| abstract |
The present invention relates to benzimidazole derivatives of formula (I) wherein: R1 represents H, C¿1-4? alkyl, C3-5 cycloalkyl; R?2¿ represents H, C¿1-4? alkyl; or R?1 and R2¿ together form with the nitrogen a 4 or 5 membered heterocyclic ring; R3 represents BR4 or R4 wherein B represents a bridging group -C(O)NH-, -C(O)NC¿1-4?alkyl-, or -C(O)O- and R?4¿ represents H, C¿1-4?alkyl, C2-6alkenyl or halo (preferably fluoro); and each n is an integer independently selected from 0, 1, or 2 (preferably 0 or 1); and geometric isomers or mixtures thereof; and physiologically functional derivatives thereof, and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to their preparation and pharmaceutical formulations containing them. |