abstract |
The invention provides an improved process for the preparation of 17-esters of 9α,21-dihalo-pregnane-11β,17α-diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids according to the above-mentioned scheme, wherein RCO, R1, X, Y and the dotted line are as defined in the specification. The novel process is especially suitable for the preparation of Mometasone Furoate. |