., W.L., D.W., M.L.N., Y.M., T.L.), Columbia, South Carolina 29208 State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, People’s Republic of China College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University; Tianjin 300071; China Institute of Chemical Biology and Drug Discovery, Stony Brook University Department of Outpatient, Yantai Penglai People's Hospital Yantai 265600, Shandong, China. Department of NeurosurgeryNanjing Drum Tower HospitalSchool of MedicineNanjing University Nanjing China General Motors Global Research and Development, Chemical Sciences and Materials Systems Lab, 30500 Mound Road, Warren, MI 48090, USA. Department of Orthopaedic Surgery, West Chian Hospital, Sichuan University, Chendu 610041, China. Department of Hematology in Caner Center, The First Hospital of Jilin University, Changchun, Jilin, China Department of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei China; Cardiovascular Research Institute of Wuhan University Wuhan Hubei China; Hubei Key Laboratory of Cardiology Wuhan Hubei China *Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195; and Eye Institute of Xiamen University Xiamen, Fujian, China 2Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China 3Xiamen University Affiliated Xiamen Eye Center, Xiamen, Fujian, China Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. University of Texas at Dallas, Department of Molecular and Cell Biology, Richardson, Texas 75080 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University; Department of Oral Radiology, School and Hospital of Stomatology, Wuhan University, Wuhan, China. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China liwei@mrbc-nccd.com. Key Laboratory of Modern Agricultural Equipment and Technology Jiangsu University, Ministry of Education Zhenjiang China Department of Laboratory, Children's Hospital of Zhejiang University School of Medicine Boston Biomedical, Inc., Cambridge, MA 02139 Faculty of Materials Metallurgy and Chemistry, Jiangxi University of Science and Technology, Ganzhou 341000, Jiangxi Province, P. R. China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and Thermodynamics Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Chemistry Capital Normal University Institute of High Energy Physics Chinese Academy of Sciences China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Key Laboratory of Low-Grade Energy Utilization Technologies and Systems (Chongqing University), Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China State Key Laboratory of Fine Chemicals, College of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China From the Department of Pathology (Metcalf, Huang, Kanaan, Li, Zhang), Department of Mechanical Engineering The University of Hong Kong Hong Kong 999077 Hong Kong Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China Department of Pathology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China Shanghai Public Health Clinical Center, Fudan University, Shanghai, China Department of Pediatrics Department of Materials Science and Engineering, Delft University of Technology, Delft, Netherlands College of Chemistry and Molecular Sciences; Key Laboratory of Biomedical Polymers of Ministry of Education; The Institute for Advanced Studies; Hubei Province Key Laboratory of Allergy and Immunology; Wuhan University National Institute for Communicable Disease Control and Prevention, Beijing, People's Republic of China.; State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China.; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. Department of Gynecology, Liaocheng People's Hospital, Liaocheng, Shandong Province, People's Republic of China. School of Water and Environment, Chang’an University, Xi’an, People’s Republic of China 0000000119573309 grid.9227.e Center for Natural Products Research, Chengdu Institute of Biology Chinese Academy of Sciences 610041 Chengdu People’s Republic of China; 0000 0004 1797 8419 grid.410726.6 University of Chinese Academy of Sciences 100049 Beijing People’s Republic of China Faculty of Pharmaceutical Science, Toho University College of Agronomy, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. School of Electrical Science and Engineering, Collaborative Innovation Centre of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Advanced Photonic and Electrical Materials, Nanjing University, Nanjing 210000, China Department of Pharmaceutical Engineering; Shenyang University of Chemical Technology; Shenyang; China Department of Radiology, Tangdu Hospital Fourth Military Medical University Xi'an China State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of China Department of Physics and Stephenson Institute for Renewable Energy, The University of Liverpool, Chadwick Building, Peach Street, Liverpool, L69 7ZF, U.K. Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, 301 Yanzhong Road, Jing’an District, Shanghai 200040, PR China; Urologic Cancer Institute, Tongji University School of Medicine, Shanghai, 301 Yanzhong Road, Jing’an District, Shanghai 200040, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, China Department of Urology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, Florida, USA Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 Department of Epidemiology and Health Statistics, School of Public Health Southeast University Nanjing China Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1-5 Beichenxi Road, Beijing 100101, P.R. China Department of Pharmacy, Southwest Hospital Third Military Medical University Chongqing China Instrumental Analysis Center Key Laboratory of Medical Genetics, Wenzhou Medical University School of Laboratory Medicine & Life Science, Wenzhou, 325035, China. Department of Vascular Intervention, Jingmen No.2 People's Hospital, Jingmen, China. Laboratory of Advanced Materials Department of Chemistry Fudan University Shanghai 200433 P. R. China Department of Psychiatry, UT Southwestern, Dallas, TX, USA. Institute of Theoretical and Computational Chemistry; Key Laboratory of Mesoscopic Chemistry of MOE; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023 Department of Radiology and Tianjin Key Laboratory of Functional Imaging; Tianjin Medical University General Hospital; Tianjin 300052 China Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou, China Medical Research & Biometrics Center, National Center for Cardiovascular Diseases, Beijing, China Yunnan Academy of Biodiversity Southwest Forestry University Kunming 650224 China Eye Institute of Xiamen University, Xiamen, China; Xiang’an Hospital of Xiamen University, Xiamen, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China College of Chemistry & Environmental Science, Hebei University, 180 Wusi Donglu, Baoding 071002, People’s Republic of China; Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, 180 Wusi Donglu, Baoding 071002, People’s Republic of China Department of Otolaryngology, Ezhou Central Hospital, Hubei, Ezhou Province, P.R. China Department of Emergency Medicine, North Shore University Hospital–New York University School of Medicine, Manhasset, New York. Department of Pathology Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Cancer Center Nanjing Medical University Nanjing China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai 200433 China Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; Department of Psychology & Neuroscience, Boston College, Chestnut Hill, MA, USA liacz@bc.edu, https://www.weiiir.xyz/ joshua.hartshorne@hey.com, https://l3atbc.org. Department of PET Center & Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States ArthroLab, Inc. Montreal Quebec Canada Environmental Soil Chemistry Research Group, Delaware Environmental Institute, University of Delaware, Newark, Delaware 19716, United States; Key Laboratory of Surficial Geochemistry, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210046, People’s Republic of China State Key Laboratory of Organic−Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China The PLA Rocket Force Characteristic Medical Center, Beijing, China School of Pharmacy, Fujian Medical University Fuzhou, China. Korean Medicine (KM) Application Center Korea Institute of Oriental Medicine Daegu South Korea Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China Department of Sport Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China Department of Urology, The First Affiliated Hospital of Xiamen University, Siming District, Xiamen, Fujian 361003, China College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, Jiangsu, China Liaoning Key Laboratory of Lignocellulose Chemistry and Biomaterials, Dalian Polytechnic University, Dalian 116034, China Department of Vascular Surgery and Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China The First Hospital of Hunan University of Chinese Medicine Department of Oncology, , Changsha 410007, Hunan Province, P.R. China From the Department of Nerve Medical Center (W.L., H.T.), The First Hospital of Changsha; and the Department of Neurology (D.H.), The Third Xiangya Hospital, Central South University, Changsha, China. College of Food Sciecne and Technology; Nanjing Agricultural University; Nanjing; P. R. China 1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of China Department of Stomatology, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China. liwei19860106@163.com Department of Women Health, Tianjin Women and Children's Health Center Tianjin China Guangzhou Institute For Drug Control, Guangzhou, China Ageing Bone Research Program, Sydney Medical School, The University of Sydney, Penrith, New South Wales, Australia Department of Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, China. Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania 15213; Tsinghua University MD Program, School of Medicine, Tsinghua University, Haidian District, Beijing 100084, PR China Beijing Key Laboratory for Genetics of Birth Defects MOE Key Laboratory of Major Diseases in Children Center for Medical Genetics Beijing Pediatric Research Institute Capital Medical University National Center for Children's Health Beijing China From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (X.G., Y.R., O.B., M.Y.L., P.J.A., E.C.B., K.A.M., Y.Q.), Department of Genetics (K.-Y.K., I.-H.P.), Department of Surgery (W.L., G.T.), Biostatistics Resource, Keck Laboratory (W.Z.), Department of Pharmacology (K.A.M.), Department of Pathology (Y.Q.), and Vascular Biology and Therapeutics Program (Y.Q.), Yale University School of Medicine, New Haven, CT; Department of Biostatistics,... State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. leways@ioz.ac.cn. University of Chinese Academy of Sciences, Beijing, 100049, China. leways@ioz.ac.cn. Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, USA. State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University 163 Xianlin Avenue Nanjing 210023 China From Master of Physician Assistant Studies, School of Health and Rehabilitation Sciences (W.L.), and School of Informatics and Computing (E.H.), Indiana University Purdue University Indianapolis; and Center for Neuroimaging (S.L.R., A.J.S.), Department of Radiology and Imaging Sciences, and Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN. Key Laboratory of Systems Bioengineering MOE and ‡Key Laboratory for Green Chemical Technology MOE, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, People’s Republic of China Department of Computer Science, University of California, Riverside, California. College of Agronomy, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan 611130, P. R. China Department of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230000 , China Engineering Research Center of Polymer Green Recycling of Ministry of Education; Fujian Normal University; Fuzhou 350007; China; College of Environmental Science and Engineering Department of ICU, Wuhan Third Hospital, Wuhan University, Wuhan, China Department of Publication; Shenyang Agricultural University; Shenyang; China Pennington Biomedical Research Center, Baton Rouge, Louisiana Fujian University of Technology Department of Orthopedics, Shangdong Provincial Hospital, Jinan, Shangdong, P. R. China 250021. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Tianjin 300193, China Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China College of Chemistry and Molecular Sciences, Wuhan University, 430072, China, and Department of Chemistry and Chemical Biology and Department of Pharmaceutical Chemistry, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States Intensive Care Unit, Affiliated Children’s Hospital of Capital Institute of Pediatrics, Beijing, China (mainland) State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Division of Anatomic Pathology, Department of Pathology, Beaumont Health System, Royal Oak, MI, USA. Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, China Zunyi Medical College, Zunyi, China Department of Pathophysiology, Wannan Medical College, Wuhu, China College of Chinese Medicinal Materials, Jilin Agricultural University, P. R. China; National & Local Joint Engineering Research, Center for Ginseng Breeding and Development, Changchun 130118, P. R. China College of Life and Environmental Sciences Huangshan University Huangshan 245041 China Department of Gynecology, Ningbo Yinzhou People’s Hospital, Ningbo, People’s Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan 430070; PR China Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada Inner Mongolia Mandela Sand Industry Development Co., Ltd., Left Banner of Alashan Inner Mongolia PR China School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical Garden and Center for Plant Ecology Core Botanical Gardens Chinese Academy of Sciences Wuhan 430074 China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration Wuhan Botanical Garden Chinese Academy of Sciences Wuhan 430074 China Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA; Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China; The First Affiliated Hospital Clinical Laboratory, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China. 3Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California. Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, College of Chemistry and Materials, Fudan University , Shanghai 200433 , China Shanghai Ninth People’s Hospital Affiliated to Shanghai JiaoTong University Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection Southwest University Chongqing China; Academy of Agricultural Sciences Southwest University Chongqing China 1Department of Pathology, University of Iowa, College of Medicine, Iowa City, Iowa. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China Division of Biostatistics, Dan L Duncan Comprehensive Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Departments of Surgery, Yale University and; Connecticut Veterans Affairs Health Care System, New Haven, Connecticut 06520-8062; and; Tianjin Medical University Cancer Hospital, Tianjin 300060, China Hangzhou Jichenjunchuang Medical Laboratory, Co., Ltd. China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China Second Hospital of Hebei Medical University Shijiazhuang China Lehigh University 1 Department of Physics, , Bethlehem, Pennsylvania 18015, USA Department of Biosystems Engineering, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Canada; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300072, China; Tianjin Engineering Research Center of Functional Fine Chemicals, Tianjin, 300072, China College of Life and Environmental Sciences, Minzu University of China, Beijing, China School of Chemistry and Physics and Centre for Materials Science, Queensland University of Technology, Brisbane, Queensland 4000, Australia Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China Authors' Affiliations: 1The Hormel Institute, University of Minnesota, Austin, Minnesota; 2Cancer Research Institute, Xiangya School of Medicine; 3Xiangya Hospital, Central South University, Changsha, Hunan; 4The First Affiliated Hospital; and 5Physiology and Pathophysiology, Basic Medical School, Zhengzhou University, Zhengzhou, Henan, China; Authors' Affiliations: 1The Hormel Institute, University of Minnesota, Austin, Minnesota; 2Cancer Research Institute, Xiangya School of Medicine; 3Xiangya Hospital, Central South University, Changsha, Hunan; 4The First Affiliated Hospital; and 5Physiology and Pathophysiology, Basic Medical School, Zhengzhou University, Zhengzhou, Henan, China Cancer Hospital of the University of Chinese Academy of Sciences Zhejiang Cancer Hospital; Institute of Cancer and Basic Medicine (IBMC) Chinese Academy of Sciences Hangzhou 310022 China Qingdao Women and Children’s Hospital, Qingdao, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; School of Mathematics and Statistics, Xidian University, Xi'an 710071, China From the Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and Angiology, University Hospital of Münster, Münster, Germany (G.-P.D., A.K., S.O., H.B.); Adult Congenital Heart Disease Program, Royal Brompton Hospital, London, UK (G.-P.D., A.K., E.L., R.A.-G., R.I., A.U., K.D., L.S., W.L., M.A.G.); and Imperial College of Science and Medicine, London, UK (G.-P.D., K.D., M.A.G.). Department of Physics and The William Mong Institute of Nano Science and Technology, the Hong Kong University of Science and Technology, Hong Kong, China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China Department of Obstetrics & Gynecology Virginia Commonwealth University Richmond Virginia Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China. School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China School of Preclinical Medicine, Chengdu University, Chengdu 610106, China Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China. liwei19860607@163.com. Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China Southern Research Institute, Birmingham, AL 35205, USA Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;; Hainan Engineering Research Center of Agarwood, Haikou 570228, China Chemical Sciences and Materials Systems Lab, General Motors Global Research and Development, Warren, Michigan 48090, United States Ernst-Berl-Institute for Chemical Engineering and Macromolecular Science; Technical University Darmstadt; 64287 Darmstadt, Germany College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, People’s Republic of China Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, China 2Department of Biological Chemistry, University of California, Irvine, Irvine, California.; 3Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas. Department of Medical Discipline Construction, West China hospital of Sichuan University, Chengdu 610041, P. R. China. Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China Department of Cardiology, Qinghai Provincial People's Hospital School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China Department of Otolaryngology, Ezhou Central Hospital, Ezhou City, Hubei Province, P.R. China, 436000. School of Chemistry and Chemical Engineering, Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing 210093, P. R. China Department of Earth System Science, Ministry of Education Key Laboratory for Earth System Modeling, Institute for Global Change Studies, Tsinghua University, Beijing 100084, China Department of Acupuncture and Moxibustion, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China Faculty of Life Science, Hubei University, Wuhan, China Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China Department of Chemistry and Biochemistry, College of Computer, Mathematical and Natural Sciences, University of Maryland, College Park, Maryland, 20472 Pathology II, Linköping University, Linköping 581 85, Sweden; Department of Pathology, The Gade Institute, University of Bergen, Bergen N-5021, Norway; and Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel Department of Materials Science and Metallurgy, The University of Cambridge, Cambridge CB2 3QZ, United Kingdom Liaoning Province Professional and Technical Innovation Center for Fine Chemical Engineering of Aromatics Downstream School of Petrochemical Engineering Shenyang University of Technology Liaoyang 111003 Liaoning P. R. China Authors' Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee CSIRO Manufacturing Flagship, Private Bag 10, Clayton, Victoria 3168, Australia State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China liwei@icdc.cn. Key Laboratory for Food Science and Engineering, Harbin University of Commerce, Harbin 150076, People’s Republic of China Department of Obstetrics and Gynecology Renmin Hospital of Wuhan University Wuhan Hubei China Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China The Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, U.K. Toho University Faculty of Pharmaceutical Science Graduate School of Pharmaceutical Science: Toho Daigaku Yakugakubu Daigakuin Yakugaku Kenkyuka Faculty of Pharmaceutical Sciences Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan Tokyo Metropolitan JAPAN Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry Education College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050024 P.R. China Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH; School of Aerospace Mechanical and Mechatronic Engineering The University of Sydney NSW 2006 Australia School of Medicine, Tsinghua University, Beijing, China grid.265050.4 0000000092909879 Faculty of Pharmaceutical Sciences Toho University 274-8510 2-2-1 Miyama Funabashi Chiba Japan School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan Key Laboratory of Materials‐Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region Engineering Research Center of Materials‐Oriented Chemical Engineering of Xinjiang Bingtuan Shihezi University Shihezi 832003 P. R. China Huazhong University of Science and Technology State Key Laboratory of Digital Manufacturing Equipment and Technology, , Wuhan 430074, China Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing 210009, P. R. China; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, P. R. China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences P.O. Box 2871 Beijing 100085 China Department of Genetics, Medical College of Soochow University, Suzhou, China Hubei Key Laboratory of Advanced Technology for Automotive Components, Wuhan University of Technology, Wuhan 430070, China; Hubei Collaborative Innovation Center for Automotive Components Technology, Wuhan University of Technology, Wuhan 430070, China; Hubei Research Center for New Energy & Intelligent Connected Vehicle, Wuhan University of Technology, Wuhan 430070, China; SAIC-GM-Wuling Automobile Co., Ltd., Liuzhou 545007, China School of Electronic Science and Engineering Nanjing University Nanjing 210093 China Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guizhou 550002, China. National Institute of Biological Sciences, Beijing 102206, China; and Guangdong Wen's Group Academy, Guangdong Wen's Foodstuffs Group Co., Ltd., Xinxing, Guangdong, China South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Science, Zhanjiang, Guangdong 524091, China. Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China State Key Laboratory of Bio-organic and Natural Products Chemistry; Shanghai Institute of Organic Chemistry; Chinese Academy of Sciences; Shanghai 200032; China School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China The Key Lab of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. School of Mathematics, Physics and Optoelectronic Engineering, and Collaborative Innovation Center for Optoelectronic Technology, Hubei University of Automotive Technology, Shiyan 442002, P. R. China; Shiyan Industrial Technology Research Institute of Chinese Academy of Engineering, Shiyan 442002, P. R. China Brain Imaging and Analysis Center School of Medicine, Duke University Durham North Carolina Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi’an, 710038, China Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China Applied Materials Physics, Department of Materials Science and Engineering, KTH Royal Institute of Technology, SE-10044 Stockholm, Sweden; Laboratory of Advanced Materials Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative Materials iChEM and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Department of Medical Ultrasonics, Ultrasomics Artificial Intelligence X‐Lab Institute of Diagnostic and Interventional Ultrasound Guangzhou China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University Beijing China; Monogenic Disease Research Center for Neurological Disorders Beijing Tiantan Hospital, Capital Medical University Beijing China for the OPTIMAL Study Group 1Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; 2Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule (Ministry of Education), Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China Department of Clinical and Diagnostic Sciences, Physician Assistant Studies School of Health Professions, University of Alabama at Birmingham Birmingham AL USA From the Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, Calif, and the Division of Cardiology (D.G.H.), Department of Medicine, Emory University School of Medicine, Atlanta, Ga. Department of Geriatric Neurology, Nanjing Medical University Affiliated to Nanjing Brain Hospital, Nanjing, Jiangsu 210029, P.R. China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Chengdu 610054 China Department of Echocardiography Royal Brompton Hospital London United Kingdom Tianjin Key Laboratory of Film Electronic & Communicate Devices, School of Integrated Circuit Science and Engineering, Tianjin University of Technology, Tianjin 300384, China Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Department of Otorhinolaryngology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, U.S.A. wli@uthsc.edu. Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen, Fujian, China; Xiamen University Affiliated Xiamen Eye Center, Xiamen, Fujian, China; The Affiliated Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China Department of Head and Neck Surgery, Hubei Cancer Hospital, Wuhan Hubei, 430079, P.R.China.liwei8211@163.com. Institute of Theoretical Chemistry, State Key Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun 130023, People’s Republic of China College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, China.; Engineering Research Center of Polymer Green Recycling of Ministry of Education, Fujian Normal University, Fuzhou, China.; Fujian Key Laboratory of Pollution Control and Resource Reuse, Fujian Normal University, Fuzhou, China. Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Weigang 1, Xuanwu District, Nanjing 210095, People’s Republic of China Shenyang Pharmaceutical University; Shenyang 110016; People's Republic of China Department of Pediatric Cardiology Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou, 510623 Guangdong China Department of General Surgery, Changhai Hospital Affiliated to The Second Military Medical University Shanghai, China. Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Genetics and Birth Defects Control Center, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China; Henan Key Laboratory of Pediatric Inherited & Metabolic Diseases, Henan Children's Hospital Zhengzhou Hospital of Beijing Children's Hospital Zhengzhou China Department of Orthopaedic Surgery, Harbin Medical University, The First Hospital of Harbin City, Harbin, Heilongjiang, China; Department of Orthopaedic Surgery, Harbin Medical University, The First Hospital of Harbin City, Harbin, Heilongjiang, China Department of Neurology Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong Province China Marine Engineering College, Dalian Maritime University, No. 1 Linghai Road, Dalian 116000, China The Key Laboratory of Urinary Tract Tumors and Calculi, Department of Urology Surgery, The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, China; National & Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection; Nantong University; Nantong 226019; P. R. China; College of Textiles and Clothing Department of Endocrine and Metabolism Center of Translational Medicine, Medical School of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China Project Office Tianjin Women’s and Children’s Health Center Tianjin China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong; Zhejiang Institute of Research and Innovation, The University of Hong Kong, 311300 Hangzhou, Zhejiang, China State Key Laboratory of Virology; Wuhan Institute of Virology; Chinese Academy of Sciences; Wuhan 430071; People's Republic of China Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, China Department of Dermatovenereology, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, PR China Department of Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, People's Republic of China Department of Echocardiography Shanghai Institute of Cardiovascular Disease, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai China International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510623, China; Retinal Neurobiology Section, National Eye Institute, US National Institutes of Health, Bethesda, MD 20892, USA Department of Nephrology Renmin Hospital of Wuhan University Wuhan China; Nephrology and Urology Research Institute of Wuhan University Wuhan Hubei China Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, China Institute of Pharmaceutical Biotechnology and The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China Laboratory of Fruit Cell and Molecular Breeding College of Agronomy and Bio‐Tech China Agricultural University Beijing 100193 China Department of Infectious Diseases, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China School of Material and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China Department of Urology, Shanghai Tenth People's Hospital, School of Medicine Tongji University Shanghai China University of Missouri, Columbia, MO, USA Chongqing Municipal Center for Disease Control and Prevention , Chongqing , China School of Chemistry and Chemical Engineering, Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Nanjing University, Nanjing, 210093, P. R. China d College of Food Science and Technology, Huazhong Agricultural University , No. 1 Shizishan Road, Wuhan , 430070 , P. R. China School of Pharmacy Guangdong Medical University Dongguan 523808 Guangdong China Materials Science & Engineering Program and Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States; Microelectronics Research Centre, The University of Texas at Austin, Austin, Texas 78758, United States NewsBreak Seattle State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China BioDuro Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China Power China Huadong Engineering Corporation (HDEC), Hangzhou 311122, China Email: liwei@cma.org.cn. Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB3 0FS, U.K. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA. College of Life Sciences, Sichuan Normal University, Chengdu 610061, People's Republic of China Lanzhou Institute of Biological Products, Lanzhou 730046, Gansu, China. Department of Rehabilitation; Beijing Rehabilitation Hospital; Capital Medical University; Beijing; China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Fraunhofer Institute for Biomedical Engineering, Department of Biohybrid Systems, Germany Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technologies and Pharmacokinetics, Tianjin, China State Key Laboratory of Tribology, Tsinghua University,Division of Intelligent and Biomechanical System,Department of Mechanical Engineering,Beijing,China,100084 Center of Interventional Oncology and Liver Diseases, Beijing You'an Hospital, Capital Medical UniversityBeijing 100069, China. Key Laboratory of Laboratory Medicine Ministry of Education Zhejiang Provincial Key Laboratory of Medical Genetics School of Laboratory Medicine Wenzhou Medical College Wenzhou, China Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT), School of Materials Science and Engineering, Peking University, Beijing 100871, China NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom Division of Advanced Nanomaterials Suzhou Institute of Nano‐tech and Nano‐bionics Chinese Academy of Sciences (CAS) Suzhou 215123 China Divisions of Experimental PathologyLinköping UniversityLinköpingSweden Department of Orthopedics, North Sichuan Medical College, Nanchong, Sichuan, China Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University, Changchun, Jilin, China College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing 210023, China; College of Integrated Circuit Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China Key Laboratory of Low-grade Energy Utilization Technologies and Systems (Chongqing University), Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China Yantai Branch of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Yantai, China; Department of Pharmaceutics, School of Pharmacy North China University of Science and Technology Tangshan China Key Laboratory of Gas and Fire Control for Coal Mines, Ministry of Education, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China 1Yan’an Hospital Affiliated to Kunming Medical University, 245 Renmin East Road, Kunming City, Yunnan Province, China Laboratory for Genetics of Birth Defects Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China; Shunyi Women and Children's Hospital of Beijing Children's Hospital Beijing China Department of Chemistry Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative Materials iChEM and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200433 P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Reproductive Medical Center Renmin Hospital of Wuhan University Wuhan China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China Jiangsu Institute of Schistosomiasis, Wuxi 214064, China. Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China; BGI-Shenzhen, Shenzhen, China Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials, Fudan University, Shanghai 200433, China. Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China Key Lab. of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China. leewei2000@hotmail.com College of Chemistry and Chemical Engineering Wuhan Textile University Wuhan 430200 P. R. China Department of Medical Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai 200433, P.R. China Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States; Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States Research Institute of Neuromuscular and Neurodegenerative Disease, Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan 250012 , China State Key Laboratory of Bio-fibers and Eco-textiles, Institute of Biochemical Engineering, The Affiliated Qingdao Central Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States Department of Clinical and Diagnostic Sciences University of Alabama at Birmingham Birmingham Alabama USA Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, China Department of Hematology, Cancer Center The First Hospital of Jilin University Changchun P.R. China Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University Department of Dermatology and the Norris Comprehensive Cancer Centre, University of Southern California Keck Medical Centre, Los Angeles, CA, USA School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China School of Materials Science and Engineering; Southwest Petroleum University; Chengdu 610500; China Department of General Surgery, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, P.R. China School of Pharmacy; Nanjing University of Chinese medicine; Nanjing Jiangsu China Yangzhou University Yangzhou China Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China. Department of Cardiology Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071 Wuhan, People’s Republic of China; Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. China Laboratory of Advanced Materials Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers School of Chemistry and Materials Fudan University Shanghai 200433 P. R. China Key Laboratory for Green Chemical Technology MOE and ‡Key Laboratory of Systems Bioengineering MOE, Tianjin University, Tianjin 300072, People’s Republic of China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China Department of Chemistry and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, China Center for Applied Statistics and School of Statistics, Renmin University of China , Beijing , P.R. China Department of Endocrinology The Affiliated Hospital of Xuzhou Medical University Xuzhou China Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, Michigan 48824, United States State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, People’s Republic of China Cancer Center, The First Affiliated Hospital, Jilin University, Changchun, China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, P. R. China; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, Guangdong 525100, P. R. China Shenyang Pharmaceutical University, Shenyang 110016, China Department of Pathophysiology, Wannan Medical College, Wuhu, China. State Key Laboratory of Pharmaceutical Biotechnology, Department of Physiology, and Institute for Brain Sciences, School of Life Sciences Nanjing University Nanjing China Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurobiology and Department of Anesthesiology of First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain–Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China; Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China; Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China College of Horticulture, Institute for Horticultural Plants, China Agricultural University, Beijing 100193, China Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Department of Systems, Populations and Leadership School of Nursing University of Michigan Ann Arbor MI USA Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; China Crop Tillage and Cultivation Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 China State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210046, China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada, and Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom Department of Echocardiography Shanghai Institute of Cardiovascular Disease Zhongshan Hospital Fudan University Shanghai China College of Chemistry and Chemical Engineering, Hunan University, Changsha, China College of Civil Engineering and Architecture, Dalian University, Liaoning, Dalian 116622, People's Republic of China Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200032, China; Department of Systems Biology for Medicine, Shanghai Pudong Hospital, Fudan University, Shanghai 200433, China Department of Medical Imaging, Jiangsu Vocational College of Medicine, W Jianjun Rd, Yancheng, 224000, China Department of Chemistry, Department of Medicinal Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States General Motors Global Research and Development; Chemical Sciences and Materials Systems Lab; Warren; USA Korea Institute of Oriental Medicine (KIOM), Korean Medicine (KM) Application Center, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea College of Life Sciences, Hubei University, Wuhan 430062, China W. Li, C. D. Whaley, D. L. Mueller, Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Department of Clinical Laboratory Qilu Hospital, Shandong University Wen Hua Xi Lu 107# 250012 Jinan Shandong China Texas A&M University, USA Division of Biostatistics, Dan L Duncan Comprehensive Cancer Center, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. Institute of Advanced Synthesis, Institute of Chemical Biology and Functional Molecules, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, 730030, China Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an P. R. China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, P. R. China Center for Applied Statistics and School of Statistics Renmin University of China Beijing China Key laboratory of Bio‐based Material Science and Technology of Ministry of Education Northeast Forestry University Hexing Road 26 Harbin 150040 P. R. China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, People’s Republic of China; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom Reproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Chemistry, Columbia University, New York, New York 10027, E. I. duPont de Nemours and Co., Central Research Department, Experimental Station, Wilmington, Delaware 19880, and University of Urbino, Institute of Chemical Sciences, Piazza Risorgimento, 6, 61029 Urbino, Italy Soochow University Laboratory of Cancer Molecular Genetics; Medical College of Soochow University; Suzhou; China Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China; National Joint Engineering Center of High-performance Wear-resistant Metallic Materials, Guangzhou 510632, China Department of Neurobiology, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294; and School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China Key Laboratory of Surficial Geochemistry, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, People’s Republic of China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, P. R. China Eye Institute and Affiliated Xiamen Eye Center, Xiamen University, Xiamen, Fujian, China Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China Cancer Center, The First Hospital of Jilin University, Changchun 130021, Jilin, China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. China Department of Thoracic Surgery, General Hospital of Chengdu Command, Chengdu 610083, China. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Pharmacy Southwest Hospital Army Medical University Chongqing P. R. China Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA College of Electronic and Electrical Engineering, Henan Normal University, Xinxiang 453600, China; Henan Key Laboratory of Optoelectronic Sensing Integrated Application, Henan Normal University, Xinxiang 453600, China; Henan Engineering Laboratory of Additive Intelligent Manufacturing, Henan Normal University, Xinxiang 453600, China Department of Hematology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061 From the Royal Brompton and Harefield NHS Trust, Imperial College School of Medicine, London, United Kingdom. Department of Medical Imaging, Affiliated Hospital Of Yangzhou University, Yangzhou, China Fujian Provincial Key Laboratory of Ophthalmology and Visual Science School of Medicine Xiamen University Xiamen 361102 China Stem Cell and Cancer Center, First Affiliated Hospital, Jilin University, Changchun, Jilin 130021, China Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China Department of Physiology, Wayne State University, Detroit, MI, USA Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences & Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, 130 Dong-An Road, Shanghai, 200032, China; Key Laboratory of Ministry of Education, Department of Molecular Biology, Fudan University, 130 Dong-An Road, Shanghai 200032, China Beijing Harmony Health Medical Diagnostics Co. Ltd Beijing China Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; School of Basic Medical Sciences, Chengdu University, Chengdu 610106, China Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China Department of Chemistry, Capital Normal University, Beijing 100048, China Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, HeBei University, 180 Wusi Donglu, Baoding 071002, P. R. China Huizhou Health Sciences Polytechnic, Huizhou, China Department of Oncology, The First Peoples Hospital of Tianmen City Tianmen 431700, Hubei Province, China. Leukemia Diagnosis and Treatment Center, Institute of Hematology and Blood Disease Hospital, CAMS and PUMC, Tianjin 300020, China. Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University Faculty of Materials and Manufacturing, Beijing Key Lab of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing 100124, P. R. China College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning, China School of Pharmacy, Naval Medical University, Shanghai 200433, China Department of Surgery, The Second Hospital, University of South China, Hengyang, Hunan, China (mainland) State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Shanghai Center for Bioinformation Research Technology, Shanghai Academy of Science and Technology, Shanghai, China Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163 Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China School of Chemistry and Chemical Engineering; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; Tianjin University of Technology; Tianjin; China Xinjiang Center for Animal Disease Control and Prevention Urumqi China Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 Urology Department The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China School of Chemical Science and Technology, Yunnan University, Kunming, China Hunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha, Hunan, China. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA. KLGHEI of Environment and Energy Chemistry; MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry; School of Chemistry and Chemical Engineering; Sun Yat-Sen University; Guangzhou 510275 Department of Joint and Musculoskeletal Tumor, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518000, P.R. China Zhejiang Research Institute of Chemical Industry, No. 387, Tianmushan Road, Hangzhou, 310023, P. R. China Department of Respiration II, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, Wuxi, Jiangsu 214122, China 1Cancer Center, The First Hospital of Jilin University, Changchun, China. Department of Ultrasound, Jingzhou Central Hospital Jingzhou, China. Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory of Carbon‐Based Functional Materials and Devices Soochow University Suzhou 215123 P. R. China Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China Department of Pathophysiology, School of Basic Medicine, Wannan Medical College, Wuhu, Anhui, China 5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China. College of Chemistry and Chemical Engineering, Tianjin University of Technology, Xiqing, Tianjin, 300384, P. R. China Department of Medical Oncology, Jiangsu Province Hospital, Nanjing, Jiangsu, China Brain Imaging & Analyses Center Duke University Durham North Carolina Hunan University Department of Medical Oncology, Fudan University, Shanghai, People's Republic of China Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P. R. China Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Cancer Center, First Hospital of Jilin University, Changchun, Jilin, China 1 National Engineering Laboratory for Industrial Wastewater Treatment, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China Department of Neurology, Huashan Hospital of Fudan University, Shanghai, People’s Republic of China; Huashan Worldwide Medical Center, Huashan Hospital of Fudan University, Shanghai, People’s Republic of China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100730 , China Medical Research and Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Email: liwei@mrbc-nccd.com. Department of Chemistry, National University of Singapore, Singapore 117543, Singapore The ART Center, Northwest Women’s and Children’s Hospital, Xi’an, PR China Department of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing China; Department of Neurosurgery Liaocheng People's Hospital Liaocheng China Faculty of Pathology, Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, China. carfield1981@126.com Colorado State University, USA Clinical Medical College of Yangzhou University Yangzhou City China International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China; State Key Laboratory of Antibody Medicine & Targeting Therapy & Shanghai Key Laboratory of Cell Engineering, 399 Libing Road, Shanghai 201203, PR China Computational Virology Group, Center for Bacteria and Viruses Resources and Bioinformation, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Chemical Engineering; Texas Tech University; Lubbock; USA Rheumatology and Immunology Department, Zhengzhou University First Affiliated Hospital, Zhengzhou, China Medical Oncology Department of Zhongshan Hospital affiliated to Fudan University Shanghai China Department of Pathophysiology, Wannan Medical College, Wuhu, P.R. China. Department of Endocrinology, Institute of Diabetes, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School Shenzhen 518055 China Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.; 3Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California. Institute of Solar Energy Materials and Devices, College of Materials Science and Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, China, 610064 Department of Gastric and Colorectal Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China Institute of Computational Quantum Chemistry; College of Chemistry and Material Science; Hebei Normal University; Shijiazhuang 050024, P. R. China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China Center for Medical Genetics, Beijing Childrens Hospital Capital Medical University, Beijing Pediatric Research Institute MOE Key Laboratory of Major Diseases in Children Beijing China; Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing China BGI Education Center University of Chinese Academy of Sciences Shenzhen China; He's university Shenyang China Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland) Research Imaging Institute University of Texas Health Science Center at San Antonio San Antonio TX USA; Department of Ophthalmology University of Texas Health Science Center at San Antonio San Antonio TX USA School of Life Sciences, Institute of Life Sciences and Green Development Hebei University Baoding 071000 China Laboratory of Mesoscopic Chemistry, Department of Chemistry, Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing, 210093, People’s Republic of China Department of Oral Pathology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, National Health Commission Key Laboratory of Digital Technology of Stomatology Peking University Beijing China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory of Carbon‐Based Functional Materials & Devices Soochow University Suzhou 215123 China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China; College of Advanced Interdisciplinary Studies, National University of Defense Technology 1 , Changsha 410073, China The Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu China Master of Physician Assistant Studies School of Health & Rehabilitation Sciences, Indiana University‐Purdue University Indianapolis Indianapolis IN USA Department of Nuclear Medicine, General Hospital of Tianjin Medical University, Tianjin, China The School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of Education Ministry of China, Huazhong University of Science and Technology, Wuhan 430074, China Respiratory Medicine Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Department of Medical Imaging , Affiliated Hospital of Yangzhou University , Yangzhou , China . Department of Vascular Surgery, Peking University People’s Hospital, Beijing, China (W.L., T.Z.). State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing China Garze Tibetan Autonomous Prefecture Center for Disease Control and Prevention, Echinococciasis Prevention and research Base of National Institute of Parasitic Disease of Chinese Center for Disease Control and Prevention, Kangding 626000, Sichuan, China. Department of Microbiology and Immunology, Indiana University, Indianapolis, Indiana Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, PR China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, PR China University of Florida, Gainesville, USA Research Imaging Institute, University of Texas Health Science Center at San Antonio; Texas USA; Department of Ophthalmology; University of Texas Health Science Center at San Antonio; Texas USA National Engineering Laboratory for Industrial Wastewater Treatment, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China; Department of Environmental Engineering, College of Environmental and Resource Science, Zhejiang University, Hangzhou 310027, China; Department of Microbiology, Cornell University, Ithaca, New York 14850, United States; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China Department of Infectious Diseases Second Xiangya Hospital, Central South University Changsha People’s Republic of China College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, Guangdong Research Center for Engineering Technology in Bioactive Natural Products, Guangzhou 510642, China Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; College of Veterinary Medicine, Northeast Agricultural University, Harbin, People's Republic of China. Cancer Center First Hospital of Jilin University Changchun China Department of Hematology, The First Bethune Hospital of Jilin University, Changchun, China Department of Radiology, Jiangmen Central Hospital, Jiangmen 529030. qflcom@126.com Department of Oncology First Affiliated Hospital of Nanjing Medical University Nanjing China State Key Laboratory of Surface Physics Department of Physics Fudan University Shanghai 200433 China Institute of Functional Nano & Soft Materials Laboratory (FUNSOM) and Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Soochow University Suzhou 215123 PR China Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut Department of Orthopedics, Chengdu Military General Hospital, Chengdu, Sichuan, China Department of Medical Ultrasonics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Microelectronics Research Center and Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, Texas 78758, United States 1Department of Microbiology and Immunology Department of Cardiology, The Royal Brompton and Harefield NHS Foundation Trust, Imperial College London, Sydney Street, London, UK The Key Laboratory of Fuel Cell Technology of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510641 P. R. China Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics (H.H., W.L., S.L., J.J., M.S., R.N., A.d.l.C), Columbus, Ohio 43210 Cyrus Tang Hematology Center, Soochow University, Suzhou, China. Department of Adult Congenital Heart Disease, National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK Department of Neurology, Daping Hospital, Third Military Medical University Chongqing 400042, China. Department of Endocrinology Key Laboratory of Endocrinology of National Health Commission Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and School of Chemistry and Materials Fudan University Shanghai 200433 P. R. China Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China Department of Obstetrics and Gynecology Renmin Hospital of Wuhan University Wuhan China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, The Floating Hospital for Children, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, Massachusetts; School of Nutrition Science and Policy, Medford, Massachusetts; and the Center for Gastroenterology Research on Absorptive and Secretory Processes, Boston, Massachusetts Department of Medical Oncology Jiangsu Province Hospital Nanjing China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, China Department of Orthopedics, The First Hospital of Harbin, Harbin, Heilongjiang, CN Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China Key Laboratory of Genetic Engineering and Medicine, Key Laboratory of Viral Biology, Jinan University, Guangzhou, Guangdong 510632, P.R. China Leukemia Diagnosis & Treatment Center, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union of Medical College, Tianjin, China Department of Cardiology School of Medicine Xinhua Hospital Shanghai Jiaotong University Shanghai China Department of Respiratory Disease The First Affiliated Hospital of Bengbu Medical College Bengbu China Department of Orthopaedics, People's Hospital of Kaizhou, Chongqing 405400, China. Engineering Research Center for Extreme Ultraviolet Science and Technology and Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, CO 80523, USA. Department of Anesthesiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China. liweigzcn@263.net Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian, China Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China International Joint Cancer Institute, Second Military Medical University, Shanghai, China; School of Pharmacy, Liaocheng University, Liaocheng, Shandong Provence, China Department of Chemistry; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Laboratory of Advanced Materials; Fudan University; Shanghai 200433 P. R. China Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd; Shanghai 200137; P. R. China; University of Shanghai for Science and Technology; School of Medical Instrument & Food Engineering School of Materials Science and Engineering; Fujian University of Technology; Fuzhou 350108; P. R. China; Fujian Provincial Key Laboratory of Advanced Materials Processing and Application *Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294; and Key Laboratory of Systems Bioengineering MOE Key Laboratory for Green Chemical Technology MOE Tianjin University Tianjin People's Republic of China Department of Urology, Second Hospital of Tianjin Medical University, Tianjin 300000, China From the Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, OH; and Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH. The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Lihu Street 1800, Wuxi, 214122, China Cell Biology Program, Sloan–Kettering Institute for Cancer Research, Memorial Sloan–Kettering Cancer Center 1275 York Avenue, Box 216 New York New York 10065 USA Department of Rehabilitation Medicine The Third Hospital of Hebei Medical University Shijiazhuang 050050 China Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China Department of Electronic and Electrical Engineering, The University of Sheffield, Sheffield S3 7HQ, U.K. Department of Cardiology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, P. R. China College of Agronomy, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan, 611130, P.R. China Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Stem Cell and Cancer Center, The First Bethune Hospital, Jilin University, Changchun, Jilin 130061, China Faculty of Engineering, China University of Geosciences, Wuhan 430074, China Department of Liver Surgery & Liver Transplantation Centre West China Hospital Sichuan University Chengdu Sichuan 610041 China Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut; Matthias Schleiden Institute of Genetics Bioinformatics and Molecular Botany Friedrich Schiller University Jena Jena 07743 Germany Shandong Forest Germplasm Resources Center, Ji’nan, Shandong Province, People’s Republic of China Heibei Medical University, China From Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, National Heart and Lung Institute, Biomedical Research Unit, Royal Brompton Hospital, Imperial College, London, UK (A.K., W.L., G.-P.D., K.D., S.T.W., M.A.G.); Department of Cardiology, Rigshospitalet, Copenhagen, Denmark (C.S.H., A.S.J., L.S.); Beijing Anzhen Hospital, Capital Medical University, China (G.H.); Boston Adult Congenital Heart and Pulmonary Hypertension Service, Boston Children’s Hospital and Brigham and... Royal Brompton Hospital (S.G., S.E., J.K., A.G., V.S., I.V., G.C.S., M.B., C.M., T.W., S.Y.H., K.P.M., D.F.S., K.D., A.U., L.S., W.L., D.J.P., M.A.G., S.V.B.-N.), London, United Kingdom.; National Heart & Lung Institute, Imperial College (S.G., S.E., J.K., A.G., T.W., S.Y.H., K.D., W.L., D.J.P., M.A.G., S.V.B.-N.), London, United Kingdom. Department of Endocrinology and Metabolism West China Hospital Sichuan University Chengdu 610041 China; Center for Diabetes and Metabolism Research West China Hospital Sichuan University Chengdu 610041 China State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, P. R. China Chengdu University of Information Technology, College of Resources and Environment, Chengdu 610225, China. liumangtu5@yahoo.com.cn Department of Vascular Surgery The Second Hospital of Yinzhou District Ningbo Zhejiang Province People's Republic of China Sichuan Normal University, Sichuan 610101, PR China Pharmacy Department of Suqian People’s Hospital, Drum Tower Hospital Group of Nanjing, Suqian 223800, China Department of Endocrinology the Affiliated Hospital of Xuzhou Medical University Xuzhou China Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 State Key Laboratory of Reproductive Biology; Institute of Zoology; Chinese Academy of Sciences; Beijing China Department of Orthopaedics Shenzhen Pingle Orthopedic Hospital & Shenzhen Pingshan Traditional Chinese Medicine Hospital Shenzhen China Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan Shandong 250000 China Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China; Wuhan Botanical Garden, University of Chinese Academy of Sciences, Beijing, China Shanghai Jiao Tong University Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Center of Oncology, The First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China. Department of Neurology Research Institute of Neuromuscular and Neurodegenerative Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan China The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China. Brain Imaging and Analysis Center Duke University Durham North Carolina USA Faculty of Pharmaceutical Sciences, Toho UniversityChibaJapan State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China State Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Endocrinology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou 075132, China Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China Xinjiang Center for Disease Control and Prevention, Urumqi 830002, Xinjiang, P.R. China. Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029 China National Engineering Research Center for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi’an, P. R. China Brain Imaging and Analysis Center Duke University Medical Center Durham NC USA Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Nuclear Medicine and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China Fujian Obstetrics and Gynecology Hospital, Fuzhou, China; Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China Qingdao Hiser Medical Group, Qingdao, China Department of Chemistry and Departments of Radiology and Psychology, Michigan State University, East Lansing, Michigan 48824, United States, and Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, Tennessee 38163, United States Department of Pharmaceutical Sciences, College of Pharmacy, and Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163 From the Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom (P.M., K.D., E.L., I.G., A.K., G.D., L.S., S.J.W., P.S.M., M.A.G., W.L.); Pasteur University Hospital, Nice, France (P.M.); and National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom (K.D., G.D., M.A.G.). National Engineering Laboratory for Forest Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China Department of Obstetrics & Gynecology Virginia Commonwealth University Richmond Virginia 23298 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; Division of Infectious Diseases, College of Medicine, University of Florida, Gainesville, Florida 32610 Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. grid.13402.34 000000041759700X College of Biosystems Engineering and Food Science, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing Zhejiang University 310058 Hangzhou Zhejiang China Department of Otorhinolaryngology Head and Neck Surgery The First Hospital of China Medical University Shenyang 110001 Liaoning China Breast Cancer Center Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing 400044 P. R. China College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, PR China Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science Institutes of Brain Science Fudan University Shanghai China College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109, People’s Republic of China Academy of Agriculture and Forestry, Qinghai University, Xining 810016, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China; Key Laboratory of Integrated Management of Agricultural Pest in Qinghai Province, Xining 810016, China Jichenjunchuang Clinical Laboratory Hangzhou China New York Medical College, Department of Physiology, Valhalla, New York 10595 Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address: wli@cpu.edu.cn. Department of Emergency Medicine The First People's Hospital of Pinghu Pinghu Zhejiang China Department of General Surgery; The First Hospital of Jilin University; Changchun 130021; China College of Energy, Soochow Institute for Energy and Materials Innovations, and Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou 215123 China First Hospital Jilin University Changchun China School of Education, Huazhong University of Science & Technology, Wuhan, China Department of Rheumatology, Shanghai East Hospital Tongji University School of Medicine Shanghai China Center for Translational Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan 475001, China College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People’s Republic of China Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. Hubei Key Laboratory of Wetland Evolution & Ecological Restoration Wuhan Botanical Garden Chinese Academy of Sciences Wuhan Hubei China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology the Chinese Academy of Science Beijing China Inflammation and Immunology, Pfizer Worldwide R&D, 610 Main Street, Cambridge, Massachusetts 02139, United States Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; College of Chinese Medicine Materials Jilin Agricultural University Chang Chun China Department of Urology, the People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China School of Public Health, Chongqing Medical University, Chongqing 400016, China School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan; Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region; Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan; Shihezi University; Shihezi 832003 Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences Deparment of Infectious Diseases, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China. Department of Geriatrics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China Institute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China Korean Medicine (KM) Application Center Korea Institute of Oriental Medicine Daegu 41062 South Korea State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Medical Research and Biometrics Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. Laboratory of Molecular Neuroscience, Institute of Biotechnology, University of Helsinki, Helsinki, Finland; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Jing Hengyi School of Education Hangzhou Normal University Hangzhou China; Institute of Psychological Sciences Hangzhou Normal University Hangzhou China National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China 1Departments of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.; 2Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Department of Geosciences and Center for Environmental Molecular Science, Stony Brook University, Stony Brook, New York 11794-2100, United States Laboratory for Bio-Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics (IHEP), Chinese Academy of Science, Beijing 100049, and National Center for Nanoscience and Technology of China (NCNST), Beijing 100190, PR China Department of Chemistry Boston College Chestnut Hill MA 02467 USA Science and Technology of Advanced Functional Composite Laboratory; Aerospace Research Institute of Materials and Technology; Beijing 100076; China Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China. njlw1218@163.com The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital Chengdu, Chengdu, Sichuan, China Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, 1530, 3rd Avenue, South Birmingham, AL 35294, USA Department of Otolaryngology, Eye, Ear, Nose, & Throat Hospital, Fudan University, Shanghai, China Department of Microbiology, and Department of Pharmacy of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China Department of Anesthesiology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China; Department of Anesthesiology, Shandong Provincial Hospital Shandong University Jinan China Division of Pharmacology; Division of Experimental Pathology, Department of Clinical and Experimental Medicine; Division of Vascular Surgery, Department of Medicine and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, SE-58185 Sweden; and Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida 32816 Department of Otolaryngology, the First People's Hospital of Anqing,Anqing 246003. Department of Chemistry, University of Utah, 315 South 1400 East, RM 2020, Salt Lake City, Utah 84112, and LCBG, Center for Cancer Research, NCI, National Institutes of Health, Besthesda, Maryland 20892 Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States Department of Oncology, First Affiliated Hospital, Nanjing Medical University, Nanjing, People's Republic of China Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 Department of Neurology, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, China School of Forensic Medicine Xinxiang Medical University Xinxiang China Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, P. R. China College of Life Science and Technology, Gansu Agricultural University, Lanzhou 730070, China The First Affiliated Hospital of Yangtze University, Department of Stomatology, The First People’s Hospital of Jingzhou, Jingzhou 434000, China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Department of Physics, Nanchang University, Nanchang 330031, P. R. China; Department of Science, Nanchang Institute of Technology, Nanchang 330099, P. R. China College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China; 1Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Pharmaceutical Sciences College of Pharmacy University of Tennessee Health Science Center Memphis Tennessee 38163 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People’s Republic of China Center for Molecular Design and Biomimetics, The Biodesign Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, United States State Key Laboratory of Silicate Materials for Architectures School of Materials Science and Engineering Wuhan University of Technology Luoshi Road 122 Wuhan 430070 P. R. China Guangdong Provincial Engineering Technology Research Center for Optical Agriculture, College of Materials and Energy and ‡College of Horticulture, South China Agricultural University, Guangzhou 510642, China Shukui Qin, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing; Jin Li, Fudan University Cancer Hospital and Tongji University East Hospital; Liwei Wang, Shanghai First People’s Hospital; Jun Zhang, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Tianshu Liu, Affiliated Zhongshan Hospital of Fudan University, Shanghai; Jianming Xu, 307 Hospital of the Chinese People’s Liberation Army; Guanghai Dai, Chinese People’s Liberation Army General Hospital; Junyuan Wang and Jiongjie... Division of Biostatistics, The Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, and Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China. International Exchange College, Hebei University of Engineering, Handan 056002, Hebei, China Institute of Clusters and Low Dimensional Nanomaterials; School of Mathematics and Physics; North China Electric Power University; Beijing; People's Republic of China Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, China Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, U.S.A. wli@uthsc.edu. Department of Endocrinology Armed Police Corps Hospital of Guangdong Province Guangzhou China Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Department of Endocrinology, Suzhou Hospital of Anhui Medical University, Suzhou, Anhui, China National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou, China Medical Research & Biometrics Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Fuwai Hospital, Xicheng District, Beijing, China. Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, PR.China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, PR.China Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Room 327B, 847 Monroe Avenue, Memphis, Tennessee 38163, United States Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033 Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China. tliwei@jnu.edu.cn Department of Otoalryngology–Head Neck Surgery Third Xiangya Hospital Central South University Changsha Hunan China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers and School of Chemistry and Materials Fudan University Shanghai 200433 P. R. China Institute of Functional Nano and Soft Materials (FUNSOM); Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Soochow University; Suzhou 215123; China Department of Hematology Qilu Hospital, Shandong University, Ji'nan 250012, China School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China. Department of Neurobiology; Civitan International Research Center, The University of Alabama at Birmingham; Birmingham Alabama National Engineering Laboratory for Forest Tree Breeding Key Laboratory for Genetics and Breeding of Forest Trees and Ornamental Plants of Ministry of Education College of biological sciences and technology Beijing Forestry University Beijing 100083 China Beijing Key Lab of Microstructure and Property of Advanced Materials, College of Materials Science & Engineering, Beijing University of Technology , Beijing 100124 , China School of Mechanical Science and Engineering, Northeast Petroleum University, Daqing 163318, China Nursing Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, China Function Test Center (W.L.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. College of Chinese Material Medicine Jilin Agricultural University Changchun P. R. China Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China Department of Obstetrics and Gynecology, National Key Laboratory of Gynecology First Affiliated Hospital, Heilongjiang University of Chinese Medicine Harbin 150040 China Department of Ultrasound Institute of Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat-sen University Guangzhou China Department of Otorhinolaryngology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. From the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Ohio. Reproductive and Genetic Hospital The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School Boston MA USA Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 P. R. China Guangxi Zhuang Autonomous Region Institute of Dermatology Prevention and Control, Nanning, Guangxi 530007, China The Department of Dermatology and the USC-Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China. Department of Clinical Research, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China; Department of Quality Management, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; China College of Agronomy and Biotechnology, China Agricultural University, Beijing 100094, China. liw21@163.com Pharmacy Department; Plastic Surgery Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Shijingshan District; Beijing 100144 China Department of Neurosurgery Jinling Hospital; Nanjing University School of Medicine; Nanjing Jiangsu Province People's Republic of China Department of Materials Science and Engineering ARC Centre of Excellence in Future Low‐Energy Electronics Technologies (FLEET) Monash University Clayton Victoria 3800 Australia Section of Molecular and Cellular Biology, University of California, Davis, CA 95616 1 *Thomas E. Starzl Transplantation Institute and Departments of Surgery and Department of Chemistry and Chemical Biology and Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020 Department of Intensive Care Unit, Foshan First People's Hospital, Sun Yat-Sen University, Foshan, China. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Diabetes, and Metabolism, Department of Molecular Medicine and Therapeutics, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, Ohio, USA.; Division of Endocrinology, Diabetes, and Metabolism, Department of Molecular Medicine and Therapeutics, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, Ohio, USA. College of Chemistry and Molecular Sciences; Key Laboratory of Biomedical Polymers of Ministry of Education; Wuhan University; Wuhan 430072; P. R. China School of Pharmacy North China University of Science and Technology Tangshan China Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China.; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China.; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, China. Engineering Research Center of High Performance Polymer and Molding Technology, Ministry of Education, and ‡College of Automation and Electronic Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Research Center of Food Fermentation Engineering and Technology, Hubei University of Technology Wuhan China Shaanxi Key Laboratory of Photoelectric Functional Materials and Devices, Engineering Research Center of Light Stabilizers for Polymer Materials, Universities of Shaanxi Province, School of Materials and Chemical Engineering, Xi'an Technological University 1 , Xi’an 710021, China Cancer Center, The First Hospital of Jilin University, Changchun 130021, China Department of Biological Chemistry, School of Medicine, University of California, Irvine Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials, Nanjing University Pediatric Surgery Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China. Division of Advanced Nanomaterials, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences (CAS), Suzhou 215123, China; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China Department of Surgery San Diego VA Health Care System and University of California San Diego California State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China Department of Chemistry; Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development; University of Minnesota; Minneapolis; USA Hainan Provincial Key Laboratory of Carcinogenesis and Intervention; Hainan Medical College; Haikou 571199 Hainan Province People's Republic of China; Key Laboratory of Molecular Biology; Hainan Medical College; Haikou 571199 People's Republic of China Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China. Department of Pain, Peking University International Hospital, Beijing, China School of Pharmacy; Fudan University; Shanghai 201203; China Department of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109-1055 Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China. Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China State Key Laboratory of Medical Molecular Biology Department of Cell Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, China Chinese Academy of Sciences 1 Institute of Acoustics,; Graduate University of Chinese Academy of Sciences 2 , NO.21, Bei-Si-huan-Xi Road, Beijing, China liwei@mail.ioa.ac.cn,maxc@mail.ioa.ac.cn,zhuyun@mail.ioa.ac.cn,yangjun@mail.ioa.ac.cn,hch@mail.ioa.ac.cn Department of Burns and Plastic Surgery, Jinshan Hospital of Fudan University, Shanghai, China From the Department of Pharmacology, College of Medicine (A.K.P., M.K., N.S.K., A.M.E., K.U.M.) and Department of Pharmaceutical Sciences, College of Pharmacy (Z.L., W.L.), University of Tennessee, Health Science Center, Memphis; and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD (F.J.G.). State Key Laboratory of Oral Diseases; National Clinical Research Center for Oral Diseases; Dept. of Cariology and Endodontics; West China Hospital of Stomatology; Sichuan University Key Laboratory of Bio-Based Material Science and Technology of the Ministry of Education, Northeast Forestry University, Harbin 150040, China; Engineering Research Center of Advanced Wooden Materials of the Ministry of Education, Northeast Forestry University, Harbin 150040, China Department of Medical Oncology, 3201 Affiliated Hospital of Medical College of Xi’an Jiaotong University, Hanzhong, 723000, Shanxi Province, P. R. China College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, China; National Center for Respiratory Medicine, Beijing 100029, China; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China General Surgical Department, Sir Run Run Shaw Hospital affiliated with The Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China Cyrus Tang Hematology Center, Soochow University c Norris Comprehensive Cancer Center Keck School of Medicine of USC, Los Angeles, California, USA; g Department of Dermatology Keck School of Medicine of USC, Los Angeles, California, USA Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China School of Materials Science and Engineering; Beihang University; Beijing; China The Second Department of Oncology, Jinan City People’s Hospital, Jinan, 271199, Shandong Province, China School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P.R.China.liweijiani@home.swjtu.edu.cn. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; State Key Laboratory of Stomatology, Sichuan University, No.14 Sec 3 Renminnan Road, Chengdu 610041, China The First School of Clinical Medical, Lanzhou University , Lanzhou, Gansu 730000, People’s Republic of China; Tianjin Key Laboratory of Neurotrauma Repair, Characteristic Medical Center of People's Armed Police Forces , Tianjin 300162, People's Republic of China National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China School of Biomedical Engineering Capital Medical University Beijing China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Capital Medical University Beijing China Department of Infectious Diseases, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, China Department of Medical Cosmetology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China Department of Stomatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Institution of Genomics and Bioinformatics South China Agricultural University Guangzhou China; Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern China Kunming Institute of Botany Chinese Academy of Sciences Kunming China Shunyi Women and Children’s Hospital of Beijing Children’s Hospital Beijing China; Beijing Key Laboratory for Genetics of Birth Defects Beijing Pediatric Research Institute Genetics and Birth Defects Control Center National Center for Children's Health MOE Key Laboratory of Major Diseases in Children Beijing Children's Hospital Capital Medical University Beijing China Department of Pharmaceutical Sciences, the University of Tennessee Health Science Center, Memphis, Tennessee 38163 Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, P.R. China; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong, Maoming 525100, P.R. China Department of Thyroid, Breast and Hernia Surgery, Changzheng Hospital Affiliated to Navy Medical University, Shanghai, China. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China Department of Endocrinology, Key Laboratory of Endocrinology of the National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China State Key Laboratory of Theoretical and Computational Chemistry; Institute of Theoretical Chemistry; Jilin University; Changchun 130023; People’s Republic of China Experimental Center, Third Hospital of Hebei Medical University, Shijiazhuang, China; Department of Sports Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China (mainland) Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, Department of Traditional Chinese Medicine, Heilongjiang Provincial Institute for Drug Control, Harbin 150001, People's Republic of China, and Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Tsukide 3-1-100, Kumamoto City, Kumamoto 862-8502, Japan Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Jiefang Road 238, Wuchang, 430060 Wuhan, P.R. China Key Laboratory of Jiangxi Province Natural Active Pharmaceutical Ingredients, College of Chemistry and Biology Engineering, Yichun University, Yichun, PR China State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; and; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, People’s Republic of China; Department of Life Science and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China Cancer Research Institute, Southern Medical University, Guangzhou, China Institute of Unmanned System, Beihang University, Beijing 100191, China General Motors Global Research and Development Center, Warren, Michigan 48090, United States Department of Urology, The Renmin Hospital of Wuhan University, Wuhan 430060, China. Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation of Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China School of Preclinical Medicine Chengdu University Chengdu China Brain Imaging & Analysis Center Duke University Medical Center Durham North Carolina USA Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China; Eye Institute of Xiamen University, Xiamen, Fujian, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine Southeast University Nanjing China Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Cancer Center, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China Department of Vascular Surgery, People's Hospital, Peking University, Beijing 100044, China. weiliwl@hotmail.com Key Laboratory of Bio-Based Material Science & Technology (Ministry of Education), College of Material Science and Engineering, Northeast Forestry University, Harbin 150040, China Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, Guangdong, P.R. China Department of Bioengineering Rice University Houston Texas Thomas E. Starzl Transplantation Institute; Department of Surgery; University of Pittsburgh Medical Center; Pittsburgh, PA Institute of Translational Medicine; Medical College; Yangzhou University; Yangzhou; PR China State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou; P. R. China Department of Neurology The Affiliated Hospital of Qingdao University Qingdao Shandong China Crop Tillage and Cultivation Institute, Heilongjiang Academy of Agricultural Sciences, Harbin, Heilongjiang, China Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha, Hunan, 410078, PR China.; Department of Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, Hunan, 410078, PR China; Institude of National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, Hunan, 410008, PR China State Key Laboratory of Organ Failure Research, Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, Guangdong, P.R. China. Center for Translational Medicine Huaihe Hospital of Henan University Kaifeng China Department of Medical Education, University of Central Florida College of Medicine, Orlando, Florida Department of Physiology, Wayne State University School of Medicine Department of Dermatology, USC-Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA. wli@usc.edu State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 China, and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061 grid.458441.8 0000000093395152 Center for Natural Products Research Chengdu Institute of Biology, Chinese Academy of Sciences 610041 Chengdu People’s Republic of China; grid.410726.6 0000000417978419 University of Chinese Academy of Sciences 100049 Beijing People’s Republic of China School of Pharmacy; China Medical University; Shenyang 110001; China Department of Pharmaceutical Science Health Science Center University of Tennessee Memphis TN USA Department of Medical Oncology Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine Shanghai China Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Research Center for Eco-environmental Engineering, Dongguan University of Technology, Dongguan 523808, China College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods Guangdong Research Center for Engineering Technology in Bioactive Natural Products Guangzhou 510642 China CAS Key Laboratory of Mental Health Institute of Psychology Beijing China Clinical Lab, Children’s Hospital, Zhejiang University School of Medicine Lawrence Livermore National Laboratory Livermore California USA Department of Pharmacy, Suqian People’s Hospital of Nanjing Drum Tower Hospital Group, Suqian 223800, Jiangsu, China; Department of Pharmacology, Suqian Hospital Affiliated with Xuzhou Medical University, Suqian 223800, Jiangsu, China The Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, Luzhou, China Department of Natural Medicines and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Wei.Li@uth.tmc.edu Cancer Center, the First Hospital of Jilin University, Changchun, China. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States Department of Physiology, Wayne State University, Detroit, Michigan Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), China Department of Healthcare-Associated Infection Control,Eastern Medical District of Chinese PLA General Hospital. Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China. liweijianili@126.net Department of External Medicine, Longlin Branch, Baise People's Hospital, Baise 533400, Guangxi, China. Shanghai Key Laboratory of Functional Materials Chemistry, and Research Center of Analysis and Test East China University of Science and Technology Meilong Road 130 Shanghai 200237 China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai 200433 P. R. China Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology 1 , Wuhan 430070, People’s Republic of China International Joint Cancer Institute, the Second Military Medical University, Shanghai 200433, China Department of Gynecologic Oncology Center, Peking University People's Hospital, Beijing 100044, China. Erythrocyte Biology Laboratory, School of Life Sciences, Zhengzhou University, Zhengzhou, China;; Laboratory of Membrane Biology, New York Blood Center, New York, NY;; Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China; Department of Neurology, Qilu Hospital of Shandong University, Shandong, China Laboratory of Cancer Molecular Genetics; Cyrus Tang Hematology Center; Jiangsu Institute of Hematology; Department of Hematology; The First Affiliated Hospital of Soochow University; Suzhou P.R. China Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China; Pancreatic Disease Centre of Xi’an Jiaotong University , Xi'an , China Department of General Surgery, Rizhao Traditional Chinese Medicine Hospital, Rizhao, Shandong, China (mainland) Unit of Retinal Neurophysiology; National Eye Institute; National Institutes of Health; Bethesda; Maryland School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261. Laboratory for Endocrinology, Metabolism and Kidney Diseases (M.I.) RIKEN Center for Integrative Medical Sciences, Yokohama, Japan 230-0045; Department of Radiology, Tangdu Hospital, Air Force Military Medical University, Xi’an 710038, China Tianjin Center for Disease Control and Prevention, Tianjin 300011, China. NCDs Preventive Department Tianjin Centers for Disease Control and Prevention Tianjin China Jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding, College of Agriculture Yangzhou University Yangzhou 225009 China; Jiangsu Co‐Innovation Center for Modern Production Technology of Grain Crops Yangzhou University Yangzhou 225009 China Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen Ø, Denmark Chemical Sciences, Inflammation, and Drug Safety and Metabolism, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140 Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China Institute of Cardiology, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430 022, China. liwei3911@sina.com Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA International Joint Cancer Institute, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China.; National Engineering Research Center for Antibody Medicine, State Key Laboratory of Antibody Medicine & Targeting Therapy & Shanghai Key Laboratory of Cell Engineering, 399 Libing Road, Shanghai 201203, PR China Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu 610041, China Department of Dermatology and Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033 Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. liwei0828@mail.hust.edu.cn Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu Unit on Retinal Neurophysiology National Eye Institute, U.S. National Institutes of Health Bethesda Maryland 20892 Clinical Medicine Education Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Institute of Semiconductors; University of Chinese Academy of Sciences Department of Oncology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China The First Affiliated Hospital of Nanjing Medical University Nanjing China Key Laboratory of Microsystems and Microstructures Manufacturing; Ministry of Education; Harbin Institute of Technology; Harbin 150001; P. R. China Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China School of Pharmacy, Fudan University; Shanghai Center for Drug Discovery & Development Eye Institute of Xiamen University & Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, Fujian, China; Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China; Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts School of Materials and Engineering, Nanchang Hangkong University, Nanchang 330063, People's Republic of China School of Electrical Engineering and Automation, Anhui University, Hefei, China. Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461 and Department of Neurosurgery The Second Affiliated Hospital‐Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang China; The Second School of Medicine Wenzhou Medical University Wenzhou Zhejiang China National Neuroscience Institute, Singapore; Parkinson’s Foundation Center of Excellence, Singapore Department of Surgery 1 , 2 , and 3; Department of Immunobiology 1 , 2 , and 3; Department of Pathology, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510 1 , 2 , and 3 From the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH (S.O.R., W.L., R.L.S.); and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI (R.L.S.). Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; MOE Key Laboratory of Major Diseases in Children; Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA Director of Statistics Medical Research & Biometrics Center, National Center for Cardiovascular Disease, Fuwai Hospital, Beijing, China. Cancer Center of the First Hospital of Jilin University, Changchun, PR China; Second Ward, Department of Thoracic Surgery, Weifang People’s Hospital, Weifang 261041, China Department of Biology, Georgia State University, Atlanta, Georgia 30303 College of Chinese Medicinal Material, Jilin Agricultural University Center of Research Laboratory, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, 222000, China Department of Dermatology and USC-Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California. Department of Pathophysiology, Wannan Medical College, Wuhu 241002, China Department of Hepatology, Division 3, Beijing Ditan Hospital, Capital Medical University and Teaching Hospital of Peking University, 8 Jingshundong Street, Beijing 100015, China National University of Defense Technology Beijing Institute of Technology Tangshan Research Institute CHINA National Center for Children's Health Beijing China; Beijing Key Laboratory for Genetics of Birth Defects Beijing China; Beijing Pediatric Research Institute Beijing China School of Medicine, Shandong University, Jinan, Shandong, China (mainland). Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, United States Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China; Medical School, Tongji University, Shanghai 200433, China The First Unit The Third Department The First Hospital National Exhibition and Convention Center (Shanghai) Fangcang Shelter Hospital Shanghai China; Operation Room Xinqiao Hospital Army Medical University Chongqing China Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland) Retinal Neurobiology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Solidification Processing Center for Nano Energy Materials Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene (NPU) Xi'an 710072 China Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine & Tongji University School of Medicine Thoracic Cancer Institute, Shanghai, China College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, P. R. China; National & Local Joint Engineering, Research Center for Ginseng Breeding and Development, Changchun 130118, P. R. China Department of Medical Science Institute of Harbin, The First Hospital of Harbin City, Harbin Medical University, Harbin, China; Tobacco Leaf Management Department, Hunan Tobacco Company, Changsha 410007, Hunan Province, China Department of Pathophysiology, Wannan Medical College, Wuhu, Anhui, China (mainland) College of Food Science and Pharmacy, Xinjiang Agricultural University, Urumqi 830052, China Department of Public Health of Nanjing University of Chinese Medicine, 210023 Nanjing, Jiangsu Province, China Royal Brompton and Harefield NHS Foundation Trust Royal Brompton Hospital London UK Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; MOE Key Laboratory of Major Diseases in Children; Genetics and Birth Defects Control Center, Beijing Children’s Hospital Capital Medical University, National Center for Children’s Health Beijing China; Henan Key Laboratory of Pediatric Inherited & Metabolic Diseases Henan Children’s Hospital Zhengzhou Hospital of Beijing Children’s Hospital Zhengzhou China South Subtropical Crops Research Institute, CATAS, Zhanjiang, Guangdong 524091, China; Key Laboratory of Hainan Province for Postharvest Physiology and Technology of Tropical Horticultural Products, Zhanjiang, Guangdong 524091, China. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, P. R. China, Department of Pharmacology, Institute of Medical Sciences, Shanghai JiaoTong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, P. R. China, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China Department of Pharmacology and Key Laboratory of Micro-nano Electronic Devices and Smart Systems of Zhejiang Province; College of Information Science & Electronic Engineering; Zhejiang University; Hangzhou 310027; China College of Life Science, Sichuan Normal University, Chengdu, Sichuan, China. College of Landscape Architecture and Forestry, Qingdao Agricultural University, Qingdao, Shandong 266109, China Hunan University of Chinese Medicine, School of Pharmacy, Innovative Drug Research Institute, TCM and Ethnomedicine Innovation & Development International Laboratory, Changsha 410208, China College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China College of Light Industry Science and Engineering, Tianjin University of Science and Technology, Tianjin 30045, China Center for Research of Medicine & Social Development, Innovation Center for Social Risk Governance in Health, School of Public Health, Chongqing Medical University, Chongqing 400016, China. State Key Laboratory of Molecular Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan, and Tervis Co., Ltd., Kodenma-Cho 4-11, Nihonbashi, Chuo-Ku, Tokyo 103-0001, Japan State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, China Department of Dermatology and USC/Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033; VA Greater Los Angeles Healthcare System, Sepulveda, California 91343 Department of Clinical and Experimental Medicine Linköping University Linköping Sweden Department of Medical Cosmetology Shanghai Dermatology Hospital Shanghai China; L'Oreal (China) Co., Ltd. Shanghai China Department of Radiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer Tianjin China Department of Antibiotics Anhui Institute for Food and Drug Control Hefei 230051 People's Republic of China CAS Key Laboratory for Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin 130021, China Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA Computational Virology Group, Center for Bacteria and Viruses Resources and Bioinformation, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071, China; University of Chinese Academy of Sciences , Beijing 100049, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, China Translational Medicine Research Group, Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology Shanghai People's Republic of China School of Materials Science and Engineering; Tianjin University of Technology; Tianjin; China Emergency Department, The First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China Royal Brompton Hospital Imperial College London London United Kingdom School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, 210023, China The Center of New Energy Materials and Technology; School of Materials Science and Engineering; Southwest Petroleum University; Chengdu 610500; China Department of Adult Congenital Heart Disease, National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, Sydney Street, London, UK State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. leways@ioz.ac.cn. Key Lab for Medical Image Processing, Southern Medical University, Guangzhou 510515, China. 1Department of Biochemistry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka; Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany Medical Research & Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, China Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu, Republic of Korea Department of Orthopaedic Surgery No. 2 People's Hospital of Fu Yang Fuyang China Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China Department of Clinical Laboratory Liuzhou People's Hospital Liuzhou China Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin) and Key Laboratory for Green Chemical Technology MOE, Tianjin University, Tianjin 300072, People’s Republic of China State Key Laboratory of Stem Cell and Reproductive Biology; Institute of Zoology, Chinese Academy of Sciences; Beijing 100101 China; University of Chinese Academy of Sciences; Beijing 100049 China Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Laboratory of Advanced Materials, and iChEM, Fudan University, Shanghai 200433, China Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden;; Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; College of Artificial Intelligence, Nankai University , Tongyan Road, 300350, Tianjin , China Department of Neurobiology, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Department of Pharmacology, New York University Medical Center, New York, NY 10016 Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; Hunan University; Changsha; P. R. China 2Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; and Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, China Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, P.R. China Department of Neurology West China Hospital Sichuan University Chengdu China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical Chemistry College of Chemistry Jilin University Changchun Jilin 130024 China State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China ; Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine Winston-Salem, NC, USA. Department of Neurosurgery The First Affiliated Hospital Jinan University Guangzhou 510632 China Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China; Clinical Center for Gene Diagnosis and Therapy The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China; Department of Radiology The Third Xiangya Hospital of Central South University Changsha Hunan 410013 China; Cell Transplantation and Gene Therapy Institute The Third Xiangya Hospital of Central South University Changsha Hunan 410013 China Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan Department of Clinical Laboratory The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health Hangzhou PR China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China Longhua Technology Group (Luoyang) Co., Ltd., LuoYang 471026, China Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China School of Pharmacy Jining Medical University Rizhao Shandong 276826 P. R. China Faculty of Science, Kunming University of Science and Technology, Kunming 650500, P. R. China; Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming 650093, P. R. China Department of Echocardiography, Royal Brompton Hospital, London, UK Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China School of Food Science and Technology, Jiangnan University, Wuxi 214122, China Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China Graduate School, Fourth Military Medical University Xi'an, Shaanxi, China. School of Automation, Huazhong University of Science and Technology 1 , Wuhan 430074, China; Image Processing and Intelligent Control Key Laboratory of the Education Ministry of China 2 , Wuhan 430074, China Department of Stomatology, Zhengzhou People's Hospital. Zhengzhou 450052, Henan Province, China. Department of Chemistry Laboratory of Advanced Materials Fudan University Shanghai 200433 P. R. China Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute Beijing Children's Hospital, Capital Medical University Center of Rare Diseases National Center for Children's Health Beijing China; MOE Key Laboratory of Major Diseases in Children Capital Medical University Beijing China Interventional Radiology Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland) Division of Biostatistics, Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Shanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China Beijing Huilongguan Hospital Department of Pathology, Shandong Second Provincial General Hospital, Jinan, Shandong China Beijing Institute of Technology Department of Chemistry Fudan University Shanghai 200433 P. R. China Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210009, Jiangsu, China. Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Department of Laboratory Medicine, Liuzhou People’s Hospital, Liuzhou, Guangxi Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, China; Hebei Clinical Research Center for Mental Disorders and Institute of Mental Health, Shijiazhuang, China; Mental Health Center, Hebei Medical University and Hebei technical Innovation Center for Mental Health assessment and Intervention, Shijiazhuang, China Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education Xiangya Hospital Central South University Hunan China; Cancer Research Institute Xiangya School of Medicine Central South University Hunan China; Department of radiology The Third Xiangya Hospital of Central South University Hunan China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China W Li, Department of Physiology, Wayne State University, Detroit, United States Department of Orthopaedics, Beijing Jishitan Hospital, Beijin China, 100035. Neurosurgery Department, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, PR China Department of Biomedical Sciences,Marshall University Joan C. Edwards School of Medicine,Huntington,WV,USA Duke University; Triangle Universities Nuclear Laboratory Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying, P.R. China Academy of Agriculture and Forestry Sciences, Qinghai University, Xining 810016, Qinghai, China; Key Laboratory of Potato Breeding of Qinghai Province, Xining 810016, Qinghai, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, Qinghai, China; Key Laboratory of Qinghai Tibet Plateau Biotechnology, Ministry of Education, Xining 810016, Qinghai, China; Northwest Potato Engineering Research Center, Ministry of Education, Xining 810016, Qinghai, China Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, P. R. China Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, #1665 Kong Jiang Road, Shanghai 200092, China Belt and Road Joint Laboratory on Measurement and Control Technology and the Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, Hainan 571199, P. R. China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, Hainan 571199, P. R. China Orthopaedics Department Hejiang County People's Hospital Luzhou Sichuan China School of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China Center of Research Laboratory, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu 222000, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, P.R. China Department of Pulmonary and Critical Care Medicine, The Third People’s Hospital of Hubei Province, Wuhan, Hubei, China From the Department of Surgery, Yale University School of Medicine, New Haven, CT (Y.J., G.L., L.Q., Q.L., W.L., G.T.); Department of Vascular Surgery, Peking University People’s Hospital, Beijing, People’s Republic of China (Y.J., Q.L., W.L.); Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, People’s Republic of China (G.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (A.K., A.W.C., M.R.B., J.D.H.); Department of Cell Biology,... Beijing Sport University Beijing China Department of Medicine and Tianjin Women's and Children's Health Center Tianjin China College of Landscape Architecture and Forestry, Qingdao Agricultural University, Qingdao, China Engineering Research Center of Optical Instrument and System; The Ministry of Education; Shanghai Key Laboratory of Modern Optical System; University of Shanghai for Science and Technology; Shanghai Department of Dermatology and the Norris Comprehensive Cancer Centre, University of Southern California Keck Medical Centre, Los Angeles, California Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China; Songshan Lake Materials Laboratory Dongguan Guangdong 523808 China Chorain Health Technology Co., Ltd., Hefei, Anhui, China Department of Biology and Chemistry, Hebei Teachers’ College for Nationality, Chengde 067000, China School of Electric and Information Engineering, Zhongyuan University of Technology, Zhengzhou, China General office, Jiangsu Institute of Parasitic Diseases, WuXi, China Innovative Institute of Animal Healthy Breeding, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Science and Technology Zhongkai University of Agriculture and Engineering Guangzhou China 7Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas. Departments of Medicine Centre for Materials Science, School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD 4001, Australia Department of Physics, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China BTR New Energy Materials, Inc., High Tech Industrial Park, Xitian, Gongming Town, Guangming New District, Shenzhen 518106, China School of Environmental Science and Engineering Tiangong University Tianjin China Endocrinology and Reproduction Research Branch, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, and Laboratory of Biophysics, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 Emergency Department Nanjing Medical University First Affiliated Hospital and Jiangsu Province Hospital Guangzhou Street 300 Nanjing Jiangsu Province China School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212003, People’s Republic of China Institute of Advanced Wear & Corrosion Resistance and Functional Materials, Jinan University, Guangzhou 510632, China Human Cancer Genetics Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210;; Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; Priority Laboratory for Molecular Medical Bacteriology, Ministry of Health; National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping; Beijing Center for Disease Control and Prevention, Beijing; Center for Functional Genomics Research, TEDA College, Nankai University, Tianjin, People’s Republic of China |
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Total number of triples: 10000.