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bibliographicCitation Zhang J, Yang C, Tang P, Chen J, Zhang D, Li Y, Yang G, Liu Y, Zhang Y, Wang Y, Liu J, Ouyang L. Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy. J Med Chem. 2022 May 12;65(9):6803–25. doi: 10.1021/acs.jmedchem.2c00135. PMID: 35442700.
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date 2022-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://doi.org/10.1021/acs.jmedchem.2c00135
https://pubmed.ncbi.nlm.nih.gov/35442700
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language English
source https://pubmed.ncbi.nlm.nih.gov/
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title Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080957_AID1909138_PMID35442700_VALUE36
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482069738_AID1909137_PMID35442700_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482064645_AID1909137_PMID35442700_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103769588_AID1909171_PMID35442700_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482082947_AID1909138_PMID35442700_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075923_AID1909137_PMID35442700_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482085695_AID1909138_PMID35442700_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909157_PMID35442700_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909233_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909187_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076534_AID1909135_PMID35442700_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482064199_AID1909137_PMID35442700_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076534_AID1909137_PMID35442700_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081948_AID1909138_PMID35442700_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909146_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081948_AID1909137_PMID35442700_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080359_AID1909135_PMID35442700_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062713_AID1909137_PMID35442700_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909222_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482060717_AID1909136_PMID35442700_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909161_PMID35442700_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482064645_AID1909138_PMID35442700_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909149_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079932_AID1909135_PMID35442700_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909212_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909150_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052089_AID1909137_PMID35442700_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074939_AID1909138_PMID35442700_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062713_AID1909136_PMID35442700_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482065199_AID1909138_PMID35442700_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909138_PMID35442700_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076534_AID1909136_PMID35442700_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909145_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909142_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088052_AID1909137_PMID35442700_VALUE47
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079932_AID1909138_PMID35442700_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087285_AID1909135_PMID35442700_VALUE45
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482064199_AID1909136_PMID35442700_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909155_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068668_AID1909137_PMID35442700_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050708_AID1909136_PMID35442700_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909147_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482065205_AID1909135_PMID35442700_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909185_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081948_AID1909135_PMID35442700_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050708_AID1909137_PMID35442700_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909222_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088283_AID1909135_PMID35442700_VALUE48
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068836_AID1909135_PMID35442700_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909224_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051795_AID1909136_PMID35442700_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482084385_AID1909138_PMID35442700_VALUE43
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909227_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909133_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909154_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909206_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909180_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080359_AID1909138_PMID35442700_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068854_AID1909137_PMID35442700_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909203_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076534_AID1909138_PMID35442700_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482082947_AID1909135_PMID35442700_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482083893_AID1909136_PMID35442700_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062713_AID1909135_PMID35442700_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074594_AID1909138_PMID35442700_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062078_AID1909138_PMID35442700_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909213_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068668_AID1909135_PMID35442700_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482055939_AID1909136_PMID35442700_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909195_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051795_AID1909135_PMID35442700_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909230_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074757_AID1909137_PMID35442700_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909134_PMID35442700_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074594_AID1909136_PMID35442700_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063564_AID1909137_PMID35442700_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068854_AID1909138_PMID35442700_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087285_AID1909138_PMID35442700_VALUE45
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909174_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103605183_AID1909228_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482083893_AID1909137_PMID35442700_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909151_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909144_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075923_AID1909138_PMID35442700_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088052_AID1909138_PMID35442700_VALUE47
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482085695_AID1909136_PMID35442700_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482060627_AID1909137_PMID35442700_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080359_AID1909137_PMID35442700_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909135_PMID35442700_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909224_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052089_AID1909138_PMID35442700_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081584_AID1909135_PMID35442700_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482083893_AID1909138_PMID35442700_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074757_AID1909136_PMID35442700_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051795_AID1909137_PMID35442700_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909209_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068836_AID1909137_PMID35442700_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050708_AID1909138_PMID35442700_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909200_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056168_AID1909135_PMID35442700_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909201_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056168_AID1909138_PMID35442700_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909137_PMID35442700_VALUE49
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087921_AID1909135_PMID35442700_VALUE46
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063564_AID1909136_PMID35442700_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909165_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909167_PMID35442700_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081584_AID1909138_PMID35442700_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087285_AID1909136_PMID35442700_VALUE45
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068082_AID1909135_PMID35442700_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909156_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909219_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909231_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482055939_AID1909138_PMID35442700_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482049971_AID1909138_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081975_AID1909135_PMID35442700_VALUE40
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909196_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909190_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076083_AID1909135_PMID35442700_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103605183_AID1909177_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482088284_AID1909207_PMID35442700_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482082947_AID1909137_PMID35442700_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482081584_AID1909137_PMID35442700_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482065199_AID1909136_PMID35442700_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909168_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482060881_AID1909135_PMID35442700_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909218_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482074757_AID1909138_PMID35442700_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909235_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482068836_AID1909136_PMID35442700_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909183_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909153_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482075862_AID1909216_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482060717_AID1909138_PMID35442700_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242552531_AID1909164_PMID35442700_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051795_AID1909138_PMID35442700_VALUE4
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID10038
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID23476
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID142

Total number of triples: 390.