| abstract |
NEW MATERIAL:A polypeptide of formula I (A is lower alkylene or phenylene; B is NHCO, S, etc.; D is lower alkylene; E is Ser residue, beta-Ala residue, etc.; F is Val residue, Gly residue, etc.; G is Lys residue, Ala residue, etc.; H is His residue, Glu residue, etc.; I is Lys residue, Gly residue, etc.; J is Yry residue, Leu residue, etc.; K is Arg residue, Asn residue, etc.; (l-n), (p-t) are 0 or 1; but when (l) is 0, A is not methylene, and when (m) is 0, A is phenylene), a salt and complex thereof. EXAMPLE:A compound of formula II. USE:A treating agent for born Paget's disease, etc., an analgesic, an anti-ulcer drug, etc. The polypeptide of formula I has an excellent Ca concentration- lowering activity, etc., in blood superior to natural calcitonin and is highly stable. PREPARATION:The polypeptide of formula I is synthesized according to the amino acid sequence of formula I by a known peptide synthetic method. |