| abstract |
3-anilino-2-cycloalkenone derivatives represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these: wherein R1 represents optionally substituted C1-8 alkyl (excluding methyl), cycloalkyl, 3-tetrahydrofuryl, 2-indanyl, etc.; R2 represents C1-4 alkyl; R3 represents H, optionally substituted C1-5 alkyl, C3-7 cycloalkyl, etc.; R4 represents H, optionally substituted C1-5 alkyl, halogeno, etc.; R5, R6, R7 and R8 each independently represents H, optionally substituted C1-5 alkyl, etc.; and X represents -(CR11R12)n - (where n is 0 to 2, and R11 and R12 each independently represents H, optionally substituted C1-5 alkyl, etc.) or -NR13- (where R13 represents H or optionally substituted C1-5 alkyl). |