author/MD5_2f7bddcb5b2a4ac4d1b5452f20ab9e18

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Predicate	Object
family-name	Hong Zhang Zhang
name	Hong Zhang
given-name	Hong
organization-name	Department of Endocrinology, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Jiangsu, China. Corresponding author: Zhang Xiangcheng, Email: zhxc0318@163.com. Department of Chemistry, Stony Brook University 1 , Stony Brook, New York 11794, USA Department of Radiology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, China Department of Nuclear Medicine, The Second Affiliated Hospital of Sun Yat-Sen University, GuangZhou, China. 3Isis Pharmaceuticals, Carlsbad, California Department of Neurology, the Second Affiliated Hospital of Xi’an Jiaotong University Department of Laboratory Medicine, the Affiliated Hospital of North Sichuan Medical College; Department of Laboratory Medicine, North Sichuan Medical College; Translational Medicine Research Center, North Sichuan Medical College, Nanchong, China Center of Breast Disease, Third Affiliated Hospital of Liaoning Medical College, Jin Zhou, Liaoning, China. Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, No.22 Qixiangtai Road, Heping District, Tianjin, 300070, China Sun Yat-sen University, Guangzhou, Guangdong, China BioCentrum‐DTU Technical University of Denmark Building 221 2800 Lyngby Denmark Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, United States School of Basic Medical Sciences, and Department of Orthopedic Surgery of The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, China.; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China School of Environment and Resources, Shanxi University, Taiyuan 030006, China. College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, PR China Department of Clinical Laboratory, Children’s Hospital of Shanghai Jiaotong University, Shanghai 200240, China 6Institutes of Biomedical Sciences, Fudan University, Shanghai, P.R. China.; 7Key Laboratory of Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, P.R. China. Central Laboratory, Shanghai Seventh People’s Hospital, Shanghai 200137, China; Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China. Clinical Laboratory School of Pharmacy and Centre for Computational Molecular Science, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia, and BIOQUANT/Cellnetworks, Universität Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany Department of Chemistry, College of Chemistry and Chemical Engineering, and State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, People's Republic of China hpxia@xmu.edu.cn; fzyang@xmu.edu.cn College of Pharmacy; Anhui University of Traditional Chinese Medicine; Hefei 230038; China Hunan Provincial Center for Disease Control and Prevention; Changsha; China Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University Changsha China Department of Cardiology, First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, China; College of Medicine, Kunming University of Science and Technology, Kunming, 650500, China Department of Out-Patient, The General Hospital of Beijing Military Region Beijing 100700, People's Republic of China. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; Engineering Research Centre of Shanghai Colleges for TCM New Drug Discovery, Shanghai, People’s Republic of China Institute of Highland Forest Science, Chinese Academy of Forestry, Kunming 650233, China EpiCept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, and Myriad Pharmaceuticals Inc., 320 Wakara Way, Salt Lake City, Utah 84108 1Department of Medical Imaging, Doctor, Department of Endocrinology, The Huai-an First Affiliated Hospital of Nanjing Medical University, Jiangsu, China Cataract Surgery, Tianjin Medical University Eye Hospital, Tianjin 300384, China. Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education, School of Physical Science and Technology and Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou 730000, China Clinical Pharmacology Institute, Nanchang University/Jiangxi Province Key Lab of Clinical Pharmacokinetics Department of Statistics and Finance, School of Management University of Science and Technology of China Anhui China Department of Health Statistics, School of Public Health, Chongqing Medical University College of Chemistry; Xiangtan University; Xiangtan 411105, China Shanxi Academy of Analytical Science 030006 Taiyuan China State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University Taian China Department of Interventional Radiology and Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States and Department of Chemistry and Biochemistry, George Mason University, Fairfax, Virginia 22030, United States School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA. Department of Infectious Diseases, Shaanxi Provincial People's Hospital and The Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710068, P.R. China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107, Yanjiang Xilu, Guangzhou, 510120, Guangdong Province, China. zhanghong8@sinamca.com. School of Architecture, Tsinghua University, Beijing, China Department of Pathology, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA; Current Address: College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China; Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing, China 1Division of Dermatology, Department of Medicine, University of California, Los Angeles, California.; 2David Geffen School of Medicine, University of California, Los Angeles, California. Department of Respiration Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China 310009 Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China Department of Ophthalmology, The Second Teaching Hospital, Tianjin Medical University, Tianjin 300211, China. eyeinst@public.tpt.tj.cn Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China. Department of Reproductive Medicine, Affiliated Jinling Hospital, Clinical School of Medical College Nanjing University Nanjing China The first Affiliated Hospital of Chengdu Medical College; Chengdu Sicuan 610500 People's Republic of China The Charles Institute of Dermatology School of Medicine and Medical Science University College Dublin 4 Dublin Ireland School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai 201203; China Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China Email: mazuimao301@yahoo.com.cn. Department of Pharmacy, Tianjin Chest Hospital, Tianjin, 300222, China Research Institute of Resource Insects Chinese Academy of Forestry Kunming China Department of Vascular Surgery, Shanxi Provincial People's Hospital, Xi'an 710068, China. Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China;; Department of Pulmonary and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing, PR China; Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, China Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China. Department of Medical Rehabilitation, Taizhou Hospital, Linhai, Zhejiang Province, China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China Department of Neurology, Jiangxi Provincial People’s Hospital, the First Affiliated to Nanchang Medical College, Nanchang 330006, Jiangxi, China Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Central Laboratory, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, P.R. China Key Laboratory for Insect-Pollinator Biology of the Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 100093, Beijing, China. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat‑sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, P.R. China State Key Laboratory of Biomacromolecules, Institute of Biophysics 2 ; and 3; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology; Chinese Academy of Sciences, Beijing 100101, China 2 ; and 3 State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081, Hunan, P.R. China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University , Guangzhou 510642, Guangdong, P.R. China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China Department of Endodontics Jilin Provincial Key Laboratory of Oral Biomedical Engineering School and Hospital of Stomatology Jilin University Changchun 130021 P. R. China Pathology Department, Peking University First Hospital, Beijing 100034, China. School of Environment, School of Marine Science and Technology (Weihai), Harbin Institute of Technology, Weihai, Shandong, 150090, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang, 150090, China Department of Day Oncology Unit Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital Beijing China Department of Cell and Developmental Biology University of Massachusetts Medical School Worcester MA 01655 USA Bio‐Medical Research Center Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou China; College of Life Sciences University of Chinese Academy of Sciences Beijing China; School of Nuclear Science and Technology University of Chinese Academy of Sciences Beijing China Southeast University 2 School of Instrument Science and Engineering, , Nanjing 210096, China Renal Division, Department of Medicine Peking University First Hospital Beijing China; Peking University Institute of Nephrology Beijing China; Key Laboratory of Renal Disease Ministry of Health of China Beijing China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) Ministry of Education of China Beijing China Department of Nuclear Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, China. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences and College of Life Sciences University of Chinese Academy of Sciences Beijing People's Republic of China Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Department of Obstetrics, Dezhou People’s Hospital, No. 1166 Dongfanghong West Road, Dezhou, Shandong Province, 253014, China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province; Shantou University, and Chemistry and Chemical Engineering Laboratory of Guangdong Province; Guangdong 515063; P. R. China Department of Obstetrics and Gynecology the Second Affiliated Hospital of Soochow University Suzhou China Hongqi Hospital, Mudanjiang Medical College, Mudanjiang, Heilongjiang, China Pediatric Surgery Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba, Japan Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China. Isis Pharmaceuticals, Department of Functional Genomics, Carlsbad, CA 92008 Department of Radiology, Institute of Modern Physics, Lanzhou, China. Departments of Physics, Department of Materials Science and Engineering, Department of Electrical and Computer Engineering, Department of Chemistry, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois, Urbana−Champaign, Illinois, Northrop Grumman Electronics Systems, Linthicum, Maryland 21090, and Department of Physics and Center for Advanced Materials and Nanotechnology, Lehigh University, Bethlehem, Pennsylvania Department of General Surgery, The Second Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. zhanghong1203@yahoo.com.cn National Laboratory of Biomacromolecules, Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;; University of the Chinese Academy of Sciences, Beijing 100049, China; School of Marine Science and Technology; Harbin Institute of Technology at Weihai; Weihai; P. R. China Clinical Pharmacology Institute, Nanchang University, Nanchang, China Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China Department of Endocrinology, Peking University First Hospital, No. 8 Xishiku Avenue, Xicheng District, Beijing 100034, China Rutgers Cancer Institute of New Jersey and Department of Pharmacology,Robert Wood Johnson Medical School,Rutgers University,New Brunswick,New Jersey,USA Department of Nuclear Medicine and PET/CT Center, The Second Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, P.R. China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310058, P.R. China Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. Institutes of Physical Science and Information Technology School of Materials Science and Engineering Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Anhui University Hefei Anhui 230601 China; Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China Email: zhanghongmd@163.com. Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Peking University Health Science Center Beijing China School of Marine Science and Technology; Harbin Institute of Technology at Weihai; Weihai; P. R. China; State Key Laboratory of Urban Water Resource and Environment Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 China Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, Gansu, China. National Institute of Biological Sciences, Beijing, People's Republic of China. Department of General Surgery, the Second Affiliated Hospital of China Medical University, Shenyang 110004. zhanghong1203@yahoo.com.cn 2ISIS Pharmaceuticals, Inc., Carlsbad, California Department of Computer Science and Technology, Tongji University, Shanghai, China; Department of Mathematics, Taiyuan Normal University, Taiyuan, Shanxi, China Hunan Provincial Center for Disease Control and Prevention, Changsha, China Hunan East Dongting Lake National Nature Reserve, Yueyang, China Northeast Agricultural University, Harbin, China Department of Veterinary Clinical Medicine, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, P.R. China. Department of Nuclear Medicine and PET/CT Center The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 P. R. China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College, Soochow University, Suzhou, China; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, Suzhou, China Key Laboratory of Advanced Technologies of Materials; Ministry of Education; School of Materials Science and Engineering; Southwest Jiaotong University; Chengdu 610031 Department of Mathematics, Shaoxing University, Shaoxing, China Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland) Department of Health Behavioral and Social Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Phase I Clinical Research Center, the First Hospital of Jilin University, Jilin, China Shengjing Hospital of China Medical University, Shenyang Department of Pathology and Cell Biology, Columbia University, New York, NY 10032;; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY 10032; College of Life Science, Sichuan Normal University, Chengdu 610101, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100000, China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China Department of Oncology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University Medical PET Center, Hangzhou, Zhejiang, China.; The Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, China.; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China. College of Marine Life Sciences, Institute of Evolution and Marine Biodiversity, MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Center for Ocean Carbon Neutrality, Ocean University of China, Qingdao, China Department of Engineering Mechanics, Southeast University, Nanjing, China. Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, China. School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710049, China. maxr@263.net Bioinformatics Group, Center for Advanced Computing Research, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China, Joint Research Development Laboratory for Advanced Computer and Communication Technologies, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100035, China, and College of Food Science and Biological Engineering, Zhejiang Gongshang University Clinical Laboratory of Medicine The Second Affiliated Hospital of Soochow University Suzhou Jiangsu China Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research, Hainan Medical University, Haikou 571199, China; Research Center for Drug Safety Evaluation of Hainan Province, Haikou 571199, China Department of Immunology, Tianjin Institute of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Diseases and Microenvironment of Ministry of Education of China, Tianjin Medical University, Tianjin 300070, P.R. China From the Department of Anatomy and Cell Biology, the Division of Hematology/Oncology, the Department of Medicine, the Center for Cardiovascular and Molecular Medicine, and the Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY; and the Department of Pathology, The Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, Birmingham, AL. 1Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts. Zhejiang Institute of Modern Physics and Department of Physics, Zhejiang University, Hangzhou 310027, China; Department of Physics and Centre for Nonlinear Studies, Hong Kong Baptist University, Hong Kong, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Suzhou Medical College of Soochow University SuZhou City China; Center for Genetic Epidemiology and Genomics, School of Public Health Suzhou Medical College of Soochow University SuZhou City China Department of Mechanical Engineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, United States; Department of Respiratory Medicine, Peking University First Hospital, Beijing, China 100034 Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry University of California, Los Angeles, California, USA; Department of Orthodontics, Guanghua School of Stomatology Sun Yat-sen University, Guangzhou, People's Republic of China Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China; Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education of China, Beijing, China Capital Medical University College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 410208, China. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA Central Laboratory, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, P.R. China Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China Clinic of Gynecological Endocrinology and Reproductive Medicine University of Basel Spitalstrasse 21 CH‐4031 Basel Switzerland; Department of Biomedicine University of Basel Hebelstrasse 20 CH‐4031 Basel Switzerland State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols−Ethers−Esters, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States Hunan Provincial Disease Control and Prevention, Changsha 410000, Hunan, China. Department of Radiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, PR China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China College of Agronomy, Liaocheng University, Liaocheng, China College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology; China Pharmaceutical University; Nanjing, China Department of Chemistry Purdue University West Lafayette IN 47907 USA; School of Environment School of Marine Science and Technology (Weihai) Harbin Institute of Technology Harbin Heilongjiang 150090 China Department of Pharmacy, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Department of the Ophthalmology, Second Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China Department of Pharmacology, Third Military Medical University, Chongqing 400038, China. Department of Neurosurgery, NO.3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Baoshan District, Shanghai, China. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, Research Institute for Information Technology, Kyushu University, 6-10-1 Hakozaki, Higashi-ku Fukuoka 812-8581, Japan, Institute for Molecular Science, Myodaiji, Okazaki 444-8585, Japan, School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom, and Centre for Computational Molecular Science, Australian Institute for Bioengineering and... National Institute of Biological Sciences, Beijing, 102206 Beijing, People's Republic of China 1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Phase I Clinical Research Center, The First Hospital of Jilin University, Changchun, Jilin, China Anji Administrative Station of Water and Soil Conservation, Huzhou 313300, China a School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials , Tianjin University , Tianjin , 300072 , People’s Republic of China State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150040, P.R. China MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Beibu Gulf University, Qinzhou, Guangxi Autonomous Regions, China; Department of Neurology, General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, Liaoning, China 2Conforma Therapeutics, San Diego, California Institute of Polyoxometalate Chemistry, Department of Chemistry, Northeast Normal University, Changchun, Jinlin 130024, P. R. China, and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P. R. China Department of Cardiac Surgery Affiliated Hospital of Qingdao University Qingdao China Orthopaedic Department The Fourth Medical Center of the Chinese People's Liberation Army General Hospital Beijing China Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China Department of Nuclear Medicine and PET Center the Second Hospital of Zhejiang University School of Medicine Hangzhou 310009 P. R. China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P.R. China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China; Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Endocrinology Department, Peking University First Hospital, Beijing, China Department of Medical Physics Institute of Modern Physics, Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou China; College of Life Sciences University of Chinese Academy of Sciences Beijing China Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Department of Chemistry, Box 5055, Tennessee Technological University, Cookeville, Tennessee 38505 Institute of Interdisciplinary Integrative Medicine Research; Shanghai University of Traditional Chinese Medicine; Shanghai; China Cerebrovascular Research GroupInstitute for Biological SciencesNational Research Council of Canada Ottawa Ontario Canada K1A 0R6 State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China. fengym@sunm.shcnc.ac.cn Department of Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Renal Division, Peking University First Hospital, Beijing, China; Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China Department of Medical Sciences, �rebro University, �rebro SE‑70182, Sweden School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710049, China maxr@263.net Charles Institute for Dermatology; University College Dublin; Dublin; Ireland Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin City, Nangang District, Heilongjiang Province, China Department of Radiology, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China College of Physics Sichuan University Chengdu 610065 China Department of Trauma Center, The First People’s Hospital of Lianyungang, Lianyungang City, Jiangsu Province, 222061, China Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan.; Department of Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan. Institute of Special Materials and Technology Fudan University Shanghai 200433 China; Department of Chemistry Fudan University Shanghai 200433 China Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, P. R. China; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China The Scientific and Technical Department Novogene Bioinformatics Institute Beijing China Department of Radiation Medicine Institute of Modern physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou China Department of Veterinary Clinical Science, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology Zhejiang Gongshang University Hangzhou China Department of Pathology, Peking University Health Science Center, 100191 Beijing, China Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, and Department of Chemistry, Beijing Polytechnic University, Beijing 100022, PRC Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China Laboratory for Advanced Lubricating Materials, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA The Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730030,China. Department of Colorectal Oncology, Fourth General Surgery Department, Shengjing Hospital, China Medical University , Shenyang , China Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, People’s Republic of China; College of Bioengineering, Chongqing University, Chongqing 400044, People’s Republic of China Department of Hematology, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. Senior Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, PR China Department of Obstetrics and Gynecology, Second Affiliated Hospital of Soochow University, Suzhou, China Z-BioMed, Inc., Rockville, Maryland. Department of Pathology Duke University School of Medicine Durham NC USA Department of Pharmacy, People's Hospital, Wuhan University, Wuhan 430060, China. zhzx8888@163.com Department of Nuclear Medicine and PET-CT Center, The Second Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P. R. China; Shanxi Medical University, Taiyuan, Shanxi 030001, P. R. China Contribution from the Molecular Photonics Laboratory, School of Natural Science, University of Newcastle, Newcastle upon Tyne, NE1 7RU, United Kingdom, and Chemistry Department, HIMS, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8816 Department of Biologic and Materials Sciences University of Michigan School of Dentistry Ann Arbor Michigan Department of Pathology, Peking University First Hospital, Beijing, China. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA USA; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Institute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, China School of Public Health; Medical College of Soochow University; Suzhou 215123; China Department of Renal Medicine, University College London Medical School, London, United Kingdom Department of Pharmacy, Tongren hospital affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan, China Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. 13873137337@vip.sina.com Department of Endocrinology，Second Affiliated Hospital，Zhejiang University School of Medicine，Hangzhou 310009，China. Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China; Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, P.R. China Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;; Institute of Nephrology, Peking University, Beijing, China;; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; and; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China;; Peking University Institute of Nephrology, Beijing, China;; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;; Ministry of Education, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Beijing, China Department of Respiratory and Critical care Medicine, Department of Pathology, Peking University First Hospital, Beijing 100034, China. Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. Department of Medical Sciences Örebro University Örebro Sweden Guangdong Provincial Key Laboratory of Advanced Drug Delivery & Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System & Class III Laboratory of Modern Chinese Medicine Preparation & Key Laboratory of Modern Chinese Medicine of Education Department of Guangdong Province, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China 1 State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai 200433, People’s Republic of China and Department of Clinical Laboratory Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai China Central Laboratory, Seventh People’s Hospital of Shanghai University of TCM, Shanghai, P. R. China Key Laboratory of Arrhythmias, Ministry of Education, China (East Hospital, Tongji University School of Medicine);; Institute of Medical Genetics, Tongji University, Shanghai; Agrochemical Discovery Department, Shenyang Research Institute of Chemical Industry, Shenyang 110021, China School of Materials and Energy, Electron Microscopy Centre, Yunnan University, Kunming 650500, P.R. China; School of Materials and Energy, Electron Microscopy Centre, Lanzhou University, Lanzhou 730000, P. R. China Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei, China Materials Directorate Air Force Research Laboratory (AFRL/MLPO) Wright-Patterson Air Force Base Fairborn, Ohio 45433 Lumin, Inc., 1936 Huntington Drive South Pasadena, California 91030 Department of Chemistry, 845 West Taylor Street University of Illinois at Chicago Chicago, Illinois 60607 Phase I Clinical Trial Unit China‐Frontage USA The First Hospital of Jilin University Jilin University Changchun People's Republic of China Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA TechData Service, King of Prussia, PA, USA Clinical Pharmacology Institute Nanchang University Nanchang P. R. China From the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China, and Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, China; Research Unit of Diagnosis and Treatment of Immune-Mediated Kidney Disease, Chinese Academy of Medical Sciences, Beijing, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, P. R. China National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology and Department of Otolaryngology-Head and Neck Surgery, the Second Hospital of Dazhou, 635000, China. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA; Xiangya Second Hospital, Changsha, China Key Laboratory of Systems Bioengineering (Ministry of Education) Department of Polymer Science School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Department of Ultrasound, Beijing Friendship Hospital Capital Medical University Beijing China State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China;; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, Jiangsu, China College of Engineering and Applied Sciences, Nanjing University 1 , Nanjing 210093, China; Nanjing Proton Source R&D Center 2 , Nanjing 210093, China Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Institute Guangzhou 510060 China Department of Orthopedic Surgery, Luoyang Orthopedic Hospital of Henan Province, Luoyang, China Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: mazuimao301@163.com. Department of Pulmonary and Critical Care Medicine Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Chao‐Yang Hospital Capital Medical University Beijing China; Beijing Institute of Respiratory Medicine Beijing China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China EpiCept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, Myriad Pharmaceuticals, Inc., 320 Wakara Way, Salt Lake City, Utah 84108 National Institute of Biological Sciences , Beijing 102206, People's Republic of China Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, Department of Physical Chemistry, Budapest University of Technology and Economics, P.O.B. 91, 1521 Budapest, Hungary, Chemical Research Center, Hungarian Academy of Sciences, P.O.B. 17, 1525 Budapest, Hungary, Faculty of Chemistry, University of Wrocław, PL-50383 Wrocław, Poland, Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw, Poland, and... Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655;; Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655; Department of Nuclear Medicine and PET Center The Second Hospital of Zhejiang University School of Medicine Hangzhou 310009 P. R. China Division of Nephrology, Guangdong General Hospital Guangdong Academy of Medical Sciences, Guangdong Provincial Institute of Geriatrics Guangzhou Guangdong PR China Tai’an Academy of Agricultural Sciences, Tai’an, Shandong 271000, China Department of Cardiology, Tianjin Chest Hospital, Tianjin Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province and Chemistry and Chemical Engineering Laboratory of Guangdong Province; Shantou University; Guangdong 515063; P. R. China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Department of Cardiology, Tongji Hospital, Tongji University School of Medicine; Key Laboratory of Arrhythmias of Ministry of Education of China Department of Chemical Engineering, Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, P. R. China Chia Tai Tianqing Pharmaceutical Group Co. Ltd., Nanjing, China Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University Nanjing, China. Medical Experiment Center Shaanxi University of Chinese Medicine Xianyang China Department of Thoracic Surgery The First Hospital of Jilin University Changchun Jilin China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, P.R. China Department of Mechanical EngineeringRowan UniversityGlassboroNJUSA China National Center for Food Safety Risk Assessment, Beijing 100022, China. Department of Pharmacy, Tongji Hospital, Tongji University, Shanghai, People’s Republic of China Centre for Computational Molecular Science, Chemistry Building (#68), The University of Queensland, Qld 4072, Brisbane, Australia Department of Endocrinology Huai'an First People's Hospital Huai'an China School of Public Health, Qingdao University, Qingdao, Shandong, P. R. China Renal Division, Peking University First Hospital, Beijing, China Huazhong University of Science and Technology, Wuhan, 430074, China. School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China School of Management University of Science and Technology of China Hefei Anhui China Eye Hospital, the First Clinical Hospital of Harbin Medical University, Harbin 150001, China. dr.hzhang2007@hotmail.com Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High Performance Polymer-Based Composites of Guangdong Province, The Key Lab of Low-Carbon Chem & Energy Conservation of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Urology The Second Hospital of Hebei Medical University Shijiazhuang China Department of Medical Sciences, Örebro University Örebro, Sweden. Department of Dermatology, Changhai Hospital, the Second Military Medical University, Shanghai 200433. Department of Clinical Laboratory, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China Department of Dermatology, Institute of Biomedicine and Surgery, Linköping University, SE-581 85 Linköping, Sweden. hong.zhang@ibk.liu.se School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. Department of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200030, China. Kinexus Bioinformatics Corporation, Vancouver, BC, Canada. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health and Key Laboratory of Chronic Kidney Disease, Prevention and Treatment, Ministry of Education Beijing China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Hangzhou, Zhejiang 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 310009, China Department of Anesthesiology; PLA General Hospital; Beijing 100853; China Key Laboratory of Magnetism and Magnetic Materials of Ministry of Education, School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Department of Gastroenterology, Xinqiao Hospital, the Second Affiliated Hospital of Army Medical University, Chongqing, China Department of Respiratory and Critical Care Diseases, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, China Department of Clinical Laboratory, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200062, China. Chongqing Medical University, Chongqing, China Department of Clinical Laboratory, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai, China Central Laboratory, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, People’s Republic of China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of China Department of Gynecologic Oncology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Maternity Hospital of Nankai University, Tianjin 300000, China Xi’an Central Hospital, Xi’an, Shaanxi 710003, China; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, and College of Life Sciences, University of Chinese Academy of Sciences, Beijing, P.R. China Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern Physics Lanzhou Gansu China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Gansu Province Lanzhou China; Gansu Wuwei Tumor Hospital Wuwei China College of Environmental & Resource Sciences, Shanxi University, Taiyuan 030006, China. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Materials Science and Engineering National University of Singapore 117574 Singapore Division of Joint Surgery and Sport Medicine, Department of Orthopaedic Surgery, the First Affiliated Hospital of People's Liberation Army General Hospital, Beijing 100048, China. Email: zhanghongmd@163.com. Renal Division Department of Medicine Peking University First Hospital, Peking University Institute of Nephrology Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) Ministry of Education Beijing China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China Neuroscience Center, Key Laboratory of Neurobiology of Chongqing, Chongqing Medical University, Chongqing 400016, P.R. China Emergency Department, First Affiliated Hospital of Anhui Medical University, Hefei, China Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 1 * Microbiology and Immunology, Department of Cardiology, Shan Xi Provincial People’s Hospital, Taiyuan City, Shanxi Province, China Institute for Biomedical Engineering, Waseda University, Tokyo 162-0041, Japan Department of Prevention, Tianjin Second People's Hospital, Tianjin 300192, P.R. China Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China.; Z-BioMed, Inc., Rockville, Maryland. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 ISIS Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA. hzhang@isisph.com School of Public Health Qingdao University Qingdao Shandong China Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands Imaging Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China Laboratory for Physical Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA Dermatology Branch, Center for Cancer Research, National Cancer Institute , Bethesda, Maryland , USA Department of Chemistry, Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, and Chemistry and Chemical Engineering Laboratory of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. China College of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; Gansu Wuwei Institute of Medical Sciences, Gansu Province, Wuwei 733000, China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China From the Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science (Y.F., Y.W., Z.T., H.Z., X.Q., Y.Z., Y.G., X.W., N.W.), Peking University, Beijing, China; the Diabetes Center (Y.F., Y.W., Z.T., H.Z., X.Q., Y.Z. Y.G., X.W., N.W.), Peking University, Beijing, China; Institut Pasteur de Lille (B.S.) INSERM U545; Université de Lille 2, Faculté de Pharmacie et Faculté de Médecine, Lille, France; and the Departments of Bioengineering and Medicine (S.C.), University... Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, China. The University of Queensland Centre for Computational Molecular Science, Australian Institute for Bioengineering and Nanotechnology, , Queensland 4072, Australia Authors' Affiliations: Departments of 1Cell Biology, 2Pathology, and 3Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University 710049, China. Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City, Fuzhou 350207 China Beijing Sport University and First Hospital of Soochow University, Beijing, Suzhou, China; and Department of Pulmonary and Critical Care Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Chao‐Yang Hospital, Capital Medical University Beijing 100020 People's Republic of China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Cardiothoracic Surgery, Bishan Hospital of Chongqing Medical University, Chongqing, China Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, China Renal Division, Peking University First Hospital Center of Smart Laboratory and Molecular Medicine Medical College Chongqing University Chongqing 400044 P. R. China; Key Laboratory of Biorheological Science and Technology State and Local Joint Engineering Laboratory for Vascular Implants Ministry of Education College of Bioengineering Chongqing University Chongqing 400044 P. R. China The Sixth People's Hospital of Jinan Jinan, Shandong Province, China. Wilmar (Shanghai) Biotechnology R&D Center Co., Ltd. No. 118 Gaodong Road, Pudong New District Shanghai 200137 China College of Physics, Sichuan University College of Physics, Sichuan University, Chengdu 610065, China Department of Ophthalmology and Vision Science Shanghai Eye, Ear, Nose and Throat Hospital Fudan University Shanghai 200030 P. R. China; Department of Ophthalmology the Affiliated Hospital of Guizhou Medical University Guiyang 550025 P. R. China College of Physics, Sichuan University, Sichuan 610065, China LPCT, UMR 7019, Université de Lorraine and CNRS, F-54000 Vandoeuvre-lès-Nancy, France; Research Center for Analytical Sciences, College of Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin 300071, China Nebraska Center for Virology, and The School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68583-0900 Contribution from the Department of Chemistry, University of York, York, YO10 5DD, United Kingdom, Van't Hoff Institute for Molecular Sciences, Molecular Photonic Materials, University of Amsterdam, Nieuwe Achtergracht 166, Amsterdam, NL-1018 WV, The Netherlands, Rutherford Appleton Laboratory, Central Laser Facility, CCLRC, Didcot, Oxon, OX11 0QX, United Kingdom, and Department of Chemistry, Queen Mary, University of London, London, E1 4NS, United Kingdom College of Physics and Electronic Engineering of Chongqing Normal University, Chongqing Key Laboratory of Optical and Electronic Functional Materials, Chongqing 401331, China Department of Radiation Medicine; Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; China State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, China Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Kidney Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education Newcastle University 2 School of Electrical and Electronic Engineering, , Newcastle upon Tyne, United Kingdom School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, China Department of Endocrinology, Huaian First People’s Hospital, Nanjing Medical University, Huai’an China Department of Ophthalmology The Second People’s Hospital of Yunnan Province The Fourth Affiliated Hospital of Kunming Medical University China; Yunnan Eye Institute Kunming China; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmologya Kunming China; Yunnan Eye Disease Clinical Medical Center Kunming China; Yunnan Eye Disease Clinical Medical Research Center Kunming China University of Pennsylvania Perelman School of Medicine, Department of Cell and Developmental Biology, 421 Curie Blvd., Philadelphia PA 19104, USA Harbin Medical University, Harbin 150001, China. dr.hzhang2007@hotmail.com Department of Statistics and Finance University of Science and Technology of China Hefei China Tulane University Department of Chemistry, , New Orleans, Louisiana 70118, USA Renal Division; Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China; Beijing People's Republic of China Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655 2 Department of Bio-nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai JiaoTong University, 800Dongchuan Road, Shanghai 200240,P.R. China, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo, 162-0041, Japan, Department of Dermatology of First Affiliated... State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Department of Gastroenterology, General Hospital of Beijing Military Area, Beijing 100700, China. Department of Anesthesiology Peking University First Hospital Beijing China State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing 100871, China Department of Geriatrics, The Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China Department of Medical Imaging The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China State Key Laboratory of Oncology in South China, and Collaborative Innovation Center for Cancer Medicine,Sun Yat‐Sen University Cancer Center,Guangzhou,China; Rutgers Cancer Institute of New Jersey and Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers,The State University of New Jersey,New Brunswick,NJ Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY 10032; and Departments of Genetics and Medicine, and Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA 94305-5120 a School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University , Tianjin , 300072 , P. R. China Center for Nanomedicine, Southwest Hospital, Third Military Medical University, Chongqing, China.; Department of Clinical and Military Laboratory Medicine, School of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, China. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Shanghai Children's Hospital Affiliated to Shanghai Jiaotong University , Shanghai, China Department of Cardiovascular Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China Department of Food and Nutrition, School of Public Health, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009 Jiangsu, P.R. China Department of Hematology, The Second People's Hospital, Jingmen 448000, China. Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei City, Anhui 230601, P. R. China Condensed Matter Science and Technology Institute School of Instrumentation Science and Engineering Harbin Institute of Technology Harbin 150080 China Department of Respiratory Medicine, Zhejiang Provincial Zhongshan Hospital, The Third Affiliated Hospital of Zhejiang Chinese Medical University, 310000, Zhejiang Province, China Department of Thoracic Surgery, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, P.R. China School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China; Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, PR China Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha 410011, China. Taub Institute for Research on Alzheimer's Disease and the Aging Brain & Department of Pathology and Cell Biology Columbia University New York New York USA Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou, Zhejiang 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, Zhejiang 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 310009, China The Medical Department of First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310006, China. Reproductive Medicine Center, Zhongda Hospital, Southeast University, Jiangsu Nanjing 210009.; Reproductive Medicine Center, Zhongda Hospital, Southeast University, Jiangsu Nanjing 210009. The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an, Shandong 271000, China 1Biogen Idec, San Diego, California, and 2Biogen Idec, Cambridge, Massachusetts 1 Department of Computer Science, University of Science and Technology of China and 2Anhui Province-MOST Co-Key Laboratory of High Performance Computing and Its Application, Hefei, Anhui 230027, P.R. China; 1 Department of Computer Science, University of Science and Technology of China and 2Anhui Province-MOST Co-Key Laboratory of High Performance Computing and Its Application, Hefei, Anhui 230027, P.R. China From the Departments of Medicine (T.L., L.-F.L., C.L.), Pathology (D.W., L.T., O.C., H.Z., M.H.Y.C., E.E.), and Surgery (J.M., H.R.), Stanford University, CA. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038, Division of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, and National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education , Peking , China Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences, Fujian Normal University,Fuzhou 350007,China. Departments of Neurology, Biochemistry and Biophysics, Cellular and Molecular Pharmacology, and Pharmaceutical Chemistry, University of California, San Francisco, California 94143 College of Food Science & Project Engineering Bohai Univ. Jinzhou 121013 China School of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China Emergency Department First Affiliated Hospital of Anhui Medical University Hefei China Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China. Department of Ophthalmology, Tong ji Hospital, Hubei Province - China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou China Wilmar (Shanghai) Biotechnology Research &Development Center Co. Ltd, Shanghai 200137, China Department of Radiation Medicine Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou 730000 China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province Lanzhou 730000 China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China; Medical PET Center, Zhejiang University, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of China Department of Applied Chemistry School of Engineering Tokai University 4‐1‐1 Kitakaname Hiratsuka Kanagawa 259‐1292 Japan Renal Division, Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People’s Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People’s Republic of China Brain Research Center and Department of Medicine, University of British Columbia, Vancouver, Canada, Kinexus Bioinformatics Corporation, Vancouver, Canada, and Signal Transduction Laboratory, Institute of Molecular and Cell Biology, Singapore, Republic of Singapore Department of Rehabilitation Medicine, The First Hospital of Jilin University, Changchun, China Department of Laboratory Medicine, Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc, Carlsbad, CA; and Department of Occupational and Environmental Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, School of Public Health, Soochow University, Suzhou 215123, PR China Epicept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, and Shire-Biochem Inc., 275 Armand-Frappier Boulevard, Laval, Quebec, Canada H7V 4A7 Department of Instrumental and Electrical Engineering, Xiamen University, Xiamen, China Hefei Institutes of Physical Science, Hefei Institute of Physical Science, Chinese Academy of Sciences, Shushanhu Road 350, Hefei 230031, China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, People’s Republic of China Key Laboratory of Glycoconjugate Research, Ministry of Public Health, Department of Biochemistry, Shanghai Medical University, Shanghai 200032, China. Division of MR Research, Department of Radiology Johns Hopkins University School of Medicine Baltimore Maryland USA Engineering Research Center of Molecular Medicine of Ministry of Education; Key Laboratory of Fujian Molecular Medicine; Key Laboratory of Xiamen Marine and Gene Drugs; School of Biomedical Sciences; Huaqiao University Department of Gynecology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201799, P.R. China Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China for the CCC-ACS Investigators Shijiazhuang Center for Disease Control and Prevention; Shijiazhuang 050011; China; Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning; Shijiazhuang 050011 Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China Key Laboratory of Magnetism and Magnetic Materials of Ministry of Education School of Physical Science and Technology Lanzhou University Lanzhou 730000 China Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin Heilongjiang 150001 China Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska 68588 and School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588 Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing100083, China; State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing100085, China Department of Orthopedics, Hubei Maternal and Child Health Hospital, Wuhan Hubei, 430070, P.R.China. College of Veterinary Medicine, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China 3Department of Laboratory Medicine, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005 , China Department of Surgical Intensive Care Unit, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China. Department of Internal Medicine, Fangshan Hospital, Beijing University of Chinese Medicine, Beijing 102400, China. Pediatric Surgery Department, The Affiliated Hospital of Qingdao University, Qingdao, China; Electron Microscopy Centre of Lanzhou University School of Materials and Energy Lanzhou University Lanzhou Gansu 730000 China Department of Cardiology, the First People’s Hospital of Yunnan, Kunming, P.R. China The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China Department of Pathology and Laboratory Medicine, Department of Colorectal Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P. R. China Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; Clinical Center for Gene Diagnosis and Therapy, the Second Xiangya Hospital of Central South University, Changsha, China Department of Cardiology The First People's Hospital of Yunnan Province Kunming 650032 China State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an 271018, Shandong, China. zhanghong260@126.com Department of Pathology, Duke University School of Medicine, Durham, NC 27710; School of Medicine, Orebro University, Örebro, Sweden Department of Microbiology-Immunology, Interdepartmental Immunobiology Center and Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, P.R. China; Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan 250033, Shandong, China Authors' Affiliations: 1Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada; 2Department of Integrative Biology and Pharmacology, University of Texas Medical School; and 3University of Texas, MD Anderson Cancer Center, Houston, Texas Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409 (J.Y., J.W., Q.L., H.Z.); Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599–7090 (J.R.H., C.P.); and Program in Molecular Cardiology and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 2 †Department of Laboratory Medicine, University of California, San Francisco, CA 94143 Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Jiangsu, PR China; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, PR China Department of Neurology, Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China d School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China College of Life Sciences, Sichuan Normal University Chengdu 610101, China Plant Functional Genome and Bioinformatics Research Center, Sichuan Normal University Chengdu 610101, China. Wilmar (Shanghai) Biotechnology R&D Center Co Ltd No.118 Gaodong Road, Pudong New District Shanghai 200137 China Anhui MicroAnaly Gene Technologies Co., Ltd, Chaohu, Anhui, China; MicroAnaly (Shanghai) Gene Technologies Co., Ltd, Shanghai, China; Bantang Genomics Center, Chaohu, Anhui, China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangzhou, Guangdong China; Department of Nuclear Medicine, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou, Guangdong China State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China Endocrinology Peking University First Hospital Beijing China Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China Department of Obstetrics and Gynecology, Second Affiliated Hospital of Soochow University, Suzhou, China. Department of Pathology Peking University First Hospital Beijing China Tianjin Medical University Eye Hospital, Tianjin 300384, China. Email:tmuechong@sina.com. School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China;; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, China; Renal Division Peking University First Hospital Institute of Nephrology Peking University Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jinlin, People's Republic of China The Key Laboratory on Reliability and Environmental Engineering Technology, Beihang University, Beijing 140191, China; School of Reliability and Systems Engineering, Beihang University, Beijing 140191, China China National Rice Research Institute, State Key Laboratory of Rice Biology, Hangzhou, Zhejiang, People’s Republic of China.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China; School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, China F. Widjaja Foundation, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048;; †Department of Gastroenterology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China; and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 The Center for Reproductive Medicine Obstetrics and Gynecology Department The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. China Department of Gynecology, The Central Hospital of Zibo, Shangdong, China Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing City, PR. China Laboratory of Fruit Tree Biotechnology, College of Horticulture, Nanjing Agricultural University, Nanjing, China Institute of Super-microstructure and Ultrafast Process in Advanced Materials; School of Physics and Electronics; Central South University; Changsha; P. R. China Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis and Department of Chemistry, Southern University of Science and Technology, Xueyuan Blvd 1088, Shenzhen, 518055, China The Institute of Molecular Pathology, University of Copenhagen Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA College of Physics Science and Technology, Shenzhen University, Shenzhen 518060, China. zhangh@snu.edu.cn Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233, China Department of Endocrinology; Huai'an First People's Hospital; Nanjing Medical University; Huai'an; P. R. China Hunan Provincial Center for Disease Control and Prevention, Changsha City, China. Van't Hoff Institute for Molecular Sciences; University of Amsterdam; , The Netherlands Wilmar (Shanghai) Biotechnology Research & Development Center Co. Ltd, Shanghai, China; Institute of Atomic and Molecular Physics; Sichuan University; Chengdu; China; Key Laboratory of High Energy Density Physics and Technology of Ministry of Education Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, Connecticut 06520, Institute of Biochemistry and Biophysics, Polish Academy of Science, Pawinskiego 5A, 02-106 Warsaw, Poland, and Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, 111 South Alexander Drive, Research Triangle Park, North Carolina 27709-2233 Renal Division, Peking University First Hospital, Peking University Institute of Nephrology , Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education , Beijing, China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing, China Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304; Jilin Broadwell Pharmaceutical Co., Ltd., Liaoyuan, Jilin 136200, P.R. China Xi'an Central Hospital Xi'an Shaanxi China The Second Affiliated Hospital of Zhengzhou University, Henan Zhengzhou,450014, China. Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Department of Thoracic Surgery, The First Hospital, Jilin University, Changchun, Jilin Province, China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Zhejiang University 1 Zhejiang Institute of Modern Physics and Department of Physics, , Hangzhou 310027, China Cancer Research Center; Tumor Biology, School of Life Sciences University of Skövde, SE-541 28 Skövde, Sweden Department of Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China. College of Agronomy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling, Shaanxi 712100, China.; College of Agronomy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling, Shaanxi 712100, China. 2nd Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang P. R. China Pathology, Peking University First Hospital, Beijing, P.R. China. Department of Orthopaedics, the Second People's Hospital of Tongxiang,Tongxiang 314511, Zhejiang, China. jiang_shumin@126.com Department of Rehabilitation medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China Genomic Testing Cooperative, Irvine, CA, USA College of Acupuncture-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, China Gynecological Oncology Center, Peking University People's Hospital, Beijing 100044, China. School of Pharmacy, Hangzhou Medical College, 311399 Hangzhou, P. R. China; College of Pharmaceutical Science, Zhejiang University of Technology, 310014 Hangzhou, P. R. China Pediatric Department, Shunyi Women's and Children's Hospital of Beijing Children's Hospital, Beijing 101300, P.R. China Charles Institute of Dermatology; School of Medicine; University College Dublin; Dublin 4; Ireland Chongqing Key Laboratory of Photo-Electric Functional Materials, College of Physics and Electronic Engineering, Chongqing Normal University , Shapingba, Chongqing 401331, People’s Republic of China Renal Division of Peking University First Hospital, Beijing, China. Department of Endocrinology and Metabolism, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China Departments of Respiratory Diseases Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730 China State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences, Shanghai 200031, China. fengym@sunm.shcnc.ac.cn Division of Joint Surgery, Department of Orthopedics Surgery, the First Affiliated Hospitalof Chinese People’s Liberation Army General Hospital, Beijing, China Vista Clara Inc. 12201 Cyrus Way, Suite 104 Mukilteo WA Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China Department of Colorectal Tumor Surgery, Shengjing Hospital, China Medical University, Shenyang, China Department of Colorectal Tumor Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China, Email:haojiubujian1203@ sina.cn. Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China; Institute of Nuclear Medicine and Molecular Imaging Zhejiang University Hangzhou Zhejiang China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou Zhejiang China; College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou Zhejiang China; Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang University Hangzhou Zhejiang China Department of Oncology, West China Hospital of Sichuan University, Chengdu, China Department of Neurosurgery, Second Hospital of Lanzhou, Lanzhou City 730046, Gansu Province, P.R. China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China The Fourth Medical Center of the Chinese People's Liberation Army General Hospital Department of Orthopaedic Beijing China Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, P.O. Box 94157, Science Park 904, 1098 XH Amsterdam, The Netherlands Phase I Clinical Trial Unit, First Hospital, Jilin University, Jilin, China Department of Gastroenterology The Second Hospital of Hebei Medical University Shijiazhuang China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University Tianjin 300072 P. R. China; Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City 350207 Fuzhou P. R. China 1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass, School of Chemical Engineering, Gansu Provincial Biomass Function Composites Engineering Research Center, University of Gansu Province, Northwest Minzu University, Lanzhou 730030, China Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin City, Nangang District, Heilongjiang Province, China; and; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Heilongjiang Province, China. Henan Tumor Research Institute, Zheng Zhou, Henan 450000, People’s Republic of China; Central Hospital, Nan Yang, Henan 473000, People’s Republic of China; People’s First Hospital of Nan Yang, Nan Yang, Henan 473000, People’s Republic of China; and Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020 Research Center for Analytical Sciences; College of Chemistry; Nankai University; Tianjin 300071; China Institute of Loess Plateau, Shanxi University, Taiyuan, 030006, China State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&D of Fine Chemicals of Guizhou University Guiyang 550025 China Biosensor National Special Laboratory, College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou China Basic Surgery Teaching Experimental Center, Clinical Medical School, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China; 610281599@qq.com. Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China Gansu Provincial People’s Armed Police Corps Hospital, Lanzhou, Gansu, China Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine Shanghai China; Department of Rehabilitation Medicine Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine Shanghai China Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China, and Department of Chemistry, Fuyang Teachers College, Fuyang 236041, People's Republic of China Institute of Biostatistics Fudan University Shanghai P.R. China Department of Materials Science and Engineering Institute of Materials for Electronics and Energy Technology (i‐MEET) Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Martensstrasse 7 91058 Erlangen Germany; Erlangen Graduate School in Advanced Optical Technologies (SAOT) Paul‐Gordan‐Str.6 91052 Erlangen Germany Department of Pathology and Cell Biology, Columbia University, New York, NY, USA; The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Department of Chemistry and Integrated Microscopy and Microanalytical Facility, Emory University, Atlanta, Georgia 30322 Shanghai Xuhui District Mental Health Center, Shanghai, China. Transportation institute, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China Department of Radiology, Tianjin Chest Hospital, Tianjin, China (mainland) Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China Department of Endocrinology, The First People’s Hospital of Lanzhou New District, Lanzhou, Gansu, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, People’s Republic of China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People’s Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People’s Republic of China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China College of Plant Science and Technology Huazhong Agricultural University The Provincial Key Laboratory of Plant Pathology of Hubei Province Wuhan 430070 China Renal Division of Internal Medicine, The First Hospital, Peking University and Peking University Institute of Nephrology, Beijing 100034, China. hongzh@bjmu.edu.cn Department of Pathology Baylor College of Medicine Houston TX USA; Department of Pathology MD Anderson Cancer Center Houston TX 77030 USA Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing China From the Department of Laboratory Medicine, University of California, San Francisco, CA; the Department of Physiology, Semmelweis University, Budapest, Hungary; and the Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA. Renal Division, Peking University First Hospital, Peking University Institute of Nephrology , Beijing , China; Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) , Ministry of Education, Beijing , China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing , China fl Chinese Academy of Sciences, Institute of Biophysics, State Key Laboratory of Biomacromolecules , Beijing , China. School of Medicine Örebro University Örebro Sweden The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of Biochemistry, Shihezi University School of Medicine, Shihezi, Xinjiang, China. Kinexus Bioinformatics Corporation, Suite 1, 8755 Ash Street, Vancouver, BC, Canada V6P 6T3, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, and Department of Reproductive and Developmental Biology, Institute of Animal Physiology and Genetics, Rumburska 89, Libechov, Czech Republic State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China School of Medicine, Department of Medical Sciences, Orebro University, Örebro, Sweden College of Physics and Information Engineering; Institute of Micro-Nano Devices and Solar Cells; Fuzhou University; Fuzhou; China Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, P.R. China College of Agronomy, Anhui Agricultural University, Hefei, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, People's Republic of China Colorectal Tumor Surgery Ward, Department of General Surgery Shengjing Hospital of China Medical University Shenyang People's Republic of China Department of Urology Affiliated Hospital of Weifang Medical University Weifang Shandong China Institute of Occupational Health and Occupational Diseases Shandong Academy of Medical Science Jinan Shandong China Department of Orthopaedic Surgery The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou China Ministry of Education‑Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China Department of Radiation Oncology, Georgia Regents University, USA. Tianjin Key Laboratory of Cellular and Molecular Immunology and Key Laboratory of the Educational Ministry of China, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, People’s Republic of China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China Key Laboratory of Anesthsiology of Zunyi Medical College, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000, China. Email:1789520047@qq.com. Department of Anesthesiology and Critical Care Medicine, Fudan University Affiliated Zhongshan Hospital, Shanghai 200032, China. Department of Dermatology The First Affiliated Hospital of Jinan University Guangzhou 510632 China; Institute of Mycology Jinan University Guangzhou 510632 China Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an, China Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P.R. China Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing City, 401120, PR. China. Department of Neurology, Zhongnan Hospital of Wuhan University, Center for Cerebral Vascular Diseases, Medical College of Wuhan University, Wuhan, Hubei 430071, China. zhangh9@yahoo.com School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China. Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;; Peking University Institute of Nephrology, Beijing, China;; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; and; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing, China From the Sol Sherry Thrombosis Research Center and the Department of Microbiology and Immunology, Temple University School of Medicine, and the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; and Pharmacia & Upjohn Inc, Kalamazoo, MI. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 P. R. China Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Science Fujian Normal University Fuzhou China Department of Nuclear Medicine and PET/CT Center The Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou Zhejiang 310009 P.R. China The Key Laboratory of Biomedical Information Engineering of Ministry of Education of China, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. maxr@263.net School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China Henan University of Traditional Chinese Medicine Zhengzhou 450003,China. School of Electrical Engineering, Xi'an Jiaotong University, 710049, Xi'an, P.R. China From the Division of Hematology/Oncology, Department of Medicine, Center for Cardiovascular and Molecular Medicine, Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY. Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409 Translational Research Unit Sanford‐Burnham Medical Research Institute La Jolla CA USA Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Phase I Clinical Trial Unit, First Hospital Jilin University Jilin China Department of Physiology, Basic School of Medical Sciences, Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China School of Information Engineering, Minzu University of China, Beijing 100080, China Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan, and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, and Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai, China College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Chao-Yang Hospital,; Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Unilever R&D Shanghai Shanghai China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Cardiology, Tianjin Nankai Hospital, Tianjin, PR China College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China College of Materials Science and Optoelectronic Technology, Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse; Research Center for Eco-Environmental Sciences; Chinese Academy of Sciences; Beijing; China Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China; Z-BioMed, Inc., Rockville, Maryland, USA Shandong University Affiliated Jinan Center Hospital Shandong China Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China. Faculty of Medicine and Health, School of Medical Sciences, Orebro University, Örebro, Sweden Kinexus Bioinformatics CorporationVancouverBritish ColumbiaCanada Institute of Endocrinology and Metabolism The Second Xiangya Hospital Central South University Changsha Hunan China Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang Province, People's Republic of China; and School of Medicine, Institute of Medical Sciences, Örebro University, SE 70182 Örebro, Sweden Department of Pathology, Peking University First Hospital, Beijing 100034, China School of Environment; School of Marine Science and Technology (Weihai); Harbin Institute of Technology; Weihai; China The First Affiliated Hospital, Jinan University, Guangzhou, People's Republic of China.; Institute of Mycology, Jinan University, Guangzhou, People's Republic of China. Krannert Institute of Cardiology and the Division of Cardiology, Department of Medicine, Indiana University School of Medicine; School of Electrical Engineering, Xi'an Jiaotong University Laboratory of Photonics and Interfaces Ecole Polytechnique Federale de Lausanne 1015 Lausanne Switzerland Department of Radiation Oncology Indiana University Indianapolis IN 46202‐5289 USA Renal Division, Department of Medicine Peking University First Hospital Beijing China; Institute of Nephrology Peking University Beijing China; Key Laboratory of Renal Disease Ministry of Health of China Beijing China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) Ministry of Education Beijing China National Laboratory for Molecular Sciences, Centre for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China The First Affiliated Hospital of the PLA General Hospital, Beijing, People’s Republic of China Merrimack Pharmaceuticals, Inc., Cambridge, MA 02139, USA. 2Wistar Institute, Philadelphia, Pennsylvania; Departments of Radiation Oncology Vanderbilt University Medical Center Nashville Tennessee USA Key Laboratory of Excited-State Processes, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, P. R. China, Graduate School of Chinese Academy of Sciences, Beijing 100039, P.R. China, and Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands School of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China. Department of Electrical and Electronic Engineering The University of Hong Kong Pok Fu Lam Road Hong Kong SAR China Department of Materials Science and Engineering National University of Singapore Singapore 117574 Singapore From the Divisions of Oncology and Cell Biology, Department of Biomedicine and Surgery, Linköping University, Linköping, Sweden. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300350, P. R. China Department of Neurology, Liaoning Health Industry Group Fukuang General Hospital, Fushun, China Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, PR China. maxr@263.net National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 1; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China 2 Department of Colorectal Surgery, Shengjing Hospital China Medical University Shenyang Liaoning China Department of Pathophysiology, Medical College of Tongji University, Shanghai 200092, China. zhangh1227@sohu.com Conforma Therapeutics Corp., San Diego, California Department of Nursing Taicang First People's Hospital Suzhou China Novozymes A/S, Smørmosevej 11, Building 6B, DK-2880 Bagsvaerd, Denmark, YKI, Institute for Surface Chemistry, Box 5607, SE-114 86 Stockholm, Sweden, and BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Tianjin Medical University Eye Hospital, Tianjin 300384, China. Email: tmuechong@sina.com. Department of Clinical Laboratory Shanghai Children's Hospital Shanghai Jiaotong University Shanghai China School of Electronic Engineering and Information, Sichuan University, Chengdu 610064, China. scu.zh@sohu.com Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen, China School of Medicine, Tianjin Tianshi College, Tianjin Institute of Crop Sciences, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China; Scientific Observing and Experimental Station of Tuber and Root Crops in South China, Ministry of Agriculture, Fuzhou, Fujian 350013, China Department of Pediatric Surgery, The Affiliated Hospital of Medical College, Qing Dao University, Qing Dao 266003, China. Clinical Pharmacology Institute Nanchang University Nanchang China College of Physics Sichuan University Chengdu 610064 China Pharmacology and Phase I Clinical Research Center The First Hospital of Jilin University Jilin China Institute of Biostatistics, School of Life Sciences, Fudan University Shanghai 200433, China. Department of Nuclear Medicine, Second Affiliated Hospital, Zhejiang University College of Medicine, 88 Jiefang Road, Hangzhou 310009, China Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China Department of Biophysics and Department of Biochemistry and ‡Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States Department of Pathology, Peking University First Hospital, Beijing 100034, China. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Institute of Biostatistics Fudan School of Life Sciences Fudan Shanghai 200433 China Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China Department of Pharmacology, Pharmacy School, Inner Mongolian Medical University, Jinshan Developing Zone, Hohhot, Inner Mongolia 010110, China Novozymes A/S Smørmosevej 11, Building 6B DK‐2880 Bagsvaerd Denmark National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Department of Pediatrics Liaocheng People's Hospital Liaocheng Shandong China Electron Microscopy Centre of Lanzhou University; Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education and School of Physical Science and Technology; Lanzhou University; Lanzhou 730000; P. R. China Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi’an 710003, China; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China Rehabilitation Department, First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China. ldzhsw@yahoo.com.cn Wilmar (Shanghai) Biotechnology Research and Development Center Co., Ltd., 118 Gaodong Road, Pudong New District, Shanghai 200137, China The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA Radiation Oncology of Cancer Center, West China Hospital of Sichuan University, Chengdu, China Faculty of Clinical Medicine, Changchun Medical College, Changchun, Jilin 130031, P.R. China Department of Surgery, Guangzhou Medical University, Guangzhou 510182, China. Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100871, China; Institute of Nephrology, Peking University, Beijing 100871, China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing 100871, China Department of Obstetrics and GynecologyIndiana University Indianapolis Indiana USA; Department of PathologyLaboratory MedicineIndiana University Indianapolis Indiana USA; Department of General SurgerySecond Hospital of Jilin University Changchun Jilin China Department of Ophthalmology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. dr_zhanghong@126.com The University of Texas MD Anderson Cancer Center; Ingenix Consulting; and Baylor College of Medicine, Houston, TX Third Affiliated Hospital of Chongqing Medical University, Chongqing, China Hebei Computational Optical Imaging and Photoelectric Detection Technology Innovation Center, Hebei International Joint Research Center for Computational Optical Imaging and Intelligent Sensing, School of Mathematics and Physics Science and Engineering, Hebei University of Engineering, Handan, Hebei 056038, P.R. China Department of Respiratory Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China College of Agronomy, Liaocheng University, Liaocheng, People’s Republic of China Perinatal Biology Center Soochow University School of Medicine Suzhou China Department of Radiation Oncology, Georgia Regents University, Augusta, GA, USA Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui Graphene Engineering Laboratory, Anhui University, Hefei, Anhui 230601, China; Hefei National Laboratory for Physical Sciences at the Microscale, Hefei, Anhui 230026, China; Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China Department of Colorectal Tumor Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China. Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742; Department of Radiation Oncology and Winship Cancer Institute, B5111, Emory University School of Medicine, 1365 B Clifton Road NE, Atlanta, GA 30322, USA. Department of Hematology, Liaocheng People's Hospital, Liaocheng, China. School of Municipal and Environmental Engineering, Harbin Institute of Technology, 150090, Harbin, Heilongjiang, People’s Republic of China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 150090, Harbin, Heilongjiang, People’s Republic of China Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Okayama 700, Japan; The Graduate School of Natural Science and Technology, Okayama University, Okayama 700, Japan Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, P.R.�China Clinical Pharmacology Institute, Nanchang University, Nanchang, P.R. China Department of Physiology, Huzhou Teachers College, Huzhou 313000, China;Department of Physiology, School of Medicine,Zhejiang University, Hangzhou 310006, China;E-mail: Shenyl@hzcnc.com. Texas Children’s Cancer Center, Department of Pediatrics 1 , 2; Department of Pathology and Immunology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 1 , 2; Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030 6 State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei 230036, Anhui, P. R. China School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai, P. R. China Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin 300384, China; Email: tmuechong@sina.com. College of Food Science and Biological Engineering, Zhejiang Gongshang University, Hangzhou, China Department of Applied Immunology and Microbiology, Wyeth Vaccines Research, 401 Middletown Road, Pearl River, New York 10965; Meningococcal Reference Unit, Manchester Medical Microbiology Partnership, Health Protection Agency Northwest, Clinical Sciences Building, Manchester M13 9WZ, United Kingdom Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species; Graduate University of the Chinese Academy of Sciences, Institute of Chemistry Northrop Grumman Electronics Systems, MS-3B10, 1212 Winterson Road, Linthicum, MD 21090 Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Wellman Laboratories of Photomedicine, Department of Photopathology and Dermatology, Massachusetts General Hospital, Harvard Medical School, 02114, Boston, Massachusetts The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University Clinical Trial Unit, First Hospital, Jilin UniversityPhase I , Changchun, Jilin, China Department of Nuclear Medicine and PET-CT Center The Second Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang Province 310009 P. R. China Research Institute of Resources Insects, Chinese Academy of Forestry, Kunming 650224, People’s Republic of China Department of Infectious Disease, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, People's Republic of China. Van't Hoff Institute for Molecular Sciences; University of Amsterdam; 1098 XH Amsterdam; The Netherlands; State Key Laboratory of Luminescence and Applications Radiology Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin, People’s Republic of China Tennessee Technological University, Cookeville, Tennessee 38505 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 66 Tong-an Road, Tianjin 300070, China. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China Mathematics and Computer Science Division Argonne National Laboratory Argonne Illinois 60439 Renal Division of Peking University First Hospital Beijing China 1Department of Functional Genomics, Isis Pharmaceuticals, Carlsbad, California and Department of Cardiology, First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29, Wangjiang Road, Chengdu 610064, P. R. China; Department of Radiology, West China Hospital, Sichuan University, No. 37, Guoxue Street, Chengdu 610041, P. R. China Department of Chemistry; Tulane University; Louisiana 70118; USA 1Dermatology and From the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Febres-Aldana, H. Zhang). Hospital of Stomatology, Jilin University, Changchun 130015, China Key Laboratory of Green Chemistry and Technology; Ministry of Education; College of Chemistry; Sichuan University; Chengdu Emergency Department, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Chengdu, Sichuan, 610072, China Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China Departement für Biomedizin, Universität Basel, Schweiz Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam Road Hong Kong Department of Rehabilitation Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, and Integrated Genomics, Inc., 2201 West Campbell Park Drive, Chicago, Illinois 60612 Department of Clinical Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200062, China Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and; Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032; and Molecular Diagnostic Laboratory, Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R China, and School of Chemistry, Northeast Normal University, Changchun 130024, P. R. China Department of Pathology, Ezhou Hospital, People’s Hospital, Wuhan University, Ezhou, China Department of Biological Sciences Texas Tech University Lubbock TX 79409 USA Department of Pharmacy Wuhan No. 1 Hospital Wuhan 430022 P. R. China College of Physical Science and Technology, Sichuan University, Chengdu 610065, China; and Department of Natural Resources and Environmental Science, University of Nevada-Reno, 1664 N Virginia Street, MS 370, Reno, Nevada 89557, Tennessee Technical University, Cookeville, Tennessee 38505, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Geological Survey, Menlo Park, California 94025, and Woodrow Wilson International Center for Scholars Department of Skull Bases & Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu 610041, China. csclss@mail.sc.cninfo.net Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences Shenzhen China Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China; College of Life Sciences University of Chinese Academy of Sciences Beijing China School of Acupuncture and Massage, Chengdu University of TCM, Chengdu 610036, China; Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Chengdu University of TMC, Chengdu 610075. Department of Nephrology, Peking University First Hospital, Beijing 100034, China. hongzh@bjmu.edu.cn National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, China Department of Respiratory Medicine, Peking University First Hospital, Beijing 100034, China. Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Institute of Coal Geology, Xi'an Branch, China Coal Research Institute (CCRI), Xi'an 710054, People's Republic of China Lankenau Institute for Medical Research Department of Science and Education, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. Clinical Pharmacology Institute, Nanchang University, Nanchang, China; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, and Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong 515063, P. R. China Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098XH Amsterdam, The Netherlands University of Rochester, Rochester, New York Department of Gynecology, Jinan Women and Children’s Health Hospital, Jinan, Shandong, P.R. China Anhui Research Academy of Environmental Sciences, Hefei 230026, China. Email: 931525821@qq.com. Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611 Department of Pharmacy, Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s Hospital, Shanghai 200233, China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650031, P.R.China.526028544@qq.com. College of Mechanical and Electric Engineering, Changchun University of Science and Technology, Changchun 130022, China; National Base of International Science and Technology Cooperation in Optics, Changchun 130022, China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, People's Republic of China Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China; Teaching and research section of Neuropsychiatry, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China School of Material Science and Engineering; Guilin University of Electronic Technology; Guilin 541004; China Research Base of Key Laboratory of Surveillance and Early Warning of Infectious Disease of China CDC Pudong New Area Center for Disease Control and Prevention Shanghai China; Pudong Institute of Preventive Medicine Fudan University Shanghai China Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People's Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education Beijing China Hunan University of Traditional Chinese Medicine, Changsha 410007, China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , 100101, Beijing , China Institute of Biostatistics, Fudan University, Shanghai, People’s Republic of China Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, Gansu, China; Gansu Wuwei Institute of Medical Sciences, Wuwei, China Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China;; Department of Gastroenterology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China. Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun City, China Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Collaborative Innovation Center for Biomedicine, Life Science Institute, Guangxi Medical University, Nanning, Guangxi, China Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China Department of Pathophysiology, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, China. zhangh1227@sohu.com Department of Chemistry, Beijing Normal University, Beijing 100875, P. R. China, and Department of Chemistry, Fuyang Teachers College, Fuyang 236400, P. R. China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Weihai China Phase 1 Clinical Research Center the First Hospital of Jilin University Changchun China National Food Research Institute, Tsukuba, Ibaraki, Japan. Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287 1 Department of Statistics and Finance, University of Science and Technology of China, Hefei, Anhui 230026, China, 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA and 3Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546; 1 Department of Statistics and Finance, University of Science and Technology of China, Hefei, Anhui 230026, China, 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA and 3Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546 The Charles Institute of Dermatology; School of Medicine and Medical Science; University College Dublin; Dublin; Ireland School of Sensing Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Eye Center and College of Optometry, Tianjin Medical University, Tianjin, China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City, Fuzhou 350207 P. R. China Department of Medicine, University of British Columbia Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.; University of Chinese Academy of Sciences, Beijing 100049, China. Joint International Research Laboratory of Biomass Energy and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, People’s Republic of China State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, China. h.zhang@uva.nl. Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands. h.zhang@uva.nl. Department of Women’s Health, Jinniu Maternity and Child Health Hospital of Chengdu, Cheng Du Shi, Si Chuan Sheng, China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Guangxi Colleges and Universities Key Laboratory of Exploitation and Protection of Beibu Gulf Marine Biological Resources, Qinzhou University, Guangxi, China College of Health Management, Henan Finance University , Zhengzhou , Henan , China College of Physics Science and Technology, Shenzhen University, Shenzhen 518060, China. Department of Thoracic Surgery, Tang Du Hospital, The Fourth Military Medical University, Xi'an 710038, China. jiangtaochest@163.com. Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China. State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu 610051, P. R. China Department of Pathophysiology, Shanxi College of Traditional Chinese Medicine, Xianyang 712046, Shanxi, China. zhangh1227@sohu.com Department of Obstetrics & Gynecology, Reproductive Medicine Center, The Second Affiliated Hospital of Soochow University, Soochow, 215004, China. Department of Phase I Clinical Trial Unit, First Hospital of Jilin University, Changchun, Jilin, China Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Nuclear Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, People’s Republic of China School of Astronautics, Beihang University, Beijing 100191, China Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang , China Zhejiang University Zhejiang Institute of Modern Physics, , Hangzhou 310027, China and Department of Physics, , Hangzhou 310027, China; Zhejiang University Zhejiang Institute of Modern Physics, , Hangzhou 310027, China and Department of Physics, , Hangzhou 310027, China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Vertex Pharmaceuticals, Incorporated, Cambridge, MA 02139, USA. Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun, PR China Renal Division, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China; Research Units of Diagnosis and Treatment of lmmune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing , China School of Acupuncture and Moxibustion, Massage and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410000. zh5381271@sina.com. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100191 China College of Mechanical Electrification Engineering Tarim University Alaer China Kinexus Bioinformatics Corporation, Suite 1, 8755 Ash Street, Vancouver, British Columbia, Canada, V6P 6T3. 2Isis Pharmaceuticals, Carlsbad, California Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200233 China Medical Review Department 1, Center for Drug Evaluation China National Medical Products Administration No. 128 Jianguo Road, Chaoyang District Beijing 100022 P. R. China Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, No. 1, Shuanghu Branch Road, Yubei District, Chongqing 401120, China Ophthalmology Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 65000, China Department of Clinical Laboratory Shanghai Children’s Hospital Shanghai Jiaotong University Shanghai China Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, People’s Republic of China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, P. R. China Renal Division, Peking University First Hospital, Peking University, Institute of Nephrology, Beijing, China Institute of Food Science and Technology Chinese Academy of Agriculture Sciences Beijing China Department of Biological Sciences; Texas Tech University; Lubbock, TX USA Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University; Chengdu 610064; P. R. China Department of Biostatistics, School of Public Health and Management, Chongqing Medical University, Chongqing, China Jilin Medical University; Jilin 132013; P. R. China Department of Endodontics School of Stomatology Jilin University Changchun China Department of Laboratory Medicine, The Sixth People’s Hospital of Yancheng City, Yancheng, Jiangsu, China; Department of Medicinal Botany, School of Pharmacy Second Military Medical University Shanghai 200433 PR China Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China. Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100080, People's Republic of China, and Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People's Republic of China Department of Thoracic Surgery, The Third Affitiated Hospital of Cqmu, Chongqing, China Department of Cardiology, First People's Hospital of Yunnan Province, Kunming 650032, China. Isis Pharmaceuticals; Carlsbad CA Molecular Discovery Research, GlaxoSmithKline, Collegeville, Pennsylvania. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY School of Physical Science and Technology, School of Materials and Energy, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou 730000, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China Phase I Clinical Trial Unit, First Hospital, Jilin University, Changchun, China a State Key Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences ; Beijing , China. Chaoyang Center for Disease Control and Prevention, Beijing 100021, China. Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York USA School of Marine Science and Technology; Harbin Institute of Technology at Weihai; Weihai; P.R. China; State Key Laboratory of Urban Water Resource & Environment Department of Laboratory Medicine, Children's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200040, P.R. China Department of Cell Biology and Molecular Genetics, The University of Maryland, College Park, MD 20742, USA Van't Hoff Institute for Molecular Sciences; University of Amsterdam; The Netherlands China Jiliang University, Hangzhou, Zhejiang, China State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China Department of Natural Product Chemistry, Graduate School of Biomedical Sciences, Nagasaki University Department of Ophthalmology, China–Japan Union Hospital of Jilin University, Changchun, China Department of Gastroenterology, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, China. Key Laboratory of Ion Beam Bio-engineering, Institute of Biotechnology and Agriculture Engineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, China Laser Centre Vrije Universiteit Amsterdam, The Netherlands, Department of Chemistry, University of Wroclaw, Poland, Institute of Physics, Polish Academy of Sciences, Warsaw, Poland, and Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands 2Department of Pathology, Duke University School of Medicine, Durham, North Carolina. Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China Institute for Interdisciplinary Biomass Functional Materials Studies, Jilin Engineering Normal University, Changchun 130052, P. R. China Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400030, P.R. China; Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong, 250033, P.R. China College of Resources and Civil Engineering, Northeast University, Shenyang 110004, People's Republic of China, Estação Vitivinícola Nacional, Instituto Nacional de Recursos Biológicos, 2565-191, Dois Portos, Portugal, and Shenyang Pharmaceutical University, Shenyang 110006, People's Republic of China Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Peoples Republic of China Renal Division Peking University First Hospital Beijing China; Peking University Institute of Nephrology Beijing China; Key Laboratory of Renal Disease Ministry of Health of China Beijing China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) Ministry of Education Beijing China Orthopedic Department, Luoyang Orthopedic Hospital of Henan Province, Luoyang, China Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Chongqing Medical University, Chongqing 400016, China; Wound Stoma Care Outpatient Center, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China. Department of Anesthesiology, First Medical Center of Chinese PLA General Hospital; Chinese PLA Medical School School of Public Health Medical College of Soochow University 199 Ren'ai Road Suzhou 215123 Jiangsu China Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409 (R.H., Y.Z., H.Z.); and Department of Laboratory Medicine, Children’s Hospital of Shanghai, Shanghai, China Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA Department of Pharmacy, Tongji Hospital, Tongji University Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences Peking University Health Science Center Beijing China Shanghai Key Laboratory of Diabetes Mellitus Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute Shanghai Jiaotong University affiliated 6th People's Hospital Shanghai China College of Physics, Sichuan University, Chengdu 610065, China; Key Laboratory of High Energy Density Physics and Technology of Ministry of Education, Sichuan University, Chengdu 610065, China Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd., Shanghai 200137, China Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, Massachusetts 02139, and Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, Connecticut 06102 Department of Gynecology, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02215, USA.; Harvard Stem Cell Institute, Boston, MA 02215, USA. Van't Hoff Institute for Molecular Sciences; University of Amsterdam; 1090 GD Amsterdam; The Netherlands Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, China College of Food Science and Biological Engineering Zhejiang Gongshang Univ Hangzhou 310035 People's Republic of China Institute of Cardiovascular Science, Peking University Health Science Center Beijing 100191, China. School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City Fuzhou 350207 China; School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education) Tianjin University Tianjin 300072 China Shenzhen “120” Emergency Medical Services Center Shenzhen China Blood Purification Center, Affiliated Ri Zhao Peoples Hospital, JiNing Medical College, RiZhao, ShanDong Province - People's Republic of China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of China School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China Luoding Zhongshukang Pharmaceutical Co., Ltd. Luoding 527217, China. Department of Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China College of Physics, Sichuan University, Chengdu 610064, China; Key Laboratory of High Energy Density Physics and Technology of Ministry of Education, Sichuan University, Chengdu 610065, China Department of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 Department of Materials Science and Engineering; National University of Singapore; Singapore Pharmacology Laboratory, Shanxi Institute for Food and Drug Control, Taiyuan, China Eye Hospital First Affiliated Hospital of Harbin Medical University Harbin China State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, People’s Republic of China Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China. Department of Animal Nutrition and Feed Science College of Animal Science and Technology Huazhong Agricultural University Wuhan 430070 P. R. China Zhejiang University Zhejiang Institute of Modern Physics and Department of Physics, , Hangzhou 310027, China Affiliated TCM Hospital/Sino‐Portugal TCM International Cooperation Center/School of Basic Medicine Southwest Medical University Luzhou China Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29, Wangjiang Road, Chengdu 610064, P. R. China Molecular Diagnostic Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200040 , China Sino‐US Diagnostics Lab Tianjin Enterprise Key Laboratory of AI‐aided Hematopathology Diagnosis Tianjin China School of Electrical Engineering, Xi’an Jiaotong University, 710049, Xi’an, China Neuroinflammation Disease Biology Unit Lundbeck Research USA, 215 College Road, Paramus, New Jersey 07652, United States Department of Biological Sciences Texas Tech University Lubbock TX USA Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada, Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, People’s Republic of China; Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People’s Republic of China Department of Orthopeadic Surgery, the Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China Department of Physiology and Acupuncture and Massage College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. hzhang0123@sina.com Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 China Department of Nuclear Medicine and PET/CT Center The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 P.R. China Department of Emergency Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 Department of Chemistry, Tulane University, 70118, New Orleans, LA, USA Department of Science and Education, People's Hospital of Deyang City, Deyang, P. R. China; Department of Gynecology, the Central Hospital of Zibo, No. 54 of Gongqingtuan West Road, Zibo 255000, Shandong, China. School of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China Department of Hepatobiliary Surgery Xijing Hospital Fourth Military Medical University Xi'an China Department of Oncology, Hefei City, Anhui Province, P.R. China Anhui No.2 People’s Hospital, No. 1868 Dangshan Road, Yaohai District Center of Smart Laboratory and Molecular Medicine, NHC Key Laboratory of Birth Defects and Reproductive Health, School of Medicine, Chongqing University, Chongqing 400044, People’s Republic of China; Department of Clinical Laboratory, The Second Hospital of Shandong University, 250033 Jinan, Shandong, People’s Republic of China Peking University First Hospital Peking University Ministry of Health of China Beijing China Department of Neurology, The Second Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. Department of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China Department of Cardiology, People’s First Hospital of Yunnan Province, Kunming, Yunnan, China the MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China. Departments of Biochemistry and Molecular Biology and Human Genetics, University of Manitoba, Winnipeg, MB R3E OW3, Canada; Division of Medical Genetics, Shriver Center for Mental Retardation, Waltham, MA, 02452; and Harvard Medical School and Massachusetts General Hospital, Boston, MA 02254 Peking University Institute of Nephrology, Beijing, China Department of Thoracic Surgery The First Hospital of Jilin University Changchun P.R. China State Key Laboratory of Luminescence and Applications. Changchun Institute of Optics; Fine Mechanics and Physics; Chinese Academy of Sciences; Changchun, China; Van't Hoff Institute for Molecular Sciences. University of Amsterdam Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan; Department of Internal Medicine, Peking University Institute of Nephrology, Beijing 100034, P.R. China; Environmental Health Science Laboratory, Sumitomo Chemical Company, Osaka 554-8558, Japan; Department of Bioscience and Biotechnology, Okayama University Faculty of Engineering, Okayama 700-8530, Japan; Sumitomo Pharmaceuticals, Takarazuka 655-8555, Japan; and... Department of Cardiology, Tianjin Nankai Hospital, Tianjin, China (mainland) State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, P. R. China; Institute of Biostatistics, School of Life Sciences, Fudan University, P. R. China Department of Image Center, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China Department of Pharmacology, University of Arizona, Tucson, AZ, USA Digestive Department, the First Affiliated Hospital, Medical College, Zhejiang University. No.79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Department of Medical Physics, Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou China; College of Life Sciences University of Chinese Academy of Sciences Beijing China; Advanced Energy Science and Technology Guangdong Laboratory Huizhou China SignalChem Lifesciences Corporation, Richmond, BC, Canada; Medical Physics Division, Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Medicine Chinese Academy of Sciences Lanzhou China; School of Life Science University of Chinese Academy of Sciences Beijing China Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Department of Nephrology, Shandong Provincial Hospital, Shandong University, Shandong 250021, China. Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA Renal Division, Peking University First Hospital, Beijing, People’s Republic of China; Peking University Institute of Nephrology, Beijing, People’s Republic of China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People’s Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People’s Republic of China Peking University First Hospital Beijing China Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China; Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200437, China Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Mineral Processing and Biometallurgy Institute, Rock and Mineral Testing Center of Henan Province, 28 Jinshui Road, Zhengzhou, Henan 450012, PR China Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 Department of Cell Resource Center,Institute of Basic Medical Science,CAMS and PUMC,Beijing 100005,China. Wilmar (Shanghai) Biotechnology Research & Development Center Co. Ltd, Shanghai 200137, China State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, P. R. China; School of Pharmacy, Guizhou Medical University, Guian New District, , Guizhou 550025, P. R. China Graduate School of Pharmaceutical Sciences, The University of Tokyo Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Advanced Materials Laboratory, Fudan University, Shanghai, 200433, P. R. China, Key Lab of Molecular Engineering of Polymers and Engineering Center of Coating of Chinese Ministry of Education, Fudan University, Shanghai 200433, P. R. China, Materials Science and Engineering, Central South University, 410083, Changsha, P. R. China, and Structural Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden Department of Archives, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China At the time of the study Bruce R. Schackman was, and Sue J. Goldie, Milton C. Weinstein, and Kenneth A. Freedberg are now, with the Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass. Elena Losina and Dr. Freedberg are with the Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston. Dr. Losina, Hong Zhang, and Dr. Freedberg are with the Division of General Medicine and Partners AIDS Research Center,... State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100, China. Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037 Department of Burns, The 159th Hospital of PLA, Zhumadian 463008, He Nan Province, P.R. China. State Key Laboratory of Luminescence and Applications; Changchun Institute of Optics; Fine Mechanics and Physics; Chinese Academy of Sciences; Changchun 130033 Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, China; Z-BioMed, Inc., Rockville, Maryland, USA Department of Respiratory Medicine, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China. Hospital of Shihezi University, Shihezi City, Xinjiang-Urygur Autonomous Region Xinjiang, PR China Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario M5S 3G9, Canada, Department of Materials Science & Engineering, University of Toronto, 184 College Street, Toronto, Ontario M5S 3E4, Canada, and Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada Zhejiang University 3 Zhejiang Institute of Modern Physics and Department of Physics, , Hangzhou 310027, China School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China Department of Ultrasound Beijing Friendship Hospital, Capital Medical University Beijing China Department of Phase I Clinical Trial Unit, The First Hospital of Jilin University, Changchun, Jilin, China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300350, China University of Texas MD Anderson Cancer Center Houston Key Laboratory of Arrhythmias of Ministry of Education of China, Tongji University, 389 Xin Cun Road; Institute of Medical Genetics, Tongji University, Shanghai 200065, China Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Pathology, Peking University, First Hospital, Beijing, China Department of Pharmacy; Zhejiang Cancer Hospital; Hangzhou; China Department of Gastroenterology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, CA; Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510180, P.R. China Institutes of Physical Science and Information Technology, School of Materials Science and Engineering, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, Anhui 230601, China; Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China School of Cyber Security and Computer, Hebei University, Baoding, China Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Sichuan University 1 Institution of Atomic and Molecular Physics, , Chengdu, 610065, People's Republic of China; Sichuan University 2 College of Physical Science and Technology, , Chengdu, 610065, People's Republic of China Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China CAS–MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, People's Republic of China; Naval Submarine Academy, Qingdao, Shandong 266000, People's Republic of China Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China; Institute of Mycology, Jinan University, Guangzhou, Guangdong, China College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. zh5381271@sina.com. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China and College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Department of Pathology, MD Anderson Cancer Center, Houston, United States State Key Laboratory of Crop Stress Biology for Arid Areas; College of Plant Protection, Northwest A&F University, Yangling; Shaanxi; P. R.; China School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China Environmental Science Institute of Shantou Shantou 515041 China Wilmar (Shanghai) Biotechnology Research & Development Center Company, Limited, Shanghai 200137, People’s Republic of China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Urban Water Resource and Environment; Harbin Institute of Technology; Harbin 150090; China 6Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China. Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University Suzhou China; Jiangsu Institute of Clinical Immunology & Jiangsu Key Laboratory of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou China General Internal Medicine The University of Texas MD Anderson Cancer Center Houston TX USA Division of Hematology/Oncology, Department of Medicine, SUNY Downstate Medical Center, Box 20, 450 Clarkson Ave, Brooklyn, NY 11203, USA. Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Beibu Gulf University, Qinzhou, China Chemical Engineering Program, University of California, San Diego, La Jolla, CA 92093; Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan; Zhejiang University Medical PET Center, Hangzhou, Zhejiang 310058, China; The Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 310009, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease School of Public Health, Soochow University Suzhou China ‡Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Mianyang Municipal Mental Health Center, Sichuan Province 621000. Department of Electrical and Electronic Engineering The University of Hong Kong Pok Fu Lam Road Hong Kong SAR P. R. China Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA State Key Laboratory of Space Power-sources Technology Shanghai Institute of Space Power-Sources Shanghai 200245 P. R. China School of Food Science and Biological Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang Province 310035, People’s Republic of China College of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, China School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China Renal Division, Peking University First Hospital, Beijing, China; Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200062, China Department of Dermatology, Institute of Biomedicine and Surgery, Linköping University, 581 85 Linköping, Sweden Department of Laboratory Medicine, University of California, San Francisco, CA 94143; and Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana; Departments of Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, and Key Laboratory of Chronic Kidney Disease Prevention and Treatment at Peking University, Ministry of Education of China Beijing China Wilmar (Shanghai) Biotechnology R&D Center Co. Ltd. No.118 Gaodong Road, Pudong New District Shanghai 200137 China Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands, Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven, The Netherlands, and Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands State Key Laboratory of Ultrasound Engineering in Medicine Co‐founded by Chongqing and the Ministry of Science College of Biomedical Engineering Chongqing Medical University Chongqing 400016 China State Key Laboratory of Physical Chemistry of Solid Surfaces and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005 Departments of Pathology Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China Department of Hand and Foot Surgery, Department of Orthropedics, Qilu Hospital of Shandong University, Jinan, P.R. China School of Life Sciences & Institute of Archaeological Science, Fudan University, Shanghai 200438, China; Departments of Otorhinolaryngology–Head and Neck Surgery, The Affiliated Hospital of Hebei University of Engineering, Handan, China Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China. hnzhangh67@yahoo.com.cn Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China Sixal Inc., Torrance, CA 90502; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, P.R. China Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Central Laboratory, Shanghai Seventh People’s Hospital, Shanghai 200137, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China Department of Biologic and Materials Sciences University of Michigan School of Dentistry Ann Arbor Michigan USA Department of Electrical and Electronic Engineering, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China Contribution from Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, and Kanebo Seiyaku, LTD., 3-1, Kanebo-machi, Takaoka 933-0856, Japan State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China Department of Radiation Oncology, Winship Cancer Center, Emory University School of Medicine, Atlanta, GA, USA. College of Physics and Energy, Shenzhen University, Shenzhen, China Renal Division, Department of Medicine Peking University First Hospital Beijing PR China; Institute of Nephrology Peking University Beijing PR China Department of Geriatric Medicine, Shanghai Jiatong School of Medicine Ruijin Hospital North Shanghai China School of Municipal and Environmental Engineering and State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, P. R. China Key Laboratory of Herbage and Endemic Crop Biology, Ministry of Education, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China; College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010070, China Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 Electron Microscopy Centre of Lanzhou University and Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education, Lanzhou University, Lanzhou 730000, China Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China Clinical Laboratory, Children’s Hospital of Shanghai Jiaotong University ajp Peking University First Hospital, Renal Division , Beijing , China. Institute of Nephrology, Peking University, Beijing, China. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle Road, Xi’an, Shaanxi 710032, China Research Center of Chinese Herbal Resource Science and Engineering Guangzhou University of Chinese Medicine Guangzhou China; Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education Guangzhou China; Joint Laboratory of National Engineering Research Center for the Pharmaceutics of Traditional Chinese Medicines Guangzhou China Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin City, Nangang District, Heilongjiang Province, Harbin, China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Heilongjiang Province, Harbin, China State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Department of Biological Sciences, Texas Tech University, Lubbock, Texas, USA. hong.zhang@ttu.edu Department of Plant Pathology, College of Agriculture, Guizhou University, Guiyang, Guizhou Province 550025, China; Guizhou Academy of Testing and Analysis, Guiyang, Guizhou Province 550014, China Institution of Quality Standard and Testing Technology for Agro-product, Shandong Academy of Agricultural Sciences, Jinan, PR China; Institution of Quality Standard and Testing Technology for Agro-product, Shandong Provincial Key Laboratory of Testing Technology for Food Quality and Security, Jinan, PR China School of Chemistry and Chemical Engineering; Shandong University; 250100 Jinan; P. R. China The University of Queensland Centre for Computational Molecular Science, Chemistry Building (No. 68), , Qld 4072, Brisbane, Australia Reproductive and Genetic Hospital of CITIC‐Xiangya Changsha China Hunan Center for Disease Control and Prevention, Changsha, China. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China Pediatric Urodynamic Center, Pediatric Surgery of First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medicine Universities Henan, PR China; Pathology Department of First Affiliated Hospital of Zhengzhou University, PR China Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan School of Science, Jiangsu Ocean University, Lianyungang 222005, China Key Laboratory of Clinical Medicine, Zhengzhou, Henan Province, China State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors of Jilin Province, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, People’s Republic of China Department of Obstetrics and Gynecology, Affiliated Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China. Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou, China. Renal Division, Peking University First Hospital, Beijing, China; Department of Nuclear Medicine Second Hospital of Zhejiang University School of Medicine Hangzhou PR China Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. Renal Division, Peking University First Hospital, Beijing; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education Beijing PR China; Research Units of Diagnosis and Treatment of Immune‐Mediated Kidney Disease Chinese Academy of Medical Sciences Beijing PR China Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, Singapore 117575, Singapore Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China Department of Clinical Medicine, Changchun Medical College, Changchun, Jilin 130031, P.R. China Jilin Medical University; Jilin 132013; China Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China Department of Obstetrics and Gynaecology, People's Hospital of Putuo District, Zhoushan, Zhejiang 316000, P.R. China Administrative Bureau of Hunan East Dongting Lake National Nature Reserve Yueyang China Department of Critical Care Medicine, Mudanjiang Medical University Hongqi Hospital, Mudanjiang 157011, Heilongjiang, China (Zhang H, Li HH, Zhang Y, Cui LM, Zhao LL, Yao QH, Xie FJ); Department of Ear-Nose-Throat, Mudanjiang Medical University Hongqi Hospital, Mudanjiang 157011, Heilongjiang, China (Xu YM). Corresponding author: Xie Fengjie, Email: mdjxfj1971@126.com. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, P. R. China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China Central Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. Micro/Nano Technology Center; Tokai University; Hiratsuka; Japan Department of Traditional Chinese Medicine, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, China Gene Expression and Protein Biochemistry, and Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China; Department of Sports Medicine Zhejiang University School of Medicine Hangzhou 310058 China; Zhejiang University‐University of Edinburgh Institute Zhejiang University School of Medicine and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of Medicine Hangzhou 310058 China Department of Biliary‑Hepatic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China Centre for Computational Molecular Science, Chemistry Building 68, The University of Queensland, Qld 4072, Brisbane, Australia Medivir AB, Lunastigen 7, S-141 44, Huddinge Division of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Departments of Pharmaceutical Chemistry, Radiology, Neurology, Cellular and Molecular Pharmacology, Medicine, and Biochemistry and Biophysics, University of California, San Francisco, CA 94143; and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037 Van't Hoff Institute for Molecular Sciences University of Amsterdam Science Park 904 Amsterdam 1098 XH The Netherlands Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China State Key Laboratory of Pharmaceutical New‐tech for Chinese Medicine Jiangsu Kanion Pharmaceutical Co. Ltd Lianyungang China Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, United States Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China. zhanghongjz@yahoo.com.cn Department of Pathology and Cell Biology Taub Institute, Columbia University New York City NY USA Department of Gastroenterology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Department of Nuclear Medicine and Medical PET Center; The Second Hospital of Zhejiang University School of Medicine; Hangzhou; China Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. maxr@263.net Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China Department of Respiratory Medicine, First Hospital, Peking University, Beijing 100034, China. Reproductive Medicine Center The Second Affiliated Hospital Soochow University Suzhou China Nanjing University Nanjing Jiangsu China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China Zhejiang Institute of Modern Physics and Department of Physics, , Hangzhou 310027, China; Zhejiang University and Department of Physics, , Hangzhou 310027, China Research Institute of Highland Forestry, Chinese Academy of Forestry, Kunming, People’s Republic of China Department of Clinical Pharmacology, Tongji Hospital, Tongji University School of Medicine, Shanghai, P.R. China Department of Laboratory Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China School of Pharmacy and Centre for Computational Molecular Science, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia School of Textile and Material Engineering, Dalian Polytechnic University, Dalian, 116034, China Anhui Institute of Environment Science, Hefei 230061, China. zhanghontkt@126.com Department of Neurology, 960th Hospital of PLA Zibo 255300, Shandong, PR China. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States College of Resource and Environment, Shanxi University, Taiyuan 030006, China. Department of Oncology, Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China, and Faculty of Science, School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, England, U.K. Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui Graphene Engineering Laboratory, Anhui University, Hefei, Anhui 230601, China; Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Anesthesiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, P. R. China Department of Gastroenterology, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, China. National Institute of Biological Sciences, Beijing 102206, People's Republic of China; Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China. Peking University First Hospital, Renal Division, Xi Cheng District, Beijing, China. Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China Department of Chemistry, National University of Singapore, Singapore 117543, Singapore College of Physics and Information Engineering, Institute of Micro-Nano Devices and Solar Cells, Fuzhou University, Fuzhou 350108, China Clinical Pharmacology Institute, Nanchang University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China College of Chemistry & Chemical Engineering, Fuyang Normal College, Fuyang, Anhui 236037, P.R. China Key Laboratory of High Energy Density Physics and Technology of Ministry of Education, Sichuan University, Chengdu 610065, China Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada, and Department of Pharmaceutical Sciences, University of Toronto, 19 Russell Street, Toronto, Ontario M5S 2S2, Canada School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China Departments of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, and Beijing Polytechnic University, Beijing 100022, PRC Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Insititute of Antibiotics, Chengdu University Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Chemistry, State University of New York Stony Brook, Stony Brook, New York11794, United States Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;; Peking University Institute of Nephrology, Beijing, China;; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; and; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China Department of Cell Biology (H.Z.), Capital Medical University, Beijing 100069, People's Republic of China d School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China; Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China Department of Orthopedics Ganzhou Municipal Hospital Ganzhou Jiangxi China Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, China Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; PR China; Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences Department of Hematology, No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine at Baltimore, Baltimore, Maryland, USA Department of Biotechnology The Technical University of Denmark Lyngby 2800 Denmark Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China;; Institute of Nephrology, Peking University, Beijing, People's Republic of China;; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People's Republic of China; and The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, China Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100730, China. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Enzymology & Mechanistic Pharmacology, Gene Expression & Protein Biochemistry, and Oncology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426 Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China and Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing 100034, China Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), HangzhouChina; Department of Orthopedic Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of Neurology The First Affiliated Hospital of Anhui Medical University 218 Jixi Road 230022 Hefei Anhui China Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655; Institutes of Physical Science and Information Technology School of Materials Science and Engineering Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Anhui Graphene Engineering Laboratory Anhui University Hefei Anhui 230601 P. R. China; Hefei National Laboratory for Physical Science at Microscale Hefei Anhui 230026 P. R. China; Department of Materials Science & Engineering University of Science and Technology of China Hefei Anhui 230026 P. R. China Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China Department of Clinical Laboratory, Wuhan City Maternal and Child Health Care Hospital, Wuhan, Hubei Province, China. Ultra-Precision Machining Center, Zhejiang University of Technology, Hangzhou 310023, China; Key Laboratory of Special Equipment and Advanced Processing Technology of Ministry of Education, Zhejiang University of Technology, Hangzhou 310023, China Asthma Center of the Gansu Provincial Hospital, Lanzhou, China Z-BioMed, Inc. Rockville, Maryland 20855 School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300350 China National Research Center for Wildlife Borne Diseases, Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of China Wilmar (Shanghai) Biotechnology Research and Development Center, Shanghai 200137, China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Collaborative Innovation Center for Genetics and Development, Shanghai Jiaotong University, Shanghai, 200240, China. State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, China Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 Department of Pathophysiology, Medical College of Tongji University, Shanghai 200331, China. Nation Center for the Develepment of TCM Technology Beijing 100027 China Department of Pathology Peking University First Hospital Beijing China; Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Radiation Oncology of Cancer Center West China Hospital of Sichuan University Chengdu China Central South University 1 Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, , No. 605 Lushan South Road, Changsha, Hunan 410012, People’s Republic of China; Central South University 2 Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, , Changsha, Hunan 410012, People’s Republic of China State Key Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences, Beijing, China hongzhang@sun5.ibp.ac.cn. Nephrology Department, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang 317000, China Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China Key Laboratory for Colloid and Interface Chemistry of State Education Ministry; School of Chemistry and Chemical Engineering; Shandong University; Jinan; China Department of Gynaecology, Guang'anmen Hospital Beijing 100053, China. Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China The First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China Air Force Engineering University Department of Psychology, Nanjing University, Nanjing, China Van't Hoff Institute for Molecular Sciences; University of Amsterdam; 1098 XH Amsterdam; The Netherlands First People's Hospital of Yunnan Province Kunming China Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Sciences Peking University Health Science Center Beijing China Department of Nephrology, Tsukuba Central Hospital, Ushiku, Japan Department of General Surgery, Second Hospital of Jilin University, Changchun 130041, China. zhanghong519@hotmail.com Department of Physics; Hebei Normal University, and Hebei Advanced Thin Film Laboratory; Shijiazhuang 050016; China; Department of Science Respiratory and Critical Care Medicine Department Peking University First Hospital Beijing China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101 , China; College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China Department of Phase I Clinical Trial Unit, The First Hospital of Jilin University, Changchun, China College of Tobacco Science Henan Agricultural University/Flavors and Fragrance Engineering & Technology Research Center of Henan Province Zhengzhou China 450046 Department of Pediatrics, Qilu Hospital of Shandong University Jinan 250012, China. Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Zhejiang, Hangzhou 310009, China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Center of Excellence in Medical Molecular Imaging of Zhejiang State, Hangzhou, 310009, China First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People’s Republic of China a College of Environment and Resources , Shanxi University , Taiyuan , P. R. China Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, and Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HA Wageningen, The Netherlands Metabolic Department, Metabolic Hospital of Tianjin Medical University, Tianjin 300000, China Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China School of Life Science and Technology, Dalian University of Technology, Dalian 116012, China for the VICTORIA Study Group Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China Institute of Nutrition & Health, Qingdao University, Qingdao, Shandong 266071, People’s Republic of China Department of Ophthalmology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China From Harvard School of Public Health, Boston University School of Public Health, Harvard Medical School, and Massachusetts General Hospital, Boston, Massachusetts; Community Research Initiative of New England, Brookline, Massachusetts; and Cooper Hospital/University of Medicine and Dentistry of New Jersey and Robert Wood Johnson Medical School, Camden, New Jersey. Department of Molecular Biology, Aarhus University, DK-8000 Aarhus, Denmark College of Physics and Electronic Engineering; Chongqing Normal University; Chongqing 401331; P. R. China Surgical Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. Institute of Special Materials and Technology, Fudan University, Shanghai 200433, P. R. China; Department of Chemistry, Fudan University, Shanghai 200438, China Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China Centre for Computational Molecular Science, AIBN Building (#75), The University of Queensland, Qld 4072, Brisbane, Australia Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 38 Zheda Road, Hangzhou 310009, China; Zhejiang University Medical PET Center, Zhejiang University, 38 Zheda Road, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, 38 Zheda Road, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China b Tennessee Technological University , Cookeville , TN , USA Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588 Laboratory of Photonics and Interfaces Department of Chemistry and Chemical Engineering École Polytechnique Fédérale de Lausanne 1015 Lausanne Switzerland Emergency Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Infectious Diseases, First Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710061, China. Hefei CAAS Nutridoer Co. Ltd. Academy of Food Nutrition and Health Innovation Chinese Academy of Agricultural Sciences Hefei China Acupuncture and Rehabilitation Department, Zigong City Hospital of Traditional Chinese Medicine, Zigong Electron Microscopy Centre of Lanzhou University School of Materials and Energy Key Laboratory of Magnetism and Magnetic Materials of Ministry of Education School of Physical Science and Technology Lanzhou University Lanzhou 730000 China Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China Eye Hospital, Harbin Medical University, Nangang District, Harbin, Heilongjiang Province, China.; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne VIC, Australia. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, PR China Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, P.R. China Department of Gynaecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China First Affiliated Hospital and Institute of Mycology, Jinan University, Guangzhou, PR China Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA Wilmar (Shanghai) Biotechnology R&D Center Co., Ltd. No.118 Gaodong Road, Pudong New District Shanghai 200137 China School of Medicine, Department of Medical Sciences, Örebro University, Örebro, Sweden Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai China Micro/Nano Technology Center Tokai University 4‐1‐1 Kitakaname Hiratsuka Kanagawa 259‐1292 Japan Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA; College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China School of Public Health Soochow University Suzhou China State Key Laboratory of Physical Chemistry of Solid Surfaces and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); and College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005; China Gansu Provincial Hospital Lanzhou China From the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA; the Medical College of Virginia, Virginia Commonwealth University, Department of Biochemistry and Molecular Biophysics, Richmond, VA; and Commonwealth Biotechnologies, Inc, Richmond, VA. Department of Rheumatology and Immunology, First People's Hospital of Yunnan, Kunming, Yunnan 650032, P.R. China Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, China; University of Chinese Academy of Sciences, Beijing, China Department of Radiology, Tianjin Chest Hospital, Tianjin, China Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892; and Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China; Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, Medivir AB, Huddinge, Sweden, and MTC, Center for Microbiology and Tumorbiology, The Karolinska Institute, Stockholm, Sweden Department of Pathology, the First Hospital of Lanzhou University, Lanzhou, Gansu, China Prysis Biotechnologies, Shanghai, China. School of Light Industry, Beijing Technology and Business University, Beijing 100048, China; China National Center for Food Safety Risk Assessment, Beijing 100022, China Central Laboratory, Seventh People’s Hospital of Shanghai University of TCM, Shanghai 200137, People’s Republic of China Department of Radiology Tianjin Chest Hospital Tianjin China Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China; School of Life Science, University of Chinese Academy of Sciences, Beijing, China Department of Stomatology The First Affiliated Hospital of Harbin Medical University Harbin China for the LASRE trial investigators Department of Cell Biology and Molecular Genetics, The University of Maryland , College Park , MD 20742 , USA Department of Chemical Engineering, Northwest Minzu University, Lanzhou 730000, China; Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Lanzhou 730000, China; Gansu Provincial Biomass Function Composites Engineering Research Center, Lanzhou 730000, China; Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Lanzhou 730000, China Department of Medical Microbiology, The People’s Hospital of Suzhou New District, Suzhou, Jiangsu, China Department of Biology School of Life Sciences Southern University of Science and Technology Shenzhen China; Institute of Plant and Food Science Southern University of Science and Technology Shenzhen China; Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes Southern University of Science and Technology Shenzhen China State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China Department of Emergency, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China Harbin Institute of Technology chemistry Xidazhi Rd 150001 Harbin CHINA Department of Biologic and Materials Sciences University of Michigan School of Dentistry Ann Arbor MI USA Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin 300070, China Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Contribution from the Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada, Institute of Biomaterials and Biomedical Engineering, Department of Materials Science and Engineering, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario M5S 3G9, Canada, and Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Department of Polymer Science School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University No. 27, Shanda Nanlu Jinan 250100 P. R. China School of Pharmacy Yantai University & State Key Laboratory of Long‐acting and Targeting Drug Delivery Technologies Yantai China State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P.R. China.; National Institute of Biological Sciences, Beijing, 102206, P.R. China. Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Chemistry; Tulane University; Louisiana 70118, USA Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA College of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Institute of Traditional Chinese Medicine Resources Protection and Development, Anhui Academy of Chinese Medicine Hefei 230012, China. Department of Computer Science, Georgia Southern University, Savannah, GA; Department of Colorectal Surgery, Shengjing Hospital, China Medical University, Shenyang, China. Department of Biostatistics and Computational Biology, School of Life Sciences; Fudan University; China Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Product Analyasis Division, Research Laboratories, Kanebo Seiyaku, Ltd., 3-1, Kanebo-machi, Takaoka 933-0856, Japan, and Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Urology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences Beijing 100101 PR China Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA Central Laboratory, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China Institute of Loess Plateau, Shanxi University , Taiyuan, Shanxi, China Tianjin Institute for Women’s Health, Tianjin, China 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Renal Division, Peking University First Hospital, Beijing, China; Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing, China Chengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu, Sichuan Province, China. Center for Medical Records, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China Department of Emergency, The First Affiliated Hospital of Anhui Medical University Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin Heilongjiang 150090 China; School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin Heilongjiang 150090 China Sichuan University Department of Developmental Biology, National Institute of Agrobiological Sciences, Oowashi 1-2, Tsukuba, Ibaraki 305-8634, Japan Department of Cardiology First People's Hospital of Yunnan Province Kunming China Department of OphthalmologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pharmacy Guizhou Province People's Hospital Guiyang Guizhou P. R. China Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, Gansu 730000, China Joint Surgery of Orthopaedic Institute the First Affiliated Hospital of General Hospital of the People's Liberation Army Beijing China Department of Neurology First Hospital of Yulin City Yulin City Shaanxi Province China Department of Statistics and Finance, University of Science and Technology of China, Hefei, Anhui, China Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China; Peking University Institute of Nephrology, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing, China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China Department of Pathogen Biology—Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen of Jiangsu Province, Key Laboratory of Human Functional Genomics of Jiangsu Province, Center of Global Health, Nanjing Medical University, Nanjing, China School of Public Health Weifang Medical University Weifang China Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Soochow University, Suzhou, China (H.Z.) National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang, Beijing 100101, People's Republic of China Department of Complex Prescription of TCM, China Pharmaceutical University, 639 Long Mian Road, Nanjing 211198, People’s Republic of China Department of Cell Biology and Genetics, College of Life Sciences School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, People’s Republic of China Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China East Hospital Tongji University School of Medicine Shanghai China; Institute of Medical Genetics Tongji University Shanghai China Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409 (J.C., R.H., Y.Z., G.S., H.Z.); and Epicept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, and Shire-BioChem Inc., 275 Armand-Frappier Boulevard, Laval, Québec H7V 4A7, Canada Research Center for Molecular Medicine, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116023, China. Key Laboratory of Hormones and Development (Chinese Ministry of Health), Metabolic Disease Hospital, Endocrinology Institute, Tianjin Medical University, Tianjinï¿½300070, P.R. China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun People's Republic of China Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, and Departments of Chemistry and Biology, State University of New York College at Fredonia, Fredonia, New York 14063 Van't Hoff Institute for Molecular Sciences, Faculty of Science, University of Amsterdam, Nieuwe Achtergracht 127-129, 1018 WV Amsterdam, The Netherlands, Faculty of Chemistry, Wrocław University, 14 Joliot-Curie Street, 50-383 Wrocław, Poland, and Department of Physics and Astronomy, Free University, Amsterdam, The Netherlands School of Marine Sciences Sun Yat-sen University, Guangzhou 519082, China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Sun Yat-sen University, Guangzhou 519082, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou 519082, China State Key Laboratory of Biocontrol and School of Life Sciences Sun Yat‐sen University Guangzhou China Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, and Department of Anesthesia, University of Michigan, Ann Arbor, Michigan, and the VA Medical Center, 2215 Fuller Road, Ann Arbor, Michigan 48105, and Department of Medicinal Chemistry, University of Washington, Seattle, Washington, 98195-7610 Department of Radiation Medicine, Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Institute of Modern Physics Lanzhou China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Institute of Modern Physics, Chinese Academy of Sciences Lanzhou China; School of Nuclear Science and Technology University of Chinese Academy of Sciences Beijing China; Department of Science and Technology Gansu Wuwei Tumor Hospital Wuwei China First Affiliated Hospital and Institute of Mycology, Jinan University, Guangdong, PR China Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 Department of Emergency, First Affiliated Hospital, Anhui Medical University, Hefei 230061, Anhui, China. Maxim Pharmaceuticals, 6650 Nancy Ridge Drive, San Diego, California 92121, and Institute for Medical Virology, Clinics of the Johann Wolfgang Goethe-University, Paul-Ehrlich-Strasse 40, 60596 Frankfurt, Germany Phase I Clinical Trial Unit First Hospital, Jilin University Jilin China Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032; Department of Ophthalmology, The People's Hospital of Deyang City, Deyang, Sichuan 618000, P.R. China Asthma Control and Prevention Center, the Gansu Provincial Hospital, Lanzhou, China; Renal Division Peking University First Hospital Peking University Institute of Nephrology Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University) Ministry of Education Beijing 100034 People's Republic of China Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University , Suzhou 215004 , China; Jiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology , Suzhou 215006 , China Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8816, and Department of Chemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505 Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Renal Division, Peking University First Hospital , Beijing , China; Institute of Nephrology, Peking University , Beijing , China; Key Laboratory of Renal Disease, Ministry of Health of China , Beijing , China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China , Beijing , China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Science , Beijing , China School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Central Laboratory, Seventh People’s Hospital of Shanghai University of TCM, Shanghai 200137, China Department of Radiology Affiliated Jiangning Hospital of Nanjing Medical University Nanjing China Department of Biomedicine (DBM), University Hospital, University of Basel, CH‑4031 Basel, Switzerland Department of Medical Laboratory, Children’s Hospital of Shanghai Jiaotong University, Shanghai, China Department of Nuclear Medicine; The Second Hospital of Zhejiang University School of Medicine; Hangzhou; China Department of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Institute of Geriatrics, Guangzhou, 510080, China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, P. R. China Taub Institute for Research on Alzheimer's Disease and Aging Brain & the Department of Pathology, Columbia University, New York, NY, USA Department of Materials Science and Engineering, National University of Singapore, 117574 Singapore Department of Rheumatology The First People's Hospital of Yunnan Province Kunming Yunnan Province China Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People's Republic of China Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology, Qingdao City 266042, People’s Republic of China Department of Radiology, Beijing Hospital, Beijing, China. School of Public Health, Ningxia Medical University, Yinchuan 750004, China. lindersy@126.com Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing; Renal Division of Peking University First Hospital, Beijing, China (H.Z.). Department of Radiology, Tianjin Chest Hospital, Tianjin 300052, China Departments of Oncological Sciences and Radiation Oncology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China Nanjing University, P.R. China Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Key Laboratory of Protein and Peptide Pharmaceutical, National Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences Beijing China 1Vanderbilt Cancer Center, Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232 Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China; Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China; Clinical medical research center for dementia and cognitive impairment in Hubei province , Wuhan 430071 , China From the Eye Hospital, the First Affiliated Hospital, Harbin Medical University, Harbin, China; and Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Houston Texas Department of Microbiology-Immunology and the Interdepartmental Immunobiology Center and the Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8816 Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, People’s Republic of China; Life Sciences Institute, Guangxi Medical University, Nanning, People’s Republic of China Experimental Oncology, Cross Cancer Institute, Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada College of Computer Science, Chongqing University, Chongqing 400030, China Jet Propulsion Laboratory California Institte of Technology Pasadena CA USA; Joint Institute for Regional Earth System Science and Engineering University of California Los Angeles CA USA Department of Radiology, Tianjin Chest Hospital, Tianjin 300222, China Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. phzhanghong@hotmail.com Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China Department of Otolaryngology-Head and Neck Surgery,the Affiliated Hospital of Hebei Engineering University, Handan, 056002, China. zh720716@sina.com Department of Chemistry and ‡Department of Physics & Engineering Physics, Tulane University, New Orleans, Louisiana 70118, United States Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China. Materials Directorate, Air Force Research Laboratory (AFRL/MLPO), Wright-Patterson AFB, Ohio 45433-7707, University of Dayton Research Institute, 300 College Park Drive, Dayton, Ohio 45469, and Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry for Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, 100190, P. R. China, and Graduate University of Chinese Academy of Sciences, Beijing, 100049, P. R. China Clinical Pharmacology Institute Nanchang University Nanchang People's Republic of China Department of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China Department of Biomedicine at University of Basel and University Hospital Basel, CH-4031, Basel, Switzerland. 1Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China Department of Colorectal Oncology, Fourth General Surgery Department, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province Zhejiang Litai Composite Material Co., Ltd., Deqing 313000, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld 4072, Australia Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, China; Research Units of Diagnosis and Treatment of Immuno-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Proteomics, State Key Laboratory of Molecular Biology, Graduate School of the Chinese Academy of Sciences, and SHARF Laboratory, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, Peoples Republic of China, and Changhai Hospital, The Second Military Medical University, Shanghai, Peoples Republic of China Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Applied Chemistry, Peking University, Beijing 100871, P.R. China Department of Joint Surgery, First Affiliated Hospital of PLA General Hospital, Beijing, 100048, P.R.China.zhanghongmd@163.com. State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China Department of Pharmacology, Key Laboratory of New Drug Screening of Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China. College of Optics and Electronic Science and Technology; China Jiliang University; Hangzhou; China Department of Obstetrics, Yantaishan Hospital Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine Tianjin Medical University, Tianjin, People’s Republic of China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University , Beijing , People’s Republic of China Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China Department of Radiology (H.Z., Y.M.), Tianjin Chest Hospital, China. Department of Rehabilitation Medicine, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, 1279 Sanmen Road, Hongkou District, Shanghai 200434, P.R. China Phase I Clinical Trial Unit, The First Hospital of Jilin University, Jilin, China Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, P.R. China Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, and Integrated Genomics, Inc., Chicago, Illinois 60612 Department of Materials Science and Engineering; National University of Singapore; Singapore 117574; Singapore Department of Orthodontics, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China; Dental and Craniofacial Research Institute, School of Dentistry, University of California, Los Angeles, CA, 90095, USA Department of Obstetrics and Gynecology, First and Second Affiliated Hospital of Soochow University, Municipal Hospital, Suzhou, China School of Materials and Energy, Electron Microscopy Centre of Lanzhou University and Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000, PR China Program on Apoptosis and Cell Death Regulation, The Burnham Institute, La Jolla, CA 92037 The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China Wilmar (Shanghai) Biotechnology Research & Development Center Co. Ltd., Shanghai 200137, China From the Section of Hematology/Oncology, the Department of Pediatrics, Children's Hospital of Pittsburgh; the Department of Molecular Genetics and Biochemistry, the University of Pittsburgh Medical Center; and the University of Pittsburgh Cancer Institute, Pittsburgh, PA. Center for Genetic Epidemiology and Genomics, School of Public Health Medical College of Soochow University Jiangsu China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health Medical College of Soochow University Jiangsu China Department of Immunology, Tianjin Medical University, Tianjin, China Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China Phase I Clinical Trial Unit, First Hospital, Jilin University Jilin China School of Medicine, Department of Medical Sciences, Örebro University, Fakultetsgatan 1, 701 82 Örebro, Sweden;n Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Thoracic Medical Oncology Peking University Cancer Hospital & Institute Beijing China Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China. Department of Animal Nutrition and Feed Science, College of Animal Science and Technology Huazhong Agricultural University Wuhan P. R. China Department of Chemistry Tulane University New Orleans LA 70118 USA Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University & Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen 361021, China Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China School of Pharmaceutical Science, Shandong University, Jinan 250012, China; Yuxi Municipal Hospital of Traditional Chinese Medicine, Yuxi 653100, China Department of Shanghai Children's Hospital Shanghai Jiaotong University Shanghai China Electron Microscopy Centre of Lanzhou University, School of Materials and Energy Lanzhou University Lanzhou Gansu 730000 China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Zhejiang University Medical PET Center; Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine Department of Hepatobiliary Surgery, Xijing Hospital The Fourth Military Medical University Xi'an China Department of Pharmacy, Wuhan First Hospital, Wuhan, China National Laboratory for Molecular Sciences; Center for Molecular Sciences; State Key Laboratory for Structural Chemistry of Unstable and Stable Species; Institute of Chemistry; Chinese Academy of Sciences Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences Peking University Health Science Center Beijing P.R. China Department of Colorectal Surgery, Shengjing Hospital of China Medical University, Shenyang 110022, China. School of Electrical Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China, 710049. Department of Nuclear Medicine, Second Affiliated Hospital of Sun Yat-Sen University, Guangdong, China. Department of Heavy Ion Radiation Medicine; Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences; Lanzhou, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province; Lanzhou, China Department of Biomedical Engineering, Shanghai Jiaotong University. Central Laboratory, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing, P. R. China Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Key Laboratory of Environmental Toxicology and Pollution Control Technology of Anhui Province, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China, and Department of Neonatal Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, P. R. China College of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China, and Centre for Computational Molecular Science, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Qld 4072, Brisbane, Australia Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University Chengdu 61064 P. R. China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of the Chinese Academy of Sciences, Beijing, China College of Chemistry Sichuan University Chengdu 610064 China State Key Laboratory of Fine Chemicals, School of Chemistry Dalian University of Technology Dalian China Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. Department of Clinical Medicine Changchun Medical College Changchun China Divison of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China Center of Smart Laboratory and Molecular Medicine, Medical School, Chongqing University, Chongqing 400044, China; Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China. Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Hebei Engineering University, Handan 056002, China. zh720716@sina.com Department of Pharmacy Fuyang People's Hospital of AHMU Anhui Medical University Fuyang 236000 China Department of Colorectal Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China Radiology Department, Tianjin Chest Hospital, Tianjin, China. State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China.; State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China. Department of Colorectal Tumor Surgery, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhanghong1203@yahoo.com.cn State Key Laboratory of Luminescence and Applications; Changchun Institute of Optics; Fine Mechanics and Physics; Chinese Academy of Sciences; Changchun 130033, China State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150040, P. R. China Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 P. R. China Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China; CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Lanzhou 730000, Gansu, China; Gansu Wuwei Tumor Hospital, Department of Science and Technology, Wuwei 733000, Gansu, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Institute of Modern Physics, Lanzhou 730000, Gansu, China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China Department of Biologic and Materials Sciences School of Dentistry University of Michigan Ann Arbor MI USA Institute of Atomic and Molecular Physics and ‡School of Physical Science & Technology, Sichuan University, Chengdu, Sichuan Province, P. R. C. Liaocheng People's Hospital; Liaocheng 252000; PR China ISIS Pharmaceuticals, Inc., Carlsbad, California 92008 Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan; Department of Mechanical and Automation Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR China; Micro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan Dr. Zhang a postdoctoral fellow, Dental Research Lab, Department of Orthodontic and Pediatric Dentistry and University of Michigan School of Dentistry, Ann Arbor, Mich., USA. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Nursing Department, Peking University Cancer Hospital & Institute, Beijing, China Hubei Longzhong Laboratory, Wuhan University of Technology (Xiangyang Demonstration Zone), Xiangyang 441000, Hubei, P. R. China; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, Hubei, P. R. China 1Maxim Pharmaceuticals, Inc., San Diego, California and SINO‐US Diagnostics Tianjin China Department Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China Academy of Agricultural Sciences in Henan, Zhengzhou 450002, China. angela9922@sina.com Department of Orthopaedic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu Province, China Department of Laboratory Medicine, University of California, San Francisco, California 94143-0134 College of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China Department of Anesthesiology the First Hospital of Lanzhou University Lanzhou China Department of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Renal Division, Peking University First Hospital, Beijing 100034, China; Kidney Genetics Center, Peking University Institute of Nephrology, Beijing 100034, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing 100034, China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing 100034, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100034, China College of Acupuncture and Tuina, Guangzhou University of Chinese Medicine, Guangdong, China Department of Pharmaceutical, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland) Department of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, China Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China Phase I Clinical Unit, China-Frontage USA, The First Hospital of Jilin University Department of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Laboratory of Photonics and Interfaces Institute of Chemical Sciences and Engineering École Polytechnique Fédérale de Lausanne Lausanne Switzerland Department of Ophthalmology, Sino-Singapore Eco-City Hospital of Tianjin Medical University, Sino-Singapore Eco-City, Tianjin, China (mainland) Department of Obstetrics and Gynecology People's Hospital of Shayang County Jingmen China Department of Radiology, Affiliated Jiangning Hospital of Nanjing Medical University, China (H.Z.). School of Cyber Security and Computer, Hebei University, Baoding, Hebei, China Department of Biotechnology Technical University of Denmark Building 221 DK‐2800 Lyngby Denmark Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China. University Women's Hospital, Basel, Switzerland School of Materials and Energy Electron Microscopy Centre Lanzhou University 730000 Lanzhou China Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA. Department of Neurology, The Second Hospital of Shandong University Jinan, Shandong Province, 250033, China. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China School and Hospital of Stomatology, Jilin University, Changchun, Jilin, China (mainland) College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, People's Republic of China. Taub Institute for Research of Alzheimer’s Disease and the Aging Brain, Columbia University, 630 W 168th Street, New York, New York 10032, United States Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R & D of Fine Chemicals of Guizhou University Guiyang 550025 China Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana Department of Science and Education, People's Hospital of Deyang City, Sichuan, China Department of Physiology Life Science and Biopharmaceutical Institution Shenyang Pharmaceutical University Shenyang P.R. China State Key Laboratory on Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 10085, China Naicher New Materials (Yingkou) Co., Ltd., Yingkou 115004, China Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, People's Republic of China; Department of Laboratory Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China State Key Laboratory of Fire Science, Department of Safety Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China Department of Phase I Clinical Trial Unit First Hospital of Jilin University Changchun Jilin China Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation & Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, People’s Republic of China Pathology and Laboratory Medicine, School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300350 China Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Tianjin Chest Hospital, Tianjin, China Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA Organ Transplantation Center, Xiangya Hospital, Central South University, Changsha 410008, China. Shenzhen University Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China Teaching and Research Office of Forensic Medicine; Hubei University of Chinese Medicine; Wuhan 430065; P.R.China Dept. of Stomatology, Dalian Medical University, Dalian 116044, China. BioCentrum‐DTU Technical University of Denmark Building 227 Kgs. Lyngby 2800 Denmark School of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China Public Health Clinical Center of Chengdu Chengdu China Department of Laboratory Medicine, University of California at San Francisco , San Francisco, California, USA Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, and Department of Chemistry, Stellenbosch University, Matieland 7602, South Africa Department of Rheumatism Immunity Nanyang Central Hospital Nanyang China Email: zh80008@163.com. School of Marine Science and Technology, Harbin Institute of Technology (WeiHai), Weihai, Shandong, China CAS Key Laboratory of Forest Ecology and Management, Institute of Applied Ecology, Chinese Academy of Sciences , Shenyang 110016, China Institute of Modern Physics, Chinese Academy of Sciences, 730000 Lanzhou, China Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655; and Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University (TWIns), 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan; Consolidated Research Institute for Advanced Science and Medical Care, Waseda University (ASMeW), 513 Waseda Tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan Department of Hepatology, First Hospital, Jilin University, Changchun, Jilin 130021, China. Unilever Research & Development Centre Shanghai, Shanghai 200335, China Department of Nephrology, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA Harvard Stem Cell Institute, Harvard Medical School, Boston, MA; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Condensed Matter Science and Technology Institute; School of Instrumentation Science and Engineering; Harbin Institute of Technology; Harbin 150080; China Jilin Medical University, Jilin, China Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China Tongji University Shanghai China; Institute of Medical Genetics Tongji University Shanghai China Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China (Email: zhangh9@yahoo.com). Maxim Pharmaceuticals, Inc., 6650 Nancy Ridge Drive, San Diego, California 92121, and Shire Biochem Inc., 275 Armand-Frappier Blvd., Laval, Quebec H7V 4A7, Canada Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, Netherlands Department of Hematology & Oncology, The 155th Central Hospital of PLA/The Key Laboratory of Hematology of Kaifeng City, Kaifeng, China Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin, China (mainland) Department of Head and Neck Cancers, West China Hospital, Sichuan University, Chengdu 610041, China Department of Rheumatology The First People's Hospital of Yunnan Province Kunming China Department of Pediatrics, Linyi Traditional Chinese Medical Hospital, Linyi, China Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital Tongji University School of Medicine Shanghai China; Institute of Medical Genetics Tongji University Shanghai China Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, P. R. China; Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P. R. China Department of Neurology, Suzhou First People’s Hospital, Suzhou, Anhui Province, China Department of Nuclear Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China †Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037 Department of Medical Biomaterials Engineering, School of Medical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, Republic of Korea Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, China Authors' Affiliations: Departments of 1Cell and Developmental Biology and 2Information Service Research Computing Group, University of Massachusetts Medical School, Worcester, Massachusetts 1] Institute of Biophysics, Chinese Academy of Sciences, #15, Datun Rd., Beijing, 100101, China [2]. Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. National Time Service Center, Lintong, Xian, Shaanxi, China Department of Ophthalmology, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. dr_zhanghong@sina.com Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China School of Electrical Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, P.R. China School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China Department of Anesthesiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China The Cardiac Department, The First Hospital of Yunnan Province, Kunming 650034, China Authors' Affiliations: 1Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; 2Department of Oncology and Clinical and Experiment Medicine, Linköping University, Linköping; 3Department of Biomedicine, University of Skövde; and 4Department of Oncology, Karolinska University Hospital, Stockholm, Sweden The Chinese Traditional Medicine Hospital of Fangshan District, Beijing, China Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease; Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China Department of Pharmaceutical Botany, School of Pharmacy Second Military Medical University Shanghai 200433 PR China Departments of Pathology, Peking University First Hospital, Beijing, P.R. China Condensed Matter Science and Technology Institute, and Department of Physics School of Science Harbin Institute of Technology Harbin 150080 PR China National Institute of Biological Sciences, Beijing 102206, People's Republic of China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cailun Road 1200, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Cailun Road 1200, Shanghai 201203, China University of California, Department of Molecular Biology and Biochemistry, 3205 Bio Sci II, Irvine, CA 92697-3900; and Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9038 Department of Ophthalmology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China The First Affiliated Hospital Health Center and School of Management, University of Science and Technology of China, Hefei, 230026, People's Republic of China School of Chemistry and Chemical Engineering, Harbin Institute of Technology Harbin Heilongjiang 150001 China Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA. Senior Department of Orthopedics, Fourth Medical Center of Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Orthopedics, Sports Medical and Rehabilitation, Beijing, China Department of Anesthesiology, Peking University People’s Hospital, Beijing, China College of Life Sciences, Liaoning Normal University Dalian China School of Plant Protection, Anhui Agricultural University, Hefei, Anhui, China Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390; Renal Division, Peking University First Hospital, Peking University Institute of Nephrology , Beijing , China; Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education , Beijing , China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing , China Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, and The College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China National Institute of Sericultural and Entomological Science, Tsukuba,1; Department of Pediatrics, University of Tsukuba, Ibaraki,2 Japan 1Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana and 22nd Hospital of Jilin University, Jilin University, Changchun, Jilin, People's Republic of China; 1Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana and 22nd Hospital of Jilin University, Jilin University, Changchun, Jilin, People's Republic of China Second Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China. Van't Hoff Institute for Molecular Sciences; University of Amsterdam; 1098 XH Amsterdam, The Netherlands State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Pathology Stanford University School of Medicine Stanford CA USA Chinese Academy of Sciences, Institute of Biophysics, National Laboratory of Biomacromolecules, Beijing, China. Department of Cell Biology, Vanderbilt Cancer Center, Vanderbilt University Key Lab of Ministry of Education for Protection and Utilization of Special Biological, Resources in Western China, Ningxia University; School of Life Science, Ningxia University Acupuncture & Rehabilitation Clinical Medicine College Guangzhou University of Chinese Medicine Guangzhou China Department of Chemistry, Linköping University, SE-581 83 Linköping, Sweden, Department of Cell and Molecular Biology, BMC, Uppsala University, Box 596, SE-751 24 Uppsala, Sweden, Medivir AB, Lunastigen 7, SE-141 44 Huddinge, Sweden, Department of Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box 574, SE-751 23 Uppsala, Sweden, and Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden Beijing Anzhen Hospital, Capital University of Medicine, Beijing 100029, China. Shanxi Institute for Food and Drug Control, Taiyuan, China College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong, China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Institute of Forestry and Pomology Beijing Academy of Agriculture and Forestry Sciences Beijing China; Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (North China) Ministry of Agriculture Beijing China Department of Biochemistry and Molecular Biology and Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA; Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, China School of Traditional Chinese Materia Medica; Shenyang Pharmaceutical University; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University); Ministry of Education; Shenyang 110016 Institute of Atomic and Molecular Physics; Sichuan University; Chengdu 610065; China; College of Physical Science and Technology Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 Department of Polymer Science, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China; Haihe Laboratory of Sustainable Chemical Transformations, Tianjin, 300192, China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China Department of Blood Transfusion Medicine, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, China. Department of Biology and §Department of Chemistry, New York University, New York, New York 10003, United States Departments of Pediatrics, Microbiology and Immunology, and Pathology, Dalhousie University , Halifax, Nova Scotia, Canada Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden, MTC, Center for Microbiology and Tumorbiology, The Karolinska Institute, Stockholm, Sweden, and Department of Molecular Biology, Uppsala University, S-751 24 Uppsala, Sweden Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China Shaanxi Research Station of Crop Gene Resources and Germplasm Enhancement, Ministry of Agriculture, Yangling, Shaanxi, China; College of Agronomy, Northwest A&F University, Yangling, Shaanxi, China Department of Traditional Chinese Medicine, The Bishan Hospital of Chongqing Department of Cardiac Surgery The Affiliated Hospital of Qingdao University, Qingdao University Qingdao China College of Tobacco Science; Henan Agricultural University; Zhengzhou; China Neurology Department, Shaanxi Provincial People’s Hospital, Xi’an, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Guangxi Collaborative Innovation Center for Biomedicine & Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment, Life Science Institute, Guangxi Medical University, Nanning, Guangxi, China Pathology Department of Pathophysiology, Medical College of Tongji University, Shanghai 200331, China. ZhangHongxue2@263.net Tianjin Key Laboratory of Low-Dimensional Materials; Physics and Preparing Technology; Faculty of Science; Tianjin University; Tianjin 300072, P. R. China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China. dr_zhanghong@sina.com Department of Medical Oncology, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, Shandong 271000, P.R. China Institute of Modern Physics Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province Lanzhou Gansu China Department of Biochemistry and Molecular Biology, College of Life Science, Sichuan Normal University , Chengdu , China Jet Propulsion Laboratory California Institute of Technology Pasadena CA USA Department of Chemistry, Southern University of Science and Technology, Xueyuan Blvd 1088, Shenzhen, 518055, China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China College of Environment and Resource, Shanxi University, Taiyuan, People’s Republic of China School of Environment School of Marine Science and Technology (Weihai) Harbin Institute of Technology Harbin Heilongjiang 150090 P.R. China; State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin 150090 P.R. China Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Teaching and Research Office of Forensic Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan 430065, People’s Republic of China Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands University Women's Hospital Basel and Research Department of University Hospital, CH-4031 Basel, Switzerland. hzhang@uhbs.ch State Key Laboratory of Natural Medicines and Laboratory of Chemical BiologyChina Pharmaceutical University Nanjing China Department of Clinical Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, 200062 Shanghai, China Department of Endodontics and Periodontics, College of Stomatology, Dalian Medical University, Dalian, Liaoning Province, China Wuhan University Renmin Hospital, Wuhan, China School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai, Shandong 264209, P. R. China Department of Gastroenterology; The Second Hospital of Hebei Medical University; Hebei Key Laboratory of Gastroenterology; Hebei Institute of Gastroenterology; Shijiazhuang China Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining, Anhui University of Science and Technology, Huainan, Anhui 232001, P.R. China Lundbeck Research USA, Paramus, NJ, USA Department of Statistics and Finance, School of Management University of Science and Technology of China Hefei PR China Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland) School of Mathematics, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China Materials Directorate, Air Force Research Laboratory (AFRL/MLPO), Wright-Patterson Air Force Base, Ohio 45433-7707, and Department of Chemistry (M/C 111), 845 West Taylor Street, University of Illinois at Chicago, Chicago, Illinois 60607 College of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, China (mainland) Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China State Key Laboratory of Fine Chemicals, School of Life Science and Technology, Dalian University of Technology, Dalian, People’s Republic of China Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease; School of Public Health; Soochow University; Suzhou; PR China Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China Department of Hepatobiliary Pancreatic Surgery, The First People’s Hospital of Qujing City, Yunnan Province (Qujing Hospital Affiliated to Kunming Medical University), Qujing 655000, China BioCentrum‐DTU Technical University of Denmark Building 221, Kgs 2800 Lyngby Denmark School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China. Renal Division of Peking University First Hospital, Beijing, China Dental and Craniofacial Research Institute, University of California, Los Angeles, Los Angeles, California. General Surgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China. Department of Pediatric Surgery, The Affiliated Hospital of Medical College Qing Dao University 16 Jiangsu Road 266003 Qing Dao City China Renal Division, Department of Medicine, Peking University First Hospital , Beijing 100034 , China; Renal Pathology Center, Institute of Nephrology, Peking University , Beijing 100034 , China; Key Laboratory of Renal Disease, Ministry of Health of China , Beijing 100034 , China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China , Beijing 100034 , China; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing 100034 , China Key Laboratory of Urban Agriculture (North) of Ministry of Agriculture; Beijing University of Agriculture; Beijing 102206; China Environmental Sciences Division (ESD), Oak Ridge National Laboratory (ORNL), P.O. Box 2008, Oak Ridge, Tennessee 37831-6038, and Oak Ridge Associated Universities (ORAU), P.O. Box 117, Oak Ridge, Tennessee 37831-0117 Department of Neonatology, Dali Bai Autonomous Prefecture Maternal and Child Health Care Hospital, Dali, China ZH720716@sina.com Department of Chemical Engineering and Key Laboratory of Advanced Materials of Ministry of Education, Tsinghua University, Beijing 100084, People’s Republic of China National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, 610064, China Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Research Center for Analytical Sciences, College of Chemistry Nankai University, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology Tianjin 300071 People's Republic of China University of Washington Seattle WA 98195‐5061 USA College of Environment and Resource Science, Shanxi University, Taiyuan 030006, China. State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, People’s Republic of China; School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150090, People’s Republic of China Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital No. 28 Fuxing Road Beijing 100853 China Central Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, China.; Central Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, China. Key Laboratory of Virtual Geographic Environment, Ministry of Education, Nanjing Normal University, Nanjing 210046, China. zhanghong1987@hotmail.com School of Physical Science and Technology & Key Laboratory for Magnetism and Magnetic Materials of MoE & Key Laboratory of Special Function Materials and Structure Design MoE & National & Local Joint Engineering Laboratory for Optical Conversion Materials and Technology Lanzhou University Lanzhou 730000 P. R. China; Electron Microscopy Centre School of Physical Science and Technology Lanzhou University Lanzhou 730000 P. R. China Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China

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