| abstract |
Novel calcitonin derivatives represented by general formula (I) of pharmacologically acceptable salts thereof, wherein Z represents Gly or Cys; Xs are the same or different and each represents an α-amino acid residue; Y represents natural calcitonin, a natural calcitonin partial peptide or a natural calcitonin-analogous peptide residue; m is an integer of 5 to 8; and n is an integer of 0 to 3, provided that when m is 5, then the sequence of four residues on the C-terminal side of -(X)m- differs from the sequence of the residues at the 3- to 6-positions of natural calcitonin. |