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contentType Journal Article
issn 0223-5234
pageRange 113724-
publicationName European Journal of Medicinal Chemistry
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bibliographicCitation Zhang D, Xu G, Zhao J, Wang Y, Wu X, He X, Li W, Zhang S, Yang S, Ma C, Jiang Y, Ding Q. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry. 2021 Dec;225():113724. doi: 10.1016/j.ejmech.2021.113724.
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date 2021-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://pubmed.ncbi.nlm.nih.gov/34391034
https://doi.org/10.1016/j.ejmech.2021.113724
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language English
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title Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812539_AID1784107_PMID34391034_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784108_PMID34391034_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784161_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818085_AID1784107_PMID34391034_VALUE46
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784158_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784112_PMID34391034_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784129_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825554_AID1784107_PMID34391034_VALUE63
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469827109_AID1784107_PMID34391034_VALUE67
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784110_PMID34391034_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784164_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784123_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784141_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818068_AID1784107_PMID34391034_VALUE45
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469817997_AID1784107_PMID34391034_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784142_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469828351_AID1784108_PMID34391034_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819827_AID1784108_PMID34391034_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784137_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818593_AID1784107_PMID34391034_VALUE50
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784117_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800538_AID1784107_PMID34391034_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784113_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784120_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801826_AID1784110_PMID34391034_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784118_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814442_AID1784107_PMID34391034_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784116_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784158_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784111_PMID34391034_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826530_AID1784107_PMID34391034_VALUE65
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826637_AID1784107_PMID34391034_VALUE66
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819827_AID1784107_PMID34391034_VALUE52
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784110_PMID34391034_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784107_PMID34391034_VALUE48
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784131_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784153_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818285_AID1784110_PMID34391034_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469828351_AID1784107_PMID34391034_VALUE69
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812082_AID1784112_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800163_AID1784107_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814259_AID1784109_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784156_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784161_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819827_AID1784115_PMID34391034_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469816706_AID1784107_PMID34391034_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801361_AID1784113_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469817738_AID1784107_PMID34391034_VALUE40
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469799358_AID1784107_PMID34391034_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469799818_AID1784113_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800185_AID1784107_PMID34391034_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784115_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784124_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784148_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826340_AID1784107_PMID34391034_VALUE64
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819827_AID1784113_PMID34391034_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469821397_AID1784107_PMID34391034_VALUE57
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784157_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784171_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469828351_AID1784115_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814259_AID1784113_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818285_AID1784107_PMID34391034_VALUE49
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826340_AID1784110_PMID34391034_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818285_AID1784111_PMID34391034_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784124_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469805061_AID1784107_PMID34391034_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784143_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784132_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784115_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784136_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469805051_AID1784107_PMID34391034_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784147_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784140_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784118_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784108_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784121_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819898_AID1784107_PMID34391034_VALUE54
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801361_AID1784109_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784167_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784155_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812082_AID1784111_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784110_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784152_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784170_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784146_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469799818_AID1784107_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784125_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469805224_AID1784107_PMID34391034_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784118_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784126_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820475_AID1784107_PMID34391034_VALUE55
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784139_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784171_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801361_AID1784111_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784119_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784115_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784157_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784114_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784109_PMID34391034_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469799818_AID1784108_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784176_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784127_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784108_PMID34391034_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469822878_AID1784107_PMID34391034_VALUE59
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784131_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823713_AID1784107_PMID34391034_VALUE61
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469817869_AID1784107_PMID34391034_VALUE43
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812082_AID1784113_PMID34391034_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820723_AID1784107_PMID34391034_VALUE56
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784107_PMID34391034_VALUE62
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784117_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784136_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784153_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784180_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784120_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784131_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812082_AID1784117_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812348_AID1784107_PMID34391034_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784148_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818285_AID1784109_PMID34391034_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784146_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819827_AID1784111_PMID34391034_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784111_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784116_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469799818_AID1784112_PMID34391034_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813032_AID1784107_PMID34391034_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784182_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784131_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784179_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469809249_AID1784107_PMID34391034_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784130_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784181_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826340_AID1784112_PMID34391034_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784167_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784150_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784119_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469815059_AID1784107_PMID34391034_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469811435_AID1784107_PMID34391034_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784126_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784116_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784123_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318406395_AID1784108_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469828351_AID1784116_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784129_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826340_AID1784111_PMID34391034_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784168_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784132_PMID34391034_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814259_AID1784111_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818276_AID1784162_PMID34391034_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469812579_AID1784107_PMID34391034_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814259_AID1784110_PMID34391034_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469823923_AID1784138_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID374328055_AID1784132_PMID34391034_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469803683_AID1784107_PMID34391034_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808613_AID1784107_PMID34391034_VALUE22
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3702
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2066
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3718
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID660
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1576
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3932
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1956
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID695
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID640

Total number of triples: 390.